Amphipathic DNA polymers exhibit antiherpetic activity in vitro and in vivo

Antimicrobial Agents and Chemotherapy

Volumn 52, Issue 8, 2008, Pages 2727-2733

  Bernstein, David I ^a,e   Goyette, Nathalie ^b   Cardin, Rhonda ^a   Kern, Earl R ^c   Boivin, Guy ^b   Ireland, James ^a   Juteau, Jean Marc ^d   Vaillant, Andrew ^d  

^a UNIVERSITY OF CINCINNATI   (United States)

^b LAVAL UNIVERSITY   (Canada)

^c UNIVERSITY OF ALABAMA SCHOOL OF MEDICINE   (United States)

^d REPLICor Inc   (Canada)

^e CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; DNA; OLIGONUCLEOTIDE; OLIGONUCLEOTIDE PHOSPHOROTHIOATE; PLACEBO; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; CYTOMEGALOVIRUS; DRUG FORMULARY; DRUG STABILITY; EPSTEIN BARR VIRUS; FEMALE; GENE SEQUENCE; GENITAL HERPES; HERPES SIMPLEX VIRUS 1; HERPES SIMPLEX VIRUS 2; HERPES VIRUS; HERPES VIRUS INFECTION; HUMAN HERPESVIRUS 6; IN VITRO STUDY; IN VIVO STUDY; INFECTION PREVENTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; THERAPY EFFECT; TREATMENT RESPONSE; VARICELLA ZOSTER VIRUS;

ANIMALS; ANTIVIRAL AGENTS; CERCOPITHECUS AETHIOPS; CYTOMEGALOVIRUS; DNA; DRUG STABILITY; FEMALE; HERPES GENITALIS; HERPESVIRUS 1, HUMAN; HERPESVIRUS 2, HUMAN; HUMANS; HYDROGEN-ION CONCENTRATION; MICE; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; VERO CELLS;

EID: 48749128890     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.00279-08     Document Type: Article

References (28)

