Oxygenation of islets and its role in transplantation

Current Opinion in Organ Transplantation

Volumn 14, Issue 6, 2009, Pages 688-693

  Lau, Joey ^a   Henriksnäs, Johanna ^a   Svensson, Johanna ^a   Carlsson, Per Ola ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Engraftment; Islet transplantation; Oxygenation; Pancreatic islets

Indexed keywords

ACETYLCYSTEINE; ALKANE; ALPHA 1 ANTITRYPSIN; ANGIOGENIC FACTOR; ANTIOXIDANT; ENDOSTATIN; FIBROBLAST GROWTH FACTOR; GELATINASE B; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; OXYGEN; PERFLUORODECALIN; PERFLUOROHEXYLOCTANE; REACTIVE OXYGEN METABOLITE; SCATTER FACTOR; THROMBOSPONDIN; THROMBOSPONDIN 1; TISSUE INHIBITOR OF METALLOPROTEINASE; VASCULOTROPIN A;

AEROBIC METABOLISM; BONE MARROW CELL; CELL DEATH; CELL FUNCTION; CELL SURVIVAL; HEMATOPOIETIC STEM CELL; HYPOXIA; IN VITRO STUDY; KIDNEY CAPSULE; MESENCHYMAL STEM CELL; NONHUMAN; OXYGEN CONSUMPTION; OXYGEN TENSION; OXYGENATION; PANCREAS ISLET; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL; PANCREAS ISLET TRANSPLANTATION; REVASCULARIZATION; REVIEW; SWINE;

ANIMALS; CELL DEATH; CELL HYPOXIA; HUMANS; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; OXYGEN; OXYGEN CONSUMPTION; TISSUE AND ORGAN HARVESTING; TISSUE CULTURE TECHNIQUES;

EID: 74349094977     PISSN: 10872418     EISSN: 15317013     Source Type: Journal    
DOI: 10.1097/MOT.0b013e32833239ff     Document Type: Review

References (48)

