메뉴 건너뛰기




Volumn 9, Issue 7, 2014, Pages

Leptin increases TNF-α expression and production through phospholipase D1 in raw 264.7 cells

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHOLIPASE C GAMMA; PHOSPHOLIPASE D1; PROTEIN TYROSINE KINASE; S6 KINASE; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; PHOSPHOLIPASE D;

EID: 84904580330     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0102373     Document Type: Article
Times cited : (40)

References (50)
  • 1
    • 0032558725 scopus 로고    scopus 로고
    • Leptin and the regulation of body weight in mammals
    • Friedman JM, Halaas JL (1998) Leptin and the regulation of body weight in mammals. Nature 395: 763-770.
    • (1998) Nature , vol.395 , pp. 763-770
    • Friedman, J.M.1    Halaas, J.L.2
  • 2
    • 0035936764 scopus 로고    scopus 로고
    • Obesity and the regulation of energy balance
    • Spiegelman BM, Flier JS (2001) Obesity and the regulation of energy balance. Cell 104: 531-543.
    • (2001) Cell , vol.104 , pp. 531-543
    • Spiegelman, B.M.1    Flier, J.S.2
  • 6
    • 0035816639 scopus 로고    scopus 로고
    • Leptin induces mitochondrial superoxide production and monocyte chemoattractant protein-1 expression in aortic endothelial cells by increasing fatty acid oxidation via protein kinase A
    • Yamagishi SI, Edelstein D, Du XL, Kaneda Y, Guzman M, et al. (2001) Leptin induces mitochondrial superoxide production and monocyte chemoattractant protein-1 expression in aortic endothelial cells by increasing fatty acid oxidation via protein kinase A. J Biol Chem276: 25096-25100.
    • (2001) J Biol Chem , vol.276 , pp. 25096-25100
    • Yamagishi, S.I.1    Edelstein, D.2    Du, X.L.3    Kaneda, Y.4    Guzman, M.5
  • 7
    • 4143146273 scopus 로고    scopus 로고
    • Leptin augments alveolar macrophage leukotriene synthesis by increasing phospholipase activity and enhancing group IVC iPLA2 (cPLA2gamma) protein expression
    • Mancuso P, Canetti C, Gottschalk A, Tithof PK, Peters-Golden M (2004) Leptin augments alveolar macrophage leukotriene synthesis by increasing phospholipase activity and enhancing group IVC iPLA2 (cPLA2gamma) protein expression. Am J Physiol Lung Cell Mol Physiol 287: L497-502.
    • (2004) Am J Physiol Lung Cell Mol Physiol , vol.287
    • Mancuso, P.1    Canetti, C.2    Gottschalk, A.3    Tithof, P.K.4    Peters-Golden, M.5
  • 8
    • 18944364947 scopus 로고    scopus 로고
    • Leptin promotes differentiation and survival of human dendritic cells and licenses them for Th1 priming
    • Mattioli B, Straface E, Quaranta MG, Giordani L, Viora M (2005) Leptin promotes differentiation and survival of human dendritic cells and licenses them for Th1 priming. J Immunol 174: 6820-6828.
    • (2005) J Immunol , vol.174 , pp. 6820-6828
    • Mattioli, B.1    Straface, E.2    Quaranta, M.G.3    Giordani, L.4    Viora, M.5
  • 10
    • 0028968879 scopus 로고
    • The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase
    • Kern PA, Saghizadeh M, Ong JM, Bosch RJ, Deem R, et al. (1995) The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase. J Clin Invest 95: 2111-2119.
    • (1995) J Clin Invest , vol.95 , pp. 2111-2119
    • Kern, P.A.1    Saghizadeh, M.2    Ong, J.M.3    Bosch, R.J.4    Deem, R.5
  • 11
    • 0025356574 scopus 로고
    • The regulation and cellular functions of phosphatidylcholine hydrolysis
    • Billah MM, Anthes JC (1990) The regulation and cellular functions of phosphatidylcholine hydrolysis. Biochem J 269: 281-291.
