Suppression of atrogin-1 and MuRF1 prevents dexamethasone-induced atrophy of cultured myotubes

Metabolism: Clinical and Experimental

Volumn 62, Issue 10, 2013, Pages 1495-1502

  Castillero, Estibaliz ^a   Alamdari, Nima ^a   Lecker, Stewart H ^a   Hasselgren, Per Olof ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Glucocorticoids; Muscle wasting; Protein synthesis; Proteolysis; Ubiquitin ligases

Indexed keywords

ATROGIN 1; DEXAMETHASONE; MESSENGER RNA; MUSCLE RING FINGER 1 PROTEIN; SMALL INTERFERING RNA; FBXO32 PROTEIN, RAT; GLUCOCORTICOID; MUSCLE PROTEIN; TRIM63 PROTEIN, RAT; UBIQUITIN; UBIQUITIN PROTEIN LIGASE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; MORPHOLOGY; MUSCLE ATROPHY; MUSCLE HYPERTROPHY; MYOTUBE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; RAT; UPREGULATION; WESTERN BLOTTING; ANIMAL; CELL CULTURE; CHEMICALLY INDUCED; DRUG EFFECTS; GENETICS; METABOLISM; MUSCLE CELL; PATHOLOGY; SKELETAL MUSCLE;

ANIMALS; CELLS, CULTURED; DEXAMETHASONE; GLUCOCORTICOIDS; MUSCLE CELLS; MUSCLE FIBERS, SKELETAL; MUSCLE PROTEINS; MUSCLE, SKELETAL; MUSCULAR ATROPHY; PROTEIN BIOSYNTHESIS; PROTEOLYSIS; RATS; RNA, MESSENGER; SKP CULLIN F-BOX PROTEIN LIGASES; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

EID: 84884530139     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2013.05.018     Document Type: Article

References (40)

