Orexin-1 receptor mediates the increased food and water intake induced by intracerebroventricular injection of the stable somatostatin pan-agonist, ODT8-SST in rats

Neuroscience Letters

Volumn 576, Issue , 2014, Pages 88-92

  Karasawa, Hiroshi ^a,b   Yakabi, Seiichi ^a,b   Wang, Lixin ^a,b   Taché, Yvette ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VA GREATER LOS ANGELES HEALTHCARE SYSTEM   (United States)

Author keywords

Food intake; ODT8 SST; Orexin A; SB 334867; Somatostatin 2 receptor; Water intake

Indexed keywords

1 (2 METHYL 6 BENZOXAZOLYL) 3 (1,5 NAPHTHYRIDIN 4 YL)UREA; ANOREXIGENIC AGENT; APPETITE STIMULANT; DIMETHYL SULFOXIDE; ODT8 SST; OREXIN 1 RECEPTOR; OREXIN A; SODIUM CHLORIDE; SOMATOSTATIN DERIVATIVE; UNCLASSIFIED DRUG; 1-(2-METHYLBENZOXAZOL-6-YL)-3-(1,5)NAPHTHYRIDIN-4-YL UREA; BENZOXAZOLE DERIVATIVE; DES-AA(1,4-6,11-13)-(4-NITROPHENYLALANYL(2)-CYSTEINYL(3)-TYROSYL(7)-4-AMINOPHENYLALANYLCARBAMOYL(8)-SOMATOSTATIN-3-(2-NAPHTHYL)-ALANINAMIDE; HCRTR1 PROTEIN, RAT; NEUROPEPTIDE; OCTREOTIDE; OREXIN RECEPTOR; OREXINS; PEPTIDE FRAGMENT; SIGNAL PEPTIDE; SOMATOSTATIN; SOMATOSTATIN RECEPTOR; SOMATOSTATIN, OCTAPEPTIDE-TRP(8)-; UREA;

ADULT; ANIMAL EXPERIMENT; APPETITE; ARTICLE; CONNECTOME; CONTROLLED STUDY; FLUID INTAKE; FOOD INTAKE; LIGHT DARK CYCLE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; THIRST; AGONISTS; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; DRINKING; DRUG EFFECTS; EATING; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; SPRAGUE DAWLEY RAT;

ANIMALS; BENZOXAZOLES; DRINKING; EATING; INJECTIONS, INTRAVENTRICULAR; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; NEUROPEPTIDES; OCTREOTIDE; OREXIN RECEPTORS; PEPTIDE FRAGMENTS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SOMATOSTATIN; SOMATOSTATIN; UREA;

EID: 84904707199     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2014.05.063     Document Type: Article

References (43)