    • (1990) Biochem J , vol.269 , pp. 281-291
    • Billah, M.M.1    Anthes, J.C.2
  • 12
    • 0032775581 scopus 로고    scopus 로고
    • Phospholipase D and membrane traffic. Potential roles in regulated exocytosis, membrane delivery and vesicle budding
    • Jones D, Morgan C, Cockcroft S (1999) Phospholipase D and membrane traffic. Potential roles in regulated exocytosis, membrane delivery and vesicle budding. Biochim Biophys Acta 1439: 229-244.
    • (1999) Biochim Biophys Acta , vol.1439 , pp. 229-244
    • Jones, D.1    Morgan, C.2    Cockcroft, S.3
  • 13
    • 0033020811 scopus 로고    scopus 로고
    • Possible role of phospholipase D in cellular differentiation and apoptosis
    • Nakashima S, Nozawa Y (1999) Possible role of phospholipase D in cellular differentiation and apoptosis. Chem Phys Lipids 98: 153-164.
    • (1999) Chem Phys Lipids , vol.98 , pp. 153-164
    • Nakashima, S.1    Nozawa, Y.2
  • 14
    • 67749111839 scopus 로고    scopus 로고
    • House dust mite allergen Der f 2-induced phospholipase D1 activation is critical for the production of interleukin-13 through activating transcription factor-2 activation in human bronchial epithelial cells
    • Park SY, Cho JH, Oh DY, Park JW, Ahn MJ, et al. (2009) House dust mite allergen Der f 2-induced phospholipase D1 activation is critical for the production of interleukin-13 through activating transcription factor-2 activation in human bronchial epithelial cells. J Biol Chem 284: 20099-20110.
    • (2009) J Biol Chem , vol.284 , pp. 20099-20110
    • Park, S.Y.1    Cho, J.H.2    Oh, D.Y.3    Park, J.W.4    Ahn, M.J.5
  • 15
    • 48049124338 scopus 로고    scopus 로고
    • Bradykinin-induced IL-6 expression through bradykinin B2 receptor, phospholipase C, protein kinase Cdelta and NF-kappaB pathway in human synovial fibroblasts
    • Lee CH, Shieh DC, Tzeng CY, Chen CP, Wang SP, et al. (2008) Bradykinin-induced IL-6 expression through bradykinin B2 receptor, phospholipase C, protein kinase Cdelta and NF-kappaB pathway in human synovial fibroblasts. Mol Immunol 45: 3693-3702.
    • (2008) Mol Immunol , vol.45 , pp. 3693-3702
    • Lee, C.H.1    Shieh, D.C.2    Tzeng, C.Y.3    Chen, C.P.4    Wang, S.P.5
  • 16
    • 60949101118 scopus 로고    scopus 로고
    • Involvement of intracellular signaling cascades in inflammatory responses in human intestinal epithelial cells following Vibrio cholerae infection
    • Bandyopadhaya A, Das D, Chaudhuri K (2009) Involvement of intracellular signaling cascades in inflammatory responses in human intestinal epithelial cells following Vibrio cholerae infection. Mol Immunol 46: 1129-1139.
    • (2009) Mol Immunol , vol.46 , pp. 1129-1139
    • Bandyopadhaya, A.1    Das, D.2    Chaudhuri, K.3
  • 17
    • 2942544361 scopus 로고    scopus 로고
    • Up-regulation of phospholipase Cgamma1 and phospholipase D during the differentiation of human monocytes to dendritic cells
    • Kang HK, Lee HY, Lee YN, Jo EJ, Kim JI, et al. (2004) Up-regulation of phospholipase Cgamma1 and phospholipase D during the differentiation of human monocytes to dendritic cells. Int Immunopharmacol 4: 911-920.
    • (2004) Int Immunopharmacol , vol.4 , pp. 911-920
    • Kang, H.K.1    Lee, H.Y.2    Lee, Y.N.3    Jo, E.J.4    Kim, J.I.5
  • 18
    • 0029936331 scopus 로고    scopus 로고
    • Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins
    • Exton JH (1996) Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins. Annu Rev Pharmacol Toxicol 36: 481-509.
    • (1996) Annu Rev Pharmacol Toxicol , vol.36 , pp. 481-509
    • Exton, J.H.1
  • 19
    • 34247477686 scopus 로고    scopus 로고
    • Phospholipase D1 activation through Src and Ras is involved in basic fibroblast growth factor-induced neurite outgrowth of H19-7 cells
    • Oh DY, Park SY, Cho JH, Lee KS, Min do S, et al. (2007) Phospholipase D1 activation through Src and Ras is involved in basic fibroblast growth factor-induced neurite outgrowth of H19-7 cells. J Cell Biochem 101: 221-234.
