Agmatine, a metabolite of L-arginine, reverses scopolamine-induced learning and memory impairment in rats

Pharmacology Biochemistry and Behavior

Volumn 102, Issue 4, 2012, Pages 578-584

  Utkan, Tijen ^a   Gocmez, Semil S ^b   Regunathan, Soundararajan ^c   Aricioglu, Feyza ^d  

^a KOCAELI UNIVERSITY   (Turkey)

^b NAMIK KEMAL UNIVERSITY   (Turkey)

^c UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

^d MARMARA UNIVERSITY   (Turkey)

Author keywords

Agmatine; Cognition; Passive avoidance; Scopolamine; Three panel runway

Indexed keywords

AGMATINE; SCOPOLAMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COGNITION; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; EMOTION; LEARNING DISORDER; MALE; MEMORY DISORDER; NONHUMAN; PASSIVE AVOIDANCE; PRIORITY JOURNAL; RAT; REFERENCE MEMORY; TASK PERFORMANCE; WORKING MEMORY;

AGMATINE; ANIMALS; LEARNING; MALE; MEMORY; RATS; RATS, WISTAR; SCOPOLAMINE HYDROBROMIDE;

RATTUS;

EID: 84864502460     PISSN: 00913057     EISSN: 18735177     Source Type: Journal    
DOI: 10.1016/j.pbb.2012.07.003     Document Type: Article

References (64)