1. Viollet C., Lepousez G., Loudes C., Videau C., Simon A., Epelbaum J. Somatostatinergic systems in brain: networks and functions. Mol. Cell. Endocrinol. 2008, 286:75-87.
2. Finley J.C., Maderdrut J.L., Roger L.J., Petrusz P. The immunocytochemical localization of somatostatin-containing neurons in the rat central nervous system. Neuroscience 1981, 6:2173-2192.
3. Guillemin R. Hypothalamic hormones a.k.a. hypothalamic releasing factors. J. Endocrinol. 2005, 184:11-28.
4. Patel Y.C. Somatostatin and its receptor family. Front. Neuroendocrinol. 1999, 20:157-198.
5. Erchegyi J., Grace C.R., Samant M., Cescato R., Piccand V., Riek R., Reubi J.C., Rivier J.E. Ring size of somatostatin analogues (ODT-8) modulates receptor selectivity and binding affinity. J. Med. Chem. 2008, 51:2668-2675.
6. Stengel A., Coskun T., Goebel M., Wang L., Craft L., Alsina-Fernandez J., Rivier J., Tache Y. Central injection of the stable somatostatin analog ODT8-SST induces a somatostatin2 receptor-mediated orexigenic effect: role of neuropeptide Y and opioid signaling pathways in rats. Endocrinology 2010, 151:4224-4235.
7. Stengel A., Goebel M., Wang L., Rivier J., Kobelt P., Monnikes H., Tache Y. Selective central activation of somatostatin receptor 2 increases food intake, grooming behavior and rectal temperature in rats. J. Physiol. Pharmacol. 2010, 61:399-407.
8. Cescato R., Erchegyi J., Waser B., Piccand V., Maecke H.R., Rivier J.E., Reubi J.C. Design and in vitro characterization of highly sst2-selective somatostatin antagonists suitable for radiotargeting. J. Med. Chem. 2008, 51:4030-4037.
9. Matsuki T., Sakurai T. Orexins and orexin receptors: from molecules to integrative physiology. Results Probl. Cell Differ. 2008, 46:27-55.
10. Date Y., Ueta Y., Yamashita H., Yamaguchi H., Matsukura S., Kangawa K., Sakurai T., Yanagisawa M., Nakazato M. Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems. Proc. Nat. Acad. Sci. U.S.A. 1999, 96:748-753.
11. Sakurai T., Amemiya A., Ishii M., Matsuzaki I., Chemelli R.M., Tanaka H., Williams S.C., Richardson J.A., Kozlowski G.P., Wilson S., Arch J.R., Buckingham R.E., Haynes A.C., Carr S.A., Annan R.S., McNulty D.E., Liu W.S., Terrett J.A., Elshourbagy N.A., Bergsma D.J., Yanagisawa M. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 1998, 92:573-585.
12. Hagan J.J., Leslie R.A., Patel S., Evans M.L., Wattam T.A., Holmes S., Benham C.D., Taylor S.G., Routledge C., Hemmati P., Munton R.P., Ashmeade T.E., Shah A.S., Hatcher J.P., Hatcher P.D., Jones D.N., Smith M.I., Piper D.C., Hunter A.J., Porter R.A., Upton N. Orexin A activates locus coeruleus cell firing and increases arousal in the rat. Proc. Nat. Acad. Sci. U.S.A. 1999, 96:10911-10916.
13. Hervieu G.J., Cluderay J.E., Harrison D.C., Roberts J.C., Leslie R.A. Gene expression and protein distribution of the orexin-1 receptor in the rat brain and spinal cord. Neuroscience 2001, 103:777-797.
14. Kunii K., Yamanaka A., Nambu T., Matsuzaki I., Goto K., Sakurai T. Orexins/hypocretins regulate drinking behaviour. Brain Res. 1999, 842:256-261.
15. Smart D., Sabido-David C., Brough S.J., Jewitt F., Johns A., Porter R.A., Jerman J.C. SB-334867-A: the first selective orexin-1 receptor antagonist. Br. J. Pharmacol. 2001, 132:1179-1182.
16. Haynes A.C., Jackson B., Chapman H., Tadayyon M., Johns A., Porter R.A., Arch J.R. A selective orexin-1 receptor antagonist reduces food consumption in male and female rats. Regul. Pept. 2000, 96:45-51.
17. Horvath T.L., Diano S., van den Pol A.N. Synaptic interaction between hypocretin (orexin) and neuropeptide Y cells in the rodent and primate hypothalamus: a novel circuit implicated in metabolic and endocrine regulations. J. Neurosci. 1999, 19:1072-1087.
18. Yamanaka A., Kunii K., Nambu T., Tsujino N., Sakai A., Matsuzaki I., Miwa Y., Goto K., Sakurai T. Orexin-induced food intake involves neuropeptide Y pathway. Brain Res. 2000, 859:404-409.
19. Hajdu I., Obal F., Gardi J., Laczi F., Krueger J.M. Octreotide-induced drinking, vasopressin, and pressure responses: role of central angiotensin and ACh. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2000, 279:R271-R277.
20. Kay K., Parise E.M., Lilly N., Williams D.L. Hindbrain orexin 1 receptors influence palatable food intake, operant responding for food, and food-conditioned place preference in rats. Psychopharmacology (Berl) 2014, 231:419-427.
