메뉴 건너뛰기




Volumn 109, Issue 1, 2014, Pages 83-96

Oligonucleotides designed to inhibit TLR9 block Herpes simplex virus type 1 infection at multiple steps

Author keywords

ARPE 19; Herpes simplex virus; ICP4; NF B; Retinal pigment epithelium; TLR9

Indexed keywords

GUANOSINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; OLIGONUCLEOTIDE; TOLL LIKE RECEPTOR 9; ANTIVIRUS AGENT; VIRUS PROTEIN;

EID: 84904564936     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2014.06.015     Document Type: Article
Times cited : (7)

References (70)
  • 1
    • 3142724031 scopus 로고    scopus 로고
    • Toll-like receptor signalling
    • S. Akira, and K. Takeda Toll-like receptor signalling Nat. Rev. Immunol. 4 2004 499 511 (Pubitemid 38931765)
    • (2004) Nature Reviews Immunology , vol.4 , Issue.7 , pp. 499-511
    • Akira, S.1    Takeda, K.2
  • 2
    • 33646372984 scopus 로고    scopus 로고
    • Herpes simplex virus disrupts NF-κB regulation by blocking its recruitment on the IκBα promoter and directing the factor on viral genes
    • DOI 10.1074/jbc.M512366200
    • C. Amici, A. Rossi, A. Costanzo, S. Ciafre, B. Marinari, M. Balsamo, M. Levrero, and M.G. Santoro Herpes simplex virus disrupts NF-kappaB regulation by blocking its recruitment on the IkappaBalpha promoter and directing the factor on viral genes J. Biol. Chem. 281 2006 7110 7117 (Pubitemid 43847475)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.11 , pp. 7110-7117
    • Amici, C.1    Rossi, A.2    Costanzo, A.3    Ciafre, S.4    Marinari, B.5    Balsamo, M.6    Levrero, M.7    Santoro, M.G.8
  • 4
    • 0032978709 scopus 로고    scopus 로고
    • The herpes simplex virus type 1 regulatory protein ICP27 is required for the prevention of apoptosis in infected human cells
    • M. Aubert, and J. Blaho The herpes simplex virus type 1 regulatory protein ICP27 is required for the prevention of apoptosis in infected human cells J. Virol. 73 1999 2803 2813 (Pubitemid 29135667)
    • (1999) Journal of Virology , vol.73 , Issue.4 , pp. 2803-2813
    • Aubert, M.1    Blaho, J.A.2
  • 5
    • 47249092785 scopus 로고    scopus 로고
    • Development of TLR inhibitors for the treatment of autoimmune diseases
    • DOI 10.1111/j.1600-065X.2008.00630.x
    • F.J. Barrat, and R.L. Coffman Development of TLR inhibitors for the treatment of autoimmune diseases Immunol. Rev. 223 2008 271 283 (Pubitemid 351986175)
    • (2008) Immunological Reviews , vol.223 , Issue.1 , pp. 271-283
    • Barrat, F.J.1    Coffman, R.L.2
  • 7
    • 84869142278 scopus 로고    scopus 로고
    • Modulation of TLR9 response in a mouse model of herpes simplex virus encephalitis
    • N. Boivin, R. Menasria, J. Piret, and G. Boivin Modulation of TLR9 response in a mouse model of herpes simplex virus encephalitis Antiviral Res. 96 2012 414 421
    • (2012) Antiviral Res. , vol.96 , pp. 414-421
    • Boivin, N.1    Menasria, R.2    Piret, J.3    Boivin, G.4
  • 8
    • 0032435640 scopus 로고    scopus 로고
    • DNA and a CpG oligonucleotide derived from Babesia bovis are mitogenic for bovine B cells
    • W.C. Brown, D.M. Estes, S.E. Chantler, K.A. Kegerreis, and C.E. Suarez DNA and a CpG oligonucleotide derived from Babesia bovis are mitogenic for bovine B cells Infect. Immun. 66 1998 5423 5432 (Pubitemid 29044640)
