Hindbrain orexin 1 receptors influence palatable food intake, operant responding for food, and food-conditioned place preference in rats

Psychopharmacology

Volumn 231, Issue 2, 2014, Pages 419-427

  Kay, Kristen ^a   Parise, Eric M ^a   Lilly, Nicole ^a   Williams, Diana L ^a  

^a FLORIDA STATE UNIVERSITY   (United States)

Author keywords

Conditioned place preference; High fat food; Hindbrain; Nucleus of the solitary tract; Orexin; Progressive ratio

Indexed keywords

1 (2 METHYL 6 BENZOXAZOLYL) 3 (1,5 NAPHTHYRIDIN 4 YL)UREA; OREXIN 1 RECEPTOR; OREXIN A; SUCROSE; 1-(2-METHYLBENZOXAZOL-6-YL)-3-(1,5)NAPHTHYRIDIN-4-YL UREA; BENZOXAZOLE DERIVATIVE; NEUROPEPTIDE; OREXIN RECEPTOR; OREXINS; SIGNAL PEPTIDE; UREA;

ANIMAL TISSUE; ARTICLE; BRAIN FOURTH VENTRICLE; CONTROLLED STUDY; FOOD CONDITIONED PLACE PREFERENCE; FOOD DEPRIVATION; FOOD INTAKE; FOOD PREFERENCE; FOOD REWARD; LIPID DIET; MALE; MOTIVATION; NONHUMAN; OPERANT BEHAVIORAL TEST; PLACE PREFERENCE; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; REWARD; RHOMBENCEPHALON; SOLITARY TRACT NUCLEUS; TRAINING; AGONISTS; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; DECISION MAKING; DRUG EFFECTS; EATING; INSTRUMENTAL CONDITIONING; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; PHYSIOLOGY; REINFORCEMENT;

ANIMALS; BENZOXAZOLES; CHOICE BEHAVIOR; CONDITIONING, OPERANT; EATING; INFUSIONS, INTRAVENTRICULAR; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; NEUROPEPTIDES; OREXIN RECEPTORS; RATS; REINFORCEMENT SCHEDULE; RHOMBENCEPHALON; SOLITARY NUCLEUS; UREA;

EID: 84892832588     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-013-3248-9     Document Type: Article

References (34)

