Inhibition of inducible NO synthase, cyclooxygenase-2 and interleukin-1β by torilin is mediated by mitogen-activated protein kinases in microglial BV2 cells

British Journal of Pharmacology

Volumn 156, Issue 6, 2009, Pages 933-940

  Choi, Y ^a   Lee, M K ^a   Lim, S Y ^a   Sung, S H ^a   Kim, Y C ^a  

^a Seoul National University   (South Korea)

Author keywords

Cyclooxygenase 2; Extracellular signal regulated kinase 1 2; Inducible nitric oxide synthase; Interleukin 1 ; Lipopolysaccharide; NF B; P38 MAPK; Torilin

Indexed keywords

ANTIINFLAMMATORY AGENT; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLOOXYGENASE 2; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; PROSTAGLANDIN E2; TORILIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; CREB1 PROTEIN, MOUSE; CYCLOOXYGENASE 2 INHIBITOR; LIPOPOLYSACCHARIDE; NONSTEROID ANTIINFLAMMATORY AGENT; SESQUITERPENE;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; DRUG MECHANISM; ELM; ENZYME INHIBITION; GENE EXPRESSION; MICROGLIA; MOUSE; NONHUMAN; PLANT ROOT; PLANT STEM; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS INHIBITION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; ULMUS DAVIDIANA; ANIMAL; BIOSYNTHESIS; CELL LINE; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL LINE; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; DINOPROSTONE; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MAP KINASE SIGNALING SYSTEM; MICE; MICROGLIA; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PHOSPHORYLATION; SESQUITERPENES, GUAIANE;

EID: 67650642539     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00022.x     Document Type: Article

References (46)