    • (1998) Infection and Immunity , vol.66 , Issue.11 , pp. 5423-5432
    • Brown, W.C.1    Estes, D.M.2    Chantler, S.E.3    Kegerreis, K.A.4    Suarez, C.E.5
  • 9
    • 84873810684 scopus 로고    scopus 로고
    • The herpes simplex virus 1-encoded envelope glycoprotein B activates NF-κB through the Toll-like receptor 2 and MyD88/TRAF6-dependent signaling pathway
    • M. Cai, M. Li, K. Wang, S. Wang, Q. Lu, J. Yan, K.L. Mossman, R. Lin, and C. Zheng The herpes simplex virus 1-encoded envelope glycoprotein B activates NF-κB through the Toll-like receptor 2 and MyD88/TRAF6-dependent signaling pathway PLoS One 8 2013 e54586
    • (2013) PLoS One , vol.8 , pp. 54586
    • Cai, M.1    Li, M.2    Wang, K.3    Wang, S.4    Lu, Q.5    Yan, J.6    Mossman, K.L.7    Lin, R.8    Zheng, C.9
  • 10
    • 38949138073 scopus 로고    scopus 로고
    • Induction of interleukin-6 in human retinal epithelial cells by an attenuated Herpes simplex virus vector requires viral replication and NFκB activation
    • DOI 10.1016/j.exer.2007.10.008, PII S0014483507003016
    • S. Cai, and C.R. Brandt Induction of interleukin-6 in human retinal epithelial cells by an attenuated Herpes simplex virus vector requires viral replication and NFkappaB activation Exp. Eye Res. 86 2008 178 188 (Pubitemid 351231882)
    • (2008) Experimental Eye Research , vol.86 , Issue.2 , pp. 178-188
    • Cai, S.1    Brandt, C.R.2
  • 13
    • 67650935408 scopus 로고    scopus 로고
    • Gumming up the works: DNA polymers as HCV entry inhibitors
    • N.A. Counihan, and B.D. Lindenbach Gumming up the works: DNA polymers as HCV entry inhibitors Gastroenterology 137 2009 427 430
    • (2009) Gastroenterology , vol.137 , pp. 427-430
    • Counihan, N.A.1    Lindenbach, B.D.2
  • 16
    • 35148894088 scopus 로고    scopus 로고
    • Human herpes simplex virus infections: Epidemiology, pathogenesis, symptomatology, diagnosis, and management
    • DOI 10.1016/j.jaad.2007.06.027, PII S0190962207010456
    • M. Fatahzadeh, and R.A. Schwartz Human herpes simplex virus infections: epidemiology, pathogenesis, symptomatology, diagnosis, and management J. Am. Acad. Dermatol. 57 2007 737 763 (Pubitemid 47553079)
    • (2007) Journal of the American Academy of Dermatology , vol.57 , Issue.5 , pp. 737-763
    • Fatahzadeh, M.1    Schwartz, R.A.2
  • 17
    • 0028893984 scopus 로고
    • Inhibition of herpes simplex virus in culture by oligonucleotides composed entirely of deoxyguanosine and thymidine
    • S.M. Fennewald, S. Mustain, J. Ojwang, and R.F. Rando Inhibition of herpes simplex virus in culture by oligonucleotides composed entirely of deoxyguanosine and thymidine Antiviral Res. 26 1995 37 54
    • (1995) Antiviral Res. , vol.26 , pp. 37-54
    • Fennewald, S.M.1    Mustain, S.2    Ojwang, J.3    Rando, R.F.4
  • 18
    • 0032853334 scopus 로고    scopus 로고
    • Antisense oligonucleotides as therapeutic agents
    • DOI 10.1002/(SICI)1097-4652(199911)181:2<251::AID-JCP7>3.0.CO;2-D
    • U. Galderisi, A. Cascino, and A. Giordano Antisense oligonucleotides as therapeutic agents J. Cell. Physiol. 181 1999 251 257 (Pubitemid 29463640)
    • (1999) Journal of Cellular Physiology , vol.181 , Issue.2 , pp. 251-257
    • Galderisi, U.1    Cascino, A.2    Giordano, A.3