21. Stengel A., Goebel-Stengel M., Wang L., Luckey A., Hu E., Rivier J., Tache Y. Central administration of pan-somatostatin agonist ODT8-SST prevents abdominal surgery-induced inhibition of circulating ghrelin, food intake and gastric emptying in rats. Neurogastroenterol. Motil. 2011, 23:e294-e308.
22. Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates 2007, Academic Press, San Diego, CA.
23. Bulbul M., Babygirija R., Ludwig K., Takahashi T. Central orexin-A increases gastric motility in rats. Peptides 2010, 31:2118-2122.
24. Lopez M., Seoane L.M., Garcia Mdel C., Dieguez C., Senaris R. Neuropeptide Y, but not agouti-related peptide or melanin-concentrating hormone, is a target peptide for orexin-A feeding actions in the rat hypothalamus. Neuroendocrinology 2002, 75:34-44.
25. Yoshida Y., Fujiki N., Nakajima T., Ripley B., Matsumura H., Yoneda H., Mignot E., Nishino S. Fluctuation of extracellular hypocretin-1 (orexin A) levels in the rat in relation to the light-dark cycle and sleep-wake activities. Eur. J. Neurosci. 2001, 14:1075-1081.
26. Parise E.M., Lilly N., Kay K., Dossat A.M., Seth R., Overton J.M., Williams D.L. Evidence for the role of hindbrain orexin-1 receptors in the control of meal size. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2011, 301:R1692-R1699.
27. Backberg M., Hervieu G., Wilson S., Meister B. Orexin receptor-1 (OX-R1) immunoreactivity in chemically identified neurons of the hypothalamus: focus on orexin targets involved in control of food and water intake. Eur. J. Neurosci. 2002, 15:315-328.
28. van den Top M., Lee K., Whyment A.D., Blanks A.M., Spanswick D. Orexigen-sensitive NPY/AgRP pacemaker neurons in the hypothalamic arcuate nucleus. Nat. Neurosci. 2004, 7:493-494.
29. Jain M.R., Horvath T.L., Kalra P.S., Kalra S.P. Evidence that NPY Y1 receptors are involved in stimulation of feeding by orexins (hypocretins) in sated rats. Regul. Pept. 2000, 87:19-24.
30. Csaba Z., Simon A., Helboe L., Epelbaum J., Dournaud P. Targeting sst2A receptor-expressing cells in the rat hypothalamus through in vivo agonist stimulation: neuroanatomical evidence for a major role of this subtype in mediating somatostatin functions. Endocrinology 2003, 144:1564-1573.
31. Dournaud P., Gu Y.Z., Schonbrunn A., Mazella J., Tannenbaum G.S., Beaudet A. Localization of the somatostatin receptor SST2A in rat brain using a specific anti-peptide antibody. J. Neurosci. 1996, 16:4468-4478.
32. Goebel M., Stengel A., Wang L., Coskun T., Alsina-Fernandez J., Rivier J., Tache Y. Pattern of Fos expression in the brain induced by selective activation of somatostatin receptor 2 in rats. Brain Res. 2010, 1351:150-164.
33. Xie X., Crowder T.L., Yamanaka A., Morairty S.R., Lewinter R.D., Sakurai T., Kilduff T.S. GABA(B) receptor-mediated modulation of hypocretin/orexin neurones in mouse hypothalamus. J. Physiol. 2006, 574:399-414.
34. Meyer D.K., Conzelmann U., Schultheiss K. Effects of somatostatin-14 on the in vitro release of [3H]GABA from slices of rat caudatoputamen. Neuroscience 1989, 28:61-68.
35. Scharfman H.E., Schwartzkroin P.A. Selective depression of GABA-mediated IPSPs by somatostatin in area CA1 of rabbit hippocampal slices. Brain Res. 1989, 493:205-211.
36. Edwards C.M., Abusnana S., Sunter D., Murphy K.G., Ghatei M.A., Bloom S.R. The effect of the orexins on food intake: comparison with neuropeptide Y, melanin-concentrating hormone and galanin. J. Endocrinol. 1999, 160:R7-R12.
37. Thorpe A.J., Mullett M.A., Wang C., Kotz C.M. Peptides that regulate food intake: regional, metabolic, and circadian specificity of lateral hypothalamic orexin A feeding stimulation. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2003, 284:R1409-R1417.
38. Espana R.A., Plahn S., Berridge C.W. Circadian-dependent and circadian-independent behavioral actions of hypocretin/orexin. Brain Res. 2002, 943:224-236.
39. Johnson R.F., Johnson A.K. Meal-related and rhythmic drinking: effects of abolition of rat's eating rhythm. Am. J. Physiol. 1991, 261:R14-R19.
40. Fitzsimons T.J., Le Magnen J. Eating as a regulatory control of drinking in the rat. J. Comp. Physiol. Psychol. 1969, 67:273-283.
41. Fitzsimons J.T. Angiotensin, thirst, and sodium appetite. Physiol. Rev. 1998, 78:583-686.
42. Oatley K. Dissociation of the circadian drinking pattern from eating. Nature 1971, 229:494-496.
43. Stanley B.G., Leibowitz S.F. Neuropeptide Y: stimulation of feeding and drinking by injection into the paraventricular nucleus. Life Sci. 1984, 35:2635-2642.