New criteria for supplementation of selected micronutrients in the era of nutrigenetics and nutrigenomics

International Journal of Food Sciences and Nutrition

Volumn 65, Issue 5, 2014, Pages 529-538

  Schwartz, Betty ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Nutrient gene interactions; Nutritional genomics; Vitamins

Indexed keywords

ASCORBIC ACID; FOLIC ACID; OMEGA 3 FATTY ACID; TRACE ELEMENT;

DIET; DIET SUPPLEMENTATION; HUMAN; NUTRIGENOMICS; PROCEDURES;

ASCORBIC ACID; DIET; DIETARY SUPPLEMENTS; FATTY ACIDS, OMEGA-3; FOLIC ACID; HUMANS; MICRONUTRIENTS; NUTRIGENOMICS;

EID: 84904423914     PISSN: 09637486     EISSN: 14653478     Source Type: Journal    
DOI: 10.3109/09637486.2014.898258     Document Type: Review

References (102)

1. Afman LA, Muller M. 2012. Human nutrigenomics of gene regulation by dietary fatty acids. Prog Lipid Res 51:63-70.
2. Applebaum J, Shimon H, Sela BA, Belmaker RH, Levine J. 2004. Homocysteine levels in newly admitted schizophrenic patients. J Psychiatr Res 38:413-416.
3. Bagley PJ, Selhub J. 1998. A common mutation in the methylenetetrahy- drofolate reductase gene is associated with an accumulation of formylated tetrahydrofolates in red blood cells. Proc Natl Acad Sci USA 95:13217-13220.
4. Balkan J, Dogru-Abbasoglu S, Aykac-Toker G, Uysal M. 2004. Serum pro-oxidant-antioxidant balance and low-density lipoprotein oxidation in healthy subjects with different cholesterol levels. Clin Exp Med 3: 237-242.
5. Bjelland I, Tell GS, Vollset SE, Refsum H, Ueland PM. 2003. Folate, vitamin B12, homocysteine, and the MTHFR 677C-4T polymorphism in anxiety and depression: the Hordaland Homocysteine Study. Arch Gen Psychiatr 60:618-626.
6. Block G, Shaikh N, Jensen CD, Volberg V, Holland N. 2011. Serum vitamin C and other biomarkers differ by genotype of phase 2 enzyme genes GSTM1 and GSTT1. Am J Clin Nutr 94:929-937.
7. Botto LD, Yang Q. 2000. 5, 10-Methylenetetrahydrofolate reductase gene variants and congenital anomalies: a HuGE review. Am J Epidemiol 151:862-867.
8. Caccamo D, Condello S, Gorgone G, Crisafulli G, Belcastro V, Gennaro S, Striano P, et al. 2004. Screening for C677T and A1298C MTHFR polymorphisms in patients with epilepsy and risk of hyperhomocys-teinemia. Neuromolecular Med 6:117-126.
9. Cahill LE, El-Sohemy A. 2009. Vitamin C transporter gene polymorphisms, dietary vitamin C and serum ascorbic acid. J Nutrigenet Nutrigenomics 2:292-301.
10. Cahill LE, El-Sohemy A. 2010. Haptoglobin genotype modifies the association between dietary vitamin C and serum ascorbic acid deficiency. Am J Clin Nutr 92:1494-1500.
11. Cahill LE, Fontaine-Bisson B, El-Sohemy A. 2009. Functional genetic variants of glutathione S-transferase protect against serum ascorbic acid deficiency. Am J Clin Nutr 90:1411-1417.
12. Carr DF, Whiteley G, Alfirevic A, Pirmohamed M. 2009. Investigation of inter-individual variability of the one-carbon folate pathway: a bioinformatic and genetic review. Pharmacogenomics J 9:291-305.
13. Chavez J, Chung WG, Miranda CL, Singhal M, Stevens JF, Maier CS. 2010. Site-specific protein adducts of 4-hydroxy-2(E)-nonenal in human THP-1 monocytic cells: protein carbonylation is diminished by ascorbic acid. Chem Res Toxicol 23:37-47.
14. Chen AA, Marsit CJ, Christensen BC, Houseman EA, McClean MD, Smith JF, Bryan JT, et al. 2009. Genetic variation in the vitamin C transporter, SLC23A2, modifies the risk of HPV16-associated head and neck cancer. Carcinogenesis 30:977-981.
15. Chen L, Liu L, Hong K, Hu J, Cheng X. 2012. Three genetic polymorphisms of homocysteine-metabolizing enzymes and risk of coronary heart disease: a meta-analysis based on 23 case-control studies. DNA Cell Biol 31:238-249.
16. Cheng CH, Huang YC, Chen FP, Chou MC, Tsai TP. 2008. B-vitamins, homocysteine and gene polymorphism in adults with fasting or post-methionine loading hyperhomocysteinemia. Eur J Nutr 47:491-498.
17. Corpe CP, Tu H, Eck P, Wang J, Faulhaber-Walter R, Schnermann J, Margolis S, et al. 2010. Vitamin C transporter Slc23a1 links renal reabsorption, vitamin C tissue accumulation, and perinatal survival in mice. J Clin Invest 120:1069-1083.
