Exploring the molecular mechanisms of glucocorticoid receptor action from sensitivity to resistance

Endocrine Development

Volumn 24, Issue , 2013, Pages 41-56

  Ramamoorthy, Sivapriya ^a   Cidlowski, John A ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; ISOPROTEIN; MESSENGER RNA;

ALTERNATIVE RNA SPLICING; ARTICLE; GENE EXPRESSION; GENE REPRESSION; GENETIC POLYMORPHISM; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN POLYMORPHISM; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION; SOMATIC MUTATION; TRANSCRIPTION INITIATION; TRANSLATION INITIATION;

EID: 84875413190     PISSN: 14217082     EISSN: 16622979     Source Type: Book Series    
DOI: 10.1159/000342502     Document Type: Article

References (28)

1. Rhen T, Cidlowski JA: Antiinflammatory action of glucocorticoids-new mechanisms for old drugs. N Engl J Med 2005;353:1711-1723.
2. Schacke H, Hennekes H, Schottelius A, Jaroch S, Lehmann M, Schmees N, Rehwinkel H, Asadullah K: SEGRAS: a novel class of anti-inflammatory compounds. Ernst Schering Res Found Workshop 2002;357-371.
3. Clark AR, Belvisi MG: Maps and legends: the quest for dissociated ligands of the glucocorticoid receptor. Pharmacol Ther 2012;134:54-67.
4. Oakley RH, Cidlowski JA: Cellular processing of the glucocorticoid receptor gene and protein: new mechanisms for generating tissue-specific actions of glucocorticoids. J Biol Chem 2011;286:3177-3184.
5. Yudt MR, Cidlowski JA: Molecular identification and characterization of a and b forms of the glucocorticoid receptor. Mol Endocrinol 2001;15:1093-1103.
6. Lu NZ, Cidlowski JA: Translational regulatory mechanisms generate n-terminal glucocorticoid receptor isoforms with unique transcriptional target genes. Mol Cell 2005;18:331-342.
7. Biddie SC, Conway-Campbell BL, Lightman SL: Dynamic regulation of glucocorticoid signalling in health and disease. Rheumatology (Oxford) 2012; 51:403-412.
8. Reddy TE, Pauli F, Sprouse RO, Neff NF, Newberry KM, Garabedian MJ, Myers RM: Genomic determination of the glucocorticoid response reveals unexpected mechanisms of gene regulation. Genome Res 2009;19:2163-2171.
9. Galliher-Beckley AJ, Cidlowski JA: Emerging roles of glucocorticoid receptor phosphorylation in modulating glucocorticoid hormone action in health and disease. IUBMB Life 2009;61:979-986.
10. Galliher-Beckley AJ, Williams JG, Cidlowski JA: Ligand-independent phosphorylation of the glucocorticoid receptor integrates cellular stress pathways with nuclear receptor signaling. Mol Cell Biol 2011;31:4663-4675.
11. Wallace AD, Cidlowski JA: Proteasome-mediated glucocorticoid receptor degradation restricts transcriptional signaling by glucocorticoids. J Biol Chem 2001;276:42714-42721.
12. Surjit M, Ganti KP, Mukherji A, Ye T, Hua G, Metzger D, Li M, Chambon P: Widespread negative response elements mediate direct repression by agonist-liganded glucocorticoid receptor. Cell 2011; 145:224-241.
13. Barnes PJ: Anti-inflammatory actions of glucocorticoids: molecular mechanisms. Clin Sci (Lond) 1998;94:557-572.
14. Tissing WJ, Meijerink JP, den Boer ML, Pieters R: Molecular determinants of glucocorticoid sensitivity and resistance in acute lymphoblastic leukemia. Leukemia 2003;17:17-25.
15. Charmandari E, Kino T, Souvatzoglou E, Vottero A, Bhattacharyya N, Chrousos GP: Natural glucocorticoid receptor mutants causing generalized glucocorticoid resistance: molecular genotype, genetic transmission, and clinical phenotype. J Clin Endocrinol Metab 2004;89:1939-1949.
16. Gross KL, Lu NZ, Cidlowski JA: Molecular mechanisms regulating glucocorticoid sensitivity and resistance. Mol Cell Endocrinol 2009;300:7-16.
17. Jewell CM, Cidlowski JA: Molecular evidence for a link between the N363S glucocorticoid receptor polymorphism and altered gene expression. J Clin Endocrinol Metab 2007;92:3268-3277.
18. Schaaf MJ, Cidlowski JA: AUUUA motifs in the 3 UTR of human glucocorticoid receptor alpha and beta mRNA destabilize mRNA and decrease receptor protein expression. Steroids 2002;67:627-636.
19. Burnstein KL, Jewell CM, Cidlowski JA: Human glucocorticoid receptor cDNA contains sequences sufficient for receptor down-regulation. J Biol Chem 1990;265:7284-7291.
20. Burnstein KL, Jewell CM, Sar M, Cidlowski JA: Intragenic sequences of the human glucocorticoid receptor complementary DNA mediate hormoneinducible receptor messenger RNA downregulation through multiple mechanisms. Mol Endocrinol 1994;8:1764-1773.
21. Wallace AD, Cao Y, Chandramouleeswaran S, Cidlowski JA: Lysine 419 targets human glucocorticoid receptor for proteasomal degradation. Steroids 2010;75:1016-1023.
22. Oakley RH, Jewell CM, Yudt MR, Bofetiado DM, Cidlowski JA: The dominant negative activity of the human glucocorticoid receptor beta isoform. Specificity and mechanisms of action. J Biol Chem 1999;274:27857-27866.
23. Barnes PJ: Mechanisms and resistance in glucocorticoid control of inflammation. J Steroid Biochem Mol Biol 2010;120:76-85.
24. Lewis-Tuffin LJ, Cidlowski JA: The physiology of human glucocorticoid receptor beta (HGRbeta) and glucocorticoid resistance. Ann N Y Acad Sci 2006;1069:1-9.
25. Hinds TD Jr, Ramakrishnan S, Cash HA, Stechschulte LA, Heinrich G, Najjar SM, Sanchez ER: Discovery of glucocorticoid receptor-beta in mice with a role in metabolism. Mol Endocrinol 2010;24:1715-1727.
26. Lu NZ, Collins JB, Grissom SF, Cidlowski JA: Selective regulation of bone cell apoptosis by translational isoforms of the glucocorticoid receptor. Mol Cell Biol 2007;27:7143-7160.
27. Gross KL, Oakley RH, Scoltock AB, Jewell CM, Cidlowski JA: Glucocorticoid receptor alpha isoform-selective regulation of antiapoptotic genes in osteosarcoma cells: a new mechanism for glucocorticoid resistance. Mol Endocrinol 2011;25:1087-1099.
28. McKay LI, Cidlowski JA: Cross-talk between nuclear factor-kappa b and the steroid hormone receptors: mechanisms of mutual antagonism. Mol Endocrinol 1998;12:45-56.