    • (2007) J Cell Biochem , vol.101 , pp. 221-234
    • Oh, D.Y.1    Park, S.Y.2    Cho, J.H.3    Lee, K.S.4    Min Do, S.5
  • 21
    • 33847393035 scopus 로고    scopus 로고
    • mTOR-dependent synthesis of Bcl-3 controls the retraction of fibrin clots by activated human platelets
    • Weyrich AS, Denis MM, Schwertz H, Tolley ND, Foulks J, et al. (2007) mTOR-dependent synthesis of Bcl-3 controls the retraction of fibrin clots by activated human platelets. Blood 109: 1975-1983.
    • (2007) Blood , vol.109 , pp. 1975-1983
    • Weyrich, A.S.1    Denis, M.M.2    Schwertz, H.3    Tolley, N.D.4    Foulks, J.5
  • 22
    • 0032834055 scopus 로고    scopus 로고
    • eIF4 initiation factors: Effectors of mRNA recruitment to ribosomes and regulators of translation
    • Gingras AC, Raught B, Sonenberg N (1999) eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Annu Rev Biochem 68: 913-963.
    • (1999) Annu Rev Biochem , vol.68 , pp. 913-963
    • Gingras, A.C.1    Raught, B.2    Sonenberg, N.3
  • 23
    • 0344663973 scopus 로고    scopus 로고
    • PLD1 regulates mTOR signaling and mediates Cdc42 activation of S6K1
    • Fang Y, Park IH, Wu AL, Du G, Huang P, et al. (2003) PLD1 regulates mTOR signaling and mediates Cdc42 activation of S6K1. Curr Biol 13: 2037-2044.
    • (2003) Curr Biol , vol.13 , pp. 2037-2044
    • Fang, Y.1    Park, I.H.2    Wu, A.L.3    Du, G.4    Huang, P.5
  • 24
    • 38349174747 scopus 로고    scopus 로고
    • Leptin induces macrophage lipid body formation by a phosphatidylinositol 3-kinase- and mammalian target of rapamycin-dependent mechanism
    • Maya-Monteiro CM, Almeida PE, D'Avila H, Martins AS, Rezende AP, et al. (2008) Leptin induces macrophage lipid body formation by a phosphatidylinositol 3-kinase- and mammalian target of rapamycin-dependent mechanism. J Biol Chem 283: 2203-2210.
    • (2008) J Biol Chem , vol.283 , pp. 2203-2210
    • Maya-Monteiro, C.M.1    Almeida, P.E.2    D'Avila, H.3    Martins, A.S.4    Rezende, A.P.5
  • 25
    • 0034751477 scopus 로고    scopus 로고
    • Leptin stimulates catecholamine synthesis in a PKC-dependent manner in cultured porcine adrenal medullary chromaffin cells
    • Takekoshi K, Ishii K, Nanmoku T, Shibuya S, Kawakami Y, et al. (2001) Leptin stimulates catecholamine synthesis in a PKC-dependent manner in cultured porcine adrenal medullary chromaffin cells. Endocrinology 142: 4861-4871.
    • (2001) Endocrinology , vol.142 , pp. 4861-4871
    • Takekoshi, K.1    Ishii, K.2    Nanmoku, T.3    Shibuya, S.4    Kawakami, Y.5
  • 26
    • 21844468939 scopus 로고    scopus 로고
    • Leptin enhances TNF-alpha production via p38 and JNK MAPK in LPS-stimulated Kupffer cells
    • Shen J, Sakaida I, Uchida K, Terai S, Okita K (2005) Leptin enhances TNF-alpha production via p38 and JNK MAPK in LPS-stimulated Kupffer cells. Life Sci 77: 1502-1515.
