메뉴 건너뛰기




Volumn 6 E, Issue 2, 2014, Pages 341-359

Role of agmatine in neurodegenerative diseases and epilepsy

Author keywords

Agmatine; Depression; Epilepsy; Neurodegenerative disease; Neuroprotection; Review

Indexed keywords

AGMATINE; FLUOXETINE; IDAZOXAN;

EID: 84904515228     PISSN: 19450494     EISSN: 19450508     Source Type: Journal    
DOI: 10.2741/e710     Document Type: Review
Times cited : (60)

References (153)
  • 2
    • 0029941131 scopus 로고    scopus 로고
    • Inhibition of mammalian nitric oxide synthases by agmatine, an endogenous polyamine formed by decarboxylation of arginine
    • E. Galea, S. Regunathan, V. Eliopoulos, D. L. Feinstein and D. J. Reis: Inhibition of mammalian nitric oxide synthases by agmatine, an endogenous polyamine formed by decarboxylation of arginine. Biochem J, 316 (Pt 1), 247-9 (1996)
    • (1996) Biochem J , vol.316 , Issue.PART 1 , pp. 247-249
    • Galea, E.1    Regunathan, S.2    Eliopoulos, V.3    Feinstein, D.L.4    Reis, D.J.5
  • 3
    • 1342305418 scopus 로고    scopus 로고
    • Regulation of inducible nitric oxide synthase and agmatine synthesis in macrophages and astrocytes
    • S. Regunathan and J. E. Piletz: Regulation of inducible nitric oxide synthase and agmatine synthesis in macrophages and astrocytes. Ann N Y Acad Sci, 1009, 20-9 (2003)
    • (2003) Ann N Y Acad Sci , vol.1009 , pp. 20-29
    • Regunathan, S.1    Piletz, J.E.2
  • 4
    • 0029789277 scopus 로고    scopus 로고
    • Agmatinase activity in rat brain: A metabolic pathway for the degradation of agmatine
    • M. Sastre, S. Regunathan, E. Galea and D. J. Reis: Agmatinase activity in rat brain: a metabolic pathway for the degradation of agmatine. J Neurochem, 67(4), 1761-5 (1996)
    • (1996) J Neurochem , vol.67 , Issue.4 , pp. 1761-1765
    • Sastre, M.1    Regunathan, S.2    Galea, E.3    Reis, D.J.4
  • 5
    • 0010490786 scopus 로고    scopus 로고
    • Agmatine: An Endogenous Ligand at Imidazoline Receptors Is a Novel Neurotransmittera
    • D. J. Reis and S. Regunathan: Agmatine: An Endogenous Ligand at Imidazoline Receptors Is a Novel Neurotransmittera. Ann N Y Acad Sci, 881(1), 65-80 (1999)
    • (1999) Ann N Y Acad Sci , vol.881 , Issue.1 , pp. 65-80
    • Reis, D.J.1    Regunathan, S.2
  • 6
    • 0028269271 scopus 로고
    • Agmatine: An endogenous clonidine-displacing substance in the brain
    • G. Li, S. Regunathan, C. J. Barrow, J. Eshraghi, R. Cooper and D. J. Reis: Agmatine: an endogenous clonidine-displacing substance in the brain. Science, 263(5149), 966-9 (1994)
    • (1994) Science , vol.263 , Issue.5149 , pp. 966-969
    • Li, G.1    Regunathan, S.2    Barrow, C.J.3    Eshraghi, J.4    Cooper, R.5    Reis, D.J.6
  • 7
    • 0029089005 scopus 로고
    • Agmatine Is Synthesized by a Mitochondrial Arginine Decarboxylase in Rat Brain
    • G. E. N. Li, S. Regunathan and D. J. Reis: Agmatine Is Synthesized by a Mitochondrial Arginine Decarboxylase in Rat Brain. Ann N Y Acad Sci, 763(1), 325-329 (1995)
    • (1995) Ann N Y Acad Sci , vol.763 , Issue.1 , pp. 325-329
    • Li, G.E.N.1    Regunathan, S.2    Reis, D.J.3
  • 8
    • 0029016845 scopus 로고
    • Agmatine, the bacterial amine, is widely distributed in mammalian tissues
    • W. Raasch, S. Regunathan, G. Li and D. J. Reis: Agmatine, the bacterial amine, is widely distributed in mammalian tissues. Life Sciences, 56(26), 2319-2330 (1995)
    • (1995) Life Sciences , vol.56 , Issue.26 , pp. 2319-2330
    • Raasch, W.1    Regunathan, S.2    Li, G.3    Reis, D.J.4
  • 9
    • 0032536718 scopus 로고    scopus 로고
    • Regional localization of agmatine in the rat brain: An immunocytochemical study
    • K. Otake, D. A. Ruggiero, S. Regunathan, H. Wang, T. A. Milner and D. J. Reis: Regional localization of agmatine in the rat brain: an immunocytochemical study. Brain Res, 787(1), 1-14 (1998)
    • (1998) Brain Res , vol.787 , Issue.1 , pp. 1-14
    • Otake, K.1    Ruggiero, D.A.2    Regunathan, S.3    Wang, H.4    Milner, T.A.5    Reis, D.J.6
  • 10
    • 0032503938 scopus 로고    scopus 로고
    • Agmatine containing axon terminals in rat hippocampus form synapses on pyramidal cells
    • D. J. Reis, X.-C. Yang and T. A. Milner: Agmatine containing axon terminals in rat hippocampus form synapses on pyramidal cells. Neuroscience Letters, 250(3), 185-188 (1998)
    • (1998) Neuroscience Letters , vol.250 , Issue.3 , pp. 185-188
    • Reis, D.J.1    Yang, X.-C.2    Milner, T.A.3
  • 11
    • 0029091243 scopus 로고
    • Agmatine (decarboxylated arginine) is synthesized and stored in astrocytes
    • S. Regunathan, D. L. Feinstein, W. Raasch and D. J. Reis: Agmatine (decarboxylated arginine) is synthesized and stored in astrocytes. Neuroreport, 6(14), 1897-900 (1995)
    • (1995) Neuroreport , vol.6 , Issue.14 , pp. 1897-1900
    • Regunathan, S.1    Feinstein, D.L.2    Raasch, W.3    Reis, D.J.4
  • 12
    • 34548003048 scopus 로고    scopus 로고
    • Agmatine: A novel neurotransmitter?
    • D. J. Reis and S. Regunathan: Agmatine: a novel neurotransmitter? Adv Pharmacol, 42, 645-9 (1998)
    • (1998) Adv Pharmacol , vol.42 , pp. 645-649
    • Reis, D.J.1    Regunathan, S.2
  • 13
    • 0030911495 scopus 로고    scopus 로고
    • Determination of agmatine in brain and plasma using high-performance liquid chromatography with fluorescence detection
    • Y. Feng, A. E. Halaris and J. E. Piletz: Determination of agmatine in brain and plasma using high-performance liquid chromatography with fluorescence detection. Journal of Chromatography B: Biomedical Sciences and Applications, 691(2), 277-286 (1997)
    • (1997) Journal of Chromatography B: Biomedical Sciences and Applications , vol.691 , Issue.2 , pp. 277-286
    • Feng, Y.1    Halaris, A.E.2    Piletz, J.E.3
  • 14
    • 35048891421 scopus 로고    scopus 로고
    • Agmatine: Metabolic pathway and spectrum of activity in brain
    • A. Halaris and J. Plietz: Agmatine: metabolic pathway and spectrum of activity in brain. CNS Drugs, 21(11), 885-900 (2007)
    • (2007) CNS Drugs , vol.21 , Issue.11 , pp. 885-900
    • Halaris, A.1    Plietz, J.2
  • 15
    • 0036787990 scopus 로고    scopus 로고
    • Agmatine suppresses nitric oxide production and attenuates hypoxic-ischemic brain injury in neonatal rats
    • Y. Feng, J. E. Piletz and M. H. Leblanc: Agmatine suppresses nitric oxide production and attenuates hypoxic-ischemic brain injury in neonatal rats. Pediatr Res, 52(4), 606-11 (2002)
    • (2002) Pediatr Res , vol.52 , Issue.4 , pp. 606-611
    • Feng, Y.1    Piletz, J.E.2    Leblanc, M.H.3
  • 16
    • 0030040402 scopus 로고
    • Agmatine Treatment Is Neuroprotective in Rodent Brain Injury Models
    • G. M. Gilad, K. Salame, J. M. Rabey and V. H. Gilad: Agmatine Treatment Is Neuroprotective in Rodent Brain Injury Models. Life Sciences, 58(2), Pl41-Pl46 (1995)
    • (1995) Life Sciences , vol.58 , Issue.2
    • Gilad, G.M.1    Salame, K.2    Rabey, J.M.3    Gilad, V.H.4
  • 19
    • 0030061499 scopus 로고    scopus 로고
    • Modulation of opioid analgesia by agmatine
    • Y. Kolesnikov, S. Jain and G. W. Pasternak: Modulation of opioid analgesia by agmatine. Eur J Pharmacol, 296(1), 17-22 (1996)
    • (1996) Eur J Pharmacol , vol.296 , Issue.1 , pp. 17-22
    • Kolesnikov, Y.1    Jain, S.2    Pasternak, G.W.3
  • 20
    • 0345149545 scopus 로고    scopus 로고
    • Effects of agmatine on ethanol withdrawal syndrome in rats
    • I. T. Uzbay, O. Yesilyurt, T. Celik, H. Ergun and A. Isimer: Effects of agmatine on ethanol withdrawal syndrome in rats. Behav Brain Res, 107(1-2), 153-9 (2000)
    • (2000) Behav Brain Res , vol.107 , Issue.1-2 , pp. 153-159
    • Uzbay, I.T.1    Yesilyurt, O.2    Celik, T.3    Ergun, H.4    Isimer, A.5
