Interleukin-6 in combination with its soluble IL-6 receptor sensitises rat skin nociceptors to heat, in vivo

Pain

Volumn 96, Issue 1-2, 2002, Pages 57-62

  Obreja, Otilia ^a   Schmelz, Martin ^a   Poole, Stephen ^b   Kress, Michaela ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b NATIONAL INSTITUTE FOR BIOLOGICAL STANDARDS AND CONTROL   (United Kingdom)

Author keywords

Calcitonin gene related peptide; Dermal microdialysis; Interleukin 6; Pain; Sensory neurones; Soluble receptor for interleukin 6

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; GLYCOPROTEIN GP 130; INTERLEUKIN 6; INTERLEUKIN 6 ANTIBODY; INTERLEUKIN 6 RECEPTOR; RINGER SOLUTION;

ABDOMEN; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIALYSATE; ENZYME IMMUNOASSAY; HEAT SENSITIVITY; HEATING; MALE; MEMBRANE; MICRODIALYSIS; NOCICEPTIVE RECEPTOR; NONHUMAN; PAIN; PERFUSION; PLASMAPHERESIS; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; PROTEIN SECRETION; RAT; SENSITIZATION; SKIN; STIMULATION;

ANIMALS; ANTIGENS, CD; CALCITONIN GENE-RELATED PEPTIDE; CYTOKINE RECEPTOR GP130; HEAT; HYPERALGESIA; INTERLEUKIN-6; MALE; MEMBRANE GLYCOPROTEINS; MICRODIALYSIS; NEURONS, AFFERENT; NOCICEPTORS; PROTEINS; RATS; RATS, WISTAR; RECEPTORS, INTERLEUKIN-6; RECOMBINANT PROTEINS;

EID: 0036212599     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3959(01)00420-1     Document Type: Article

References (46)

1. A rapid and sensitive method for the quantitation of microgramm quantities of protein utilizing the principle of protein-dye binding
2. Effect of soluble interleukin-6 receptor on interleukin-6 synthesis in human skin fibroblasts
3. Response of serum interleukin-6 in patients undergoing elective surgery of varying severity
4. The pivotal role of tumour necrosis factor alpha in the development of inflammatory hyperalgesia
5. Interleukin-6-mediated hyperalgesia/allodynia and increased spinal IL-6 expression in a rat mononeuropathy model
6. Tissue-specific regulation of IL-6 production by IL-4: Differential effects of IL-4 on nuclear factor-kappa B activity in monocytes and fibroblasts
7. Production and in situ localization of cutaneous tumour necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6) following skin sensitization
8. Postnatal expression of interleukin-6 (IL-6) and IL-6 receptor (IL-6R) mRNAs in rat sympathetic and sensory ganglia
9. Ultrastructural evidence for the coexistence of calcitonin gene-related peptide and substance P in secretory vesicles of peripheral nerves in the guinea pig
10. Human soluble IL-6 receptor: Its detection and enhanced release by HIV infection
11. Ca(2+)-dependent exocytosis in the somata of dorsal root ganglion neurons
12. Production of systemic and hypothalamic cytokines during the early phase of endotoxin fever
13. C-reactive protein: A physiological activator of interleukin 6 receptor shedding
14. The soluble interleukin 6 receptor: Mechanisms of production and implications in disease
15. Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses
16. Heat-induced release of CGRP from isolated rat skin and effects of bradykinin and the protein kinase C activator PMA
17. IFN-beta 2 B cell differentiation factor 2 or hybridoma growth factor (IL-6) is expressed and released by human epidermal cells and epidermoid carcinoma cell lines
18. Interleukin-6 family of cytokines and gp130
19. Calcitonin gene-related peptide and prostaglandin E2 but not substance P release induced by antidromic nerve stimulation from rat skin in vitro
20. Production of interleukin-6 by human mast cells and basophilic cells
21. Autocrine and paracrine regulation by cytokines and growth factors in melanoma
22. Isolation of an mRNA encoding a soluble form of the human interleukin-6 receptor
23. Interleukin-6 (IL-6) and soluble forms of IL-6 receptors are not altered in cerebrospinal fluid of Alzheimer's disease patients
24. Neural activities of IL-6-type cytokines often depend on soluble cytokine receptors
25. Soluble IL-6 receptor potentiates the antagonistic activity of soluble gp130 on IL-6 responses
26. IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase
27. Nature of the retrograde signal from injured nerves that induce interleukin-6 mRNA in neurons
28. Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130
29. Increased IL-6 production by monocytes and keratinocytes in patients with psoriasis
30. Immunohistochemical localization of interleukin-6-like immunoreactivity to peripheral nerve-like structures in normal and inflamed human skin
31. Soluble cytokine receptors are present in normal human urine
32. Intracerebroventricular injection of interleukin-6 induces thermal hyperalgesia in rats
33. Involvement of the proinflammatory cytokines tumor necrosis factor-alpha, IL-1 beta, and IL-6 but not IL-8 in the development of heat hyperalgesia: Effects on heat-evoked calcitonin gene-related peptide release from rat skin
34. Soluble IL-6 receptor leads to a paracrine modulation of the IL-6-induced hepatic acute phase response in double transgenic mice
35. Rat interleukin 6: Expression in recombinant Escherichia coli
36. Interleukin 6 in intact and injured mouse peripheral nerves
37. Soluble receptors for cytokines and growth factors: Generation and biological function
38. Simultaneous depletion of neurokinin A, substance P and calcitonin gene-related peptide from the caudal trigeminal nucleus of the rat during electrical stimulation of the trigeminal ganglion
39. Electrically evoked neuropeptide release and neurogenic inflammation differ between rat and human skin
40. Tachykinins and calcitonin gene-related peptide: Co-existence in sensory nerves of the nasal mucosa and effects on blood flow
41. Interleukin-6 triggers the association of its receptor with a possible signal transducer gp130
42. Circulating IL-6-type cytokines and sIL-6R in patients with multiple myeloma
43. Nociceptive responses in interleukin-6-deficient mice to peripheral inflammation and peripheral nerve section
44. Sensory impairments and delayed regeneration of sensory axons in interleukin-6-deficient mice