1. Bonner-Weir S. The microvasculature of the pancreas, with emphasis on that of the islets of Langerhans. 2nd ed. The pancreas: biology, pathobiology and disease. In: Liang,VW, DiMagno, EP, Gardner et al., editors. New York: Raven Press Ltd; 1993. pp. 759-768.
2. Lifson N, Kramlinger KG, Mayrand RR, Lender EJ. Blood flow to the rabbit pancreas with special reference to the islets of Langerhans. Gastroenterology 1980; 79:466-473.
3. Carlsson PO, Liss P, Andersson A, Jansson L. Measurements of oxygen tension in native and transplanted rat pancreatic islets. Diabetes 1998; 47:1027-1032.
4. Carlsson PO, Olsson R, Kallskog O, et al. Glucose-induced islet blood flow increase in rats: Interaction between nervous and metabolic mediators. Am J Physiol Endocrinol Metab 2002; 283:E457-E464.
5. Carlsson PO, Jansson L, Palm F. Unaltered oxygen tension in rat pancreatic islets despite dissociation of insulin release and islet blood flow. Acta Physiol Scand 2002; 176:275-281.
6. Olsson R. The microvasculature of endogenous and transplanted pancreatic islets. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine Uppsala, Sweden; 2006. pp. 1-83.
7. Sekine N, Cirulli V, Regazzi R, et al. Low lactate dehydrogenase and high mitochondrial glycerol phosphate dehydrogenase in pancreatic beta-cells. Potential role in nutrient sensing. J Biol Chem 1994; 269:4895-4902.
8. Li X, Chen H, Epstein PN. Metallothionein protects islets from hypoxia and extends islet graft survival by scavenging most kinds of reactive oxygen species. J Biol Chem 2004; 279:765-771.
9. Bertuzzi F, Marzorati S, Maffi P, et al. Tissue factor and CCL2/monocyte chemoattractant protein-1 released by human islets affect islet engraftment in type 1 diabetic recipients. J Clin Endocrinol Metab 2004; 89:5724-5728.
10. Mattsson G, Jansson L, Carlsson PO. Decreased vascular density in mouse pancreatic islets after transplantation. Diabetes 2002; 51:1362-1366.
11. Carlsson PO, Palm F, Andersson A, Liss P. Markedly decreased oxygen tension in transplanted rat pancreatic islets irrespective of the implantation site. Diabetes 2001; 50:489-495.
12. Lau J, Carlsson PO. Low revascularization of human islets when experimentally transplanted into the liver. Transplantation 2009; 87:322-325.
13. Iwanaga Y, Sutherland DE, Harmon JV, Papas KK. Pancreas preservation for pancreas and islet transplantation. Curr Opin Organ Transplant 2008; 13:135-141.
14. Brandhorst H, Muehling B, Yamaya H, et al. New class of oxygen carriers improves islet isolation from long-term stored rat pancreata. Transplant Proc 2008; 40:393-394.
15. Brandhorst H, Theisinger B, Yamaya H, et al. Perfluorohexyloctane improves long-term storage of pancreata for subsequent islet isolation. Transplant Int 2009; 22:1017-1022.
16. Hoerauf H, Kobuch K, Dresp J, Menz DH. Combined use of partially fluorinated alkanes, perfluorocarbon liquids and silicone oil: An experimental study. Graefes Arch Clin Exp Ophthalmol 2001; 239:373-381.
17. Iken M, Brandhorst H, Korsgren O, Brandhorst D. Pig pancreas oxygenation at 208C increases islet ATP generation but deteriorates islet function. Cell Transplant (in press).
18. Avgoustiniatos ES, Colton CK. Effect of external oxygen mass transfer resistances on viability of immunoisolated tissue. Ann N Y Acad Sci 1997; 831:145-167.
19. Olsson R, Carlsson PO. Oxygenation of cultured pancreatic islets. Adv Exp Med Biol 2006; 578:263-268.
20. Avgoustiniatos ES, Hering BJ, Rozak PR, et al. Commercially available gaspermeable cell culture bags may not prevent anoxia in cultured or shipped islets. Transplant Proc 2008; 40:395-400.
21. Ortsater H, Liss P, Lund PE, et al. Oscillations in oxygen tension and insulin release of individual pancreatic ob/ob mouse islets. Diabetologia 2000; 43:1313-1318.
22. Ma N, Chalmers JJ, Aunins JG, et al. Quantitative studies of cell-bubble interactions and cell damage at different pluronic F-68 and cell concentrations. Biotechnol Prog 2004; 20:1183-1191.
23. Rozak PR, Weegman BP, Avgoustiniatos ES, et al. Devices and methods for maintenance of temperature and pressure during islet shipment. Transplant Proc 2008; 40:407-410.
24. Papas KK, Avgoustiniatos ES, Tempelman LA, et al. High-density culture of human islets on top of silicone rubber membranes. Transplant Proc 2005; 37:3412-3414.