  • 21
    • 0037307143 scopus 로고    scopus 로고
    • An in vivo evaluation of the antiseizure activity and acute neurotoxicity of agmatine
    • A. K. Bence, D. R. Worthen, J. P. Stables and P. A. Crooks: An in vivo evaluation of the antiseizure activity and acute neurotoxicity of agmatine. Pharmacol Biochem Behav, 74(3), 771-5 (2003)
    • (2003) Pharmacol Biochem Behav , vol.74 , Issue.3 , pp. 771-775
    • Bence, A.K.1    Worthen, D.R.2    Stables, J.P.3    Crooks, P.A.4
  • 23
    • 0038392436 scopus 로고    scopus 로고
    • Antidepressant-like effect of agmatine and its possible mechanism
    • Y. F. Li, Z. H. Gong, J. B. Cao, H. L. Wang, Z. P. Luo and J. Li: Antidepressant-like effect of agmatine and its possible mechanism. Eur J Pharmacol, 469(1-3), 81-8 (2003)
    • (2003) Eur J Pharmacol , vol.469 , Issue.1-3 , pp. 81-88
    • Li, Y.F.1    Gong, Z.H.2    Cao, J.B.3    Wang, H.L.4    Luo, Z.P.5    Li, J.6
  • 24
    • 0037171030 scopus 로고    scopus 로고
    • Agmatine produces antidepressant-like effects in two models of depression in mice
    • A. D. Zomkowski, L. Hammes, J. Lin, J. B. Calixto, A. R. Santos and A. L. Rodrigues: Agmatine produces antidepressant-like effects in two models of depression in mice. Neuroreport, 13(4), 387-91 (2002)
    • (2002) Neuroreport , vol.13 , Issue.4 , pp. 387-391
    • Zomkowski, A.D.1    Hammes, L.2    Lin, J.3    Calixto, J.B.4    Santos, A.R.5    Rodrigues, A.L.6
  • 27
    • 26244454404 scopus 로고    scopus 로고
    • Neurochemical evidence for agmatine modulation of 1-methyl-4-phenyl-1,2, 3,6-tetrahydropyridine (MPTP) neurotoxicity
    • G. M. Gilad, V. H. Gilad, J. P. Finberg and J. M. Rabey: Neurochemical evidence for agmatine modulation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity. Neurochem Res, 30(6-7), 713-9 (2005)
    • (2005) Neurochem Res , vol.30 , Issue.6-7 , pp. 713-719
    • Gilad, G.M.1    Gilad, V.H.2    Finberg, J.P.3    Rabey, J.M.4
  • 29
    • 0025096770 scopus 로고
    • Agmatine Acts as an Antagonist of Neuronal Nicotinic Receptors
    • R. H. Loring: Agmatine Acts as an Antagonist of Neuronal Nicotinic Receptors. Br J Pharmacol, 99(1), 207-211 (1990)
    • (1990) Br J Pharmacol , vol.99 , Issue.1 , pp. 207-211
    • Loring, R.H.1
  • 30
    • 0033020806 scopus 로고    scopus 로고
    • Agmatine selectively blocks the N-methyl-D-aspartate subclass of glutamate receptor channels in rat hippocampal neurons
    • X. C. Yang and D. J. Reis: Agmatine selectively blocks the N-methyl-D-aspartate subclass of glutamate receptor channels in rat hippocampal neurons. J Pharmacol Exp Ther, 288(2), 544-9 (1999)
    • (1999) J Pharmacol Exp Ther , vol.288 , Issue.2 , pp. 544-549
    • Yang, X.C.1    Reis, D.J.2
  • 34
    • 77953056325 scopus 로고    scopus 로고
    • Agmatine prevents the Ca(2+)-dependent induction of permeability transition in rat brain mitochondria
    • V. Battaglia, S. Grancara, J. Satriano, S. Saccoccio, E. Agostinelli and A. Toninello: Agmatine prevents the Ca(2+)-dependent induction of permeability transition in rat brain mitochondria. Amino Acids, 38(2), 431-7 (2010)
    • (2010) Amino Acids , vol.38 , Issue.2 , pp. 431-437
    • Battaglia, V.1    Grancara, S.2    Satriano, J.3    Saccoccio, S.4    Agostinelli, E.5    Toninello, A.6
  • 35
    • 33750316946 scopus 로고    scopus 로고
    • Agmatine increases proliferation of cultured hippocampal progenitor cells and hippocampal neurogenesis in chronically stressed mice
    • Y. F. Li, H. X. Chen, Y. Liu, Y. Z. Zhang, Y. Q. Liu and J. Li: Agmatine increases proliferation of cultured hippocampal progenitor cells and hippocampal neurogenesis in chronically stressed mice. Acta Pharmacol Sin, 27(11), 1395-400 (2006)
    • (2006) Acta Pharmacol Sin , vol.27 , Issue.11 , pp. 1395-1400
    • Li, Y.F.1    Chen, H.X.2    Liu, Y.3    Zhang, Y.Z.4    Liu, Y.Q.5    Li, J.6
  • 36
    • 40949127037 scopus 로고    scopus 로고
    • Exogenous agmatine has neuroprotective effects against restraint-induced structural changes in the rat brain
    • M. Y. Zhu, W. P. Wang, Z. W. Cai, S. Regunathan and G. Ordway: Exogenous agmatine has neuroprotective effects against restraint-induced structural changes in the rat brain. Eur J Neurosci, 27(6), 1320-32 (2008)
    • (2008) Eur J Neurosci , vol.27 , Issue.6 , pp. 1320-1332
    • Zhu, M.Y.1    Wang, W.P.2    Cai, Z.W.3    Regunathan, S.4    Ordway, G.5
  • 37
    • 1342305408 scopus 로고    scopus 로고
    • Is agmatine an endogenous anxiolytic/antidepressant agent?
    • F. Aricioglu and H. Altunbas: Is agmatine an endogenous anxiolytic/antidepressant agent? Ann N Y Acad Sci, 1009, 136-40 (2003)
    • (2003) Ann N Y Acad Sci , vol.1009 , pp. 136-140
    • Aricioglu, F.1    Altunbas, H.2
  • 38
    • 33750352828 scopus 로고    scopus 로고
    • Putrescine produces antidepressant-like effects in the forced swimming test and in the tail suspension test in mice
    • A. D. Zomkowski, A. R. Santos and A. L. Rodrigues: Putrescine produces antidepressant-like effects in the forced swimming test and in the tail suspension test in mice. Prog Neuropsychopharmacol Biol Psychiatry, 30(8), 1419-25 (2006)
    • (2006) Prog Neuropsychopharmacol Biol Psychiatry , vol.30 , Issue.8 , pp. 1419-1425
    • Zomkowski, A.D.1    Santos, A.R.2    Rodrigues, A.L.3
  • 39
    • 34249328527 scopus 로고    scopus 로고
    • Evidence for imidazoline receptors involvement in the agmatine antidepressant-like effect in the forced swimming test
    • M. P. Zeidan, A. D. Zomkowski, A. O. Rosa, A. L. Rodrigues and N. H. Gabilan: Evidence for imidazoline receptors involvement in the agmatine antidepressant-like effect in the forced swimming test. Eur J Pharmacol, 565(1-3), 125-31 (2007)
    • (2007) Eur J Pharmacol , vol.565 , Issue.1-3 , pp. 125-131
    • Zeidan, M.P.1    Zomkowski, A.D.2    Rosa, A.O.3    Rodrigues, A.L.4    Gabilan, N.H.5
  • 40
    • 38349186799 scopus 로고    scopus 로고
    • Cellular mechanisms underlying the antidepressant effects of ketamine: Role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors
    • S. Maeng, C. A. Zarate, Jr., J. Du, R. J. Schloesser, J. McCammon, G. Chen and H. K. Manji: Cellular mechanisms underlying the antidepressant effects of ketamine: role of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors. Biol Psychiatry, 63(4), 349-52 (2008)
    • (2008) Biol Psychiatry , vol.63 , Issue.4 , pp. 349-352
    • Maeng, S.1    Zarate Jr., C.A.2    Du, J.3    Schloesser, R.J.4    McCammon, J.5    Chen, G.6    Manji, H.K.7
  • 42
    • 80051878511 scopus 로고    scopus 로고
    • Involvement of nitric oxide-cGMP pathway in the antidepressant-like effect of ascorbic acid in the tail suspension test
    • M. Moretti, A. E. Freitas, J. Budni, S. C. Fernandes, O. Balen Gde and A. L. Rodrigues: Involvement of nitric oxide-cGMP pathway in the antidepressant-like effect of ascorbic acid in the tail suspension test. Behav Brain Res, 225(1), 328-33 (2011)
    • (2011) Behav Brain Res , vol.225 , Issue.1 , pp. 328-333
    • Moretti, M.1    Freitas, A.E.2    Budni, J.3    Fernandes, S.C.4    Balen Gde, O.5    Rodrigues, A.L.6
  • 43
    • 0034890832 scopus 로고    scopus 로고
    • Biological significance of agmatine, an endogenous ligand at imidazoline binding sites
    • W. Raasch, U. Schafer, J. Chun and P. Dominiak: Biological significance of agmatine, an endogenous ligand at imidazoline binding sites. Br J Pharmacol, 133(6), 755-80 (2001)
    • (2001) Br J Pharmacol , vol.133 , Issue.6 , pp. 755-780
    • Raasch, W.1    Schafer, U.2    Chun, J.3    Dominiak, P.4
  • 44
    • 0034193104 scopus 로고    scopus 로고
    • Is agmatine a novel neurotransmitter in brain?
