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Volumn 66, Issue , 2014, Pages 306-314

Ginsenoside-Rb2 displays anti-osteoporosis effects through reducing oxidative damage and bone-resorbing cytokines during osteogenesis

Author keywords

Bone resorbing cytokine; Osteogenesis; Osteoporosis; Ovariectomized mouse; Oxidative damage

Indexed keywords

ALKALINE PHOSPHATASE; CALCIUM; CYTOKINE; GINSENOSIDE RB 2; GLUTATHIONE; HYDROGEN PEROXIDE; INTERLEUKIN 6; MALONALDEHYDE; MESSENGER RNA; OSTEOCALCIN; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPONTIN; REACTIVE OXYGEN METABOLITE; GINSENOSIDE;

EID: 84904569485     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2014.06.010     Document Type: Article
Times cited : (73)

References (56)
  • 2
    • 0027222768 scopus 로고
    • Consensus development conference: diagnosis, prophylaxis and treatment of osteoporosis
    • Bouillon, Burckhardt R., Christiansen P., Fleisch C., Fujita H.A., Gennari T., et al. Consensus development conference: diagnosis, prophylaxis and treatment of osteoporosis. Am J Med 1993, 94:646-650.
    • (1993) Am J Med , vol.94 , pp. 646-650
    • Bouillon, B.R.1    Christiansen, P.2    Fleisch, C.3    Fujita, H.A.4    Gennari, T.5
  • 3
    • 70350109016 scopus 로고    scopus 로고
    • Antioxidant status in patients with osteoporosis: a controlled study
    • Sendur O.F., Turan Y., Tastaban E., Serter M. Antioxidant status in patients with osteoporosis: a controlled study. Joint Bone Spine 2009, 76:514-518.
    • (2009) Joint Bone Spine , vol.76 , pp. 514-518
    • Sendur, O.F.1    Turan, Y.2    Tastaban, E.3    Serter, M.4
  • 5
    • 33846546145 scopus 로고    scopus 로고
    • Role of antioxidant systems, lipid peroxidation, and nitric oxide in postmenopausal osteoporosis
    • Ozgocmen S., Kaya H., Fadillioglu E., Aydogan R., Yilmaz Z. Role of antioxidant systems, lipid peroxidation, and nitric oxide in postmenopausal osteoporosis. Mol Cell Biochem 2007, 295:45-52.
    • (2007) Mol Cell Biochem , vol.295 , pp. 45-52
    • Ozgocmen, S.1    Kaya, H.2    Fadillioglu, E.3    Aydogan, R.4    Yilmaz, Z.5
  • 6
    • 33846141111 scopus 로고    scopus 로고
    • Effects of calcitonin, risedronate, and raloxifene on erythrocyte antioxidant enzyme activity, lipid peroxidation, and nitric oxide in postmenopausal osteoporosis
    • Ozgocmen S., Kaya H., Fadillioglu E., Yilmaz Z. Effects of calcitonin, risedronate, and raloxifene on erythrocyte antioxidant enzyme activity, lipid peroxidation, and nitric oxide in postmenopausal osteoporosis. Arch Med Res 2007, 38:196-205.
    • (2007) Arch Med Res , vol.38 , pp. 196-205
    • Ozgocmen, S.1    Kaya, H.2    Fadillioglu, E.3    Yilmaz, Z.4
  • 8
    • 33744477074 scopus 로고    scopus 로고
    • Cellular redox regulation and prooxidant signaling systems: a new perspective on the free radical theory of aging
    • Linnane A.W., Eastwood H. Cellular redox regulation and prooxidant signaling systems: a new perspective on the free radical theory of aging. Ann N Y Acad Sci 2006, 1067:47.
    • (2006) Ann N Y Acad Sci , vol.1067 , pp. 47
    • Linnane, A.W.1    Eastwood, H.2
  • 9
    • 75149129597 scopus 로고    scopus 로고
    • From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis
    • Manolagas S.C. From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis. Endocr Rev 2010, 31:266-300.
    • (2010) Endocr Rev , vol.31 , pp. 266-300
    • Manolagas, S.C.1
  • 10
    • 0036218666 scopus 로고    scopus 로고
    • RANK-L and RANK: T cells, bone loss, and mammalian evolution
    • Theill L.E., Boyle W.J., Penninger J.M. RANK-L and RANK: T cells, bone loss, and mammalian evolution. Annu Rev Immunol 2002, 20:795-823.