    • (2005) Life Sci , vol.77 , pp. 1502-1515
    • Shen, J.1    Sakaida, I.2    Uchida, K.3    Terai, S.4    Okita, K.5
  • 27
    • 43149122023 scopus 로고    scopus 로고
    • A novel role of hippocalcin in bFGF-induced neurite outgrowth of H19-7 cells
    • Oh DY, Cho JH, Park SY, Kim YS, Yoon YJ, et al. (2008) A novel role of hippocalcin in bFGF-induced neurite outgrowth of H19-7 cells. J Neurosci Res 86: 1557-1565.
    • (2008) J Neurosci Res , vol.86 , pp. 1557-1565
    • Oh, D.Y.1    Cho, J.H.2    Park, S.Y.3    Kim, Y.S.4    Yoon, Y.J.5
  • 28
    • 33845261493 scopus 로고
    • A rapid method of total lipid extraction and purification
    • Bligh EG, Dyer WJ (1959) A rapid method of total lipid extraction and purification. Can J Biochem Physiol 37: 911-917.
    • (1959) Can J Biochem Physiol , vol.37 , pp. 911-917
    • Bligh, E.G.1    Dyer, W.J.2
  • 29
    • 78649348967 scopus 로고    scopus 로고
    • Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress
    • Sengupta S, Peterson TR, Sabatini DM (2010) Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress. Mol Cell 40: 310-322.
    • (2010) Mol Cell , vol.40 , pp. 310-322
    • Sengupta, S.1    Peterson, T.R.2    Sabatini, D.M.3
  • 30
    • 79954576972 scopus 로고    scopus 로고
    • Transcriptional control of cellular metabolism by mTOR signaling
    • Yecies JL, Manning BD (2011) Transcriptional control of cellular metabolism by mTOR signaling. Cancer Res 71: 2815-2820.
    • (2011) Cancer Res , vol.71 , pp. 2815-2820
    • Yecies, J.L.1    Manning, B.D.2
  • 32
    • 77949743206 scopus 로고
    • Obesity, airway hyperresponsiveness, and inflammation
    • Shore SA (2010) Obesity, airway hyperresponsiveness, and inflammation. J Appl Physiol (1985) 108: 735-743.
    • (1985) J Appl Physiol , vol.108 , pp. 735-743
    • Shore, S.A.1
  • 33
    • 78650186690 scopus 로고    scopus 로고
    • Leptin potentiates Prevotella intermedia lipopolysaccharide-induced production of TNF-alpha in monocyte-derived macrophages
    • Kim SJ (2010) Leptin potentiates Prevotella intermedia lipopolysaccharide-induced production of TNF-alpha in monocyte-derived macrophages. J Periodontal Implant Sci 40: 119-124.
    • (2010) J Periodontal Implant Sci , vol.40 , pp. 119-124
    • Kim, S.J.1
  • 34
    • 77955510312 scopus 로고    scopus 로고
    • Molecular mechanism underlying the inflammatory complication of leptin in macrophages
    • Vaughan T, Li L (2010) Molecular mechanism underlying the inflammatory complication of leptin in macrophages. Mol Immunol 47: 2515-2518.
    • (2010) Mol Immunol , vol.47 , pp. 2515-2518
    • Vaughan, T.1    Li, L.2
  • 36
    • 27644598295 scopus 로고    scopus 로고
    • Phosphatidylinositol (3,4,5)-trisphosphate specifically interacts with the phox homology domain of phospholipase D1 and stimulates its activity
    • Lee JS, Kim JH, Jang IH, Kim HS, Han JM, et al. (2005) Phosphatidylinositol (3,4,5)-trisphosphate specifically interacts with the phox homology domain of phospholipase D1 and stimulates its activity. J Cell Sci 118: 4405-4413.
    • (2005) J Cell Sci , vol.118 , pp. 4405-4413
    • Lee, J.S.1    Kim, J.H.2    Jang, I.H.3    Kim, H.S.4    Han, J.M.5
  • 37
    • 49549095115 scopus 로고    scopus 로고
    • Lysophosphatidic acid upregulates vascular endothelial growth factor-C and tube formation in human endothelial cells through LPA(1/3), COX-2, and NF-kappaB activation- and EGFR transactivation-dependent mechanisms
    • Lin CI, Chen CN, Huang MT, Lee SJ, Lin CH, et al. (2008) Lysophosphatidic acid upregulates vascular endothelial growth factor-C and tube formation in human endothelial cells through LPA(1/3), COX-2, and NF-kappaB activation- and EGFR transactivation-dependent mechanisms. Cell Signal 20: 1804-1814.
