Dexamethasone-induced autophagy mediates muscle atrophy through mitochondrial clearance

Cell Cycle

Volumn 13, Issue 14, 2014, Pages 2281-2295

  Troncoso, Rodrigo ^a   Paredes, Felipe ^a   Parra, Valentina ^a,b   Gatica, Damián ^a   Vásquez Trincado, César ^a   Quiroga, Clara ^a   Bravo Sagua, Roberto ^a   Loṕez Crisosto, Camila ^a   Rodriguez, Andrea E ^a   Oyarzuń, Alejandra P ^a   Kroemer, Guido ^c,d,e,f   Lavandero, Sergio ^a,b  

^a UNIVERSITY OF CHILE   (Chile)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c INSERM   (France)

^d INSTITUT GUSTAVE ROUSSY   (France)

^e HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

^f UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Autophagy; Dexamethasone; Glucocorticoid; Mitophagy; Muscle atrophy

Indexed keywords

AUTOPHAGY PROTEIN 5; BECLIN 1; DEXAMETHASONE; DNM1L PROTEIN; GLUCOCORTICOID RECEPTOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LC 3 PROTEIN; MDIVI 1 PROTEIN; PROTEIN; PROTEIN KINASE; SQSTM 1 PROTEIN; UNCLASSIFIED DRUG; 3-(2,4-DICHLORO-5-METHOXYPHENYL)-2-SULFANYL-4(3H)-QUINAZOLINONE; APOPTOSIS REGULATORY PROTEIN; ATG5 PROTEIN, RAT; BECN1 PROTEIN, RAT; DRP1 PROTEIN, RAT; DYNAMIN; GLUCOCORTICOID; HEAT SHOCK PROTEIN; LC3 PROTEIN, RAT; MICROTUBULE ASSOCIATED PROTEIN; QUINAZOLINONE DERIVATIVE; SQSTM1 PROTEIN, RAT;

ANIMAL CELL; ARTICLE; ATROPHY; AUTOPHAGOSOME; AUTOPHAGY; CELLS; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; IMMUNOFLUORESCENCE; MITOCHONDRIAL DYNAMICS; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MITOCHONDRIAL VOLUME; MITOCHONDRION; MITOPHAGY; MOUSE; MUSCLE ATROPHY; MYOBLAST; MYOTUBE; NONHUMAN; OXYGEN CONSUMPTION; PROTEIN DEGRADATION; PROTEIN SYNTHESIS; RAT; SKELETAL MUSCLE; WESTERN BLOTTING; AGONISTS; ANIMAL; CELL LINE; CHEMICALLY INDUCED; DEFICIENCY; DOSE RESPONSE; DRUG EFFECTS; GENETICS; METABOLISM; MUSCLE MITOCHONDRION; PATHOLOGY; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TIME;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; CELL LINE; DEXAMETHASONE; DOSE-RESPONSE RELATIONSHIP, DRUG; DYNAMINS; GLUCOCORTICOIDS; HEAT-SHOCK PROTEINS; MICROTUBULE-ASSOCIATED PROTEINS; MITOCHONDRIA, MUSCLE; MITOCHONDRIAL DEGRADATION; MUSCLE FIBERS, SKELETAL; MUSCULAR ATROPHY; PROTEINS; QUINAZOLINONES; RATS; RECEPTORS, GLUCOCORTICOID; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION;

EID: 84904498044     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.29272     Document Type: Article

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