    • D. J. Reis and S. Regunathan: Is agmatine a novel neurotransmitter in brain? Trends Pharmacol Sci, 21(5), 187-93 (2000)
    • (2000) Trends Pharmacol Sci , vol.21 , Issue.5 , pp. 187-193
    • Reis, D.J.1    Regunathan, S.2
  • 45
    • 4544249477 scopus 로고    scopus 로고
    • Evidence for serotonin receptor subtypes involvement in agmatine antidepressant like-effect in the mouse forced swimming test
    • A. Dias Elpo Zomkowski, A. Oscar Rosa, J. Lin, A. R. Santos, J. B. Calixto and A. Lucia Severo Rodrigues: Evidence for serotonin receptor subtypes involvement in agmatine antidepressant like-effect in the mouse forced swimming test. Brain Res, 1023(2), 253-63 (2004)
    • (2004) Brain Res , vol.1023 , Issue.2 , pp. 253-263
    • Dias Elpo Zomkowski, A.1    Oscar Rosa, A.2    Lin, J.3    Santos, A.R.4    Calixto, J.B.5    Lucia Severo Rodrigues, A.6
  • 46
    • 68749114959 scopus 로고    scopus 로고
    • Antidepressant like effect of selective serotonin reuptake inhibitors involve modulation of imidazoline receptors by agmatine
    • B. G. Taksande, N. R. Kotagale, S. J. Tripathi, R. R. Ugale and C. T. Chopde: Antidepressant like effect of selective serotonin reuptake inhibitors involve modulation of imidazoline receptors by agmatine. Neuropharmacology, 57(4), 415-24 (2009)
    • (2009) Neuropharmacology , vol.57 , Issue.4 , pp. 415-424
    • Taksande, B.G.1    Kotagale, N.R.2    Tripathi, S.J.3    Ugale, R.R.4    Chopde, C.T.5
  • 47
    • 39149099970 scopus 로고    scopus 로고
    • Antidepressant-like effect of agmatine is not mediated by serotonin
    • M. Krass, G. Wegener, E. Vasar and V. Volke: Antidepressant-like effect of agmatine is not mediated by serotonin. Behav Brain Res, 188(2), 324-8 (2008)
    • (2008) Behav Brain Res , vol.188 , Issue.2 , pp. 324-328
    • Krass, M.1    Wegener, G.2    Vasar, E.3    Volke, V.4
  • 48
    • 19344375685 scopus 로고    scopus 로고
    • Evidence for the involvement of the opioid system in the agmatine antidepressant-like effect in the forced swimming test
    • A. D. Zomkowski, A. R. Santos and A. L. Rodrigues: Evidence for the involvement of the opioid system in the agmatine antidepressant-like effect in the forced swimming test. Neurosci Lett, 381(3), 279-83 (2005)
    • (2005) Neurosci Lett , vol.381 , Issue.3 , pp. 279-283
    • Zomkowski, A.D.1    Santos, A.R.2    Rodrigues, A.L.3
  • 49
    • 35348890947 scopus 로고    scopus 로고
    • Role of different types of potassium channels in the antidepressant-like effect of agmatine in the mouse forced swimming test
    • J. Budni, V. M. Gadotti, M. P. Kaster, A. R. Santos and A. L. Rodrigues: Role of different types of potassium channels in the antidepressant-like effect of agmatine in the mouse forced swimming test. Eur J Pharmacol, 575(1-3), 87-93 (2007)
    • (2007) Eur J Pharmacol , vol.575 , Issue.1-3 , pp. 87-93
    • Budni, J.1    Gadotti, V.M.2    Kaster, M.P.3    Santos, A.R.4    Rodrigues, A.L.5
  • 50
    • 56349095206 scopus 로고    scopus 로고
    • Repeated immobilization stress alters rat hippocampal and prefrontal cortical morphology in parallel with endogenous agmatine and arginine decarboxylase levels
    • M. Y. Zhu, W. P. Wang, J. Huang, Y. Z. Feng, S. Regunathan and G. Bissette: Repeated immobilization stress alters rat hippocampal and prefrontal cortical morphology in parallel with endogenous agmatine and arginine decarboxylase levels. Neurochem Int, 53(6-8), 346-54 (2008)
    • (2008) Neurochem Int , vol.53 , Issue.6-8 , pp. 346-354
    • Zhu, M.Y.1    Wang, W.P.2    Huang, J.3    Feng, Y.Z.4    Regunathan, S.5    Bissette, G.6
  • 51
    • 36248974226 scopus 로고    scopus 로고
    • Chronic treatment with glucocorticoids alters rat hippocampal and prefrontal cortical morphology in parallel with endogenous agmatine and arginine decarboxylase levels
    • M. Y. Zhu, W. P. Wang, J. Huang and S. Regunathan: Chronic treatment with glucocorticoids alters rat hippocampal and prefrontal cortical morphology in parallel with endogenous agmatine and arginine decarboxylase levels. J Neurochem, 103(5), 1811-20 (2007)
    • (2007) J Neurochem , vol.103 , Issue.5 , pp. 1811-1820
    • Zhu, M.Y.1    Wang, W.P.2    Huang, J.3    Regunathan, S.4
  • 53
    • 0032806929 scopus 로고    scopus 로고
    • Plasma agmatine and platelet imidazoline receptors in depression
    • A. Halaris, H. Zhu, Y. Feng and J. E. Piletz: Plasma agmatine and platelet imidazoline receptors in depression. Ann N Y Acad Sci, 881, 445-51 (1999)
    • (1999) Ann N Y Acad Sci , vol.881 , pp. 445-451
    • Halaris, A.1    Zhu, H.2    Feng, Y.3    Piletz, J.E.4
  • 54
    • 84880268014 scopus 로고    scopus 로고
    • The clinical antidepressant effect of exogenous agmatine is not reversed by parachlorophenylalanine: A pilot study
    • B. Shopsin: The clinical antidepressant effect of exogenous agmatine is not reversed by parachlorophenylalanine: a pilot study. Acta Neuropsychiatrica, 25(02), 113-118 (2013)
    • (2013) Acta Neuropsychiatrica , vol.25 , Issue.2 , pp. 113-118
    • Shopsin, B.1
  • 55
    • 0029162119 scopus 로고
    • Polyamines and their metabolizing enzymes in human frontal cortex and hippocampus: Preliminary measurements in affective disorders
    • G. M. Gilad, V. H. Gilad, M. F. Casanova and R. A. Casero, Jr.: Polyamines and their metabolizing enzymes in human frontal cortex and hippocampus: preliminary measurements in affective disorders. Biol Psychiatry, 38(4), 227-34 (1995)
    • (1995) Biol Psychiatry , vol.38 , Issue.4 , pp. 227-234
    • Gilad, G.M.1    Gilad, V.H.2    Casanova, M.F.3    Casero Jr., R.A.4
  • 56
    • 0035930459 scopus 로고    scopus 로고
    • Influence of SAMe on the modifications of brain polyamine levels in an animal model of depression
    • S. Genedani, S. Saltini, A. Benelli, M. Filaferro and A. Bertolini: Influence of SAMe on the modifications of brain polyamine levels in an animal model of depression. Neuroreport, 12(18), 3939-42 (2001)
    • (2001) Neuroreport , vol.12 , Issue.18 , pp. 3939-3942
    • Genedani, S.1    Saltini, S.2    Benelli, A.3    Filaferro, M.4    Bertolini, A.5
  • 57
    • 41149114638 scopus 로고    scopus 로고
    • Implication of the polyamine system in mental disorders
    • L. M. Fiori and G. Turecki: Implication of the polyamine system in mental disorders. J Psychiatry Neurosci, 33(2), 102-10 (2008)
    • (2008) J Psychiatry Neurosci , vol.33 , Issue.2 , pp. 102-110
    • Fiori, L.M.1    Turecki, G.2
  • 58
    • 0035798238 scopus 로고    scopus 로고
    • The molecular biology of memory storage: A dialogue between genes and synapses
    • E. R. Kandel: The molecular biology of memory storage: a dialogue between genes and synapses. Science, 294(5544), 1030-8 (2001)
    • (2001) Science , vol.294 , Issue.5544 , pp. 1030-1038
    • Kandel, E.R.1
  • 59
    • 0032032006 scopus 로고    scopus 로고
    • Cognitive neuroscience and the study of memory
    • B. Milner, L. R. Squire and E. R. Kandel: Cognitive neuroscience and the study of memory. Neuron, 20(3), 445-68 (1998)
    • (1998) Neuron , vol.20 , Issue.3 , pp. 445-468
    • Milner, B.1    Squire, L.R.2    Kandel, E.R.3
  • 61
    • 55549139201 scopus 로고    scopus 로고
    • Spatial learning results in elevated agmatine levels in the rat brain