  • 20
    • 37249074364 scopus 로고    scopus 로고
    • Bcl-2 antisense in the treatment of human malignancies: A delusion in targeted therapy
    • DOI 10.2174/138920107783018381
    • B.T. Gjertsen, T. Bredholt, N. Anensen, and O.K. Vintermyr Bcl-2 antisense in the treatment of human malignancies: a delusion in targeted therapy Curr. Pharm. Biotechnol. 8 2007 373 381 (Pubitemid 350268196)
    • (2007) Current Pharmaceutical Biotechnology , vol.8 , Issue.6 , pp. 373-381
    • Gjertsen, B.T.1    Bredholt, T.2    Anensen, N.3    Vintermyr, O.K.4
  • 21
    • 0038678185 scopus 로고    scopus 로고
    • NF-κB is required for apoptosis prevention during herpes simplex virus type 1 infection
    • DOI 10.1128/JVI.77.13.7261-7280.2003
    • M.L. Goodkin, A.T. Ting, and J.A. Blaho NF-kappaB is required for apoptosis prevention during herpes simplex virus type 1 infection J. Virol. 77 2003 7261 7280 (Pubitemid 36734495)
    • (2003) Journal of Virology , vol.77 , Issue.13 , pp. 7261-7280
    • Goodkin, M.L.1    Ting, A.T.2    Blaho, J.A.3
  • 22
    • 0024805851 scopus 로고
    • Herpes simplex virus stromal keratitis is not titer-dependent and does not correlate with neurovirulence
    • D.R. Grau, R.J. Visalli, and C.R. Brandt Herpes simplex virus stromal keratitis is not titer-dependent and does not correlate with neurovirulence Invest. Ophthalmol. Vis. Sci. 30 1989 2474 2480 (Pubitemid 20021787)
    • (1989) Investigative Ophthalmology and Visual Science , vol.30 , Issue.12 , pp. 2474-2480
    • Grau, D.R.1    Visalli, R.J.2    Brandt, C.R.3
  • 23
    • 10044241988 scopus 로고    scopus 로고
    • Efficient replication by herpes simplex virus type 1 involves activation of the IκB kinase-IκB-p65 pathway
    • DOI 10.1128/JVI.78.24.13582-13590.2004
    • D. Gregory, D. Hargett, D. Holmes, E. Money, and S.L. Bachenheimer Efficient replication by herpes simplex virus type 1 involves activation of the IkappaB kinase-IkappaB-p65 pathway J. Virol. 78 2004 13582 13590 (Pubitemid 39612758)
    • (2004) Journal of Virology , vol.78 , Issue.24 , pp. 13582-13590
    • Gregory, D.1    Hargett, D.2    Holmes, D.3    Money, E.4    Bachenheimer, S.L.5
  • 26
    • 33750285635 scopus 로고    scopus 로고
    • Herpes simplex virus type 1 ICP27-dependent activation of NF-κB
    • DOI 10.1128/JVI.01119-06
    • D. Hargett, S. Rice, and S.L. Bachenheimer Herpes simplex virus type 1 ICP27-dependent activation of NF-kappaB J. Virol. 80 2006 10565 10578 (Pubitemid 44628903)
    • (2006) Journal of Virology , vol.80 , Issue.21 , pp. 10565-10578
    • Hargett, D.1    Rice, S.2    Bachenheimer, S.L.3
  • 27
    • 33746790577 scopus 로고    scopus 로고
    • Herpes simplex virus 1 (HSV-1) DNA and immune complex (HSV-1-human IgG) elicit vigorous interleukin 6 release from infected corneal cells via Toll-like receptors
    • DOI 10.1099/vir.0.81772-0
    • K. Hayashi, L.C. Hooper, M.S. Chin, C.N. Nagineni, B. Detrick, and J.J. Hooks Herpes simplex virus 1 (HSV-1) DNA and immune complex (HSV-1-human IgG) elicit vigorous interleukin 6 release from infected corneal cells via Toll-like receptors J. Gen. Virol. 87 2006 2161 2169 (Pubitemid 44178094)
    • (2006) Journal of General Virology , vol.87 , Issue.8 , pp. 2161-2169