1. Balzarini, J., and L. Van Damme. 2007. Microbicide drug candidates to prevent HIV infection. Lancet 369:787-797.
2. Bernstein, D. I., L. R. Stanberry, S. Sacks, N. K. Ayisi, Y. H. Gong, J. Ireland, R. J. Mumper, G. Holan, B. Matthews, T. McCarthy, and N. Bourne. 2003. Evaluations of unformulated and formulated dendrimer-based microbicide candidates in mouse and guinea pig models of genital herpes. Antimicrob. Agents Chemother. 47:3784-3788.
3. Bourne, N., L. R. Stanberry, E. R. Kern, G. Holan, B. Matthews, and D. I. Bernstein. 2000. Dendrimers, a new class of candidate topical microbicides with activity against herpes simplex virus infection. Antimicrob. Agents Chemother. 44:2471-2474.
4. Bullough, P. A., F. M. Hughson, J. J. Skehel, and D. C. Wiley. 1994. Structure of influenza haemagglutinin at the pH of membrane fusion. Nature 371:37-43.
5. Chan, D. C., and P. S. Kim. 1998. HIV entry and its inhibition. Cell 93:681-684.
6. Check, E. 2007. Scientists rethink approach to HIV gels. Nature 446:12.
7. Chen, J., J. J. Skehel, and D. C. Wiley. 1999. N- and C-terminal residues combine in the fusion-pH influenza hemagglutinin HA(2) subunit to form an N cap that terminates the triple-stranded coiled coil. Proc. Natl. Acad. Sci. USA 96:8967-8972.
8. Corey, L., A. Wald, C. L. Celum, and T. C. Quinn. 2004. The effects of herpes simplex virus-2 on HIV-1 acquisition and transmission: a review of two overlapping epidemics. J. Acquir. Immune. Defic. Syndr. 35:435-445.
9. Dhawan, D., and K. H. Mayer. 2006. Microbicides to prevent HIV transmission: overcoming obstacles to chemical barrier protection. J. Infect. Dis. 193:36-44.
10. Fennewald, S. M., S. Mustain, J. Ojwang, and R. F. Rando. 1995. Inhibition of herpes simplex virus in culture by oligonucleotides composed entirely of deoxyguanosine and thymidine. Antivir. Res. 26:37-54.
11. Freeman, E. E., H. A. Weiss, J. R. Glynn, P. L. Cross, J. A. Whitworth, and R. J. Hayes. 2006. Herpes simplex virus 2 infection increases HIV acquisition in men and women: systematic review and meta-analysis of longitudinal studies. AIDS 20:73-83.
12. Gao, W. Y., R. N. Hanes, M. A. Vazquez-Padua, C. A. Stein, J. S. Cohen, and Y. C. Cheng. 1990. Inhibition of herpes simplex virus type 2 growth by phosphorothioate oligodeoxynucleotides. Antimicrob. Agents Chemother. 34:808-812.
13. Gao, W. Y., J. W. Jaroszewski, J. S. Cohen, and Y. C. Cheng. 1990. Mechanisms of inhibition of herpes simplex virus type 2 growth by 28-mer phosphorothioate oligodeoxycytidine. J. Biol. Chem. 265:20172-20178.
14. Gaudreau, A., E. Hill, H. H. Balfour, Jr., A. Erice, and G. Boivin. 1998. Phenotypic and genotypic characterization of acyclovir-resistant herpes simplex viruses from immunocompromised patients. J. Infect. Dis. 178:297-303.
15. Gianni, T., P. L. Martelli, R. Casadio, and G. Campadelli-Fiume. 2005. The ectodomain of herpes simplex virus glycoprotein H contains a membrane alpha-helix with attributes of an internal fusion peptide, positionally conserved in the Herpesviridae family. J. Virol. 79:2931-2940.
16. Gianni, T., L. Menotti, and G. Campadelli-Fiume. 2005. A heptad repeat in herpes simplex virus 1 gH, located downstream of the alpha-helix with attributes of a fusion peptide, is critical for virus entry and fusion. J. Virol. 79:7042-7049.
17. Guzman, E. M., N. Cheshenko, V. Shende, M. J. Keller, N. Goyette, J. M. Juteau, G. Boivin, A. Vaillant, and B. C. Herold. 2007. Amphipathic DNA polymers are candidate vaginal microbicides and block herpes simplex virus binding, entry and viral gene expression. Antivir. Ther. 12:1147-1156.
18. Heldwein, E. E., H. Lou, F. C. Bender, G. H. Cohen, R. J. Eisenberg, and S. C. Harrison. 2006. Crystal structure of glycoprotein B from herpes simplex virus 1. Science 313:217-220.
19. Keller, M. J., and B. C. Herold. 2006. Impact of microbicides and sexually transmitted infections on mucosal immunity in the female genital tract. Am. J. Reprod. Immunol. 56:356-363.
20. Keller, M. J., A. Tuyama, M. J. Carlucci, and B. C. Herold. 2005. Topical microbicides for the prevention of genital herpes infection. J. Antimicrob. Chemother. 55:420-423.
21. Kim, J., C. Cheong, and P. B. Moore. 1991. Tetramerization of an RNA oligonucleotide containing a GGGG sequence. Nature 351:331-332.
22. Lee, A. M., J. M. Rojek, A. Gundersen, U. Stroher, J. M. Juteau, A. Vaillant, and S. Kunz. 2008. Inhibition of cellular entry of lymphocytic choriomeningitis virus by amphipathic DNA polymers. Virology 372:107-117.
23. Patel, S., E. Hazrati, N. Cheshenko, B. Galen, H. Yang, E. Guzman, R. Wang, B. C. Herold, and M. J. Keller. 2007. Seminal plasma reduces the effectiveness of topical polyanionic microbicides. J. Infect. Dis. 196:1394-1402.
24. Sajic, D., A. A. Ashkar, A. J. Patrick, M. J. McCluskie, H. L. Davis, K. L. Levine, R. Holl, and K. L. Rosenthal. 2003. Parameters of CpG oligodeoxynucleotide-induced protection against intravaginal HSV-2 challenge. J. Med. Virol. 71:561-568.
25. Schmit, I., and G. Boivin. 1999. Characterization of the DNA polymerase and thymidine kinase genes of herpes simplex virus isolates from AIDS patients in whom acyclovir and foscarnet therapy sequentially failed. J. Infect. Dis. 180:487-490.
26. Tuyama, A. C., N. Cheshenko, M. J. Carlucci, J. H. Li, C. L. Goldberg, D. P. Waller, R. A. Anderson, A. T. Profy, M. E. Klotman, M. J. Keller, and B. C. Herold. 2006. ACIDFORM inactivates herpes simplex virus and prevents genital herpes in a mouse model: optimal candidate for microbicide combinations. J. Infect. Dis. 194:795-803.
27. Vaillant, A., J. M. Juteau, H. Lu, S. Liu, C. Lackman-Smith, R. Ptak, and S. Jiang. 2006. Phosphorothioate oligonucleotides inhibit human immunodeficiency virus type 1 fusion by blocking gp41 core formation. Antimicrob. Agents Chemother. 50:1393-1401.
28. Williams-Aziz, S. L., C. B. Hartline, E. A. Harden, S. L. Daily, M. N. Prichard, N. L. Kushner, J. R. Beadle, W. B. Wan, K. Y. Hostetler, and E. R. Kern. 2005. Comparative activities of lipid esters of cidofovir and cyclic cidofovir against replication of herpesviruses in vitro. Antimicrob. Agents Chemother. 49:3724-3733.