    • P. Liu, N. D. Collie, S. Chary, Y. Jing and H. Zhang: Spatial learning results in elevated agmatine levels in the rat brain. Hippocampus, 18(11), 1094-8 (2008)
    • (2008) Hippocampus , vol.18 , Issue.11 , pp. 1094-1098
    • Liu, P.1    Collie, N.D.2    Chary, S.3    Jing, Y.4    Zhang, H.5
  • 62
    • 78650034964 scopus 로고    scopus 로고
    • Spatial learning-induced increase in agmatine levels at hippocampal CA1 synapses
    • B. Leitch, O. Shevtsova, K. Reusch, D. H. Bergin and P. Liu: Spatial learning-induced increase in agmatine levels at hippocampal CA1 synapses. Synapse, 65(2), 146-53 (2011)
    • (2011) Synapse , vol.65 , Issue.2 , pp. 146-153
    • Leitch, B.1    Shevtsova, O.2    Reusch, K.3    Bergin, D.H.4    Liu, P.5
  • 63
    • 80052271496 scopus 로고    scopus 로고
    • Spatial learning-induced accumulation of agmatine and glutamate at hippocampal CA1 synaptic terminals
    • S. Seo, P. Liu and B. Leitch: Spatial learning-induced accumulation of agmatine and glutamate at hippocampal CA1 synaptic terminals. Neuroscience, 192, 28-36 (2011)
    • (2011) Neuroscience , vol.192 , pp. 28-36
    • Seo, S.1    Liu, P.2    Leitch, B.3
  • 64
    • 84870919090 scopus 로고    scopus 로고
    • Participation of hippocampal agmatine in spatial learning: An in vivo microdialysis study
    • M. Rushaidhi, Y. Jing, H. Zhang and P. Liu: Participation of hippocampal agmatine in spatial learning: an in vivo microdialysis study. Neuropharmacology, 65, 200-5 (2013)
    • (2013) Neuropharmacology , vol.65 , pp. 200-205
    • Rushaidhi, M.1    Jing, Y.2    Zhang, H.3    Liu, P.4
  • 65
    • 62249150177 scopus 로고    scopus 로고
    • Differential effects of i.C.V. microinfusion of agmatine on spatial working and reference memory in the rat
    • P. Liu and D. H. Bergin: Differential effects of i.c.v. microinfusion of agmatine on spatial working and reference memory in the rat. Neuroscience, 159(3), 951-61 (2009)
    • (2009) Neuroscience , vol.159 , Issue.3 , pp. 951-961
    • Liu, P.1    Bergin, D.H.2
  • 66
    • 68349127366 scopus 로고    scopus 로고
    • Behavioral effects of agmatine in naive rats are task- and delay-dependent
    • P. Liu and N. D. Collie: Behavioral effects of agmatine in naive rats are task- and delay-dependent. Neuroscience, 163(1), 82-96 (2009)
    • (2009) Neuroscience , vol.163 , Issue.1 , pp. 82-96
    • Liu, P.1    Collie, N.D.2
  • 67
    • 84863783388 scopus 로고    scopus 로고
    • Agmatine selectively improves behavioural function in aged male Sprague-Dawley rats
    • M. Rushaidhi, N. D. Collie, H. Zhang and P. Liu: Agmatine selectively improves behavioural function in aged male Sprague-Dawley rats. Neuroscience, 218, 206-15 (2012)
    • (2012) Neuroscience , vol.218 , pp. 206-215
    • Rushaidhi, M.1    Collie, N.D.2    Zhang, H.3    Liu, P.4
  • 68
    • 84873502995 scopus 로고    scopus 로고
    • Effects of prolonged agmatine treatment in aged male Sprague-Dawley rats
    • M. Rushaidhi, H. Zhang and P. Liu: Effects of prolonged agmatine treatment in aged male Sprague-Dawley rats. Neuroscience, 234, 116-24 (2013)
    • (2013) Neuroscience , vol.234 , pp. 116-124
    • Rushaidhi, M.1    Zhang, H.2    Liu, P.3
  • 69
    • 67649672109 scopus 로고    scopus 로고
    • Memory-related changes in L-citrulline and agmatine in the rat brain
    • P. Liu, Y. Jing, N. D. Collie, S. Chary and H. Zhang: Memory-related changes in L-citrulline and agmatine in the rat brain. Hippocampus, 19(7), 597-602 (2009)
    • (2009) Hippocampus , vol.19 , Issue.7 , pp. 597-602
    • Liu, P.1    Jing, Y.2    Collie, N.D.3    Chary, S.4    Zhang, H.5
  • 70
    • 77957761382 scopus 로고    scopus 로고
    • Agmatine inhibits morphine-induced memory impairment in the mouse step-down inhibitory avoidance task
    • W. Lu, H. J. Dong, Z. H. Gong, R. B. Su and J. Li: Agmatine inhibits morphine-induced memory impairment in the mouse step-down inhibitory avoidance task. Pharmacol Biochem Behav, 97(2), 256-61 (2010)
    • (2010) Pharmacol Biochem Behav , vol.97 , Issue.2 , pp. 256-261
    • Lu, W.1    Dong, H.J.2    Gong, Z.H.3    Su, R.B.4    Li, J.5
  • 71
  • 72
    • 78649720715 scopus 로고    scopus 로고
    • Agmatine modulates neuroadaptations of glutamate transmission in the nucleus accumbens of repeated morphine-treated rats
    • X. F. Wang, N. Wu, R. B. Su, X. Q. Lu, Y. Liu and J. Li: Agmatine modulates neuroadaptations of glutamate transmission in the nucleus accumbens of repeated morphine-treated rats. Eur J Pharmacol, 650(1), 200-5 (2011)
    • (2011) Eur J Pharmacol , vol.650 , Issue.1 , pp. 200-205
    • Wang, X.F.1    Wu, N.2    Su, R.B.3    Lu, X.Q.4    Liu, Y.5    Li, J.6
  • 73
    • 84856034604 scopus 로고    scopus 로고
    • Neuroinflammation: A common pathway in CNS diseases as mediated at the blood-brain barrier
    • M. A. Erickson, K. Dohi and W. A. Banks: Neuroinflammation: a common pathway in CNS diseases as mediated at the blood-brain barrier. Neuroimmunomodulation, 19(2), 121-30 (2012)
    • (2012) Neuroimmunomodulation , vol.19 , Issue.2 , pp. 121-130
    • Erickson, M.A.1    Dohi, K.2    Banks, W.A.3
  • 75
    • 84864502460 scopus 로고    scopus 로고
    • Agmatine, a metabolite of L-arginine, reverses scopolamine-induced learning and memory impairment in rats
    • T. Utkan, S. S. Gocmez, S. Regunathan and F. Aricioglu: Agmatine, a metabolite of L-arginine, reverses scopolamine-induced learning and memory impairment in rats. Pharmacol Biochem Behav, 102(4), 578-84 (2012)
    • (2012) Pharmacol Biochem Behav , vol.102 , Issue.4 , pp. 578-584
    • Utkan, T.1    Gocmez, S.S.2    Regunathan, S.3    Aricioglu, F.4
  • 76
    • 80053600171 scopus 로고    scopus 로고
    • Scopolamine impairs behavioural function and arginine metabolism in the rat dentate gyrus
    • L. T. Knox, Y. Jing, M. S. Fleete, N. D. Collie, H. Zhang and P. Liu: Scopolamine impairs behavioural function and arginine metabolism in the rat dentate gyrus. Neuropharmacology, 61(8), 1452-62 (2011)
    • (2011) Neuropharmacology , vol.61 , Issue.8 , pp. 1452-1462
    • Knox, L.T.1    Jing, Y.2    Fleete, M.S.3    Collie, N.D.4    Zhang, H.5    Liu, P.6
  • 77
    • 84857039173 scopus 로고    scopus 로고
    • Agmatine protects against scopolamine-induced water maze performance impairment and hippocampal ERK and Akt inactivation
    • M. Moosavi, G. Y. Khales, L. Abbasi, A. Zarifkar and K. Rastegar: Agmatine protects against scopolamine-induced water maze performance impairment and hippocampal ERK and Akt inactivation. Neuropharmacology, 62(5-6), 2018-23 (2012)
    • (2012) Neuropharmacology , vol.62 , Issue.5-6 , pp. 2018-2023
    • Moosavi, M.1    Khales, G.Y.2    Abbasi, L.3    Zarifkar, A.4    Rastegar, K.5
  • 78
    • 84857783771 scopus 로고    scopus 로고
    • Agmatine, an endogenous ligand of imidazoline receptor protects against memory impairment and biochemical alterations in streptozotocin-induced diabetic rats
    • P. Bhutada, Y. Mundhada, V. Humane, A. Rahigude, P. Deshmukh, S. Latad and K. Jain: Agmatine, an endogenous ligand of imidazoline receptor protects against memory impairment and biochemical alterations in streptozotocin-induced diabetic rats. Prog Neuropsychopharmacol Biol Psychiatry, 37(1), 96-105 (2012)
    • (2012) Prog Neuropsychopharmacol Biol Psychiatry , vol.37 , Issue.1 , pp. 96-105
