Selective central activation of somatostatin receptor 2 increases food intake, grooming behavior and rectal temperature in rats

Journal of Physiology and Pharmacology

Volumn 61, Issue 4, 2010, Pages 399-407

  Stengel, A ^a   Goebel, M ^a   Wang, L ^a   Rivier, J ^b   Kobelt, P ^c   Monnikes, H ^d   Tache, Y ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d MARTIN LUTHER KRANKENHAUS   (Germany)

Author keywords

Behavior; Body temperature; Feeding; Food intake; Gastric emptying; Grooming; Rat; Somatostatin; Somatostatin receptor 2

Indexed keywords

PEPTIDE DERIVATIVE; SOMATOSTATIN RECEPTOR 2;

ADULT ANIMAL; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRINKING BEHAVIOR; FEEDING; FOOD INTAKE; GROOMING; LIGHT DARK CYCLE; LOCOMOTION; MALE; NONHUMAN; RAT; RECTUM TEMPERATURE; STOMACH EMPTYING; THERMOREGULATION;

ANIMALS; BODY TEMPERATURE; BRAIN; EATING; GASTRIC EMPTYING; GROOMING; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SOMATOSTATIN; SOMATOSTATIN;

EID: 77956175010     PISSN: 08675910     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (62)

1. Brazeau P, Vale W, Burgus R, et al. Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone. Science 1973; 179: 77-79.
2. Brown M, Taché Y. Hypothalamic peptides: central nervous system control of visceral functions. Fed Proc 1981; 40: 2565-2569.
3. Guillemin R. Hypothalamic hormones a.k.a. hypothalamic releasing factors. J Endocrinol 2005; 184: 11-28.
4. Danguir J. Food intake in rats is increased by intracerebroventricular infusion of the somatostatin analogue SMS 201-995 and is decreased by somatostatin antiserum. Peptides 1988; 9: 211-213.
5. Feifel D, Vaccarino FJ. Central somatostatin: a re-examination of its effects on feeding. Brain Res 1990; 535: 189-194.
6. Tachibana T, Cline MA, Sugahara K, et al. Central administration of somatostatin stimulates feeding behavior in chicks. Gen Comp Endocrinol 2009; 161: 354-359.
7. Feifel D, Vaccarino FJ, Rivier J, Vale WW. Evidence for a common neural mechanism mediating growth hormonereleasing factor-induced and somatostatin-induced feeding. Neuroendocrinology 1993; 57: 299-305.
8. Rezek M, Havlicek V, Hughes KR, Friesen H. Central site of action of somatostatin (SRIF): role of hippocampus. Neuropharmacology 1976; 15: 499-504.
9. Lin MT, Chen JJ, Ho LT. Hypothalamic involvement in the hyperglycemia and satiety actions of somatostatin in rats. Neuroendocrinology 1987; 45: 62-67.
10. Vijayan E, McCann SM. Suppression of feeding and drinking activity in rats following intraventricular injection of thyrotropin releasing hormone (TRH). Endocrinology 1977; 100: 1727-1730.
11. Aponte G, Leung P, Gross D, Yamada T. Effects of somatostatin on food intake in rats. Life Sci 1984; 35: 741-746.
12. Cummings SL, Truong BG, Gietzen DW. Neuropeptide Y and somatostatin in the anterior piriform cortex alter intake of amino acid-deficient diets. Peptides 1998; 19: 527-535.
13. Tannenbaum GS, Patel YC. On the fate of centrally administered somatostatin in the rat: massive hypersomatostatinemia resulting from leakage into the peripheral circulation has effects on growth hormone secretion and glucoregulation. Endocrinology 1986; 118: 2137-2143.
14. de la Cour CD, Norlen P, Hakanson R. Secretion of ghrelin from rat stomach ghrelin cells in response to local microinfusion of candidate messenger compounds: a microdialysis study. Regul Pept 2007; 143: 118-126.
15. Silva AP, Bethmann K, Raulf F, Schmid HA. Regulation of ghrelin secretion by somatostatin analogs in rats. Eur J Endocrinol 2005; 152: 887-894.
16. Patel YC. Somatostatin and its receptor family. Front Neuroendocrinol 1999; 20: 157-198.
17. Vanetti M, Kouba M, Wang X, et al. Cloning and expression of a novel mouse somatostatin receptor (SSTR2B). FEBS Lett 1992; 311: 290-294.
