Protection by Salidroside against Bone Loss via Inhibition of Oxidative Stress and Bone-Resorbing Mediators

PLoS ONE

Volumn 8, Issue 2, 2013, Pages

  Zhang, Jin Kang ^a   Yang, Liu ^a   Meng, Guo Lin ^a   Yuan, Zhi ^a   Fan, Jing ^a   Li, Dan ^a   Chen, Jian Zong ^a   Shi, Tian Yao ^b   Hu, Hui Min ^a   Wei, Bo Yuan ^a   Luo, Zhuo Jing ^a   Liu, Jian ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE BONE ISOENZYME; AMINO TERMINAL TELOPEPTIDE; BETA ACTIN; CALCIUM; GLUTATHIONE; HYDROGEN PEROXIDE; INTERLEUKIN 6; MALONALDEHYDE; OSTEOCALCIN; OSTEOCLAST DIFFERENTIATION FACTOR; SALIDROSIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; BONE DENSITY; BONE MASS; CELL DIFFERENTIATION; CELL PROTECTION; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIET SUPPLEMENTATION; DISEASE MODEL; DRUG DOSE COMPARISON; DRUG STRUCTURE; ENZYME ACTIVITY; FEMALE; FEMUR; HISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; LUMBAR VERTEBRA; MICRO-COMPUTED TOMOGRAPHY; MOUSE; NONHUMAN; OSSIFICATION; OSTEOCLAST; OSTEOLYSIS; OSTEOPOROSIS; OVARIECTOMY; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN INDUCTION; TRABECULAR BONE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ALKALINE PHOSPHATASE; ANIMALS; BONE AND BONES; BONE DENSITY CONSERVATION AGENTS; BONE RESORPTION; CELL SURVIVAL; COLLAGEN TYPE I; DISEASE MODELS, ANIMAL; FEMALE; GLUCOSIDES; HUMANS; INTERLEUKIN-6; MEMBRANE PROTEINS; MICE; OSTEOBLASTS; OSTEOCALCIN; OSTEOCLASTS; OSTEOPOROSIS; PHENOLS; PLANT EXTRACTS; RANK LIGAND; REACTIVE OXYGEN SPECIES; RHODIOLA; TRANSCRIPTION, GENETIC;

EID: 84874243081     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0057251     Document Type: Article

References (46)