25. Biarnes M, Montolio M, Nacher V, et al. Beta-cell death and mass in syngeneically transplanted islets exposed to short- and long-term hyperglycemia. Diabetes 2002; 51:66-72.
26. Davalli AM, Scaglia L, Zangen DH, et al. Vulnerability of islets in the immediate posttransplantation period. Dynamic changes in structure and function. Diabetes 1996; 45:1161-1167.
27. Miao G, Ostrowski RP, Mace J, et al. Dynamic production of hypoxia-inducible factor-1alpha in early transplanted islets. Am J Transplant 2006; 6:2636-2643.
28. Ko SH, Ryu GR, Kim S, et al. Inducible nitric oxide synthase-nitric oxide plays an important role in acute and severe hypoxic injury to pancreatic beta cells. Transplantation 2008; 85:323-330.
29. Eizirik DL, Pipeleers DG, Ling Z, et al. Major species differences between humans and rodents in the susceptibility to pancreatic beta-cell injury. Proc Natl Acad Sci U S A 1994; 91:9253-9256.
30. Ryu GR, Lee MK, Lee E, et al. Activation of AMP-activated protein kinase mediates acute and severe hypoxic injury to pancreatic beta cells. Biochem Biophys Res Commun 2009; 386:356-362.
31. Arteel GE, Thurman RG, Yates JM, Raleigh JA. Evidence that hypoxia markers detect oxygen gradients in liver: Pimonidazole and retrograde perfusion of rat liver. Br J Cancer 1995; 72:889-895.
32. Moberg L, Johansson H, Lukinius A, et al. Production of tissue factor by pancreatic islet cells as a trigger of detrimental thrombotic reactions in clinical islet transplantation. Lancet 2002; 360:2039-2045.
33. Menger MD, Jaeger S, Walter P, et al. Angiogenesis and hemodynamics of microvasculature of transplanted islets of Langerhans. Diabetes 1989; 38 (Suppl 1):199-201.
34. Dionne KE, Colton CK, Yarmush ML. Effect of oxygen on isolated pancreatic tissue. ASAIO Trans 1989; 35:739-741.
35. Papas KK, Long RC Jr, Constantinidis I, Sambanis A. Effects of oxygen on metabolic and secretory activities of beta TC3 cells. Biochim Biophys Acta 1996; 1291:163-166.
36. Carlsson PO, Kiuru A, Nordin A, et al. Microdialysis measurements demonstrate a shift to nonoxidative glucose metabolism in rat pancreatic islets transplanted beneath the renal capsule. Surgery 2002; 132:487-494.
37. Carlsson PO, Nordin A, Palm F. pH is decreased in transplanted rat pancreatic islets. Am J Physiol Endocrinol Metab 2003; 284:E499-E504.
38. Ahn YB, Xu G, Marselli L, et al. Changes in gene expression in beta cells after islet isolation and transplantation using laser-capture microdissection. Diabetologia 2007; 50:334-342.
39. Lau J, Mattsson G, Carlsson C, et al. Implantation site-dependent dysfunction of transplanted pancreatic islets. Diabetes 2007; 56:1544-1550.
40. Zhang N, Richter A, Suriawinata J, et al. Elevated vascular endothelial growth factor production in islets improves islet graft vascularization. Diabetes 2004; 53:963-970.
41. Kim HA, Lee BW, Kang D, et al. Delivery of hypoxia-inducible VEGF gene to rat islets using polyethylenimine. J Drug Target 2009; 17:1-9.
42. Lee BW, Chae HY, Tuyen TT, et al. A comparison of nonviral vectors for gene delivery to pancreatic beta-cells: Delivering a hypoxia-inducible vascular endothelial growth factor gene to rat islets. Int J Mol Med 2009; 23:757-762.
43. Contreras JL, Smyth CA, Eckstein C, et al. Peripheral mobilization of recipient bone marrow-derived endothelial progenitor cells enhances pancreatic islet revascularization and engraftment after intraportal transplantation. Surgery 2003; 134:390-398.
44. Miller R, Cirulli V, Diaferia GR, et al. Switching-on survival and repair response programs in islet transplants by bone marrow-derived vasculogenic cells. Diabetes 2008; 57:2402-2412.
45. Olerud J, Johansson M, Lawler J, et al. Improved vascular engraftment and graft function after inhibition of the angiostatic factor thrombospondin-1 in mouse pancreatic islets. Diabetes 2008; 57:1870-1877.
46. Johansson M, Olerud J, Jansson L, Carlsson PO. Prolactin treatment improves engraftment and function of transplanted pancreatic islets. Endocrinology 2009; 150:1646-1653.
47. Johansson U, Rasmusson I, Niclou SP, et al. Formation of composite endothelial cell-mesenchymal stem cell islets: A novel approach to promote islet revascularization. Diabetes 2008; 57:2393-2401.
48. Lau J, Kampf C, Mattsson G, et al. Beneficial role of pancreatic microenvironment for angiogenesis in transplanted pancreatic islets. Cell Transplantation 2009; 18:23-30.