18. Da Costa LA, Badawi A, El-Sohemy A. 2012. Nutrigenetics and modulation of oxidative stress. Ann Nutr Metab 60:27-36.
19. De Mattia E, Toffoli G. 2009. C677T and A1298C MTHFR polymorphisms, a challenge for antifolate and fluoropyrimidine-based therapy personalisation. Eur J Cancer 45:1333-1351.
20. de Roos B. 2013. Personalised nutrition: ready for practice? Proc Nutr Soc 72:48-52.
21. Delanghe JR, Langlois MR. 2002. Haptoglobin polymorphism and body iron stores. Clin Chem Lab Med 40:212-216.
22. Delanghe JR, Langlois MR, De Buyzere ML, Torck MA. 2007. Vitamin C deficiency and scurvy are not only a dietary problem but are codetermined by the haptoglobin polymorphism. Clin Chem 53: 1397-1400.
23. DellaPenna D. 1999. Nutritional genomics: manipulating plant micronu-trients to improve human health. Science 285:375-379.
24. Dusinska M, Ficek A, Horska A, Raslova K, Petrovska H, Vallova B, Drlickova M, et al. 2001. Glutathione S-transferase polymorphisms influence the level of oxidative DNA damage and antioxidant protection in humans. Mutat Res 482:47-55.
25. Elmadfa I, Meyer AL. 2008. Body composition, changing physiological functions and nutrient requirements of the elderly. Ann Nutr Metab 52: 2-5.
26. Erichsen HC, Eck P, Levine M, Chanock S. 2001. Characterization of the genomic structure of the human vitamin C transporter SVCT1 (SLC23A2). J Nutr 131:2623-2627.
27. Erichsen HC, Engel SA, Eck PK, Welch R, Yeager M, Levine M, Siega-Riz AM, et al. 2006. Genetic variation in the sodium-dependent vitamin C transporters, SLC23A1, and SLC23A2 and risk for preterm delivery. Am J Epidemiol 163:245-254.
28. Erichsen HC, Peters U, Eck P, Welch R, Schoen RE, Yeager M, Levine M, et al. 2008. Genetic variation in sodium-dependent vitamin C transporters SLC23A1 and SLC23A2 and risk of advanced colorectal adenoma. Nutr Cancer 60:652-659.
29. Faraci FM, Lentz SR. 2004. Hyperhomocysteinemia, oxidative stress, and cerebral vascular dysfunction. Stroke 35:345-347.
30. Farris PK. 2005. Topical vitamin C: a useful agent for treating photoaging and other dermatologic conditions. Dermatol Surg 31:814-817; discussion 818.
31. Fenech M, El-Sohemy A, Cahill L, Ferguson LR, French TA, Tai ES, Milner J, et al. 2011. Nutrigenetics and nutrigenomics: viewpoints on the current status and applications in nutrition research and practice. J Nutrigenet Nutrigenomics 4:69-89.
32. Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJ, et al. 1995. A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 10:111-113.
33. German JB, Zivkovic AM, Dallas DC, Smilowitz JT. 2011. Nutrigenomics and personalized diets: what will they mean for food? Annu Rev Food Sci Technol 2:97-123.
34. Gilbody S, Lewis S, Lightfoot T. 2007. Methylenetetrahydrofolate reductase (MTHFR) genetic polymorphisms and psychiatric disorders: a HuGE review. Am J Epidemiol 165:1-13.
35. Gu P, DeFina LF, Leonard D, John S, Weiner MF, Brown ES. 2012. Relationship between serum homocysteine levels and depressive symptoms: the Cooper Center Longitudinal Study. J Clin Psychiatry 73:691-695.
36. Harding AH, Wareham NJ, Bingham SA, Khaw K, Luben R, Welch A, Forouhi NG. 2008. Plasma vitamin C level, fruit and vegetable consumption, and the risk of new-onset type 2 diabetes mellitus: the European prospective investigation of cancer-Norfolk prospective study. Arch Intern Med 168:1493-1499.
37. Hayes JD, Flanagan JU, Jowsey IR. 2005. Glutathione transferases. Annu Rev Pharmacol Toxicol 45:51-88.
38. Herrmann W, Obeid R, Schorr H, Zarzour W, Geisel J. 2003. Homocysteine, methylenetetrahydrofolate reductase C677T polymorphism and the B-vitamins: a facet of nature-nurture interplay. Clin Chem Lab Med 41:547-553.
39. Horska A, Mislanova C, Bonassi S, Ceppi M, Volkovova K, Dusinska M. 2011. Vitamin C levels in blood are influenced by polymorphisms in glutathione S-transferases. Eur J Nutr 50:437-446.