1. Aga M, Watters JJ, Pfeiffer ZA, Wiepz GJ, Sommer JA, Bertics PJ (2004). Evidence for nucleotide receptor modulation of cross talk between MAP kinase and NF-kappa B signaling pathways in murine RAW 264.7 macrophages. Am J Physiol Cell Physiol 286 : C923 C930.
2. Alexander SPH, Mathie A, Peters JA (2008). Guide to Receptors and Channels (GRAC), 3rd edn. Br J Pharmacol 153 (Suppl. 2 S1 S209.
3. Appleby SB, Ristimäki A, Neilson K, Narko K, Hla T (1994). Structure of the human cyclo-oxygenase-2 gene. Biochem J 302 : 723 727.
4. Baldassare JJ, Bi Y, Bellone CJ (1999). The role of p38 mitogen-activated protein kinase in IL-1β transcription. J Immunol 162 : 5367 5373.
5. Baldwin AS (1996). The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol 14 : 649 683.
6. Bhat NR, Zhang P, Lee JC, Hogan EL (1998). Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures. J Neurosci 18 : 1633 1641.
7. Blasi E, Barluzzi R, Bocchini V, Mazzolla R, Bistoni F (1990). Immortalization of murine microglial cells by a v-raf/v-myc carrying retrovirus. J Neuroimmunol 27 : 229 237.
8. Bogdan C (2001). Nitric oxide and the immune response. Nat Immunol 2 : 907 916.
9. Caivano M, Cohen P (2000). Role of mitogen-activated protein kinase cascades in mediating lipopolysaccharide-stimulated induction of cyclooxygenase-2 and IL-1β in RAW264 macrophages. J Immunol 164 : 3018 3025.
10. Choi Y, Moon A, Kim YC (2008). A pinusolide derivative, 15-methoxypinusolidic acid from Biota orientalis inhibits inducible nitric oxide synthase in microglial cells: implication for a potential anti-inflammatory effect. Int Immunopharmacol 8 : 548 555.
11. Clark AK, D'Aquisto F, Gentry C, Marchand F, McMahon SB, Malcangio M (2006). Rapid co-release of interleukin 1β and caspase 1 in spinal cord inflammation. J Neurochem 99 : 868 880.
12. Crofford LJ, Wilder RL, Ristimäki AP, Sano H, Remmers EF, Epps HR et al. (1994). Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues. Effects of interleukin-1β, phorbol ester, and corticosteroids. J Clin Invest 93 : 1095 1101.
13. Cuadros MA, Navascués J (1998). The origin and differentiation of microglial cells during development. Prog Neurobiol 56 : 173 189.
14. Dubois RN, Abramson SB, Crofford L, Gupta RA, Simon LS, Van De Putte LB et al. (1998). Cyclooxygenase in biology and disease. FASEB J 12 : 1063 1073.
15. Eliopoulos AG, Dumitru CD, Wang CC, Cho J, Tsichlis PN (2002). Induction of COX-2 by LPS in macrophages is regulated by Tpl2-dependent CREB activation signals. EMBO J 21 : 4831 4840.
16. 2 regulates the level and stability of cyclooxygenase-2 mRNA through activation of p38 mitogen-activated protein kinase in interleukin-1β-treated human synovial fibroblasts. J Biol Chem 276 : 31720 31731.
17. Finco TS, Baldwin AS, Jr. (1993). κB site-dependent induction of gene expression by diverse inducers of nuclear factor κB requires Raf-1. J Biol Chem 268 : 17676 17679.
18. 15N]nitrate in biological fluids. Anal Biochem 126 : 131 138.
19. Kaur C, Hao AJ, Wu CH, Ling EA (2001). Origin of microglia. Microsc Res Tech 54 : 2 9.
20. Kim SH, Smith CJ, Van Eldik LJ (2004). Importance of MAPK pathways for microglial pro-inflammatory cytokine IL-1β production. Neurobiol Aging 25 : 431 439.
21. Kim YC, Lee MK, Sung SH, Kim SH (2007). Sesquiterpenes from Ulmus davidiana var. japonica with the inhibitory effects on lipopolysaccharide- induced nitric oxide production. Fitoterapia 78 : 196 199.
22. Kim YJ, Hwang SY, Oh ES, Oh S, Han IO (2006). IL-1beta, an immediate early protein secreted by activated microglia, induces iNOS/NO in C6 astrocytoma cells through p38 MAPK and NF-kappaB pathways. J Neurosci Res 84 : 1037 1046.
23. Kim YS, Joh TH (2006). Microglia, major player in the brain inflammation: their roles in the pathogenesis of Parkinson's disease. Exp Mol Med 38 : 333 347.
24. Kleinert H, Pautz A, Linker K, Schwarz PM (2004). Regulation of the expression of inducible nitric oxide synthase. Eur J Pharmacol 500 : 255 266.
25. Kröncke KD, Fehsel K, Kolb-Bachofen V (1998). Inducible nitric oxide synthase in human diseases. Clin Exp Immunol 113 : 147 156.
26. Lai AY, Todd KG (2006). Microglia in cerebral ischemia: molecular actions and interactions. Can J Physiol Pharmacol 84 : 49 59.
27. Laporte JD, Moore PE, Lahiri T, Schwartzman IN, Panettieri RA, Jr., Shore SA (2000). p38 MAP kinase regulates IL-1β responses in cultured airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 279 : L932 L941.
28. Lee SJ (1966). Korean Folk Medicine. Seoul National University Press : Seoul.
29. Lin AW, Chang CC, McCormick CC (1996). Molecular cloning and expression of an avian macrophage nitric-oxide synthase cDNA and the analysis of the genomic 5′-flanking region. J Biol Chem 271 : 11911 11919.
30. Liu B, Hong JS (2003). Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention. J Pharmacol Exp Ther 304 : 1 7.
31. Liu W, Reinmuth N, Stoeltzing O, Parikh AA, Tellez C, Williams S et al. (2003). Cyclooxygenase-2 is up-regulated by interleukin-1β in human colorectal cancer cells via multiple signaling pathways. Cancer Res 63 : 3632 3636.
32. Loddick SA, Rothwell NJ (1999). Mechanisms of tumor necrosis factor alpha action on neurodegeneration: interaction with insulin-like growth factor-1. Proc Natl Acad Sci USA 96 : 9449 9451.
33. Lowenstein CJ, Alley EW, Raval P, Snowman AM, Snyder SH, Russell SW et al. (1993). Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide. Proc Natl Acad Sci USA 90 : 9730 9734.
34. Lu YC, Yeh WC, Ohashi PS (2008). LPS/TLR4 signal transduction pathway. Cytokine 42 : 145 151.
35. Minghetti L, Levi G (1998). Microglia as effector cells in brain damage and repair: focus on prostanoids and nitric oxide. Prog Neurobiol 54 : 99 125.
36. 2 biosynthesis by IL-1β is mediated by PKC and mitogen-activated protein kinases in murine astrocytes. Br J Pharmacol 131 : 152 159.
37. Mollace V, Muscoli C, Masini E, Cuzzocrea S, Salvemini D (2005). Modulation of prostaglandin biosynthesis by nitric oxide and nitric oxide donors. Pharmacol Rev 57 : 217 252.
38. Nakajima T, Kinoshita S, Sasagawa T, Sasaki K, Naruto M, Kishimoto T et al. (1993). Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6. Proc Natl Acad Sci USA 90 : 2207 2211.
39. Pyo H, Jou I, Jung S, Hong S, Joe EH (1998). Mitogen-activated protein kinases activated by lipopolysaccharide and beta-amyloid in cultured rat microglia. Neuroreport 9 : 871 874.
40. Sriram K, O'Callaghan JP (2007). Divergent roles for tumor necrosis factor-alpha in the brain. J Neuroimmune Pharmacol 2 : 140 153.
41. Stoll G, Jander S (1999). The role of microglia and macrophages in the pathophysiology of the CNS. Prog Neurobiol 58 : 233 247.
42. Streit WJ, Mrak RE, Griffin WS (2004). Microglia and neuroinflammation: a pathological perspective. J Neuroinflammation 1 : 14.
43. Sung SS, Walters JA (1991). Increased cyclic AMP levels enhance IL-1α and IL-1β mRNA expression and protein production in human myelomonocytic cell lines and monocytes. J Clin Invest 88 : 1915 1923.
44. Tsukada J, Saito K, Waterman WR, Webb AC, Auron PE (1994). Transcription factors NF-IL6 and CREB recognize a common essential site in the human prointerleukin 1β gene. Mol Cell Biol 14 : 7285 7297.
45. Yamamoto K, Arakawa T, Ueda N, Yamamoto S (1995). Transcriptional roles of nuclear factor kappa B and nuclear factor-interleukin-6 in the tumor necrosis factor alpha-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells. J Biol Chem 270 : 31315 31320.
46. Zhai W, Eynott PR, Oltmanns U, Leung SY, Chung KF (2004). Mitogen-activated protein kinase signalling pathways in IL-1β-dependent rat airway smooth muscle proliferation. Br J Pharmacol 143 : 1042 1049.