Deletion of interleukin-6 signal transducer gp130 in small sensory neurons attenuates mechanonociception and down-regulates TRPA1 expression

Journal of Neuroscience

Volumn 34, Issue 30, 2014, Pages 9845-9856

  Malsch, Philipp ^a   Andratsch, Manfred ^a   Vogl, Christian ^a,g   Link, Andrea S ^b   Alzheimer, Christian ^b   Brierley, Stuart M ^c,d,e   Hughes, Patrick A ^e,f   Kress, Michaela ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c UNIVERSITY OF ADELAIDE   (Australia)

^d ROYAL ADELAIDE HOSPITAL   (Australia)

^e UNIVERSITY OF ADELAIDE   (Australia)

^f Women's and Children's Health Research Institute   (Australia)

^g UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

Author keywords

Cytokine; Il 6 signal transducer; JAK STAT signaling; Mechanonociceptor; Mechanotransduction; Pain

Indexed keywords

CALCIUM; GLYCOPROTEIN GP 130; INTERLEUKIN 6; JANUS KINASE; MESSENGER RNA; RNA; TRANSIENT RECEPTOR POTENTIAL CHANNEL A1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; FLUORESCENCE IN SITU HYBRIDIZATION; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SIGNALING; MALE; MECHANICAL STRESS; MECHANONOCICEPTION; MICROFLUOROMETRY; MOUSE; NERVE POTENTIAL; NOCICEPTION; NONHUMAN; PAIN THRESHOLD; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSORY NERVE CELL; SOMATOSENSORY SYSTEM; UPREGULATION;

CYTOKINE; IL-6 SIGNAL TRANSDUCER; JAK/STAT SIGNALING; MECHANONOCICEPTOR; MECHANOTRANSDUCTION; PAIN;

ANIMALS; CELLS, CULTURED; CYTOKINE RECEPTOR GP130; DOWN-REGULATION; FEMALE; GENE DELETION; MALE; MECHANORECEPTORS; MICE; MICE, KNOCKOUT; RNA, MESSENGER; SENSORY RECEPTOR CELLS; SIGNAL TRANSDUCTION; TRANSIENT RECEPTOR POTENTIAL CHANNELS;

EID: 84904555971     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5161-13.2014     Document Type: Article

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