    • Bhutada, P.1    Mundhada, Y.2    Humane, V.3    Rahigude, A.4    Deshmukh, P.5    Latad, S.6    Jain, K.7
  • 79
    • 0034704417 scopus 로고    scopus 로고
    • Accelerated functional recovery and neuroprotection by agmatine after spinal cord ischemia in rats
    • G. M. Gilad and V. H. Gilad: Accelerated functional recovery and neuroprotection by agmatine after spinal cord ischemia in rats. Neurosci Lett, 296(2-3), 97-100 (2000)
    • (2000) Neurosci Lett , vol.296 , Issue.2-3 , pp. 97-100
    • Gilad, G.M.1    Gilad, V.H.2
  • 80
    • 33748049466 scopus 로고    scopus 로고
    • Protective effect of agmatine on a reperfusion model after transient cerebral ischemia: Temporal evolution on perfusion MR imaging and histopathologic findings
    • D. J. Kim, D. I. Kim, S. K. Lee, S. H. Suh, Y. J. Lee, J. Kim, T. S. Chung and J. E. Lee: Protective effect of agmatine on a reperfusion model after transient cerebral ischemia: Temporal evolution on perfusion MR imaging and histopathologic findings. AJNR Am J Neuroradiol, 27(4), 780-5 (2006)
    • (2006) AJNR Am J Neuroradiol , vol.27 , Issue.4 , pp. 780-785
    • Kim, D.J.1    Kim, D.I.2    Lee, S.K.3    Suh, S.H.4    Lee, Y.J.5    Kim, J.6    Chung, T.S.7    Lee, J.E.8
  • 81
    • 77956455342 scopus 로고    scopus 로고
    • Beneficial effect of agmatine on brain apoptosis, astrogliosis, and edema after rat transient cerebral ischemia
    • C. C. Wang, C. C. Chio, C. H. Chang, J. R. Kuo and C. P. Chang: Beneficial effect of agmatine on brain apoptosis, astrogliosis, and edema after rat transient cerebral ischemia. BMC Pharmacol, 10, 11 (2010)
    • (2010) BMC Pharmacol , vol.10 , pp. 11
    • Wang, C.C.1    Chio, C.C.2    Chang, C.H.3    Kuo, J.R.4    Chang, C.P.5
  • 83
    • 36349012390 scopus 로고    scopus 로고
    • Agmatine protects retinal ganglion cells from hypoxia-induced apoptosis in transformed rat retinal ganglion cell line
    • S. Hong, J. E. Lee, C. Y. Kim and G. J. Seong: Agmatine protects retinal ganglion cells from hypoxia-induced apoptosis in transformed rat retinal ganglion cell line. BMC Neurosci, 8, 81 (2007)
    • (2007) BMC Neurosci , vol.8 , pp. 81
    • Hong, S.1    Lee, J.E.2    Kim, C.Y.3    Seong, G.J.4
  • 84
    • 67649394099 scopus 로고    scopus 로고
    • Neuroprotective effects of agmatine on oxygen-glucose deprived primary-cultured astrocytes and nuclear translocation of nuclear factor-kappa B
    • W. T. Lee, S. Hong, S. H. Yoon, J. H. Kim, K. A. Park, G. J. Seong and J. E. Lee: Neuroprotective effects of agmatine on oxygen-glucose deprived primary-cultured astrocytes and nuclear translocation of nuclear factor-kappa B. Brain Res, 1281, 64-70 (2009)
    • (2009) Brain Res , vol.1281 , pp. 64-70
    • Lee, W.T.1    Hong, S.2    Yoon, S.H.3    Kim, J.H.4    Park, K.A.5    Seong, G.J.6    Lee, J.E.7
  • 85
    • 77952011417 scopus 로고    scopus 로고
    • Agmatine attenuates brain edema through reducing the expression of aquaporin-1 after cerebral ischemia
    • J. H. Kim, Y. W. Lee, K. A. Park, W. T. Lee and J. E. Lee: Agmatine attenuates brain edema through reducing the expression of aquaporin-1 after cerebral ischemia. J Cereb Blood Flow Metab, 30(5), 943-9 (2010)
    • (2010) J Cereb Blood Flow Metab , vol.30 , Issue.5 , pp. 943-949
    • Kim, J.H.1    Lee, Y.W.2    Park, K.A.3    Lee, W.T.4    Lee, J.E.5
  • 86
    • 81855166649 scopus 로고    scopus 로고
    • Agmatine-reduced collagen scar area accompanied with surface righting reflex recovery after complete transection spinal cord injury
    • J. H. Kim, Y. W. Lee, Y. M. Park, K. A. Park, S. H. Park, W. T. Lee and J. E. Lee: Agmatine-reduced collagen scar area accompanied with surface righting reflex recovery after complete transection spinal cord injury. Spine (Phila Pa 1976), 36(25), 2130-8 (2011)
    • (2011) Spine (Phila Pa 1976) , vol.36 , Issue.25 , pp. 2130-2138
    • Kim, J.H.1    Lee, Y.W.2    Park, Y.M.3    Park, K.A.4    Park, S.H.5    Lee, W.T.6    Lee, J.E.7
  • 87
    • 84872657724 scopus 로고    scopus 로고
    • The multifaceted effects of agmatine on functional recovery after spinal cord injury through Modulations of BMP-2/4/7 expressions in neurons and glial cells
    • Y. M. Park, W. T. Lee, K. K. Bokara, S. K. Seo, S. H. Park, J. H. Kim, M. A. Yenari, K. A. Park and J. E. Lee: The multifaceted effects of agmatine on functional recovery after spinal cord injury through Modulations of BMP-2/4/7 expressions in neurons and glial cells. PLoS One, 8(1), e53911 (2013)
    • (2013) PLoS One , vol.8 , Issue.1
    • Park, Y.M.1    Lee, W.T.2    Bokara, K.K.3    Seo, S.K.4    Park, S.H.5    Kim, J.H.6    Yenari, M.A.7    Park, K.A.8    Lee, J.E.9
  • 89
    • 33646395679 scopus 로고    scopus 로고
    • Agmatine protects against cell damage induced by NMDA and glutamate in cultured hippocampal neurons
    • W. P. Wang, A. H. Iyo, J. Miguel-Hidalgo, S. Regunathan and M. Y. Zhu: Agmatine protects against cell damage induced by NMDA and glutamate in cultured hippocampal neurons. Brain Res, 1084, 210-216 (2006)
    • (2006) Brain Res , vol.1084 , pp. 210-216
    • Wang, W.P.1    Iyo, A.H.2    Miguel-Hidalgo, J.3    Regunathan, S.4    Zhu, M.Y.5
  • 90
    • 0041315718 scopus 로고    scopus 로고
    • Effect of agmatine against cell death induced by NMDA and glutamate in neurons and PC12 cells
    • M. Y. Zhu, J. E. Piletz, A. Halaris and S. Regunathan: Effect of agmatine against cell death induced by NMDA and glutamate in neurons and PC12 cells. Cell Mol Neurobiol, 23(4-5), 865-72 (2003)
    • (2003) Cell Mol Neurobiol , vol.23 , Issue.4-5 , pp. 865-872
    • Zhu, M.Y.1    Piletz, J.E.2    Halaris, A.3    Regunathan, S.4
  • 91
    • 33646395679 scopus 로고    scopus 로고
    • Agmatine protects against cell damage induced by NMDA and glutamate in cultured hippocampal neurons
    • W. P. Wang, A. H. Iyo, J. Miguel-Hidalgo, S. Regunathan and M. Y. Zhu: Agmatine protects against cell damage induced by NMDA and glutamate in cultured hippocampal neurons. Brain Res, 1084(1), 210-6 (2006)
    • (2006) Brain Res , vol.1084 , Issue.1 , pp. 210-216
    • Wang, W.P.1    Iyo, A.H.2    Miguel-Hidalgo, J.3    Regunathan, S.4    Zhu, M.Y.5
  • 92
    • 26944494168 scopus 로고    scopus 로고
    • Agmatine reduces extracellular glutamate during pentylenetetrazole- induced seizures in rat brain: A potential mechanism for the anticonvulsive effects
    • Y. Feng, M. H. LeBlanc and S. Regunathan: Agmatine reduces extracellular glutamate during pentylenetetrazole-induced seizures in rat brain: a potential mechanism for the anticonvulsive effects. Neurosci Lett, 390(3), 129-33 (2005)
    • (2005) Neurosci Lett , vol.390 , Issue.3 , pp. 129-133
    • Feng, Y.1    LeBlanc, M.H.2    Regunathan, S.3
  • 93
    • 58349094747 scopus 로고    scopus 로고
    • Agmatine pretreatment protects retinal ganglion cells (RGC-5 cell line) from oxidative stress in vitro
    • I. Yoko, S. Hong, C. Y. Kim, S. K. Kim and G. J. Seong: Agmatine pretreatment protects retinal ganglion cells (RGC-5 cell line) from oxidative stress in vitro. Biocell, 32(3), 245-250 (2008)
    • (2008) Biocell , vol.32 , Issue.3 , pp. 245-250
    • Yoko, I.1    Hong, S.2    Kim, C.Y.3    Kim, S.K.4    Seong, G.J.5
  • 94
    • 0042521076 scopus 로고    scopus 로고
    • The environment and Parkinson's disease: Is the nigrostriatal system preferentially targeted by neurotoxins?