18. Leroux P, Bucharles C, Bologna E, Vaudry H. des-AA-1,2,5[D-Trp8, IAmp9]somatostatin-14 allows the identification of native rat somatostatin sst1 receptor subtype. Eur J Pharmacol 1997; 337: 333-336.
19. Schulz S, Handel M, Schreff M, et al. Localization of five somatostatin receptors in the rat central nervous system using subtype-specific antibodies. J Physiol (Paris) 2000; 94: 259-264.
20. Moller LN, Stidsen CE, Hartmann B, Holst JJ. Somatostatin receptors. Biochim Biophys Acta 2003; 1616: 1-84.
21. Fehlmann D, Langenegger D, Schuepbach E, et al. Distribution and characterisation of somatostatin receptor mRNA and binding sites in the brain and periphery. J Physiol (Paris) 2000; 94: 265-281.
22. Stepanyan Z, Kocharyan A, Pyrski M, et al. Leptin-target neurones of the rat hypothalamus express somatostatin receptors. J Neuroendocrinol 2003; 15: 822-830.
23. Csaba Z, Simon A, Helboe L, et al. Targeting sst2A receptorexpressing cells in the rat hypothalamus through in vivo agonist stimulation: neuroanatomical evidence for a major role of this subtype in mediating somatostatin functions. Endocrinology 2003; 144: 1564-1573.
24. Grace CR, Erchegyi J, Koerber SC, et al. Novel sst2-selective somatostatin agonists. Three-dimensional consensus structure by NMR. J Med Chem 2006; 49: 4487-4496.
25. Wolkenberg SE, Thut CJ. Recent progress in the discovery of selective, non-peptide ligands of somatostatin receptors. Curr Opin Drug Discov Devel 2008; 11: 446-457.
26. Stepanyan Z, Kocharyan A, Behrens M, et al. Somatostatin, a negative-regulator of central leptin action in the rat hypothalamus. J Neurochem 2007; 100: 468-478.
27. Rezek M, Havlicek V, Leybin L, et al. Neostriatal administration of somatostatin: differential effect of small and large doses on behavior and motor control. Can J Physiol Pharmacol 1977; 55: 234-242.
28. Lin MT, Uang WN, Ho LT, et al. Somatostatin: a hypothalamic transmitter for thermoregulation in rats. Pflugers Arch 1989; 413: 528-532.
29. Hoyer D, Bell GI, Berelowitz M, et al. Classification and nomenclature of somatostatin receptors. Trends Pharmacol Sci 1995; 16: 86-88.
30. Yoneda M, Raybould H, Tache Y. Central action of somatostatin analog, SMS 201-995, to stimulate gastric acid secretion in rats. Peptides 1991; 12: 401-406.
31. Cescato R, Erchegyi J, Waser B, et al. Design and in vitro characterization of highly sst2-selective somatostatin antagonists suitable for radiotargeting. J Med Chem 2008; 51: 4030-4037.
32. Martinez V, Taché Y. Role of CRF receptor 1 in central CRFinduced stimulation of colonic propulsion in rats. Brain Res 2001; 893: 29-35.
33. Paxinos G, Watson, C. The Rat Brain in Stereotaxic Coordinates. San Diego, Academic Press, 2007.
34. Ishikawa Y, Shimatsu A, Murakami Y, Imura H. Barrel rotation in rats induced by SMS 201-995: suppression by ceruletide. Pharmacol Biochem Behav 1990; 37: 523-526.
35. Martinez V, Barquist E, Rivier J, Tache Y. Central CRF inhibits gastric emptying of a nutrient solid meal in rats: the role of CRF2 receptors. Am J Physiol 1998; 274: G965-970.
36. Burke RE, Fahn S. Studies of somatostatin-induced barrel rotation in rats. Regul Pept 1983; 7: 207-220.
37. Vecsei L, Pavo I, Zsigo J, et al. Comparative studies of somatostatin-14 and some of its fragments on passive avoidance behavior, open field activity and on barrel rotation phenomenon in rats. Peptides 1989; 10: 1153-1157.
38. Lamberts SW, van der Lely AJ, de Herder WW, Hofland LJ. Octreotide. N Engl J Med 1996; 334: 246-254.
39. Rosenwasser AM, Boulos Z, Terman M. Circadian organization of food intake and meal patterns in the rat. Physiol Behav 1981; 27: 33-39.
40. Lawrence CB, Snape AC, Baudoin FM, Luckman SM. Acute central ghrelin and GH secretagogues induce feeding and activate brain appetite centers. Endocrinology 2002; 143: 155-162.
41. Asakawa A, Inui A, Kaga T, et al. Ghrelin is an appetitestimulatory signal from stomach with structural resemblance to motilin. Gastroenterology 2001; 120: 337-345.