    • (2002) Annu Rev Immunol , vol.20 , pp. 795-823
    • Theill, L.E.1    Boyle, W.J.2    Penninger, J.M.3
  • 11
    • 0037673945 scopus 로고    scopus 로고
    • Osteoclast differentiation and activation
    • Boyle W.J., Simonet W.S., Lacey D.L. Osteoclast differentiation and activation. Nature 2003, 423:337-342.
    • (2003) Nature , vol.423 , pp. 337-342
    • Boyle, W.J.1    Simonet, W.S.2    Lacey, D.L.3
  • 12
    • 0036225281 scopus 로고    scopus 로고
    • Reaching a genetic and molecular understanding of skeletal development
    • Karsenty G., Wagner E.F. Reaching a genetic and molecular understanding of skeletal development. Dev Cell 2002, 2:389-406.
    • (2002) Dev Cell , vol.2 , pp. 389-406
    • Karsenty, G.1    Wagner, E.F.2
  • 13
    • 58849090069 scopus 로고    scopus 로고
    • Signaling networks that control the lineage commitment and differentiation of bone cells
    • Soltanoff C.S., Yang S., Chen W., Li Y.P. Signaling networks that control the lineage commitment and differentiation of bone cells. Crit Rev Eukaryot Gene Expr 2009, 19:1-46.
    • (2009) Crit Rev Eukaryot Gene Expr , vol.19 , pp. 1-46
    • Soltanoff, C.S.1    Yang, S.2    Chen, W.3    Li, Y.P.4
  • 14
    • 34347257781 scopus 로고    scopus 로고
    • Signaling and transcriptional regulation in osteoblast commitment and differentiation
    • Huang W., Yang S., Shao J., Li Y.P. Signaling and transcriptional regulation in osteoblast commitment and differentiation. Front Biosci 2007, 12:3068-3092.
    • (2007) Front Biosci , vol.12 , pp. 3068-3092
    • Huang, W.1    Yang, S.2    Shao, J.3    Li, Y.P.4
  • 15
    • 10744224511 scopus 로고    scopus 로고
    • Bone metabolism and oxidative stress in postmenopausal rats with iron overload
    • Isomura H., Fujie K., Shibata K., Inoue N., Iizuka T., Takebe G., et al. Bone metabolism and oxidative stress in postmenopausal rats with iron overload. Toxicology 2004, 197:93-100.
    • (2004) Toxicology , vol.197 , pp. 93-100
    • Isomura, H.1    Fujie, K.2    Shibata, K.3    Inoue, N.4    Iizuka, T.5    Takebe, G.6
  • 16
    • 22144457305 scopus 로고    scopus 로고
    • A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation
    • Lee N.K., Choi Y.G., Baik J.Y., Han S.Y., Jeong D.W., Bae Y.S., et al. A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation. Blood 2005, 106:852-859.
    • (2005) Blood , vol.106 , pp. 852-859
    • Lee, N.K.1    Choi, Y.G.2    Baik, J.Y.3    Han, S.Y.4    Jeong, D.W.5    Bae, Y.S.6
  • 17
    • 0142186681 scopus 로고    scopus 로고
    • A crucial role for thiol antioxidants in estrogen-deficiency bone loss
    • Lean J.M., Davies J.T., Fuller K., Jagger C.J., Kirstein B., et al. A crucial role for thiol antioxidants in estrogen-deficiency bone loss. J Clin Invest 2003, 112:915-923.
    • (2003) J Clin Invest , vol.112 , pp. 915-923
    • Lean, J.M.1    Davies, J.T.2    Fuller, K.3    Jagger, C.J.4    Kirstein, B.5
  • 18
    • 12344281693 scopus 로고    scopus 로고
    • Hydrogen peroxide is essential for estrogen-deficiency bone loss and osteoclast formation
    • Lean J.M., Jagger C.J., Kirstein B., Fuller K., Chambers T.J. Hydrogen peroxide is essential for estrogen-deficiency bone loss and osteoclast formation. Endocrinology 2005, 146:728-735.