1. F. Aricioglu, and H. Altunbaş Is agmatine an endogenous anxiolytic/antidepressant agent? Ann N Y Acad Sci 1009 2003 136 140 (Pubitemid 38265098)
2. F. Aricioglu, B. Kan, O. YIllar, E. Körcegez, and K. Berkman Effect of agmatine on electrically and chemically induced seizures in mice Ann N Y Acad Sci 1009 2003 141 146 (Pubitemid 38265099)
3. F. Aricioglu, E. Körceǧez, A. Bozkurt, and S. ÖzyalçIn Effect of agmatine on acute and mononeuropathic pain Ann N Y Acad Sci 1009 2003 106 115 (Pubitemid 38265094)
4. F. Aricioglu, A. Means, and S. Regunathan Effect of agmatine on the development of morphine dependence in rats: potential role of cAMP system Eur J Pharmacol 504 2004 191 197 (Pubitemid 39489902)
5. F. Aricioglu, and S. Regunathan Agmatine attenuates stress-and lipopolysaccaride-induced fever in rats Physiol Behav 85 2005 370 375 (Pubitemid 40846471)
6. F. Aricioglu, S. Regunathan, and J.E. Piletz Is agmatine an endogenous factor against stress? Ann N Y Acad Sci 1009 2003 127 132 (Pubitemid 38265096)
7. F. Aricioglu, I.A. Paul, and S. Regunathan Agmatine reduces only peripheral-related behavioral signs, not the central sings, of morphine withdrawal in nNOS deficient transgenic mice Neurosci Lett 354 2004 153 157 (Pubitemid 38032856)
8. F. Aricioglu-Kartal, E. Ercil, and G. Dülger Agmatine inhibits naloxone-induced contractions in morphine-dependent guinea pig ileum Ann N Y Acad Sci 1009 2003 147 152
9. F. Aricioglu-Kartal, and S. Regunathan Effect of chronic morphine treatment on the biosynthesis of agmatine in rat brain and other tissues Life Sci 71 2002 1695 1701 (Pubitemid 34874493)
10. F. Aricioglu-Kartal, and I.T. Uzbay Inhibitory effect of agmatine on naloxone precipitated abstinence syndrome in morphine dependent rats Life Sci 61 1997 1775 1781 (Pubitemid 27440632)
11. N.S. Arteni, D. Lavinsky, A.L. Rodrigues, V.B. Frison, and C.A. Netto Agmatine facilitates memory of an inhibitory avoidance task in adult rats Neurobiol Learn Mem 78 2002 465 469 (Pubitemid 35366023)
12. C.A. Barnes, L. Nadel, and W.K. Honig Spatial memory deficit in senescent rats Can J Psychol 34 1980 29 39
13. D.H. Bergin, and P. Liu Agmatine protects against beta amyloid25-35-induced memory impairments in the rat Neuroscience 169 2010 794 811
14. S. Blackshaw, M.J. Eliasson, A. Sawa, C.C. Watkins, D. Krug, and A. Gupta Species, strain and developmental variations in hippocampal neuronal and endothelial nitric oxide synthase clarify discrepancies in nitric oxide-dependent synaptic plasticity Neuroscience 119 2003 979 990 (Pubitemid 36776448)
15. A. Blokland Acetylcholine: a neurotransmitter for learning and memory? Brain Res Rev 21 1995 285 300 (Pubitemid 26188014)
16. J.C. de la Torre, and G.B. Stefano Evidence that Alzheimer's disease is a microvascular disorder: the role of constitutive nitric oxide Brain Res Rev 34 2000 119 136
17. S. Demehri, H. Homayoun, H. Honar, K. Riazi, K. Vafaie, and F. Roushanzamir Agmatine exerts anticonvulsant effect in mice: modulation by alpha 2-adrenoceptors and nitric oxide Neuropharmacology 45 2003 534 542 (Pubitemid 36936986)
18. J.L. Dinerman, T.M. Dawson, M.J. Schell, A. Snowman, and H.S. Soloman Endothelial nitric oxide synthase localized to hippocampal pyramidal cells: implications for synaptic plasticity Proc Natl Acad Sci USA 91 1994 4214 4218 (Pubitemid 24143403)
19. B.A. Ellenbroek Pre-attentive processing and schizophrenia: animal studies Psychopharmacology (Berl) 174 2004 65 74 (Pubitemid 38925092)
20. C.A. Fairbanks, K.L. Schreiber, K.L. Brewer, C.G. Yu, L.S. Stone, and K.F. Kito Agmatine reverses pain induced by inflammation, neuropathy, and spinal cord injury Proc Natl Acad Sci USA 97 2000 10584 10589
21. R. Feil, and T. Kleppisch NO/cGMP-dependent modulation of synaptic transmission Handb Exp Pharmacol 184 2008 529 560