    • (2008) Cell Signal , vol.20 , pp. 1804-1814
    • Lin, C.I.1    Chen, C.N.2    Huang, M.T.3    Lee, S.J.4    Lin, C.H.5
  • 38
    • 45949108853 scopus 로고    scopus 로고
    • The tyrosine kinase Pyk2 mediates lipopolysaccharide-induced IL-8 expression in human endothelial cells
    • Anand AR, Cucchiarini M, Terwilliger EF, Ganju RK (2008) The tyrosine kinase Pyk2 mediates lipopolysaccharide-induced IL-8 expression in human endothelial cells. J Immunol 180: 5636-5644.
    • (2008) J Immunol , vol.180 , pp. 5636-5644
    • Anand, A.R.1    Cucchiarini, M.2    Terwilliger, E.F.3    Ganju, R.K.4
  • 39
    • 0034651941 scopus 로고    scopus 로고
    • Lipopolysaccharide induces actin reorganization and tyrosine phosphorylation of Pyk2 and paxillin in monocytes and macrophages
    • Williams LM, Ridley AJ (2000) Lipopolysaccharide induces actin reorganization and tyrosine phosphorylation of Pyk2 and paxillin in monocytes and macrophages. J Immunol 164: 2028-2036.
    • (2000) J Immunol , vol.164 , pp. 2028-2036
    • Williams, L.M.1    Ridley, A.J.2
  • 40
    • 84883389372 scopus 로고    scopus 로고
    • SHP-1-Pyk2-Src protein complex and p38 MAPK pathways independently regulate IL-10 production in lipopolysaccharide-stimulated macrophages
    • Okenwa C, Kumar A, Rego D, Konarski Y, Nilchi L, et al. (2013) SHP-1-Pyk2-Src protein complex and p38 MAPK pathways independently regulate IL-10 production in lipopolysaccharide-stimulated macrophages. J Immunol 191: 2589-2603.
    • (2013) J Immunol , vol.191 , pp. 2589-2603
    • Okenwa, C.1    Kumar, A.2    Rego, D.3    Konarski, Y.4    Nilchi, L.5
  • 41
    • 38149083478 scopus 로고    scopus 로고
    • Regulation of interleukin-6-induced hepatic insulin resistance by mammalian target of rapamycin through the STAT3-SOCS3 pathway
    • Kim JH, Kim JE, Liu HY, Cao W, Chen J (2008) Regulation of interleukin-6-induced hepatic insulin resistance by mammalian target of rapamycin through the STAT3-SOCS3 pathway. J Biol Chem 283: 708-715.
    • (2008) J Biol Chem , vol.283 , pp. 708-715
    • Kim, J.H.1    Kim, J.E.2    Liu, H.Y.3    Cao, W.4    Chen, J.5
  • 42
    • 52949104386 scopus 로고    scopus 로고
    • Inhibition of lipopolysaccharide-induced nitric oxide synthesis by nicotine through S6K1-p42/44 MAPK pathway and STAT3 (Ser 727) phosphorylation in Raw 264.7 cells
    • Park SY, Baik YH, Cho JH, Kim S, Lee KS, et al. (2008) Inhibition of lipopolysaccharide-induced nitric oxide synthesis by nicotine through S6K1-p42/44 MAPK pathway and STAT3 (Ser 727) phosphorylation in Raw 264.7 cells. Cytokine 44: 126-134.
    • (2008) Cytokine , vol.44 , pp. 126-134
    • Park, S.Y.1    Baik, Y.H.2    Cho, J.H.3    Kim, S.4    Lee, K.S.5
  • 43
    • 0041344629 scopus 로고    scopus 로고
    • Activation of the p70 S6 kinase and phosphorylation of the 4E-BP1 repressor of mRNA translation by type I interferons
    • Lekmine F, Uddin S, Sassano A, Parmar S, Brachmann SM, et al. (2003) Activation of the p70 S6 kinase and phosphorylation of the 4E-BP1 repressor of mRNA translation by type I interferons. J Biol Chem 278: 27772-27780.