    • (2005) Endocrinology , vol.146 , pp. 728-735
    • Lean, J.M.1    Jagger, C.J.2    Kirstein, B.3    Fuller, K.4    Chambers, T.J.5
  • 19
    • 33847046732 scopus 로고    scopus 로고
    • Effects of reactive oxygen species (ROS) on antioxidant system and osteoblastic differentiation in MC3T3-E1 cells
    • Arai M., Shibata Y., Pugdee K., Abiko Y., Ogata Y. Effects of reactive oxygen species (ROS) on antioxidant system and osteoblastic differentiation in MC3T3-E1 cells. IUBMB Life 2007, 59:27-33.
    • (2007) IUBMB Life , vol.59 , pp. 27-33
    • Arai, M.1    Shibata, Y.2    Pugdee, K.3    Abiko, Y.4    Ogata, Y.5
  • 20
    • 34848878406 scopus 로고    scopus 로고
    • Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids
    • Almeida M., Han L., Martin-Millan M., Plotkin L.I., Stewart S.A., Roberson P.K., et al. Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids. J Biol Chem 2007, 282:27285-27297.
    • (2007) J Biol Chem , vol.282 , pp. 27285-27297
    • Almeida, M.1    Han, L.2    Martin-Millan, M.3    Plotkin, L.I.4    Stewart, S.A.5    Roberson, P.K.6
  • 21
    • 78349266526 scopus 로고    scopus 로고
    • Decreased oxidative stress and greater bone anabolism in the aged, as compared to the young, murine skeleton by parathyroid hormone
    • Jilka R.L., Almeida M., Ambrogini E., Han L., Roberson P.K., et al. Decreased oxidative stress and greater bone anabolism in the aged, as compared to the young, murine skeleton by parathyroid hormone. Aging Cell 2010, 9:851-867.
    • (2010) Aging Cell , vol.9 , pp. 851-867
    • Jilka, R.L.1    Almeida, M.2    Ambrogini, E.3    Han, L.4    Roberson, P.K.5
  • 24
    • 66849099356 scopus 로고    scopus 로고
    • 2 lowers cholesterol and triacylglycerol levels in 3T3-L1 adipocytes cultured under high cholesterol or fatty acids conditions
    • 2 lowers cholesterol and triacylglycerol levels in 3T3-L1 adipocytes cultured under high cholesterol or fatty acids conditions. BMB Rep 2009, 42(4):194-199.
    • (2009) BMB Rep , vol.42 , Issue.4 , pp. 194-199
    • Kim, E.J.1    Lee, H.I.2    Chung, K.J.3    Noh, Y.H.4    Ro, Y.5    Koo, J.H.6
  • 28
    • 0000626726 scopus 로고    scopus 로고
    • 2 extracted from a medicinal plant, Panax ginseng
    • 2 extracted from a medicinal plant, Panax ginseng. J Biol Chem 1996, 40:24539-24543.
    • (1996) J Biol Chem , vol.40 , pp. 24539-24543
    • Kim, Y.H.1    Park, K.H.2    Rho, H.M.3
  • 29
    • 78249287258 scopus 로고    scopus 로고
    • Up-regulation of MMP-13 and TIMP-1 expression in response to mechanical strain in MC3T3-E1 osteoblastic cells
    • Li Y., Tang L., Duan Y., Ding Y. Up-regulation of MMP-13 and TIMP-1 expression in response to mechanical strain in MC3T3-E1 osteoblastic cells. BMC Res Notes 2010, 3:309.
    • (2010) BMC Res Notes , vol.3 , pp. 309
    • Li, Y.1    Tang, L.2    Duan, Y.3    Ding, Y.4
  • 30
    • 84871384434 scopus 로고    scopus 로고
    • Effects of irradiation on osteoblast-like cells on different titanium surfaces in vitro
    • Li Y., Ma W., Feng Z., Wang Z., Zha N., Deng B., et al. Effects of irradiation on osteoblast-like cells on different titanium surfaces in vitro. J Biomed Mater Res B Appl Biomater 2012, 101B:9-17.
