Agmatine-reduced collagen scar area accompanied with surface righting reflex recovery after complete transection spinal cord injury

Spine

Volumn 36, Issue 25, 2011, Pages 2130-2138

  Kim, Jae Hwan ^a   Lee, Yong Woo ^a   Park, Yu Mi ^a   Park, Kyung Ah ^a   Park, Seung Hwa ^b   Lee, Won Taek ^a   Lee, Jong Eun ^a  

^a Yonsei University College of Medicine   (South Korea)

^b Konkuk University   (South Korea)

Author keywords

agmatine; BMP 7; neuroprotection; spinal cord injury; TGF 2

Indexed keywords

AGMATINE; COLLAGEN; OSTEOGENIC PROTEIN 1; TRANSFORMING GROWTH FACTOR BETA2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; MALE; MOUSE; NERVE FIBER REGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RIGHTING REFLEX; SCAR; SPINAL CORD TRANSSECTION; SURFACE PROPERTY; SURVIVAL;

AGMATINE; ANIMALS; BONE MORPHOGENETIC PROTEIN 7; CICATRIX; COLLAGEN; DISEASE MODELS, ANIMAL; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED ICR; MOTOR ACTIVITY; RECOVERY OF FUNCTION; REFLEX, RIGHTING; SPINAL CORD; SPINAL CORD INJURIES; THORACIC VERTEBRAE; TRANSFORMING GROWTH FACTOR BETA2;

EID: 81855166649     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/BRS.0b013e318205e3f7     Document Type: Article

References (35)

