Agmatine facilitates memory of an inhibitory avoidance task in adult rats

Neurobiology of Learning and Memory

Volumn 78, Issue 2, 2002, Pages 465-469

  Arteni, Nice S ^a   Lavinsky, Daniel ^a   Rodrigues, Analú L ^a   Frison, Verônica B ^a   Netto, Carlos A ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Agmatine; Consolidation; Imidazoline binding sites; Inhibitory avoidance task; Locus coeruleus; Memory; Retrieval

Indexed keywords

AGMATINE; NEUROTRANSMITTER; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ARTICLE; AVOIDANCE BEHAVIOR; COGNITION; CONTROLLED STUDY; DRUG EFFECT; LOCUS CERULEUS; MALE; MEMORY; NONHUMAN; RAT; TASK PERFORMANCE;

EID: 0036434752     PISSN: 10747427     EISSN: None     Source Type: Journal    
DOI: 10.1006/nlme.2002.4076     Document Type: Article

References (20)

1. Bianchin, M., Mello e Souza, T., Medina, J. H., & Izquierdo, I. (1999). The amygdala is involved in the modulation of long-term memory, but not in working or short-term memory. Neurobiology of Learning and Memory, 71, 127-131, doi: nlme.198.3881.
2. Clayton, E. C., & Williams, C. L. (2000). Adrenergic activation of the nucleus tractus solitarius potentiates amygdala noreipinephrine release and enhances retention performance in emotionally arousing and spatial memory tasks. Behavioural Brain Research, 112, 151-158.
3. Clayton, E. C., & Williams, C. L. (2000). Posttraining inactivation of excitatory afferent input to the locus coeruleus impairs retention in an inhibitory avoidance learning task. Neurobiology of Learning and Memory, 73, 127-140, doi: 10.1006/nlme.1999.3924.
4. Devauges, V., & Sara, S. J. (1991). Memory retrieval enhancement by locus coeruleus stimulation: Evidence for mediation by beta-receptors. Behavioural Brain Research, 43, 93-97.
5. Eglen, R. M., Hudson, A. L., Kendall, D. A., Nutt, D. J., Morgan, N. G., Wilson, V. G., & Dillon, M. P. (1998). 'Seeing through a glass darkly': Casting light on imidazline 'I' sites. Trends in Pharmacological Sciences, 19, 381-390.
6. Galea, E., Regunathan, S., Eliopoulos, V., Feinstein, D. L., & Reis, D. J. (1996). Inhibition of mammalian nitric oxide synthases by agmatine, an endogenous polyamine formed by decarboxylation of arginine. Biochemical Journal, 316, 247-249.
7. Izquierdo, L. A., Schroder, N., Ardenghi, P., Quevedo, J., Netto, C. A., Medina, J. H., & Izquierdo, I. (1997). Systemic administration of ACTH or vasopressin reverses the amnestic effect of posttraining b-endorphin or electroconvulsive shock but not that of intrahippocampal infusion of protein kinase inhibitors. Neurobiology of Learning and Memory, 68, 197-202.
8. Li, G., Regunathan, S., Barrow, C. J., Eshragi, J., Cooper, R., & Reis, D. J. (1994). Agmatine: An endogenous clonidine-displacing substance in the brain. Science, 263, 966-969.
9. Loughlin, S., Foote, S., & Bloom, F. (1986). Efferent projections of nucleus locus coeruleus: Topographic organization of cells of origin demonstrated by three-dimensional reconstruction. Neuroscience, 18, 291-306.
10. Louring, R. H. (1990). Agmatine acts as an antagonist of neuronal nicotinic receptors. British Journal of Pharmacology, 99, 207-201.
11. Mahar, K. M., Lakhman, S. S., & Boje, K. M. (2000) Blood-brain barrier transport studies of organic guanidino cations using an in situ brain perfusion technique. Brain Research, 876, 141-147.
12. Otake, K., Ruggiero, D. A., Regunathan, S., Wang, H., Milner, T. A., & Reis, D. J. (1998). Regional localization of agmatine in the rat brain: An immunocytochemical study. Brain Research, 787, 1-14.
13. Pineda, J., Ruiz-Ortega, J. A., Martín-Ruiz, R., & Ugedo, L. (1996). Agmatine does not have activity at alpha2-adrenoceptores which modulate the firing rate of locus coeruleus neurons: An electrophysiological study in rat. Neuroscience Letters, 219, 103-106.
14. Pinthong, D., Wright, I. K., Hanmer, C., Millns, P., Mason, R., Kendall, D. A., & Wilson, V. G. (1995). Agmatine recognizes alpha 2-adrenoceptores binding sites but neither activates nor inhibits alpha 2-adrenoceptores. Archives of Pharmacology, 351, 10-16.
15. Reis, D. J., & Regunathan, S. (2000) Is agmatine a novel neurotransmitter in brain? Trends in Pharmacological Sciences, 21, 187-193.
16. Rubin, M. A., Boemo, R. L., Jurach, A., Rojas, D. B., Zanolla, G. R., Obregon, A. D. C., Souza, D. O., & Mello, C. F. (2000). Intrahippocampal spermine administration improves inhibitory avoidance performance in rats. Behavioural Pharmacology, 11, 57-61.
17. Ruiz-Ortega, A. J., & Ugedo, L. (1997). The stimulatory effect of clonidine on locus coeruleus neurons of rats with inactivated alpha2-adrenoceptores: Involvement of imidazoline receptors located in the nucleus paragigantocellularis. Archives of Pharmacology, 355, 288-294.
18. Stewart, L. S., & McKay, B. E. Acquisition deficit and time-dependent retrograde amnesia for contextual fear conditioning in agmatine-treated rats. Behavioural Pharmacology, 11, 93-97, 2000.
19. Van Bockstaele, E., Colago, E., & Aicher, S. (1998). Light and electron microscopic evidence for topographic and monosynaptic projections from neurons in the ventral medulla to noradrenergic dendrites in the rat locus coeruleus. Brain Research, 784, 123-138.
20. Yang, X.-C., & Reis, D. J. (1999). Agmatine selectively blocks the N-methyl-D-aspartate subclass of glutamate receptor channels in the hippocampal neurons. Journal of Pharmacology and Experimental Therapeutics, 288, 544-549.