    • D. A. Di Monte: The environment and Parkinson's disease: is the nigrostriatal system preferentially targeted by neurotoxins? Lancet Neurol, 2(9), 531-8 (2003)
    • (2003) Lancet Neurol , vol.2 , Issue.9 , pp. 531-538
    • Di Monte, D.A.1
  • 95
    • 38949091068 scopus 로고    scopus 로고
    • Gene-environment interactions in Parkinson's disease
    • C. A. Ross and W. W. Smith: Gene-environment interactions in Parkinson's disease. Parkinsonism Relat Disord, 13 Suppl 3, S309-15 (2007)
    • (2007) Parkinsonism Relat Disord , vol.13 , Issue.SUPPL. 3
    • Ross, C.A.1    Smith, W.W.2
  • 96
    • 33846077467 scopus 로고    scopus 로고
    • Circuits and circuit disorders of the basal ganglia
    • M. R. DeLong and T. Wichmann: Circuits and circuit disorders of the basal ganglia. Arch Neurol, 64(1), 20-4 (2007)
    • (2007) Arch Neurol , vol.64 , Issue.1 , pp. 20-24
    • DeLong, M.R.1    Wichmann, T.2
  • 98
    • 33847135804 scopus 로고    scopus 로고
    • Altered expression of vesicular glutamate transporters VGLUT1 and VGLUT2 in Parkinson disease
    • A. Kashani, C. Betancur, B. Giros, E. Hirsch and S. El Mestikawy: Altered expression of vesicular glutamate transporters VGLUT1 and VGLUT2 in Parkinson disease. Neurobiol Aging, 28(4), 568-78 (2007)
    • (2007) Neurobiol Aging , vol.28 , Issue.4 , pp. 568-578
    • Kashani, A.1    Betancur, C.2    Giros, B.3    Hirsch, E.4    El Mestikawy, S.5
  • 99
    • 0031696407 scopus 로고    scopus 로고
    • Subthalamic nucleus-mediated excitotoxicity in Parkinson's disease: A target for neuroprotection
    • M. C. Rodriguez, J. A. Obeso and C. W. Olanow: Subthalamic nucleus-mediated excitotoxicity in Parkinson's disease: a target for neuroprotection. Ann Neurol, 44(3 Suppl 1), S175-88 (1998)
    • (1998) Ann Neurol , vol.44 , Issue.3 SUPPL. 1
    • Rodriguez, M.C.1    Obeso, J.A.2    Olanow, C.W.3
  • 101
    • 0031689728 scopus 로고    scopus 로고
    • Amantadine reduces levodopa-induced dyskinesias in parkinsonian monkeys
    • P. J. Blanchet, S. Konitsiotis and T. N. Chase: Amantadine reduces levodopa-induced dyskinesias in parkinsonian monkeys. Mov Disord, 13(5), 798-802 (1998)
    • (1998) Mov Disord , vol.13 , Issue.5 , pp. 798-802
    • Blanchet, P.J.1    Konitsiotis, S.2    Chase, T.N.3
  • 104
    • 0034531781 scopus 로고    scopus 로고
    • Effect of glutamate and antagonists of N-methyl-D-aspartate receptors on experimental parkinsonian syndrome in rats
    • V. G. Kucheryanu and G. N. Kryzhanovskii: Effect of glutamate and antagonists of N-methyl-D-aspartate receptors on experimental parkinsonian syndrome in rats. Bull Exp Biol Med, 130(7), 629-32 (2000)
    • (2000) Bull Exp Biol Med , vol.130 , Issue.7 , pp. 629-632
    • Kucheryanu, V.G.1    Kryzhanovskii, G.N.2
  • 105
    • 78650163483 scopus 로고    scopus 로고
    • Agmatine effects on mitochondrial membrane potential and NF-kappaB activation protect against rotenone-induced cell damage in human neuronal-like SH-SY5Y cells
    • S. Condello, M. Curro, N. Ferlazzo, D. Caccamo, J. Satriano and R. Ientile: Agmatine effects on mitochondrial membrane potential and NF-kappaB activation protect against rotenone-induced cell damage in human neuronal-like SH-SY5Y cells. J Neurochem, 116(1), 67-75 (2011)
    • (2011) J Neurochem , vol.116 , Issue.1 , pp. 67-75
    • Condello, S.1    Curro, M.2    Ferlazzo, N.3    Caccamo, D.4    Satriano, J.5    Ientile, R.6
  • 106
    • 84861693017 scopus 로고    scopus 로고
    • Protective effects of agmatine in rotenone-induced damage of human SH-SY5Y neuroblastoma cells: Fourier transform infrared spectroscopy analysis in a model of Parkinson's disease
    • S. Condello, E. Calabro, D. Caccamo, M. Curro, N. Ferlazzo, J. Satriano, S. Magazu and R. Ientile: Protective effects of agmatine in rotenone-induced damage of human SH-SY5Y neuroblastoma cells: fourier transform infrared spectroscopy analysis in a model of Parkinson's disease. Amino Acids, 42(2-3), 775-81 (2012)
    • (2012) Amino Acids , vol.42 , Issue.2-3 , pp. 775-781
    • Condello, S.1    Calabro, E.2    Caccamo, D.3    Curro, M.4    Ferlazzo, N.5    Satriano, J.6    Magazu, S.7    Ientile, R.8
  • 107
    • 84868127393 scopus 로고    scopus 로고
    • From mitochondrial dysfunction to amyloid beta formation: Novel insights into the pathogenesis of Alzheimer's disease
    • K. Leuner, W. E. Muller and A. S. Reichert: From mitochondrial dysfunction to amyloid beta formation: novel insights into the pathogenesis of Alzheimer's disease. Mol Neurobiol, 46(1), 186-93 (2012)
    • (2012) Mol Neurobiol , vol.46 , Issue.1 , pp. 186-193
    • Leuner, K.1    Muller, W.E.2    Reichert, A.S.3
  • 108
    • 77954621167 scopus 로고    scopus 로고
    • Agmatine protects against beta-amyloid25-35-induced memory impairments in the rat
    • D. H. Bergin and P. Liu: Agmatine protects against beta-amyloid25-35- induced memory impairments in the rat. Neuroscience, 169(2), 794-811 (2010)
    • (2010) Neuroscience , vol.169 , Issue.2 , pp. 794-811
    • Bergin, D.H.1    Liu, P.2
  • 109
    • 80052448797 scopus 로고    scopus 로고
    • Pre-aggregated Abeta(25-35) alters arginine metabolism in the rat hippocampus and prefrontal cortex
    • P. Liu, Y. Jing, N. D. Collie, S. A. Campbell and H. Zhang: Pre-aggregated Abeta(25-35) alters arginine metabolism in the rat hippocampus and prefrontal cortex. Neuroscience, 193, 269-82 (2011)
    • (2011) Neuroscience , vol.193 , pp. 269-282
    • Liu, P.1    Jing, Y.2    Collie, N.D.3    Campbell, S.A.4    Zhang, H.5
  • 110
    • 0031812234 scopus 로고    scopus 로고
    • Ornithine decarboxylase in human brain: Influence of aging, regional distribution, and Alzheimer's disease
    • L. D. Morrison, X. C. Cao and S. J. Kish: Ornithine decarboxylase in human brain: influence of aging, regional distribution, and Alzheimer's disease. J Neurochem, 71(1), 288-94 (1998)
    • (1998) J Neurochem , vol.71 , Issue.1 , pp. 288-294
    • Morrison, L.D.1    Cao, X.C.2    Kish, S.J.3
  • 111
    • 0028961549 scopus 로고
    • Increased immunostaining for L-ornithine decarboxylase occurs in neocortical neurons of Alzheimer's disease patients
    • H. G. Bernstein and M. Muller: Increased immunostaining for L-ornithine decarboxylase occurs in neocortical neurons of Alzheimer's disease patients. Neurosci Lett, 186(2-3), 123-6 (1995)
    • (1995) Neurosci Lett , vol.186 , Issue.2-3 , pp. 123-126
    • Bernstein, H.G.1    Muller, M.2
  • 113
    • 0033583252 scopus 로고    scopus 로고
    • Alzheimer's amyloid beta-peptide associated free radicals increase rat embryonic neuronal polyamine uptake and ornithine decarboxylase activity: Protective effect of vitamin E
    • S. M. Yatin, M. Yatin, T. Aulick, K. B. Ain and D. A. Butterfield: Alzheimer's amyloid beta-peptide associated free radicals increase rat embryonic neuronal polyamine uptake and ornithine decarboxylase activity: protective effect of vitamin E. Neurosci Lett, 263(1), 17-20 (1999)
    • (1999) Neurosci Lett , vol.263 , Issue.1 , pp. 17-20