1. Osteoporosis prevention, diagnosis, and therapy. JAMA 285: 785-795.
2. Sendur OF, Turan Y, Tastaban E, Serter M, (2009) Antioxidant status in patients with osteoporosis: a controlled study. Joint Bone Spine 76: 514-518.
3. Ozgocmen S, Kaya H, Fadillioglu E, Aydogan R, Yilmaz Z, (2007) Role of antioxidant systems, lipid peroxidation, and nitric oxide in postmenopausal osteoporosis. Mol Cell Biochem 295: 45-52.
4. Ozgocmen S, Kaya H, Fadillioglu E, Yilmaz Z, (2007) Effects of calcitonin, risedronate, and raloxifene on erythrocyte antioxidant enzyme activity, lipid peroxidation, and nitric oxide in postmenopausal osteoporosis. Arch Med Res 38: 196-205.
5. Muthusami S, Ramachandran I, Muthusamy B, Vasudevan G, Prabhu V, et al. (2005) Ovariectomy induces oxidative stress and impairs bone antioxidant system in adult rats. Clin Chim Acta 360: 81-86.
6. Manolagas SC, (2010) From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis. Endocr Rev 31: 266-300.
7. Seeman E, Delmas PD, (2006) Bone quality--the material and structural basis of bone strength and fragility. N Engl J Med 354: 2250-2261.
8. Lee NK, Choi YG, Baik JY, Han SY, Jeong DW, et al. (2005) A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation. Blood 106: 852-859.
9. Arai M, Shibata Y, Pugdee K, Abiko Y, Ogata Y, (2007) Effects of reactive oxygen species (ROS) on antioxidant system and osteoblastic differentiation in MC3T3-E1 cells. IUBMB Life 59: 27-33.
10. Isomura H, Fujie K, Shibata K, Inoue N, Iizuka T, et al. (2004) Bone metabolism and oxidative stress in postmenopausal rats with iron overload. Toxicology 197: 93-100.
11. Mao GX, Deng HB, Yuan LG, Li DD, Li YY, et al. (2010) Protective role of salidroside against aging in a mouse model induced by D-galactose. Biomed Environ Sci 23: 161-166.
12. Skopinska-Rozewska E, Malinowski M, Wasiutynski A, Sommer E, Furmanowa M, et al. (2008) The influence of Rhodiola quadrifida 50% hydro-alcoholic extract and salidroside on tumor-induced angiogenesis in mice. Pol J Vet Sci 11: 97-104.
13. Yu S, Liu M, Gu X, Ding F, (2008) Neuroprotective effects of salidroside in the PC12 cell model exposed to hypoglycemia and serum limitation. Cell Mol Neurobiol 28: 1067-1078.
14. Yu P, Hu C, Meehan EJ, Chen L, (2007) X-ray crystal structure and antioxidant activity of salidroside, a phenylethanoid glycoside. Chem Biodivers 4: 508-513.
15. Qian EW, Ge DT, Kong SK, (2012) Salidroside Protects Human Erythrocytes against Hydrogen Peroxide-Induced Apoptosis. J Nat Prod 75: 531-537.
16. Zhu Y, Shi YP, Wu D, Ji YJ, Wang X, et al. (2011) Salidroside protects against hydrogen peroxide-induced injury in cardiac H9c2 cells via PI3K-Akt dependent pathway. DNA Cell Biol 30: 809-819.
17. Li X, Ye X, Li X, Sun X, Liang Q, et al. (2011) Salidroside protects against MPP(+)-induced apoptosis in PC12 cells by inhibiting the NO pathway. Brain Res 1382: 9-18.
18. Shi TY, Feng SF, Xing JH, Wu YM, Li XQ, et al. (2012) Neuroprotective effects of Salidroside and its analogue tyrosol galactoside against focal cerebral ischemia in vivo and H2O2-induced neurotoxicity in vitro. Neurotox Res 21: 358-367.
19. Fatokun AA, Stone TW, Smith RA, (2008) Responses of differentiated MC3T3-E1 osteoblast-like cells to reactive oxygen species. Eur J Pharmacol 587: 35-41.
20. Li Y, Tang L, Duan Y, Ding Y, (2010) Upregulation of MMP-13 and TIMP-1 expression in response to mechanical strain in MC3T3-E1 osteoblastic cells. BMC Res Notes 3: 309.
21. Li Y, Ma W, Feng Z, Wang Z, Zha N, et al. (2012) Effects of irradiation on osteoblast-like cells on different titanium surfaces in vitro. J Biomed Mater Res B Appl Biomater.
22. Stanford CM, Jacobson PA, Eanes ED, Lembke LA, Midura RJ, (1995) Rapidly forming apatitic mineral in an osteoblastic cell line (UMR 106-01 BSP). J Biol Chem 270: 9420-9428.
23. Baek KH, Oh KW, Lee WY, Lee SS, Kim MK, et al. (2010) Association of oxidative stress with postmenopausal osteoporosis and the effects of hydrogen peroxide on osteoclast formation in human bone marrow cell cultures. Calcif Tissue Int 87: 226-235.
24. Maggio D, Barabani M, Pierandrei M, Polidori MC, Catani M, et al. (2003) Marked decrease in plasma antioxidants in aged osteoporotic women: results of a cross-sectional study. J Clin Endocrinol Metab 88: 1523-1527.
