Phosphatidylinositol (3,4,5)- trisphosphate specifically intracts with the phox homology domain of phospholipase D1 and stimulates its activity

Journal of Cell Science

Volumn 118, Issue 19, 2005, Pages 4405-4413

  Lee, Jun Sung ^a   Kim, Jong Hyun ^a   Jang, Il Ho ^a   Kim, Hyeon Soo ^a   Han, Jung Min ^a   Kazlauskas, Andrius ^b   Yagisawa, Hitoshi ^a,c   Suh, Pann Ghill ^a   Ryu, Sung Ho ^a  

^a Pohang University of Science and Technology (POSTECH)   (South Korea)

^b SCHEPENS EYE RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF HYOGO   (Japan)

Author keywords

ERK phosphorylation; PDGF; Phosphoinositides; PLD; PX domain

Indexed keywords

ALANINE; GREEN FLUORESCENT PROTEIN; LYSINE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITIDE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PHOSPHOLIPASE D; PHOSPHOLIPASE D1; PHOSPHOLIPASE D2; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR; SMALL INTERFERING RNA;

ARTICLE; BINDING SITE; CATALYSIS; CELL MEMBRANE; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; ENZYME SPECIFICITY; FEMALE; HUMAN; HUMAN CELL; HYDROLYSIS; IN VITRO STUDY; MOLECULAR DYNAMICS; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; WILD TYPE;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION; PHOSPHATIDYLINOSITOL PHOSPHATES; PHOSPHOLIPASE D; PLATELET-DERIVED GROWTH FACTOR; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; SEQUENCE ALIGNMENT;

EID: 27644598295     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.02564     Document Type: Article

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