22. Y. Feng, M.H. LeBlanc, and S. Regunathan Agmatine reduces extracellular glutamate during pentylenetetrazole-induced seizures in rat brain: a potential mechanism for the anticonvulsive effects Neurosci Lett 390 2005 129 133 (Pubitemid 41483608)
23. Y. Furuya, T. Yamamoto, S. Yatsugi, and S. Ueki A new method for studying working memory by using the three-panel runway apparatus in rats Jpn J Pharmacol 46 1988 183 188 (Pubitemid 18055015)
24. E. Galea, S. Regunathan, V. Eliopoulus, D.L. Feinstein, and D.J. Reis Inhibition of mammalian nitric oxide syntheses by agmatine, an endogenous polyamine formed by decarboxylation of arginine Biochem J 316 1996 247 249
25. G.M. Gilad, and V.H. Gilad Accelerated functional recovery and neuroprotection by agmatine after spinal cord ischemia in rats Neurosci Lett 296 2000 97 100
26. G.M. Gilad, K. Salame, J.M. Rabey, and V.H. Gilad Agmatine treatment is neuroprotective in rodent brain injury models Life Sci 58 1996 41 46
27. A. Halaris, and J. Piletz Agmatine: metabolic pathway and spectrum of activity in brain CNS Drugs 21 2007 885 900 (Pubitemid 47557104)
28. R.A. Hooper, and J. Garthwaite Tonic and phasic nitric oxide signals in hippocampal long-term potentiation J Neurosci 26 2006 11513 11521 (Pubitemid 44772122)
29. J. Jonides, R.L. Lewis, D.E. Nee, C.A. Lustig, M.G. Berman, and K.S. Moore The mind and brain of short-term memory Annu Rev Psychol 59 2008 193 224
30. T. Kameyama, T. Nabeshima, and T. Kozawa Step-down-type passive avoidance- and escape-learning method. Suitability for experimental amnesia models J Pharmacol Methods 16 1986 39 52 (Pubitemid 16068438)
31. E.R. Kandel The molecular biology of memory storage: a dialogue between genes and synapses Science 294 2001 1030 1038 (Pubitemid 33041851)
32. J.H. Kim, M.A. Yenari, R.G. Giffard, S.W. Cho, K.A. Park, and J.E. Lee Agmatine reduces infarct area in a mouse model of transient focal cerebral ischemia and protects cultured neurons from ischemia-like injury Exp Neurol 189 2004 122 130 (Pubitemid 39024461)
33. Y. Kolesnikov, S. Jain, and G.W. Pasternak Modulation of opioid analgesia by agmatine Eur J Pharmacol 296 1996 17 22 (Pubitemid 26032232)
34. D. Lavinsky, N.S. Arteni, and C.A. Netto Agmatine induces anxiolysis in the elevated plus maze task in adult rats Behav Brain Res 141 2003 19 24 (Pubitemid 36382913)
35. G. Li, S. Regunathan, C.J. Barrow, J. Eshraghi, R. Cooper, and D.J. Reis Agmatine: an endogenous clonidine-displacing substance in the brain Science 263 1994 966 969 (Pubitemid 24094560)
36. P. Liu, and D.H. Bergin Differential effects of i.c.v. microinfusion of agmatine on spatial working and reference memory in the rat Neuroscience 159 2009 951 961
37. P. Liu, S. Chary, R. Devaraj, Y. Jing, C.L. Darlington, and P.F. Smith Effects of aging on agmatine levels in memory-associated brain structures Hippocampus 18 2008 853 856
38. P. Liu, and N.D. Collie Behavioral effects of agmatine in naive rats are task- and delay-dependent Neuroscience 163 2009 82 96
39. P. Liu, N.D. Collie, S. Chary, Y. Jing, and H. Zhang Spatial learning results in elevated agmatine levels in the rat brain Hippocampus 18 2008 1094 1098
40. P. Liu, Y. Jing, N.D. Collie, S. Chary, and H. Zhang Memory-related changes in L-citrulline and agmatine in the rat brain Hippocampus 19 2009 597 602
41. J. Malaterre, C. Strambi, A. Aouane, A. Strambi, G. Rougon, and M. Cayre A novel role for polyamines in adult neurogenesis in rodent brain Eur J Neurosci 20 2004 317 330 (Pubitemid 38969617)
42. B.E. McKay, W.E. Lado, L.J. Martin, M.A. Galic, and N.M. Fournier Learning and memory in agmatine-treated rats Pharmacol Biochem Behav 72 2002 551 557 (Pubitemid 34450855)
43. C.H. Mun, W.T. Lee, K.A. Park, and J.E. Lee Regulation of endothelial nitric oxide synthase by agmatine after transient global cerebral ischemia in rat brain Anat Cell Biol 43 2010 230 240