    • (2012) J Biomed Mater Res B Appl Biomater , vol.101 B , pp. 9-17
    • Li, Y.1    Ma, W.2    Feng, Z.3    Wang, Z.4    Zha, N.5    Deng, B.6
  • 31
    • 33748162992 scopus 로고    scopus 로고
    • Monitoring individual morphological changes over time in ovariectomized rats by in vivo micro-computed tomography
    • Boyd Steven K., Davison Peter, Müller Ralph, Gasser Jürg A. Monitoring individual morphological changes over time in ovariectomized rats by in vivo micro-computed tomography. Bone 2006, 39:854-862.
    • (2006) Bone , vol.39 , pp. 854-862
    • Boyd, S.K.1    Davison, P.2    Müller, R.3    Gasser Jürg, A.4
  • 32
    • 84874243081 scopus 로고    scopus 로고
    • Protection by salidroside against bone loss via inhibition of oxidative stress and bone-resorbing mediators
    • Zhang J.K., Yang L., Meng G.L., Yuan Z., Fan J., Li D., et al. Protection by salidroside against bone loss via inhibition of oxidative stress and bone-resorbing mediators. PLoS ONE 2013, 8(2):e57251.
    • (2013) PLoS ONE , vol.8 , Issue.2
    • Zhang, J.K.1    Yang, L.2    Meng, G.L.3    Yuan, Z.4    Fan, J.5    Li, D.6
  • 33
    • 84870591168 scopus 로고    scopus 로고
    • Autophagy protects against oxaliplatin-induced cell death via ER stress and ROS in Caco-2 cells
    • Shi Y., Tang B., Yu P.W., Tang B., Hao Y.X., Lei X., et al. Autophagy protects against oxaliplatin-induced cell death via ER stress and ROS in Caco-2 cells. PLoS ONE 2012, 7:e51076.
    • (2012) PLoS ONE , vol.7
    • Shi, Y.1    Tang, B.2    Yu, P.W.3    Tang, B.4    Hao, Y.X.5    Lei, X.6
  • 34
    • 85027957985 scopus 로고    scopus 로고
    • Association of oxidative stress with postmenopausal osteoporosis and the effects of hydrogen peroxide on osteoclast formation in human bone marrow cell cultures
    • Baek K.H., Oh K.W., Lee W.Y., Lee S.S., Kim M.K., Kwon H.S., et al. Association of oxidative stress with postmenopausal osteoporosis and the effects of hydrogen peroxide on osteoclast formation in human bone marrow cell cultures. Calcif Tissue Int 2010, 87:226-235.
    • (2010) Calcif Tissue Int , vol.87 , pp. 226-235
    • Baek, K.H.1    Oh, K.W.2    Lee, W.Y.3    Lee, S.S.4    Kim, M.K.5    Kwon, H.S.6
  • 35
    • 0038360770 scopus 로고    scopus 로고
    • Marked decrease in plasma antioxidants in aged osteoporotic women: results of a cross-sectional study
    • Maggio D., Barabani M., Pierandrei M., Polidori M.C., Catani M., Catani M., et al. Marked decrease in plasma antioxidants in aged osteoporotic women: results of a cross-sectional study. J Clin Endocrinol Metab 2003, 88:1523-1527.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 1523-1527
    • Maggio, D.1    Barabani, M.2    Pierandrei, M.3    Polidori, M.C.4    Catani, M.5    Catani, M.6
  • 36
    • 0035868417 scopus 로고    scopus 로고
    • Role of membrane lipids in regulation of vulnerability to oxidative stress in PC12 cells: implication for aging
    • Denisova N.A., Cantuti-Castelvetri I., Hassan W.N., Paulson K.E., Joseph J.A. Role of membrane lipids in regulation of vulnerability to oxidative stress in PC12 cells: implication for aging. Free Radic Biol Med 2001, 30:671-678.
    • (2001) Free Radic Biol Med , vol.30 , pp. 671-678
    • Denisova, N.A.1    Cantuti-Castelvetri, I.2    Hassan, W.N.3    Paulson, K.E.4    Joseph, J.A.5
  • 37
    • 9644284321 scopus 로고    scopus 로고
    • Metallothionein protects bone marrow stromal cells against hydrogen peroxide-induced inhibition of osteoblastic differentiation
    • Liu A.L., Zhang Z.M., Zhu B.F., Liao Z.H., Liu Z. Metallothionein protects bone marrow stromal cells against hydrogen peroxide-induced inhibition of osteoblastic differentiation. Cell Biol Int 2004, 28:905-911.