    • Hayashi, K.1    Hooper, L.C.2    Chin, M.S.3    Nagineni, C.N.4    Detrick, B.5    Hooks, J.J.6
  • 29
    • 64049098693 scopus 로고    scopus 로고
    • Innate immune recognition of viruses and viral vectors
    • X. Huang, and Y. Yang Innate immune recognition of viruses and viral vectors Hum. Gene Ther. 20 2009 293 301
    • (2009) Hum. Gene Ther. , vol.20 , pp. 293-301
    • Huang, X.1    Yang, Y.2
  • 30
    • 0842304592 scopus 로고    scopus 로고
    • Biology of Toll receptors: Lessons from insects and mammals
    • DOI 10.1189/jlb.0403160
    • J.L. Imler, and L. Zheng Biology of Toll receptors: lessons from insects and mammals J. Leukoc. Biol. 75 2004 18 26 (Pubitemid 38166775)
    • (2004) Journal of Leukocyte Biology , vol.75 , Issue.1 , pp. 18-26
    • Imler, J.-L.1    Zheng, L.2
  • 32
    • 31344461659 scopus 로고    scopus 로고
    • Innate immune recognition of viral infection
    • DOI 10.1038/ni1303, PII N1303
    • T. Kawai, and S. Akira Innate immune recognition of viral infection Nat. Immunol. 7 2006 131 137 (Pubitemid 43135878)
    • (2006) Nature Immunology , vol.7 , Issue.2 , pp. 131-137
    • Kawai, T.1    Akira, S.2
  • 35
    • 0842328805 scopus 로고    scopus 로고
    • Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9
    • DOI 10.1182/blood-2003-08-2674
    • A. Krug, G.D. Luker, W. Barchet, D.A. Leib, S. Akira, and M. Colonna Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9 Blood 103 2004 1433 1437 (Pubitemid 38168659)
    • (2004) Blood , vol.103 , Issue.4 , pp. 1433-1437
    • Krug, A.1    Luker, G.D.2    Barchet, W.3    Leib, D.A.4    Akira, S.5    Colonna, M.6
  • 36
    • 3242670505 scopus 로고    scopus 로고
    • Innate immunity in the retina: Toll-like receptor (TLR) signaling in human retinal pigment epithelial cells
    • DOI 10.1016/j.jneuroim.2004.04.018, PII S0165572804001444
    • M.V. Kumar, C.N. Nagineni, M.S. Chin, J.J. Hooks, and B. Detrick Innate immunity in the retina: Toll-like receptor (TLR) signaling in human retinal pigment epithelial cells J. Neuroimmunol. 153 2004 7 15 (Pubitemid 38950922)
    • (2004) Journal of Neuroimmunology , vol.153 , Issue.1-2 , pp. 7-15
    • Kumar, M.V.1    Nagineni, C.N.2    Chin, M.S.3    Hooks, J.J.4    Detrick, B.5
  • 39
    • 38949217075 scopus 로고    scopus 로고
    • Inhibition of cellular entry of lymphocytic choriomeningitis virus by amphipathic DNA polymers
    • DOI 10.1016/j.virol.2007.10.016, PII S0042682207006915
    • A.M. Lee, J.M. Rojek, A. Gundersen, U. Ströher, J.M. Juteau, A. Vaillant, and S. Kunz Inhibition of cellular entry of lymphocytic choriomeningitis virus by amphipathic DNA polymers Virology 372 2008 107 117 (Pubitemid 351215460)
    • (2008) Virology , vol.372 , Issue.1 , pp. 107-117
    • Lee, A.M.1    Rojek, J.M.2    Gundersen, A.3    Stroher, U.4    Juteau, J.-M.5    Vaillant, A.6    Kunz, S.7
  • 40
    • 84864010826 scopus 로고    scopus 로고
    • Herpes simplex virus glycoproteins gH/gL and gB bind Toll-like receptor 2, and soluble gH/gL is sufficient to activate NF-κB
    • V. Leoni, T. Gianni, S. Salvioli, and G. Campadelli-Fiume Herpes simplex virus glycoproteins gH/gL and gB bind Toll-like receptor 2, and soluble gH/gL is sufficient to activate NF-κB J. Virol. 86 2012 6555 6562
    • (2012) J. Virol. , vol.86 , pp. 6555-6562