1. Ammoun S, Holmqvist T, Shariatmadari R, Oonk HB, Detheux M, Parmentier M, Akerman KE, Kukkonen JP (2003) Distinct recognition of OX1 and OX2 receptors by orexin peptides. J Pharmacol Exp Ther 305:507-514. doi: 10.1124/jpet.102.048025
2. Baird JP, Choe A, Loveland JL, Beck J, Mahoney CE, Lord JS, Grigg LA (2009) Orexin-A hyperphagia: hindbrain participation in consummatory feeding responses. Endocrinology 150:1202-1216. doi: 10.1210/en.2008-0293
3. Blevins JE, Stanley BG, Reidelberger RD (2002) DMSO as a vehicle for central injections: tests with feeding elicited by norepinephrine injected into the paraventricular nucleus. Pharmacol Biochem Behav 71:277-282
4. Borgland SL, Chang SJ, Bowers MS, Thompson JL, Vittoz N, Floresco SB, Chou J, Chen BT, Bonci A (2009) Orexin A/hypocretin-1 selectively promotes motivation for positive reinforcers. J Neurosci 29:11215-11225. doi: 10.1523/JNEUROSCI.6096-08.2009
5. Cason AM, Aston-Jones G (2013) Role of orexin/hypocretin in conditioned sucrose-seeking in rats. Psychopharmacology (Berl) 226:155-165. doi: 10.1007/s00213-012-2902-y
6. Cason AM, Smith RJ, Tahsili-Fahadan P, Moorman DE, Sartor GC, Aston-Jones G (2010) Role of orexin/hypocretin in reward-seeking and addiction: implications for obesity. Physiol Behav 100:419-428. doi: 10.1016/j.physbeh. 2010.03.009
7. Choi DL, Davis JF, Fitzgerald ME, Benoit SC (2010) The role of orexin-A in food motivation, reward-based feeding behavior and food-induced neuronal activation in rats. Neuroscience 167:11-20. doi: 10.1016/j.neuroscience.2010.02. 002
8. Choi DL, Davis JF, Magrisso IJ, Fitzgerald ME, Lipton JW, Benoit SC (2012) Orexin signaling in the paraventricular thalamic nucleus modulates mesolimbic dopamine and hedonic feeding in the rat. Neuroscience 210:243-248. doi: 10.1016/j. neuroscience.2012.02.036
9. España RA, Oleson EB, Locke JL, Brookshire BR, Roberts DC, Jones SR (2010) The hypocretin-orexin system regulates cocaine self-administration via actions on the mesolimbic dopamine system. Eur J Neurosci 31:336-348. doi: 10.1111/j.1460-9568.2009.07065.x
10. Figlewicz DP, Higgins MS, Ng-Evans SB, Havel PJ (2001) Leptin reverses sucrose-conditioned place preference in food-restricted rats. Physiol Behav 73:229-234
11. Figlewicz DP, Bennett J, Evans SB, Kaiyala K, Sipols AJ, Benoit SC (2004) Intraventricular insulin and leptin reverse place preference conditioned with high-fat diet in rats. Behav Neurosci 118:479-487. doi: 10.1037/0735-7044.118.3. 479
12. Grill HJ (2010) Leptin and the systems neuroscience of meal size control. Front Neuroendocrinol 31:61-78. doi: 10.1016/j.yfrne.2009.10.005
13. Haynes AC, Jackson B, Overend P, Buckingham RE, Wilson S, Tadayyon M, Arch JR (1999) Effects of single and chronic intracerebroventricular administration of the orexins on feeding in the rat. Peptides 20:1099-1105
14. Hervieu GJ, Cluderay JE, Harrison DC, Roberts JC, Leslie RA (2001) Gene expression and protein distribution of the orexin-1 receptor in the rat brain and spinal cord. Neuroscience 103:777-797
15. Ishii Y, Blundell JE, Halford JC, Upton N, Porter R, Johns A, Rodgers RJ (2004) Differential effects of the selective orexin-1 receptor antagonist SB-334867 and lithium chloride on the behavioural satiety sequence in rats. Physiol Behav 81:129-140. doi: 10.1016/j.physbeh.2004.01.009
16. Marcus JN, Aschkenasi CJ, Lee CE, Chemelli RM, Saper CB, Yanagisawa M, Elmquist JK (2001) Differential expression of orexin receptors 1 and 2 in the rat brain. J Comp Neurol 435:6-25
17. Nair SG, Golden SA, Shaham Y (2008) Differential effects of the hypocretin 1 receptor antagonist SB 334867 on high-fat food self-administration and reinstatement of food seeking in rats. Br J Pharmacol 154:406-416. doi: 10.1038/bjp.2008.3