    • (2004) Cell Biol Int , vol.28 , pp. 905-911
    • Liu, A.L.1    Zhang, Z.M.2    Zhu, B.F.3    Liao, Z.H.4    Liu, Z.5
  • 38
    • 0032540319 scopus 로고    scopus 로고
    • Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
    • Lacey D.L., Timms E., Tan H.L., Kelley M.J., Dunstan C.R., Burgess T., et al. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 1998, 93:165-176.
    • (1998) Cell , vol.93 , pp. 165-176
    • Lacey, D.L.1    Timms, E.2    Tan, H.L.3    Kelley, M.J.4    Dunstan, C.R.5    Burgess, T.6
  • 39
    • 20444474124 scopus 로고    scopus 로고
    • Reactive oxygen species stimulates receptor activator of NF-kappaB ligand expression in osteoblast
    • Bai X.C., Lu D., Liu A.L., Zhang Z.M., Li X.M., Zou Z.P., et al. Reactive oxygen species stimulates receptor activator of NF-kappaB ligand expression in osteoblast. J Biol Chem 2005, 280:17497-17506.
    • (2005) J Biol Chem , vol.280 , pp. 17497-17506
    • Bai, X.C.1    Lu, D.2    Liu, A.L.3    Zhang, Z.M.4    Li, X.M.5    Zou, Z.P.6
  • 40
    • 0026516415 scopus 로고
    • 17 beta-estradiol inhibits interleukin-6 production by bone marrow-derived stromal cells and osteoblasts in vitro: a potential mechanism for the antiosteoporotic effect of estrogens
    • Girasole G., Jilka R.L., Passeri G., Boswell S., Boder G., Williams D.C., et al. 17 beta-estradiol inhibits interleukin-6 production by bone marrow-derived stromal cells and osteoblasts in vitro: a potential mechanism for the antiosteoporotic effect of estrogens. J Clin Invest 1992, 89:883-891.
    • (1992) J Clin Invest , vol.89 , pp. 883-891
    • Girasole, G.1    Jilka, R.L.2    Passeri, G.3    Boswell, S.4    Boder, G.5    Williams, D.C.6
  • 41
    • 0025313227 scopus 로고
    • IL-6 stimulates osteoclast-like multinucleated cell formation in long term human marrow cultures by inducing IL-1 release
    • Kurihara N., Bertolini D., Suda T., Akiyama Y., Roodman G.D. IL-6 stimulates osteoclast-like multinucleated cell formation in long term human marrow cultures by inducing IL-1 release. J Immunol 1990, 144:4226-4230.
    • (1990) J Immunol , vol.144 , pp. 4226-4230
    • Kurihara, N.1    Bertolini, D.2    Suda, T.3    Akiyama, Y.4    Roodman, G.D.5
  • 43
    • 0028151432 scopus 로고
    • Interleukin-1 receptor antagonist and tumor necrosis factor binding protein decrease osteoclast formation and bone resorption in ovariectomized mice
    • Kitazawa R., Kimble R.B., Vannice J.L., Kung V.T., Pacifici R. Interleukin-1 receptor antagonist and tumor necrosis factor binding protein decrease osteoclast formation and bone resorption in ovariectomized mice. J Clin Invest 1994, 94:2397-2406.
    • (1994) J Clin Invest , vol.94 , pp. 2397-2406
    • Kitazawa, R.1    Kimble, R.B.2    Vannice, J.L.3    Kung, V.T.4    Pacifici, R.5
  • 44
    • 34249281690 scopus 로고    scopus 로고
    • Stressing the role of FoxO proteins in lifespan and disease
    • Van der H.A., Burgering B.M. Stressing the role of FoxO proteins in lifespan and disease. Nat Rev Mol Cell Biol 2007, 8:440-450.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 440-450
    • Van der, H.A.1    Burgering, B.M.2
  • 45
    • 27844497945 scopus 로고    scopus 로고
    • FOXO transcription factors at the interface between longevity and tumor suppression
    • Greer E.L., Brunet A. FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene 2005, 24:7410-7425.