    • Leoni, V.1    Gianni, T.2    Salvioli, S.3    Campadelli-Fiume, G.4
  • 42
    • 40549122643 scopus 로고    scopus 로고
    • Phosphorothioate-modified oligodeoxynucleotides inhibit human cytomegalovirus replication by blocking virus entry
    • DOI 10.1128/AAC.00987-07
    • A. Luganini, F. Caposio, S. Landolfo, and G. Gribaudo Phosphorothioate-modified oligodeoxynucleotides inhibit human cytomegalovirus replication by blocking virus entry Antimicrob. Agents Chemother. 52 2008 1111 1120 (Pubitemid 351358395)
    • (2008) Antimicrobial Agents and Chemotherapy , vol.52 , Issue.3 , pp. 1111-1120
    • Luganini, A.1    Caposio, P.2    Landolfo, S.3    Gribaudo, G.4
  • 43
    • 0042123694 scopus 로고    scopus 로고
    • Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells
    • DOI 10.1084/jem.20030162
    • J. Lund, A. Sato, S. Akira, R. Medzhitov, and A. Iwasaki Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells J. Exp. Med. 198 2003 513 520 (Pubitemid 36976063)
    • (2003) Journal of Experimental Medicine , vol.198 , Issue.3 , pp. 513-520
    • Lund, J.1    Sato, A.2    Akira, S.3    Medzhitov, R.4    Iwasaki, A.5
  • 44
    • 77957302953 scopus 로고    scopus 로고
    • Toll-like receptor-mediated recognition of herpes simplex virus
    • N. Martinez-Martin, and A. Viejo-Borbolla Toll-like receptor-mediated recognition of herpes simplex virus Front. Biosci. (Schol Ed) S2 2010 718 729
    • (2010) Front. Biosci. (Schol Ed) , vol.2 S , pp. 718-729
    • Martinez-Martin, N.1    Viejo-Borbolla, A.2
  • 46
    • 79952151936 scopus 로고    scopus 로고
    • Oligomeric nucleic acids as antivirals
    • A. Mescalchin, and T. Restle Oligomeric nucleic acids as antivirals Molecules 16 2011 1271 1296
    • (2011) Molecules , vol.16 , pp. 1271-1296
    • Mescalchin, A.1    Restle, T.2
  • 47
    • 84885929771 scopus 로고    scopus 로고
    • Nucleic acid polymers inhibit duck hepatitis B virus infection in vitro
    • F. Noordeen, A. Vaillant, and A.R. Jilbert Nucleic acid polymers inhibit duck hepatitis B virus infection in vitro Antimicrob. Agents Chemother. 57 2013 5291 5298
    • (2013) Antimicrob. Agents Chemother. , vol.57 , pp. 5291-5298
    • Noordeen, F.1    Vaillant, A.2    Jilbert, A.R.3
  • 48
    • 84885942075 scopus 로고    scopus 로고
    • Nucleic acid polymers prevent the establishment of duck hepatitis B virus infection in vivo
    • F. Noordeen, A. Vaillant, and A.R. Jilbert Nucleic acid polymers prevent the establishment of duck hepatitis B virus infection in vivo Antimicrob. Agents Chemother. 57 2013 5299 5306
    • (2013) Antimicrob. Agents Chemother. , vol.57 , pp. 5299-5306
    • Noordeen, F.1    Vaillant, A.2    Jilbert, A.R.3
  • 49
    • 37149024435 scopus 로고    scopus 로고
    • Characterization of suppressive oligodeoxynucleotides that inhibit Toll-like receptor-9-mediated activation of innate immunity
    • DOI 10.1111/j.1365-2567.2007.02718.x
    • M. Peter, K. Bode, G.B. Lipford, F. Eberle, K. Heeg, and A.H. Dalpke Characterization of suppressive oligodeoxynucleotides that inhibit Toll-like receptor-9-mediated activation of innate immunity Immunology 123 2007 118 128 (Pubitemid 350256002)
    • (2008) Immunology , vol.123 , Issue.1 , pp. 118-128