1. T.B. Vanitallie Frailty in the elderly: contributions of sarcopenia and visceral protein depletion Metabolism 52 2003 22 26
2. F. Puleo, K. Meirelles, and M. Navaratnarajah Skeletal muscle catabolism in trinitrobenzene sulfonic acid-induced murine colitis Metabolism 59 2010 1680 1690
3. Y.Y. Wang, S.Y. Lin, and Y.H. Chuang Protein nitration is associated with increased proteolysis in skeletal muscle of bile duct ligation-induced cirrhotic rats Metabolism 59 2010 468 472
4. Z. Aversa, N. Alamdari, and P.O. Hasselgren Molecules modulating gene transcription during muscle wasting in cancer, sepsis, and other critical illness Crit Rev Clin Lab Sci 48 2011 71 86
5. N. Alamdari, Z. Aversa, and E. Castillero Acetylation and deacetylation - novel factors in muscle wasting Metabolism 62 2013 1 11
6. S.H. Lecker Ubiquitin-protein ligases in muscle wasting: multiple parallel pathways? Curr Opin Clin Nutr Metab Care 6 2003 271 275
7. M.D. Petroski, and R.J. Deshaies Function and regulation of cullin-RING ubiquitin ligases Nat Rev Mol Cell Biol 6 2005 9 20
8. S.H. Witt, H. Granzier, and C.C. Witt MURF-1 and MURF-2 target a specific subset of myofibrillar proteins redundantly: towards understanding MURF-dependent muscle ubiquitination J Mol Biol 350 2005 713 722
9. S.C. Bodine, E. Latres, and S. Baumhueter Identification of ubiquitin ligases required for skeletal muscle atrophy Science 294 2001 1704 1708
10. M.D. Gomes, S.H. Lecker, and R.T. Jagoe Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy Proc Natl Acad Sci U S A 98 2001 14440 14445
11. J. Lagirand-Cantaloube, K. Cornille, and A. Csibi Inhibition of atrogin-1/MAFbx mediated MyoD proteolysis prevents skeletal muscle atrophy in vivo PLoS One 4 2009 e4973
12. H. Cong, L. Sun, and C. Liu Inhibition of atrogin-1/MAFbx expression by adenovirus-delivered small hairpin RNAs attenuates muscle atrophy in fasting mice Hum Gene Ther 22 2011 313 324
13. D. Cai, J.D. Frantz, and N.E. Tawa IKKβ/NF-kB activation causes severe muscle wasting in mice Cell 119 2004 285 298
14. V. Adams, N. Mangner, and A. Gasch Induction of MuRF1 is essential for TNF-α-induced loss of muscle function in mice J Mol Biol 384 2008 48 59
15. S. Labeit, C.H. Kohl, and C.C. Witt Modulation of muscle atrophy, fatigue and MLC phosphorylation by MuRF1 as indicated by hindlimb suspension studies on MuRF1-KO mice J Biomed Biotechnol 2010 2010 693741
16. S. Koyama, S. Hata, and C.C. Witt Muscle RING-finger protein-1 (MuRF1) as a connector of muscle energy metabolism and protein synthesis J Mol Biol 376 2008 1224 1236
17. P.O. Hasselgren Glucocorticoids and muscle catabolism Curr Opin Clin Nutr Metab Care 2 1999 201 205
18. B. Salehian, V. Mahabadi, and J. Bilas The effect of glutamine on prevention of glucocorticoid-induced skeletal muscle atrophy is associated with myostatin suppression Metabolism 55 2006 1239 1247
19. O. Schakman, H. Gilson, and J.P. Thissen Mechanisms of glucocorticoid-induced myopathy J Endocrinol 197 2008 1 10
20. P.O. Hasselgren, N. Alamdari, and Z. Aversa Corticosteroids and muscle wasting - role of transcription factors, nuclear cofactors, and hyperacetylation Curr Opin Clin Nutr Metab Care 13 2010 423 428
21. G. Tiao, J. Fagan, and V. Roegner Energy-ubiquitin-dependent muscle proteolysis during sepsis in rats is regulated by glucocorticoids J Clin Invest 97 1996 339 348
22. C.H. Fang, J.H. James, and C. Ogle Influence of burn injury on protein metabolism in different types of skeletal muscle and the role of glucocorticoids J Am Coll Surg 180 1995 33 42
23. Z. Hu, H. Wang, and I.H. Lee Endogenous glucocorticoids and impaired insulin signaling are both required to stimulate muscle wasting under pathophysiological conditions in mice J Clin Invest 119 2009 3059 3069
24. R.H. Fitts, J.G. Romatowski, and J.R. Peters The deleterious effects of bed rest on human skeletal muscle fibers are exacerbated by hypercortisolemia and ameliorated by dietary supplementation Am J Physiol Cell Physiol 293 2007 C313 C320
25. L.M. Baehr, J.D. Furlow, and S.C. Bodine Muscle sparing in muscle RING finger null mice: response to synthetic glucocorticoids J Physiol 589.19 2011 4759 4776
26. B.A. Clarke, D. Drijan, and M.S. Willis The E3 ligase MuRF1 degrades myosin heavy chain protein in dexamethasone-treated skeletal muscle Cell Metab 6 2007 376 385
27. A.V. Gomes, D.S. Waddell, and R. Sin Upregulation of proteasome activity in muscle RING finger 1-null mice following denervation FASEB J 26 2012 2986 2999
28. D. Yamamoto, T. Maki, and E.H. Herningtyas Branched-chain amino acids protect against dexamethasone-induced soleus muscle atrophy in rats Muscle Nerve 41 2010 819 827
29. K. Biedasek, J. Andres, and K. Mai Skeletal muscle 11beta-HSD1 controls glucocorticoid-induced proteolysis and expression of E3 ubiquitin ligases atrogin-1 and MuRF1 PLoS One 6 2011 e16674
30. M. Menconi, P. Gonnella, and V. Petkova Dexamethasone and corticosterone induce similar, but not identical, muscle wasting responses in cultured L6 and C2C12 myotubes J Cell Biochem 105 2008 353 364
31. P. Gonnella, N. Alamdari, and S. Tizio C/EBPβ regulates dexamethasone-induced muscle cell atrophy and expression of atrogin-1 and MuRF1 J Cell Biochem 112 2011 1737 1748
32. M.J. Menconi, Z.P. Arany, and N. Alamdari Sepsis and glucocorticoids downregulate the expression of the nuclear cofactor PGC-1β in skeletal muscle Am J Physiol Endocrinol Metab 299 2010 E533 E543
33. I. Smith, N. Alamdari, and P. O'Neal Sepsis increases the expression and activity of the transcription factor forkhead box O 1 (FOXO1) in skeletal muscle by a glucocorticoid-dependent mechanism Int J Biochem Cell Biol 42 2010 701 711
34. J. Lagirand-Cantaloube, N. Offner, and A. Csibi The initiation factor eIF3-f is a major target for atrogin-1/MAFbx function in skeletal muscle atrophy EMBO J 27 2008 1266 1276
35. C.C. Witt, S.H. Witt, and S. Lerche Cooperative control of striated muscle mass and metabolism by MuRF1 and MuRF2 EMBO J 27 2008 350 360
36. S. Hirner, C. Krohne, and A. Schuster MuRF1-dependent regulation of systemic carbohydrate metabolism as revealed from transgenic mouse studies J Mol Biol 379 2008 666 677
37. J. Ochala, A.M. Gustafson, and M.L. Diez Preferential skeletal muscle myosin loss in response to mechanical silencing in a novel rat intensive care unit model: underlying mechanisms J Physiol 589 2011 2007 2026
38. M. Sandri Autophagy in health and disease. 3. Involvement of autophagy in muscle atrophy Am J Physiol Cell Physiol 298 2010 C1291 C1297
39. S. Rossi, E. Stoppani, and W. Martinet The cytosloic sialidase Neu2 is degraded by autophagy during myoblast atrophy Biochim Biophys Acta 1790 2009 817 828
40. J.M. McClung, A.R. Judge, and S.K. Powers p38 MAPK links oxidative stress to autophagy-related gene expression in cachectic muscle wasting Am J Physiol Cell Physiol 298 2010 C542 C549