    • Yatin, S.M.1    Yatin, M.2    Aulick, T.3    Ain, K.B.4    Butterfield, D.A.5
  • 114
    • 46849094295 scopus 로고    scopus 로고
    • Moderate and severe traumatic brain injury in adults
    • A. I. Maas, N. Stocchetti and R. Bullock: Moderate and severe traumatic brain injury in adults. Lancet Neurol, 7(8), 728-41 (2008)
    • (2008) Lancet Neurol , vol.7 , Issue.8 , pp. 728-741
    • Maas, A.I.1    Stocchetti, N.2    Bullock, R.3
  • 116
    • 77954862661 scopus 로고    scopus 로고
    • Blood-brain barrier breakdown as a therapeutic target in traumatic brain injury
    • D. Shlosberg, M. Benifla, D. Kaufer and A. Friedman: Blood-brain barrier breakdown as a therapeutic target in traumatic brain injury. Nat Rev Neurol, 6(7), 393-403 (2010)
    • (2010) Nat Rev Neurol , vol.6 , Issue.7 , pp. 393-403
    • Shlosberg, D.1    Benifla, M.2    Kaufer, D.3    Friedman, A.4
  • 117
    • 33749064984 scopus 로고    scopus 로고
    • Mechanical cell injury
    • K. A. Barbee: Mechanical cell injury. Ann N Y Acad Sci, 1066, 67-84 (2005)
    • (2005) Ann N Y Acad Sci , vol.1066 , pp. 67-84
    • Barbee, K.A.1
  • 118
    • 34447527791 scopus 로고    scopus 로고
    • Pathophysiology of traumatic brain injury
    • C. Werner and K. Engelhard: Pathophysiology of traumatic brain injury. Br J Anaesth, 99(1), 4-9 (2007)
    • (2007) Br J Anaesth , vol.99 , Issue.1 , pp. 4-9
    • Werner, C.1    Engelhard, K.2
  • 120
    • 0037451325 scopus 로고    scopus 로고
    • 4: Rehabilitation after traumatic brain injury
    • F. Khan, I. J. Baguley and I. D. Cameron: 4: Rehabilitation after traumatic brain injury. Med J Aust, 178(6), 290-5 (2003)
    • (2003) Med J Aust , vol.178 , Issue.6 , pp. 290-295
    • Khan, F.1    Baguley, I.J.2    Cameron, I.D.3
  • 121
    • 0037069271 scopus 로고    scopus 로고
    • Epilepsy after brain insult: Targeting epileptogenesis
    • S. T. Herman: Epilepsy after brain insult: targeting epileptogenesis. Neurology, 59(9 Suppl 5), S21-6 (2002)
    • (2002) Neurology , vol.59 , Issue.9 SUPPL. 5
    • Herman, S.T.1
  • 122
    • 2642548363 scopus 로고    scopus 로고
    • Traumatic brain injury as a risk factor for Alzheimer disease. Comparison of two retrospective autopsy cohorts with evaluation of ApoE genotype
    • K. A. Jellinger, W. Paulus, C. Wrocklage and I. Litvan: Traumatic brain injury as a risk factor for Alzheimer disease. Comparison of two retrospective autopsy cohorts with evaluation of ApoE genotype. BMC Neurol, 1, 3 (2001)
    • (2001) BMC Neurol , vol.1 , pp. 3
    • Jellinger, K.A.1    Paulus, W.2    Wrocklage, C.3    Litvan, I.4
  • 123
    • 84877578442 scopus 로고    scopus 로고
    • Changing patterns in the epidemiology of traumatic brain injury
    • B. Roozenbeek, A. I. Maas and D. K. Menon: Changing patterns in the epidemiology of traumatic brain injury. Nat Rev Neurol, 9(4), 231-6 (2013)
    • (2013) Nat Rev Neurol , vol.9 , Issue.4 , pp. 231-236
    • Roozenbeek, B.1    Maas, A.I.2    Menon, D.K.3
  • 124
    • 50249147729 scopus 로고    scopus 로고
    • A preliminary histopathological study of the effect of agmatine on diffuse brain injury in rats
    • G. Sengul, E. Takci, U. A. Malcok, A. Akar, F. Erdogan, H. H. Kadioglu and I. H. Aydin: A preliminary histopathological study of the effect of agmatine on diffuse brain injury in rats. J Clin Neurosci, 15(10), 1125-9 (2008)
    • (2008) J Clin Neurosci , vol.15 , Issue.10 , pp. 1125-1129
    • Sengul, G.1    Takci, E.2    Malcok, U.A.3    Akar, A.4    Erdogan, F.5    Kadioglu, H.H.6    Aydin, I.H.7
  • 125
    • 35748939047 scopus 로고    scopus 로고
    • Resuscitation from experimental traumatic brain injury by agmatine therapy
    • J. R. Kuo, C. J. Lo, C. C. Chio, C. P. Chang and M. T. Lin: Resuscitation from experimental traumatic brain injury by agmatine therapy. Resuscitation, 75(3), 506-14 (2007)
    • (2007) Resuscitation , vol.75 , Issue.3 , pp. 506-514
    • Kuo, J.R.1    Lo, C.J.2    Chio, C.C.3    Chang, C.P.4    Lin, M.T.5
  • 126
    • 80054019938 scopus 로고    scopus 로고
    • Agmatine-promoted angiogenesis, neurogenesis, and inhibition of gliosis-reduced traumatic brain injury in rats
    • J. R. Kuo, C. J. Lo, C. P. Chang, K. C. Lin, M. T. Lin and C. C. Chio: Agmatine-promoted angiogenesis, neurogenesis, and inhibition of gliosis-reduced traumatic brain injury in rats. J Trauma, 71(4), E87-93 (2011)
    • (2011) J Trauma , vol.71 , Issue.4
    • Kuo, J.R.1    Lo, C.J.2    Chang, C.P.3    Lin, K.C.4    Lin, M.T.5    Chio, C.C.6
  • 129
    • 0028037991 scopus 로고
    • The global burden of disease in 1990: Summary results, sensitivity analysis and future directions
    • C. J. Murray, A. D. Lopez and D. T. Jamison: The global burden of disease in 1990: summary results, sensitivity analysis and future directions. Bull World Health Organ, 72(3), 495-509 (1994)
    • (1994) Bull World Health Organ , vol.72 , Issue.3 , pp. 495-509
    • Murray, C.J.1    Lopez, A.D.2    Jamison, D.T.3
  • 131
    • 0035310424 scopus 로고    scopus 로고
    • Initiation of network bursts by Ca2+-dependent intrinsic bursting in the rat pilocarpine model of temporal lobe epilepsy
    • E. R. Sanabria, H. Su and Y. Yaari: Initiation of network bursts by Ca2+-dependent intrinsic bursting in the rat pilocarpine model of temporal lobe epilepsy. J Physiol, 532(Pt 1), 205-16 (2001)
    • (2001) J Physiol , vol.532 , Issue.PART 1 , pp. 205-216
    • Sanabria, E.R.1    Su, H.2    Yaari, Y.3
  • 133
    • 0025176816 scopus 로고
    • Intrinsic firing patterns of diverse neocortical neurons
    • B. W. Connors and M. J. Gutnick: Intrinsic firing patterns of diverse neocortical neurons. Trends Neurosci, 13(3), 99-104 (1990)
    • (1990) Trends Neurosci , vol.13 , Issue.3 , pp. 99-104
    • Connors, B.W.1    Gutnick, M.J.2
  • 134
    • 0024239764 scopus 로고
    • The intrinsic electrophysiological properties of mammalian neurons: Insights into central nervous system function
    • R. R. Llinas: The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function. Science, 242(4886), 1654-64 (1988)
    • (1988) Science , vol.242 , Issue.4886 , pp. 1654-1664
    • Llinas, R.R.1
  • 135
    • 0035044178 scopus 로고    scopus 로고
    • On the cellular and network bases of epileptic seizures
    • D. A. McCormick and D. Contreras: On the cellular and network bases of epileptic seizures. Annu Rev Physiol, 63, 815-46 (2001)
    • (2001) Annu Rev Physiol , vol.63 , pp. 815-846
    • McCormick, D.A.1    Contreras, D.2
  • 136
    • 77955915853 scopus 로고    scopus 로고
    • Spontaneous epileptiform activity in rat neocortex after controlled cortical impact injury
    • L. Yang, S. Afroz, H. B. Michelson, J. H. Goodman, H. A. Valsamis and D. S. Ling: Spontaneous epileptiform activity in rat neocortex after controlled cortical impact injury. J Neurotrauma, 27(8), 1541-8 (2010)
    • (2010) J Neurotrauma , vol.27 , Issue.8 , pp. 1541-1548
    • Yang, L.1    Afroz, S.2    Michelson, H.B.3    Goodman, J.H.4    Valsamis, H.A.5    Ling, D.S.6
  • 137