    • Peter, M.1    Bode, K.2    Lipford, G.B.3    Eberle, F.4    Heeg, K.5    Dalpke, A.H.6
  • 50
    • 37049010982 scopus 로고    scopus 로고
    • Type I interferon production during herpes simplex virus infection is controlled by cell-type-specific viral recognition through toll-like receptor 9, the mitochondrial antiviral signaling protein pathway, and novel recognition systems
    • DOI 10.1128/JVI.01167-07
    • S.B. Rasmussen, L.N. Sørensen, L. Malmgaard, N. Ank, J.D. Baines, Z.J. Chen, and S.R. Paludan Type I interferon production during herpes simplex virus infection is controlled by cell-type-specific viral recognition through Toll-like receptor 9, the mitochondrial antiviral signaling protein pathway, and novel recognition systems J. Virol. 81 2007 13315 13324 (Pubitemid 350247828)
    • (2007) Journal of Virology , vol.81 , Issue.24 , pp. 13315-13324
    • Rasmussen, S.B.1    Sorensen, L.N.2    Malmgaard, L.3    Ank, N.4    Baines, J.D.5    Chen, Z.J.6    Paludan, S.R.7
  • 51
    • 82955178645 scopus 로고    scopus 로고
    • Cytosolic surveillance and antiviral immunity
    • V.A.K. Rathinam, and K.A. Fitzgerald Cytosolic surveillance and antiviral immunity Curr. Opin. Virol. 1 2011 455 462
    • (2011) Curr. Opin. Virol. , vol.1 , pp. 455-462
    • Rathinam, V.A.K.1    Fitzgerald, K.A.2
  • 52
    • 79955439173 scopus 로고    scopus 로고
    • UL31 of Herpes simplex virus 1 is necessary for optimal NF-{kappa}B activation and expression of viral gene products
    • K.L. Roberts, and J.D. Baines UL31 of Herpes simplex virus 1 is necessary for optimal NF-{kappa}B activation and expression of viral gene products J. Virol. 85 2011 4947 4953
    • (2011) J. Virol. , vol.85 , pp. 4947-4953
    • Roberts, K.L.1    Baines, J.D.2
  • 55
    • 33646443203 scopus 로고    scopus 로고
    • Virucidal activity of a GT-rich oligonucleotide against herpes simplex virus mediated by glycoprotein B
    • B. Shogan, L. Kruse, G.B. Mulamba, A. Hu, and D.M. Coen Virucidal activity of a GT-rich oligonucleotide against herpes simplex virus mediated by glycoprotein B J. Virol. 80 2006 4740 4747
    • (2006) J. Virol. , vol.80 , pp. 4740-4747
    • Shogan, B.1    Kruse, L.2    Mulamba, G.B.3    Hu, A.4    Coen, D.M.5
  • 56
    • 0030770508 scopus 로고    scopus 로고
    • Immunity causing blindness: Five different paths to herpes stromal keratitis
    • DOI 10.1016/S0167-5699(97)01114-6, PII S0167569997011146
    • J.W. Streilein, M.R. Dana, and B.R. Ksander Immunity causing blindness: five different paths to herpes stromal keratitis Immunol. Today 18 1997 443 449 (Pubitemid 27381987)
    • (1997) Immunology Today , vol.18 , Issue.9 , pp. 443-449
    • Streilein, J.W.1    Dana, M.R.2    Ksander, B.R.3
  • 57
    • 0031252286 scopus 로고    scopus 로고
    • Mitogenicity of DNA from Different Organisms for Murine B Cells
    • S. Sun, C. Beard, R. Jaenisch, P. Jones, and J. Sprent Mitogenicity of DNA from different organisms for murine B cells J. Immunol. 159 1997 3119 3125 (Pubitemid 127482068)
    • (1997) Journal of Immunology , vol.159 , Issue.7 , pp. 3119-3125
    • Sun, S.1    Beard, C.2    Jaenisch, R.3    Jones, P.4    Sprent, J.5
  • 61
    • 33645781308 scopus 로고    scopus 로고
    • Phosphorothioate oligonucleotides inhibit human immunodeficiency virus type 1 fusion by blocking gp41 core formation