44. H.O. Nguyen, C.J. Goracke-Postle, L.L. Kaminski, A.C. Overland, A.D. Morgan, and C.A. Fairbanks Neuropharmacokinetic and dynamic studies of agmatine (decarboxylated arginine) Ann N Y Acad Sci 1009 2003 82 105 (Pubitemid 38265093)
45. M. Ohno, T. Yamamoto, and S. Watanabe Effects of intrahippocampal injections of N-methyl-d-aspartate receptor antagonists and scopolamine on working and reference memory assessed in rats by a three-panel runway task J Pharmacol Exp Ther 263 1992 943
46. D.S. Olton, and B.C. Paras Spatial memory and hippocampal function Neuropsychology 17 1979 667 682
47. S.M. Oredsson Polyamine dependence of normal cell-cycle progression Biochem Soc Trans 31 2003 366 370 (Pubitemid 36520678)
48. A.M. Palmer Neurochemical studies of Alzheimer's disease Neurodegeneration 5 1996 381 391 (Pubitemid 27077898)
49. E. Palsson, K. Fejgin, C. Wass, and D. Klamer Agmatine attenuates the disruptive effects of phencyclidine on prepulse inhibition Eur J Pharmacol 590 2008 212 216
50. W. Raasch, S. Regunathan, G. Li, and D.J. Reis Agmatine is widely and unequally distributed in rat organs Ann N Y Acad Sci 763 1995 330 334
51. D.J. Reis, and S. Regunathan Agmatine: an endogenous ligand at imidazoline receptors is a novel neurotransmitter Ann N Y Acad Sci 881 1999 65 80 (Pubitemid 29349491)
52. D.J. Reis, and S. Regunathan Is agmatine a novel neurotransmitter in brain? Trends Pharmacol Sci 21 2000 187 193 (Pubitemid 30243201)
53. E. Ruiz-Durántez, J.A. Ruiz-Ortega, J. Pineda, and L. Ugedo Effect of agmatine on locus coeruleus neuron activity: possible involvement of nitric oxide Br J Pharmacol 135 2002 1152 1158 (Pubitemid 34259115)
54. A.V. Santhanam, S. Viswanathan, and M. Dikshit Activation of protein kinase B/Akt and endothelial nitric oxide synthase mediates agmatine-induced endothelium-dependent relaxation Eur J Pharmacol 572 2007 189 196 (Pubitemid 47429648)
55. A.R.S. Santos, V.M. Gadotti, G.L. Oliveira, D. Tibola, A.F. Paszcuk, and A. Neto Mechanisms involved in the antinociception caused by agmatine in mice Neuropharmacology 48 2005 1021 1034 (Pubitemid 40602610)
56. L.S. Stewart, and B.E. McKay Acquisition deficit and time-dependent retrograde amnesia for contextual fear conditioning in agmatine-treated rats Behav Pharmacol 11 2000 93 97 (Pubitemid 30223763)
57. H.M. Wallace The physiological role of the polyamines Eur J Clin Invest 30 2000 1 3
58. W.P. Wang, A.H. Iyo, J. Miguel-Hidalgo, S. Regunathan, and M.Y. Zhu Agmatine protects against cell damage induced by NMDA and glutamate in cultured hippocampal neurons Brain Res 1084 2006 210 216
59. K. Williams Interactions of polyamines with ion channels Biochem J 325 1997 289 297 (Pubitemid 27338704)
60. H. Yananli, M.Z. Gören, K. Berkman, and F. Aricioglu Effect of agmatine on brain L-citrulline production during morphine withdrawal in rats: a microdialysis study in nucleus accumbens Brain Res 32 2007 51 58 (Pubitemid 46099006)
61. X.C. Yang, and D.J. Reis Agmatine selectively blocks the NMDA subclass of glutamate receptor channels in cultured mouse hippocampal neurons J Pharmacol Exp Ther 8 1999 544 549 (Pubitemid 29119663)
62. A.D. Zomkowski, L. Hammes, J. Lin, J.B. Calixto, A.R. Santos, and A.L. Rodrigues Agmatine produces antidepressant-like effects in two models of depression in mice Neuroreport 13 2002 387 391 (Pubitemid 34293175)
63. A.D. Zomkowski, A.O. Rosa, J. Lin, A.R. Santos, J.B. Calixto, and A.L. Rodrigues Evidence for serotonin receptor subtypes involvement in agmatine antidepressant like-effect in the mouse forced swimming test Brain Res 1023 2004 253 263 (Pubitemid 39221428)
64. A.D. Zomkowski, A.R. Santos, and A.L. Rodrigues Evidence for the involvement of the opioid system in the agmatine antidepressant-like effect in the forced swimming test Neurosci Lett 381 2005 279 283 (Pubitemid 40719172)