Protection by-imidazol(ine) drugs and agmatine of glutamate-induced neurotoxicity in cultured cerebellar granule cells through blockade of NMDA receptor

British Journal of Pharmacology

Volumn 127, Issue 6, 1999, Pages 1317-1326

  Olmos, Gabriel ^a   DeGregorio Rocasolano, Nuria ^b   Regalado, M Paz ^a   Gasull, Teresa ^b   Boronat, M Assumpció ^a   Trullas, Ramón ^b   Villarroel, Alvaro ^a   Lerma, Juan ^a   García Sevilla, Jesús A ^a  

^a INSTITUTO CAJAL   (Spain)

^b INST D INVESTIGACIONS B   (Spain)

Author keywords

Agmatine; Cerebellar granule cells; Glutamate; Imidazoline; N melhyl D aspartate receptors; Neuroprotection; Neurotoxicity

Indexed keywords

2 (1,4 BENZODIOXAN 6 YL) 2 IMIDAZOLINE; 2 (2 BENZOFURANYL)IMIDAZOLE; 2 (2 METHOXY 1,4 BENZODIOXAN 2 YL) 2 IMIDAZOLINE; 3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; AGMATINE; ANTAZOLINE; CIRAZOLINE; DIZOCILPINE; FORMAZAN; GLUTAMIC ACID; IDAZOXAN; IMIDAZOLINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; POTASSIUM ION; RECEPTOR SUBUNIT; TRACIZOLINE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; BINDING SITE; CEREBELLUM; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; GENETIC TRANSFECTION; GRANULE CELL; NERVE CELL CULTURE; NEUROPROTECTION; NEUROTOXICITY; NEWBORN; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT;

AGMATINE; ANIMALS; ANTAZOLINE; BENZOFURANS; CELL LINE; CELLS, CULTURED; CEREBELLUM; DIOXANES; DIZOCILPINE MALEATE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; GLUTAMIC ACID; HUMANS; IDAZOXAN; IMIDAZOLES; NEUROPROTECTIVE AGENTS; PATCH-CLAMP TECHNIQUES; POTASSIUM; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE; STYRENES;

EID: 0032772901     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702679     Document Type: Article

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