Agmatinase activity in rat brain: A metabolic pathway for the degradation of agmatine

Journal of Neurochemistry

Volumn 67, Issue 4, 1996, Pages 1761-1765

  Sastre, Magdalena ^a   Regunathan, Soundararajan ^a   Galea, Elena ^a   Reis, Donald J ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Agmatine; Arginine decarboxylase; Hypothalamus; Imidazoline receptors; Mitochondria

Indexed keywords

AGMATINE; ARGININE DECARBOXYLASE; IMIDAZOLINE RECEPTOR; PUTRESCINE;

ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN METABOLISM; CELL FRACTIONATION; CORPUS STRIATUM; DRUG DEGRADATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; HYDROLYSIS; HYPOTHALAMUS; METABOLIC REGULATION; MITOCHONDRIAL MEMBRANE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALIA;

EID: 0029789277     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1996.67041761.x     Document Type: Article

References (22)

1. Bradford M. M. (1976) A rapid sensitive method for the quantitation of protein using the principle of protein-dye binding. Anal. Biochem. 72, 248-252.
2. 3H] rauwolscine. Brain Res. 566, 13-20.
3. Kalra S. P., Pearson E., Sahu A., and Kalra P. S. (1995) Agmatine, a novel hypothalamic amine, stimulates pituitary luteinizing hormone release in vivo and hypothalamic luteinizing hormone-releasing hormone release in vitro. Neurosci. Lett. 194, 165-168.
4. Kolesnikov Y., Jain S., and Pasternak G. W. (1996) Modulation of opioid analgesia by agmatine. Eur. J. Pharmacol. 296, 17-22.
5. Li G., Regunathan S., Barrow C. J., Eshraghi J., Cooper R., and Reis D. J. (1994) Agmatine: an endogenous clonidine-displacing substance in the brain. Science 263, 966-969.
6. Li G., Regunathan S., and Reis D. J. (1995) Agmatine is synthesized by a mitochondrial arginine decarboxylase in rat. Ann. NY Acad. Sci. 763, 315-324.
7. Lortie M. J., Novotny W. F., Peterson O. W., Vallon V., Malvey K., Mendonca M., Satriano J., Insel P., Thomson S. C., and Blantz R. C. (1996) Agmatine, a bioactive metabolite of arginine. Production, degradation and functional effects in the kidney of the rat. J. Clin. Invest. 97, 413-420.
8. Mallard N. J., Hudson A. L., and Nutt D. J. (1992) Characterization and autoradiographical localization of non-adrenoceptor idazoxan binding sites in rat brain. Br. J. Pharmacol. 106, 1019-1027.
9. Nakamura H., Saheki T., and Nakagawa S. (1990) Differential cellular localization of enzymes of L-arginine metabolism in the rat brain. Brain Res. 530, 108-112.
10. Piletz J. E., Chikkala D. N., and Ernsberger P. (1995) Comparison of the properties of agmatine and endogenous clonidine-displacing substance at imidazoline and alpha-2 adrenergic receptors. J. Pharmacol. Exp. Ther. 272, 581-587.
11. Raasch W., Regunathan S., Li G., and Reis D. J. (1995) Agmatine, the bacterial amine, is widely distributed in mammalian tissues. Life Sci. 56, 2319-2330.
12. Ratner S., Morell H., and Carvalho E. (1960) Enzymes of arginine metabolism in brain. Arch. Biochem. Biophys. 91, 280-289.
13. Reczkowski R. S. and Ash D. E. (1994) Rat liver arginase: kinetic mechanism, alternate substrates, and inhibitors. Arch. Biochem. Biophys. 312, 31-37.
14. Regunathan S., Meeley M. P., and Reis D. J. (1993) Expression of non-adrenergic imidazoline sites in chromaffin cells and mitochondrial membranes of bovine adrenal medulla. Biochem. Pharmacol. 45, 1667-1675.
15. Regunathan S., Youngson C., Raasch W., Wang H., and Reis D. J. (1996) Imidazoline receptors and agmatine in blood vessels: a novel system inhibiting vascular smooth muscle proliferation. J. Pharmacol. Exp. Ther. 276, 1272-1282.
16. Reichelt K. L. and Poulsen E. (1992) γ-Glutamylaminotransferase and transglutaminase in subcellular fractions of rat cortex and in cultured astrocytes. J. Neurochem. 59, 500-504.
17. Ruggiero D. A., Regunathan S., Wang H., Milner T., and Reis D. J. (1995) Distribution of imidazoline receptor binding protein in the central nervous system. Ann. NY Acad. Sci. 763, 195-221.
18. Satishchandran C. and Boyle S. (1986) Purification and properties of agmatine ureohydrolase, a putrescine biosynthetic enzyme in Escherichia coli. J. Bacteriol. 165, 843-848.
19. Szumanski M. B. W. and Boyle S. (1990) Analysis and sequence of the spe B gene encoding agmatine ureohydrolase, a putrescine biosynthetic enzyme in Escherichia coli. J. Bacteriol. 172, 538-547.
20. Tabor C. W. and Tabor H. (1984) Polyamines. Annu. Rev. Biochem. 53, 749-790.
21. Tesson F. and Parmi A. (1991) Identification of an imidazoline-guanidinium receptive site in mitochondria from rabbit cerebral cortex. Eur. J. Pharmacol. 208, 81-83.
22. Wang H., Otake K., Ruggiero D. A., Milner T. A., Li G., Raasch W., Youngson C., Regunathan S., and Reis D. J. (1994) Regional distribution of agmatine and arginine decarboxylase in rat brain. Soc. Neurosci. Abstr. 20, 1060.