    • (2003) J Biol Chem , vol.278 , pp. 27772-27780
    • Lekmine, F.1    Uddin, S.2    Sassano, A.3    Parmar, S.4    Brachmann, S.M.5
  • 44
    • 1642502331 scopus 로고    scopus 로고
    • Interferon-gamma engages the p70 S6 kinase to regulate phosphorylation of the 40S S6 ribosomal protein
    • Lekmine F, Sassano A, Uddin S, Smith J, Majchrzak B, et al. (2004) Interferon-gamma engages the p70 S6 kinase to regulate phosphorylation of the 40S S6 ribosomal protein. Exp Cell Res 295: 173-182.
    • (2004) Exp Cell Res , vol.295 , pp. 173-182
    • Lekmine, F.1    Sassano, A.2    Uddin, S.3    Smith, J.4    Majchrzak, B.5
  • 45
    • 33748490486 scopus 로고    scopus 로고
    • The effects of cardamonin on lipopolysaccharide-induced inflammatory protein production and MAP kinase and NFkappaB signalling pathways in monocytes/macrophages
    • Hatziieremia S, Gray AI, Ferro VA, Paul A, Plevin R (2006) The effects of cardamonin on lipopolysaccharide-induced inflammatory protein production and MAP kinase and NFkappaB signalling pathways in monocytes/macrophages. Br J Pharmacol 149: 188-198.
    • (2006) Br J Pharmacol , vol.149 , pp. 188-198
    • Hatziieremia, S.1    Gray, A.I.2    Ferro, V.A.3    Paul, A.4    Plevin, R.5
  • 46
    • 20044390358 scopus 로고    scopus 로고
    • Inhibition of p38 pathway suppresses human islet production of pro-inflammatory cytokines and improves islet graft function
    • Matsuda T, Omori K, Vuong T, Pascual M, Valiente L, et al. (2005) Inhibition of p38 pathway suppresses human islet production of pro-inflammatory cytokines and improves islet graft function. Am J Transplant 5: 484-493.
    • (2005) Am J Transplant , vol.5 , pp. 484-493
    • Matsuda, T.1    Omori, K.2    Vuong, T.3    Pascual, M.4    Valiente, L.5
  • 47
    • 34547161916 scopus 로고    scopus 로고
    • Activation of the c-Jun N-terminal kinase pathway by MST1 is essential and sufficient for the induction of chromatin condensation during apoptosis
    • Ura S, Nishina H, Gotoh Y, Katada T (2007) Activation of the c-Jun N-terminal kinase pathway by MST1 is essential and sufficient for the induction of chromatin condensation during apoptosis. Mol Cell Biol 27: 5514-5522.
    • (2007) Mol Cell Biol , vol.27 , pp. 5514-5522
    • Ura, S.1    Nishina, H.2    Gotoh, Y.3    Katada, T.4
  • 48
    • 67650642539 scopus 로고    scopus 로고
    • Inhibition of inducible NO synthase, cyclooxygenase-2 and interleukin-1beta by torilin is mediated by mitogen-activated protein kinases in microglial BV2 cells
    • Choi Y, Lee MK, Lim SY, Sung SH, Kim YC (2009) Inhibition of inducible NO synthase, cyclooxygenase-2 and interleukin-1beta by torilin is mediated by mitogen-activated protein kinases in microglial BV2 cells. Br J Pharmacol 156: 933-940.
    • (2009) Br J Pharmacol , vol.156 , pp. 933-940
    • Choi, Y.1    Lee, M.K.2    Lim, S.Y.3    Sung, S.H.4    Kim, Y.C.5
  • 49
    • 0037266126 scopus 로고    scopus 로고
    • Effects of phosphatidylserine on p38 mitogen activated protein kinase, cyclic AMP responding element binding protein and nuclear factor-kappaB activation in resting and activated microglial cells
    • Ajmone-Cat MA, De Simone R, Nicolini A, Minghetti L (2003) Effects of phosphatidylserine on p38 mitogen activated protein kinase, cyclic AMP responding element binding protein and nuclear factor-kappaB activation in resting and activated microglial cells. J Neurochem 84: 413-416.
    • (2003) J Neurochem , vol.84 , pp. 413-416
    • Ajmone-Cat, M.A.1    De Simone, R.2    Nicolini, A.3    Minghetti, L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.