1. Aguayo A. Axonal regeneration from injured neurons in the adult mammalian central nervous system. Synaptic Plast 1985:457-38.
2. David S, Aguayo AJ. Axonal elongation into peripheral nervous system "bridges" after central nervous system injury in adult rats. Science 1981;214:931-3.
3. Grimpe B, Silver J. The extracellular matrix in axon regeneration. Prog Brain Res 2002;137:333-49.
4. Silver J, Miller JH. Regeneration beyond the glial scar. Nat Rev Neurosci 2004;5:146-56.
5. Allan SM, Rothwell NJ. Cytokines and acute neurodegeneration. Nat Rev Neurosci 2001;2:734-44.
6. Logan A, Green J, Hunter A, et al. Inhibition of glial scarring in the injured rat brain by a recombinant human monoclonalantibody to transforming growth factor-beta2. Eur J Neurosci 1999;11:2367-74.
7. Schwab JM, Beschorner R, Nguyen TD, et al. Differential cellular accumulation of connective tissue growth factor defines a subset of reactive astrocytes, invading fibroblasts, and endothelial cells following central nervous system injury in rats and humans. J Neurotrauma 2001;18:377-88.
8. Lagord C, Berry M, Logan A. Expression of TGFbeta2 but not TGFbeta1 correlates with the deposition of scar tissue in the lesioned spinal cord. Mol Cell Neurosci 2002;20:69-92.
9. Setoguchi T, Yone K, Matsuoka E, et al. Traumatic injury-induced BMP7 expression in the adult rat spinal cord. Brain Res 2001; 921:219-25.
10. Kawamata T, Ren J, Chan TC, et al. Intracisternal osteogenic protein-1 enhances functional recovery following focal stroke. Neuroreport 1998;9:1441-5.
11. Yang XC, Reis DJ. Agmatine selectively blocks the N-methyl-Daspartate subclass of glutamate receptor channels in rat hippocampal neurons. J Pharmacol Exp Ther 1999;288:544-9.
12. Li G, Regunathan S, Barrow CJ, et al. Agmatine: An endogenous clonidine-displacing substance in the brain. Science 1994;263:966-9.
13. Feng Y, Piletz JE, Leblanc MH. Agmatine suppresses nitric oxide production and attenuates hypoxic-ischemic brain injury in neonatal rats. Pediatr Res 2002;52:606-11.
14. Gilad GM, Gilad VH. Accelerated functional recovery and neuroprotection by agmatine after spinal cord ischemia in rats. Neurosci Lett 2000;296:97-100.
15. Gilad GM, Salame K, Rabey JM, et al. Agmatine treatment is neuroprotective in rodent brain injury models. Life Sci 1996;58:PL 41-6.
16. Kim JH, Yenari MA, Giffard RG, et al. Agmatine reduces infarct area in a mouse model of transient focal cerebral ischemia and protects cultured neurons from ischemia-like injury. Exp Neurol 2004;189:122-30.
17. Yu CG, Marcillo AE, Fairbanks CA, et al. Agmatine improves locomotor function and reduces tissue damage following spinal cord injury. Neuroreport 2000;11:3203-7.
18. Lu J, Feron F, Ho SM, et al. Transplantation of nasal olfactory tissue promotes partial recovery in paraplegic adult rats. Brain Res 2001;889:344-57.
19. Lee WT, Oh HS, Jeong HS, et al. The effect of ependymal cell transplantation on nerve regeneration after spinal cord injury in rats. Korean J Anatomy 2004;37:529-38.
20. Basso DM, Beattie MS, Bresnahan JC. A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma 1995;12:1-21.
21. Kerasidis H, Wrathall JR, Gale K. Behavioralassessment of functional deficit in rats with contusive spinal cord injury. J Neurosci Methods 1987;20:167-79.
22. Piletz JE, Chikkala DN, Ernsberger P. Comparison of the properties of agmatine and endogenous clonidine-displacing substance at imidazoline and alpha-2 adrenergic receptors. J Pharmacol Exp Ther 1995;272:581-7.
23. Reynolds IJ. Arcaine uncovers dual interactions of polyamines with the N-methyl-D-aspartate receptor. J Pharmacol Exp Ther 1990;255:1001-7.
24. Olmos G, DeGregorio-Rocasolano N, Paz Regalado M, et al. Protection by imidazol(ine) drugs and agmatine of glutamateinduced neurotoxicity in cultured cerebellar granule cells through blockade of nmda receptor. Br J Pharmacol 1999;127:1317-26.
25. Auguet M, Viossat I, Marin JG, et al. Selective inhibition of inducible nitric oxide synthase by agmatine. Jpn J Pharmacol 1995;69:285-7.
26. Liu Y, Belayev L, Zhao W, et al. The effect of bone morphogenetic protein-7 (BMP-7) on functional recovery, local cerebral glucose utilization and blood fl ow after transient focal cerebral ischemia in rats. Brain Res 2001;905:81-90.
27. Harvey BK, Hoffer BJ, Wang Y. Stroke and TGF-beta proteins: Glial cell line-derived neurotrophic factor and bone morphogenetic protein. Pharmacol Ther 2005;105:113-25.
28. Ren J, Kaplan PL, Charette MF, et al. Time window of intracisternal osteogenic protein-1 in enhancing functional recovery after stroke. Neuropharmacology 2000;39:860-5.
29. Hong CC, Yu PB. Applications of small molecule BMP inhibitors in physiology and disease. Cytokine Growth Factor Rev 2009;20:409-18.
30. Traister A, Abashidze S, Gold V, et al. BMP controls nitric oxide-mediated regulation of cell numbers in the developing neural tube. Cell Death Differ 2004;11:832-41.
31. Hermanns S, Reiprich P, Muller HW. A reliable method to reduce collagen scar formation in the lesioned rat spinal cord. J Neurosci Methods 2001;110:141-6.
32. Klapka N, Hermanns S, Straten G, et al. Suppression of fibrous scarring in spinal cord injury of rat promotes long-distance regeneration of corticospinal tract axons, rescue of primary motoneurons in somatosensory cortex and significant functional recovery. Eur J Neurosci 2005;22:3047-58.
33. Stichel CC, Hermanns S, Luhmann HJ, et al. Inhibition of collagen IV deposition promotes regeneration of injured CNS axons. Eur J Neurosci 1999;11:632-46.
34. Maxwell WL, Duance VC, Lehto M, et al. The distribution of types I, III, IV and V collagens in penetrant lesions of the central nervous system of the rat. Histochem J 1984;16:1215-29.
35. Marx M, Trittenwein G, Aufricht C, et al. Agmatine and spermidine reduce collagen accumulation in kidneys of diabetic db/db mice. Nephron 1995;69:155-8.