Hypoxia lowers SLC30A8/ZnT8 expression and free cytosolic Zn2+ in pancreatic beta cells

Diabetologia

Volumn 57, Issue 8, 2014, Pages 1635-1644

  Gerber, Philipp A ^a,b   Bellomo, Elisa A ^a   Hodson, David J ^a   Meur, Gargi ^a   Solomou, Antonia ^a   Mitchell, Ryan K ^a   Hollinshead, Michael ^a   Chimienti, Fabrice ^c   Bosco, Domenico ^d   Hughes, Stephen J ^e,f   Johnson, Paul R V ^e,f   Rutter, Guy A ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c Mellitech   (France)

^d GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^e UNIVERSITY OF OXFORD   (United Kingdom)

^f NIHR OXFORD BIOMEDICAL RESEARCH CENTRE   (United Kingdom)

Author keywords

Hypoxia; Metallothionein; Type 2 diabetes; Zinc; Zinc transporter

Indexed keywords

INSULIN; MESSENGER RNA; METALLOTHIONEIN I; METALLOTHIONEIN II; OXYGEN; ZINC; CATION TRANSPORT PROTEIN; METALLOTHIONEIN; SLC30A8 PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL HYPOXIA; CELL SURVIVAL; CONTROLLED STUDY; CYTOSOLIC FRACTION; FEMALE; GENE; GENE EXPRESSION; GENE INDUCTION; GENETIC POLYMORPHISM; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; MALE; METALLOTHIONEIN I GENE; METALLOTHIONEIN II GENE; MOUSE; NONHUMAN; OXYGEN TENSION; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SECRETORY GRANULE; WESTERN BLOTTING; ZINC TRANSPORTER 8 GENE; ANIMAL; ANOXIA; CYTOSOL; GENETICS; METABOLISM;

ANIMALS; ANOXIA; CATION TRANSPORT PROTEINS; CYTOSOL; HUMANS; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; METALLOTHIONEIN; MICE; RATS; ZINC;

EID: 84904717362     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-014-3266-0     Document Type: Article

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