    • (2005) Oncogene , vol.24 , pp. 7410-7425
    • Greer, E.L.1    Brunet, A.2
  • 46
    • 11244320393 scopus 로고    scopus 로고
    • FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK
    • Essers M.A., Weijzen S., Vries-Smits A.M., Saarloos I., de Ruiter N.D., Bos J.L., et al. FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK. EMBO J 2004, 23:4802-4812.
    • (2004) EMBO J , vol.23 , pp. 4802-4812
    • Essers, M.A.1    Weijzen, S.2    Vries-Smits, A.M.3    Saarloos, I.4    de Ruiter, N.D.5    Bos, J.L.6
  • 47
    • 33646934067 scopus 로고    scopus 로고
    • A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span
    • Lehtinen M.K., Yuan Z., Boag P.R., Yang Y., Villen J., Becker E.B., et al. A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. Cell 2006, 125:987-1001.
    • (2006) Cell , vol.125 , pp. 987-1001
    • Lehtinen, M.K.1    Yuan, Z.2    Boag, P.R.3    Yang, Y.4    Villen, J.5    Becker, E.B.6
  • 48
    • 17044408768 scopus 로고    scopus 로고
    • JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling
    • Wang M.C., Bohmann D., Jasper H. JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling. Cell 2005, 121:115-125.
    • (2005) Cell , vol.121 , pp. 115-125
    • Wang, M.C.1    Bohmann, D.2    Jasper, H.3
  • 49
    • 15444371989 scopus 로고    scopus 로고
    • JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16
    • Oh S.W., Mukhopadhyay A., Svrzikapa N., Jiang F., Davis R.J., Tissenbaum H.A. JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16. Proc Natl Acad Sci U S A 2005, 102:4494-4499.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 4494-4499
    • Oh, S.W.1    Mukhopadhyay, A.2    Svrzikapa, N.3    Jiang, F.4    Davis, R.J.5    Tissenbaum, H.A.6
  • 50
    • 75149146587 scopus 로고    scopus 로고
    • FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice
    • Ambrogini E., Almeida M., Martin-Millan M., Paik J.H., DePinho R.A., Han L., et al. FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice. Cell Metab 2010, 11(2):136.
    • (2010) Cell Metab , vol.11 , Issue.2 , pp. 136
    • Ambrogini, E.1    Almeida, M.2    Martin-Millan, M.3    Paik, J.H.4    DePinho, R.A.5    Han, L.6
  • 51
    • 77249115309 scopus 로고    scopus 로고
    • Gender-dependent variations in systemic biomarkers of oxidative protein, DNA, and lipid damage in aged rats
    • Cakatay U., Aydin S., Yanar K., Uzun H. Gender-dependent variations in systemic biomarkers of oxidative protein, DNA, and lipid damage in aged rats. Aging Male 2010, 13:51.
    • (2010) Aging Male , vol.13 , pp. 51
    • Cakatay, U.1    Aydin, S.2    Yanar, K.3    Uzun, H.4
  • 54
    • 78649931136 scopus 로고    scopus 로고
    • The effects of luteolin on osteoclast differentiation, function in vitro and ovariectomy-induced bone loss
    • Kim T.H., Jung J.W., Ha B.G., Hong J.M., Park E.K., Kim H.J., et al. The effects of luteolin on osteoclast differentiation, function in vitro and ovariectomy-induced bone loss. J Nutr Biochem 2011, 22:8-15.
    • (2011) J Nutr Biochem , vol.22 , pp. 8-15
    • Kim, T.H.1    Jung, J.W.2    Ha, B.G.3    Hong, J.M.4    Park, E.K.5    Kim, H.J.6
  • 56
    • 51249122470 scopus 로고    scopus 로고
    • Signs of irreversible architectural changes occur early in the development of experimental osteoporosis as assessed by in vivo micro-CT
    • Campbell G.M., Buie H.R., Boyd S.K. Signs of irreversible architectural changes occur early in the development of experimental osteoporosis as assessed by in vivo micro-CT. Osteoporos Int 2008, 19:1409-1419.
    • (2008) Osteoporos Int , vol.19 , pp. 1409-1419
    • Campbell, G.M.1    Buie, H.R.2    Boyd, S.K.3


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