    • 34547123577 scopus 로고    scopus 로고
    • The neurobiology of epilepsy
    • H. E. Scharfman: The neurobiology of epilepsy. Curr Neurol Neurosci Rep, 7(4), 348-54 (2007)
    • (2007) Curr Neurol Neurosci Rep , vol.7 , Issue.4 , pp. 348-354
    • Scharfman, H.E.1
  • 141
    • 84857648355 scopus 로고    scopus 로고
    • Identification of new epilepsy treatments: Issues in preclinical methodology
    • C. American Epilepsy Society Basic Science and D. The International League Against Epilepsy Working Group On Recommendations For Preclinical Epilepsy Drug
    • A. S. Galanopoulou, P. S. Buckmaster, K. J. Staley, S. L. Moshe, E. Perucca, J. Engel, Jr., W. Loscher, J. L. Noebels, A. Pitkanen, J. Stables, H. S. White, T. J. O'Brien, M. Simonato, C. American Epilepsy Society Basic Science and D. The International League Against Epilepsy Working Group On Recommendations For Preclinical Epilepsy Drug: Identification of new epilepsy treatments: issues in preclinical methodology. Epilepsia, 53(3), 571-82 (2012)
    • (2012) Epilepsia , vol.53 , Issue.3 , pp. 571-582
    • Galanopoulou, A.S.1    Buckmaster, P.S.2    Staley, K.J.3    Moshe, S.L.4    Perucca, E.5    Engel Jr., J.6    Loscher, W.7    Noebels, J.L.8    Pitkanen, A.9    Stables, J.10    White, H.S.11    O'Brien, T.J.12    Simonato, M.13
  • 142
    • 84879463258 scopus 로고    scopus 로고
    • Time-dependent modulation of AMPA receptor phosphorylation and mRNA expression of NMDA receptors and glial glutamate transporters in the rat hippocampus and cerebral cortex in a pilocarpine model of epilepsy
    • M. W. Lopes, F. M. Soares, N. de Mello, J. C. Nunes, A. G. Cajado, D. de Brito, F. M. de Cordova, R. M. da Cunha, R. Walz and R. B. Leal: Time-dependent modulation of AMPA receptor phosphorylation and mRNA expression of NMDA receptors and glial glutamate transporters in the rat hippocampus and cerebral cortex in a pilocarpine model of epilepsy. Exp Brain Res, 226(2), 153-63 (2013)
    • (2013) Exp Brain Res , vol.226 , Issue.2 , pp. 153-163
    • Lopes, M.W.1    Soares, F.M.2    De Mello, N.3    Nunes, J.C.4    Cajado, A.G.5    De Brito, D.6    De Cordova, F.M.7    Da Cunha, R.M.8    Walz, R.9    Leal, R.B.10
  • 143
    • 84866733316 scopus 로고    scopus 로고
    • Time-dependent modulation of mitogen activated protein kinases and AKT in rat hippocampus and cortex in the pilocarpine model of epilepsy
    • M. W. Lopes, F. M. Soares, N. de Mello, J. C. Nunes, F. M. de Cordova, R. Walz and R. B. Leal: Time-dependent modulation of mitogen activated protein kinases and AKT in rat hippocampus and cortex in the pilocarpine model of epilepsy. Neurochem Res, 37(9), 1868-78 (2012)
    • (2012) Neurochem Res , vol.37 , Issue.9 , pp. 1868-1878
    • Lopes, M.W.1    Soares, F.M.2    De Mello, N.3    Nunes, J.C.4    De Cordova, F.M.5    Walz, R.6    Leal, R.B.7
  • 145
    • 77950973481 scopus 로고    scopus 로고
    • Safety and Efficacy of Dietary Agmatine Sulfate in Lumbar Disc-associated Radiculopathy. An Open-label, Dose-escalating Study Followed by a Randomized, Double-blind, Placebo-controlled Trial
    • O. Keynan, Y. Mirovsky, S. Dekel, V. H. Gilad and G. M. Gilad: Safety and Efficacy of Dietary Agmatine Sulfate in Lumbar Disc-associated Radiculopathy. An Open-label, Dose-escalating Study Followed by a Randomized, Double-blind, Placebo-controlled Trial. Pain Med, 11(3), 356-68 (2010)
    • (2010) Pain Med , vol.11 , Issue.3 , pp. 356-368
    • Keynan, O.1    Mirovsky, Y.2    Dekel, S.3    Gilad, V.H.4    Gilad, G.M.5
  • 146
    • 1342326712 scopus 로고    scopus 로고
    • Effect of agmatine on electrically and chemically induced seizures in mice
    • F. Aricioglu, B. Kan, O. Yillar, E. Korcegez and K. Berkman: Effect of agmatine on electrically and chemically induced seizures in mice. Ann N Y Acad Sci, 1009, 141-6 (2003)
    • (2003) Ann N Y Acad Sci , vol.1009 , pp. 141-146
    • Aricioglu, F.1    Kan, B.2    Yillar, O.3    Korcegez, E.4    Berkman, K.5
  • 147
    • 77954386710 scopus 로고    scopus 로고
    • Agmatine enhances the anticonvulsant effect of lithium chloride on pentylenetetrazole-induced seizures in mice: Involvement of L-arginine/nitric oxide pathway
    • A. Bahremand, P. Ziai, T. K. Khodadad, B. Payandemehr, R. Rahimian, A. Ghasemi, M. Ghasemi, T. Hedayat and A. R. Dehpour: Agmatine enhances the anticonvulsant effect of lithium chloride on pentylenetetrazole-induced seizures in mice: Involvement of L-arginine/nitric oxide pathway. Epilepsy Behav, 18(3), 186-92 (2010)
    • (2010) Epilepsy Behav , vol.18 , Issue.3 , pp. 186-192
    • Bahremand, A.1    Ziai, P.2    Khodadad, T.K.3    Payandemehr, B.4    Rahimian, R.5    Ghasemi, A.6    Ghasemi, M.7    Hedayat, T.8    Dehpour, A.R.9
  • 149
    • 0042698307 scopus 로고    scopus 로고
    • Agmatine exerts anticonvulsant effect in mice: Modulation by alpha 2-adrenoceptors and nitric oxide
    • S. Demehri, H. Homayoun, H. Honar, K. Riazi, K. Vafaie, F. Roushanzamir and A. R. Dehpour: Agmatine exerts anticonvulsant effect in mice: modulation by alpha 2-adrenoceptors and nitric oxide. Neuropharmacology, 45(4), 534-42 (2003)
    • (2003) Neuropharmacology , vol.45 , Issue.4 , pp. 534-542
    • Demehri, S.1    Homayoun, H.2    Honar, H.3    Riazi, K.4    Vafaie, K.5    Roushanzamir, F.6    Dehpour, A.R.7
  • 150
    • 55349134543 scopus 로고    scopus 로고
    • Agmatine enhances the anticonvulsant action of phenobarbital and valproate in the mouse maximal electroshock seizure model
    • J. J. Luszczki, R. Czernecki, K. Wojtal, K. K. Borowicz and S. J. Czuczwar: Agmatine enhances the anticonvulsant action of phenobarbital and valproate in the mouse maximal electroshock seizure model. J Neural Transm, 115(11), 1485-94 (2008)
    • (2008) J Neural Transm , vol.115 , Issue.11 , pp. 1485-1494
    • Luszczki, J.J.1    Czernecki, R.2    Wojtal, K.3    Borowicz, K.K.4    Czuczwar, S.J.5
  • 151
    • 67650237081 scopus 로고    scopus 로고
    • Influence of agmatine on the protective action of numerous antiepileptic drugs against pentetrazole-induced seizures in mice
    • J. J. Luszczki, R. Czernecki, M. Dudra-Jastrzebska, K. K. Borowicz and S. J. Czuczwar: Influence of agmatine on the protective action of numerous antiepileptic drugs against pentetrazole-induced seizures in mice. Pharmacol Rep, 61(2), 252-60 (2009)
    • (2009) Pharmacol Rep , vol.61 , Issue.2 , pp. 252-260
    • Luszczki, J.J.1    Czernecki, R.2    Dudra-Jastrzebska, M.3    Borowicz, K.K.4    Czuczwar, S.J.5
  • 152
    • 80053384017 scopus 로고    scopus 로고
    • The interaction of melatonin and agmatine on pentylenetetrazole-induced seizure threshold in mice
    • L. Moezi, H. Shafaroodi, A. Hojati and A. R. Dehpour: The interaction of melatonin and agmatine on pentylenetetrazole-induced seizure threshold in mice. Epilepsy Behav, 22(2), 200-6 (2011)
    • (2011) Epilepsy Behav , vol.22 , Issue.2 , pp. 200-206
    • Moezi, L.1    Shafaroodi, H.2    Hojati, A.3    Dehpour, A.R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.