18. Nowend KL, Arizzi M, Carlson BB, Salamone JD (2001) D1 or D2 antagonism in nucleus accumbens core or dorsomedial shell suppresses lever pressing for food but leads to compensatory increases in chow consumption. Pharmacol Biochem Behav 69:373-382
19. Parise EM, Lilly N, Kay K, Dossat AM, Seth R, Overton JM, Williams DL (2011) Evidence for the role of hindbrain orexin-1 receptors in the control of meal size. Am J Physiol Regul Integr Comp Physiol 301:R1692-R1699. doi: 10.1152/ajpregu.00044.2011
20. Paxinos G, Watson C (2007) The rat brain in stereotaxic coordinates. Academic, New York
21. Peyron C, Tighe DK, van den Pol AN, de Lecea L, Heller HC, Sutcliffe JG, Kilduff TS (1998) Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci 18:9996-10015
22. Porter RA, Chan WN, Coulton S, Johns A, Hadley MS, Widdowson K, Jerman JC, Brough SJ, Coldwell M, Smart D, Jewitt F, Jeffrey P, Austin N (2001) 1,3-Biarylureas as selective non-peptide antagonists of the orexin-1 receptor. Bioorg Med Chem Lett 11:1907-1910
23. Richards JK, Simms JA, Steensland P, Taha SA, Borgland SL, Bonci A, Bartlett SE (2008) Inhibition of orexin-1/hypocretin-1 receptors inhibits yohimbine-induced reinstatement of ethanol and sucrose seeking in Long-Evans rats. Psychopharmacology (Berl) 199:109-117. doi: 10.1007/s00213-008-1136-5
24. Richardson NR, Roberts DC (1996) Progressive ratio schedules in drug self-administration studies in rats: a method to evaluate reinforcing efficacy. J Neurosci Methods 66:1-11
25. Ritter RC, Slusser PG, Stone S (1981) Glucoreceptors controlling feeding and blood glucose: location in the hindbrain. Science 213:451-452
26. Ritter S, Dinh TT, Zhang Y (2000) Localization of hindbrain glucoreceptive sites controlling food intake and blood glucose. Brain Res 856:37-47
27. Sakurai T, Amemiya A, Ishii M, Matsuzaki I, Chemelli RM, Tanaka H, Williams SC, Richarson JA, Kozlowski GP, Wilson S, Arch JR, Buckingham RE, Haynes AC, Carr SA, Annan RS, McNulty DE, Liu WS, Terrett JA, Elshourbagy NA, Bergsma DJ, Yanagisawa M (1998) Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92:1 page following 696
28. Sharf R, Sarhan M, Brayton CE, Guarnieri DJ, Taylor JR, DiLeone RJ (2010) Orexin signaling via the orexin 1 receptor mediates operant responding for food reinforcement. Biol Psychiatry 67:753-760. doi: 10.1016/j.biopsych.2009.12.035
29. Skibicka KP, Shirazi RH, Rabasa-Papio C, Alvarez-Crespo M, Neuber C, Vogel H, Dickson SL (2013) Divergent circuitry underlying food reward and intake effects of ghrelin: dopaminergic VTA-accumbens projection mediates ghrelin's effect on food reward but not food intake. Neuropharmacology 73C:274-283. doi: 10.1016/j.neuropharm.2013.06.004
30. Volkow ND, Wang GJ, Tomasi D, Baler RD (2013) The addictive dimensionality of obesity. Biol Psychiatry. doi: 10.1016/j.biopsych.2012.12.020
31. Williams DL, Baskin DG, Schwartz MW (2009) Hindbrain leptin receptor stimulation enhances the anorexic response to cholecystokinin. Am J Physiol Regul Integr Comp Physiol 297:R1238-R1246. doi: 10.1152/ajpregu.00182.2009
32. Zheng H, Corkern M, Stoyanova I, Patterson LM, Tian R, Berthoud HR (2003) Peptides that regulate food intake: appetite-inducing accumbens manipulation activates hypothalamic orexin neurons and inhibits POMC neurons. Am J Physiol Regul Integr Comp Physiol 284:R1436-R1444. doi: 10.1152/ajpregu.00781.2002
33. Zheng H, Patterson LM, Berthoud HR (2005) Orexin-A projections to the caudal medulla and orexin-induced c-Fos expression, food intake, and autonomic function. J Comp Neurol 485:127-142. doi: 10.1002/cne.20515
34. Zheng H, Patterson LM, Berthoud HR (2007) Orexin signaling in the ventral tegmental area is required for high-fat appetite induced by opioid stimulation of the nucleus accumbens. J Neurosci 27:11075-11082. doi: 10.1523/JNEUROSCI. 3542-07.2007