25. Lean JM, Jagger CJ, Kirstein B, Fuller K, Chambers TJ, (2005) Hydrogen peroxide is essential for estrogen-deficiency bone loss and osteoclast formation. Endocrinology 146: 728-735.
26. Fatokun AA, Stone TW, Smith RA, (2006) Hydrogen peroxide-induced oxidative stress in MC3T3-E1 cells: The effects of glutamate and protection by purines. Bone 39: 542-551.
27. Liu AL, Zhang ZM, Zhu BF, Liao ZH, Liu Z, (2004) Metallothionein protects bone marrow stromal cells against hydrogen peroxide-induced inhibition of osteoblastic differentiation. Cell Biol Int 28: 905-911.
28. Hessle L, Johnson KA, Anderson HC, Narisawa S, Sali A, et al. (2002) Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization. Proc Natl Acad Sci U S A 99: 9445-9449.
29. Bai XC, Lu D, Bai J, Zheng H, Ke ZY, et al. (2004) Oxidative stress inhibits osteoblastic differentiation of bone cells by ERK and NF-kappaB. Biochem Biophys Res Commun 314: 197-207.
30. Arai M, Shibata Y, Pugdee K, Abiko Y, Ogata Y, (2007) Effects of reactive oxygen species (ROS) on antioxidant system and osteoblastic differentiation in MC3T3-E1 cells. IUBMB Life 59: 27-33.
31. Boyle WJ, Simonet WS, Lacey DL, (2003) Osteoclast differentiation and activation. Nature 423: 337-342.
32. Li J, Sarosi I, Yan XQ, Morony S, Capparelli C, et al. (2000) RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism. Proc Natl Acad Sci U S A 97: 1566-1571.
33. Bai XC, Lu D, Liu AL, Zhang ZM, Li XM, et al. (2005) Reactive oxygen species stimulates receptor activator of NF-kappaB ligand expression in osteoblast. J Biol Chem 280: 17497-17506.
34. Girasole G, Jilka RL, Passeri G, Boswell S, Boder G, et al. (1992) 17 beta-estradiol inhibits interleukin-6 production by bone marrow-derived stromal cells and osteoblasts in vitro: a potential mechanism for the antiosteoporotic effect of estrogens. J Clin Invest 89: 883-891.
35. Kurihara N, Bertolini D, Suda T, Akiyama Y, Roodman GD, (1990) IL-6 stimulates osteoclast-like multinucleated cell formation in long term human marrow cultures by inducing IL-1 release. J Immunol 144: 4226-4230.
36. Papanicolaou DA, Vgontzas AN, (2000) Interleukin-6: the endocrine cytokine. J Clin Endocrinol Metab 85: 1331-1333.
37. Kitazawa R, Kimble RB, Vannice JL, Kung VT, Pacifici R, (1994) Interleukin-1 receptor antagonist and tumor necrosis factor binding protein decrease osteoclast formation and bone resorption in ovariectomized mice. J Clin Invest 94: 2397-2406.
38. Naka K, Muraguchi T, Hoshii T, Hirao A, (2008) Regulation of reactive oxygen species and genomic stability in hematopoietic stem cells. Antioxid Redox Signal 10: 1883-1894.
39. Wiegant FA, Surinova S, Ytsma E, Langelaar-Makkinje M, Wikman G, et al. (2009) Plant adaptogens increase lifespan and stress resistance in C. elegans. Biogerontology 10: 27-42.
40. Nielsen F, Mikkelsen BB, Nielsen JB, Andersen HR, Grandjean P, (1997) Plasma malondialdehyde as biomarker for oxidative stress: reference interval and effects of life-style factors. Clin Chem 43: 1209-1214.
41. Yang P, He XQ, Peng L, Li AP, Wang XR, et al. (2007) The role of oxidative stress in hormesis induced by sodium arsenite in human embryo lung fibroblast (HELF) cellular proliferation model. J Toxicol Environ Health A 70: 976-983.
42. Ning J, Grant MH, (2000) The role of reduced glutathione and glutathione reductase in the cytotoxicity of chromium (VI) in osteoblasts. Toxicol In Vitro 14: 329-335.
43. Kinov P, Leithner A, Radl R, Bodo K, Khoschsorur GA, et al. (2006) Role of free radicals in aseptic loosening of hip arthroplasty. J Orthop Res 24: 55-62.
44. Kazakia GJ, Majumdar S, (2006) New imaging technologies in the diagnosis of osteoporosis. Rev Endocr Metab Disord 7: 67-74.
45. Teo JC, Si-Hoe KM, Keh JE, Teoh SH, (2006) Relationship between CT intensity, micro-architecture and mechanical properties of porcine vertebral cancellous bone. Clin Biomech (Bristol, Avon) 21: 235-244.
46. Peng ZQ, Vaananen HK, Zhang HX, Tuukkanen J, (1997) Long-term effects of ovariectomy on the mechanical properties and chemical composition of rat bone. Bone 20: 207-212.