42. Lawrence CB, Baudoin FM, Luckman SM. Centrally administered galanin-like peptide modifies food intake in the rat: a comparison with galanin. J Neuroendocrinol 2002; 14: 853-860.
43. Konturek SJ, Konturek JW, Lamers CB, et al. Role of secretin and CCK in the stimulation of pancreatic secretion in conscious dogs. Effects of atropine and somatostatin. Int J Pancreatol 1987; 2: 223-235.
44. Kim MS, Rossi M, Abbott CR, et al. Sustained orexigenic effect of Agouti related protein may be not mediated by the melanocortin 4 receptor. Peptides 2002; 23: 1069-1076.
45. Schwartz MW, Woods SC, Porte D, Jr, et al. Central nervous system control of food intake. Nature 2000; 404: 661-671.
46. Lanneau C, Peineau S, Petit F, et al. Somatostatin modulation of excitatory synaptic transmission between periventricular and arcuate hypothalamic nuclei in vitro. J Neurophysiol 2000; 84: 1464-1474.
47. Stengel A, Goebel M, Wang L, Tache Y. Ghrelin, des-acyl ghrelin and nesfatin-1 in gastric X/A-like cells: role as regulators of food intake and body weight. Peptides 2010; 31: 357-369.
48. Stengel A, Coskun T, Goebel M, et al. Central injection of the stable somatostatin analog, ODT8-SST induces a somatostatin2 receptor mediated orexigenic effect: role of neuropeptide Y and opioid signaling pathways in rats. Endocrinology 2010; in press.
49. Mundinger TO, Cummings DE, Taborsky GJ, Jr. Direct stimulation of ghrelin secretion by sympathetic nerves. Endocrinology 2006; 147: 2893-2901.
50. Somiya H, Tonoue T. Neuropeptides as central integrators of autonomic nerve activity: effects of TRH, SRIF, VIP and bombesin on gastric and adrenal nerves. Regul Pept 1984; 9: 47-52.
51. Fisher DA, Brown MR. Somatostatin analog: plasma catecholamine suppression mediated by the central nervous system. Endocrinology 1980; 107: 714-718.
52. Gardi J, Obal F, Jr, Fang J, et al. Diurnal variations and sleep deprivation-induced changes in rat hypothalamic GHRH and somatostatin contents. Am J Physiol 1999; 277: R1339-R1344.
53. Allen JP, Hathway GJ, Clarke NJ, et al. Somatostatin receptor 2 knockout/lacZ knockin mice show impaired motor coordination and reveal sites of somatostatin action within the striatum. Eur J Neurosci 2003; 17: 1881-1895.
54. Viollet C, Vaillend C, Videau C, et al. Involvement of sst2 somatostatin receptor in locomotor, exploratory activity and emotional reactivity in mice. Eur J Neurosci 2000; 12: 3761-3770.
55. Brown M, Ling N, Rivier J. Somatostatin-28, somatostatin-14 and somatostatin analogs: effects on thermoregulation. Brain Res 1981; 214: 127-135.
56. Erchegyi J, Waser B, Schaer JC, et al. Novel sst(4)-selective somatostatin (SRIF) agonists. 3. Analogues amenable to radiolabeling. J Med Chem 2003; 46: 5597-5605.
57. Lawrence CB, Rothwell NJ. Anorexic but not pyrogenic actions of interleukin-1 are modulated by central melanocortin-3/4 receptors in the rat. J Neuroendocrinol 2001; 13: 490-495.
58. Suto G, Kiraly A, Tache Y. Interleukin 1 beta inhibits gastric emptying in rats: mediation through prostaglandin and corticotropin-releasing factor. Gastroenterology 1994; 106: 1568-1575.
59. Brown MR, Fisher LA. Central nervous system actions of somatostatin-related peptides. Adv Exp Med Biol 1985; 188: 217-228.
60. Ao Y, Go VL, Toy N, et al. Brainstem thyrotropin-releasing hormone regulates food intake through vagal-dependent cholinergic stimulation of ghrelin secretion. Endocrinology 2006; 147: 6004-6010.
61. Maeda-Hagiwara M, Tache Y. Central nervous system action of TRH to stimulate gastric emptying in rats. Regul Pept 1987; 17: 199-207.
62. Martinez V, Rivier J, Coy D, Tache Y. Intracisternal injection of somatostatin receptor 5-preferring agonists induces a 406 vagal cholinergic stimulation of gastric emptying in rats. J Pharmacol Exp Ther 2000; 293: 1099-1105.