    • A. Vaillant, J. Juteau, H. Lu, S. Liu, C. Lackman-Smith, R. Ptak, and S. Jiang Phosphorothioate oligonucleotides inhibit human immunodeficiency virus type 1 fusion by blocking gp41 core formation Antimicrob. Agents Chemother. 50 2006 1393 1401
    • (2006) Antimicrob. Agents Chemother. , vol.50 , pp. 1393-1401
    • Vaillant, A.1    Juteau, J.2    Lu, H.3    Liu, S.4    Lackman-Smith, C.5    Ptak, R.6    Jiang, S.7
  • 63
    • 0027209533 scopus 로고
    • The HSV-1 UL45 18 kDa gene product is a true late protein and a component of the virion
    • DOI 10.1016/0168-1702(93)90057-T
    • R.J. Visalli, and C.R. Brandt The HSV-1 UL45 18 kDa gene product is a true late protein and a component of the virion Virus Res. 29 1993 167 178 (Pubitemid 23235071)
    • (1993) Virus Research , vol.29 , Issue.2 , pp. 167-178
    • Visalli, R.J.1    Brandt, C.R.2
  • 64
    • 0000314691 scopus 로고    scopus 로고
    • Herpes simplex viruses
    • B.N. Fields, D.M. Knipe, P.M. Howley, Lippincott-Raven Philadelphia
    • R.J. Whitley Herpes simplex viruses B.N. Fields, D.M. Knipe, P.M. Howley, Fields Virology vol. 2 1996 Lippincott-Raven Philadelphia 2297 2342
    • (1996) Fields Virology , vol.2 , pp. 2297-2342
    • Whitley, R.J.1
  • 65
    • 77955098945 scopus 로고    scopus 로고
    • Off-target effects related to the phosphorothioate modification of nucleic acids
    • J. Winkler, M. Stessl, J. Amartey, and C.R. Noe Off-target effects related to the phosphorothioate modification of nucleic acids ChemMedChem 5 2010 1344 1352
    • (2010) ChemMedChem , vol.5 , pp. 1344-1352
    • Winkler, J.1    Stessl, M.2    Amartey, J.3    Noe, C.R.4
  • 67
    • 33947589836 scopus 로고    scopus 로고
    • Nucleic acid-based antiviral drugs against seasonal and avian influenza viruses
    • DOI 10.1016/j.vaccine.2007.01.051, PII S0264410X07000618
    • J.P. Wong, M.E. Christopher, A.M. Salazar, R.M. Dale, L.Q. Sun, and M. Wang Nucleic acid-based antiviral drugs against seasonal and avian influenza viruses Vaccine Res. 25 2007 3175 3178 (Pubitemid 46482750)
    • (2007) Vaccine , vol.25 , Issue.16 SPEC. ISS. , pp. 3175-3178
    • Wong, J.P.1    Christopher, M.E.2    Salazar, A.M.3    Dale, R.M.K.4    Sun, L.-Q.5    Wang, M.6
  • 68
    • 0027271987 scopus 로고
    • Potent inhibition of Epstein-Barr virus by phosphorothioate oligodeoxynucleotides without sequence specification
    • G.-Q. Yao, S. Grill, W. Egan, and Y.-C. Gheng Potent inhibition of Epstein-Barr virus by phosphorothioate oligodeoxynucleotides without sequence specification Antimicrob. Agents Chemother. 37 1993 1420 1425 (Pubitemid 23202365)
    • (1993) Antimicrobial Agents and Chemotherapy , vol.37 , Issue.7 , pp. 1420-1425
    • Yao, G.-Q.1    Grill, S.2    Egan, W.3    Cheng, Y.-C.4
  • 70
    • 80052969639 scopus 로고    scopus 로고
    • The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells
    • Z. Zhang, B. Yuan, M. Bao, N. Lu, T. Kim, and Y.-J. Liu The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells Nat. Immunol. 12 2011 959 965
    • (2011) Nat. Immunol. , vol.12 , pp. 959-965
    • Zhang, Z.1    Yuan, B.2    Bao, M.3    Lu, N.4    Kim, T.5    Liu, Y.-J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.