40. Jokic M, Brcic-Kostic K, Stefulj J, Catela Ivkovic T, Bozo L, Gamulin M, Kapitanovic S. 2011. Association of MTHFR, MTR, MTRR, RFC1, and DHFR gene polymorphisms with susceptibility to sporadic colon cancer. DNA Cell Biol 30:771-776.
41. Kasvosve I, Speeckaert MM, Speeckaert R, Masukume G, Delanghe JR. 2010. Haptoglobin polymorphism and infection. Adv Clin Chem 50: 23-46.
42. Kirkbride JB, Susser E, Kundakovic M, Kresovich JK, Davey Smith G, Relton CL. 2012. Prenatal nutrition, epigenetics and schizophrenia risk: can we test causal effects? Epigenomics 4:303-315.
43. Kolb AF, Petrie L. 2013. Folate deficiency enhances the inflammatory response of macrophages. Mol Immunol 54:164-172.
44. Lachapelle MY, Drouin G. 2011. Inactivation dates of the human and guinea pig vitamin C genes. Genetica 139:199-207.
45. Lai CQ, Corella D, Demissie S, Cupples LA, Adiconis X, Zhu Y, Parnell LD, et al. 2006. Dietary intake of n-6 fatty acids modulates effect of apolipoprotein A5 gene on plasma fasting triglycerides, remnant lipoprotein concentrations, and lipoprotein particle size: the Framingham Heart Study. Circulation 113: 2062-2070.
46. Lang UE, Borgwardt S. 2013. Molecular mechanisms of depression: perspectives on new treatment strategies. Cell Physiol Biochem 31: 761-777.
47. Langlois MR, Delanghe JR, De Buyzere ML, Bernard DR, Ouyang J. 1997. Effect of haptoglobin on the metabolism of vitamin C. Am J Clin Nutr 66:606-610.
48. Langlois MR, Martin ME, Boelaert JR, Beaumont C, Taes YE, De Buyzere ML, Bernard DR, et al. 2000. The haptoglobin 2-2 phenotype affects serum markers of iron status in healthy males. Clin Chem 46:1619-1625.
49. Levine J, Stahl Z, Sela BA, Gavendo S, Ruderman V, Belmaker RH. 2002. Elevated homocysteine levels in young male patients with schizophrenia. Am J Psychiatr 159:1790-1792.
50. Levine M, Conry-Cantilena C, Wang Y, Welch RW, Washko PW, Dhariwal KR, Park JB, et al. 1996. Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance. Proc Natl Acad Sci USA 93:3704-3709.
51. Lewis SJ, Araya R, Leary S, Smith GD, Ness A. 2012. Folic acid supplementation during pregnancy may protect against depression 21 months after pregnancy, an effect modified by MTHFR C677T genotype. Eur J Clin Nutr 66:97-103.
52. Liu B, Qian SB. 2011. Translational regulation in nutrigenomics. Adv Nutr 2:511-519.
53. Lizer MH, Bogdan RL, Kidd RS. 2011. Comparison of the frequency of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in depressed versus nondepressed patients. J Psychiatr Pract 17: 404-409.
54. Lottenberg AM, Afonso Mda S, Lavrador MS, Machado RM, Nakandakare ER. 2012. The role of dietary fatty acids in the pathology of metabolic syndrome. J Nutr Biochem 23:1027-1040.
55. Malouf M, Grimley EJ, Areosa SA. 2003. Folic acid with or without vitamin B12 for cognition and dementia. Cochrane Database Syst Rev 4:CD004514.
56. Mamede AC, Tavares SD, Abrantes AM, Trindade J, Maia JM, Botelho MF. 2011. The role of vitamins in cancer: a review. Nutr Cancer 63: 479-494.
57. Mandl J, Szarka A, Banhegyi G. 2009. Vitamin C: update on physiology and pharmacology. Br J Pharmacol 157:1097-1110.
58. Marriage B, Clandinin MT, Glerum DM. 2003. Nutritional cofactor treatment in mitochondrial disorders. J Am Diet Assoc 103:1029-1038.
59. Masi LN, Rodrigues AC, Curi R. 2013. Fatty acids regulation of inflammatory and metabolic genes. Curr Opin Clin Nutr Metab Care 16:418-424.
60. Michels AJ, Hagen TM. 2009. Hepatocyte nuclear factor 1 is essential for transcription of sodium-dependent vitamin C transporter protein 1. Am J Physiol Cell Physiol 297:C1220-C1227.
61. Michels AJ, Hagen TM, Frei B. 2013. Human genetic variation influences vitamin C homeostasis by altering vitamin C transport and antioxidant enzyme function. Annu Rev Nutr 33:45-70.
62. Michels AJ, Joisher N, Hagen TM. 2003. Age-related decline of sodium-dependent ascorbic acid transport in isolated rat hepatocytes. Arch Biochem Biophys 410:112-120.
63. Millan MJ. 2013. An epigenetic framework for neurodevelopmental disorders: from pathogenesis to potential therapy. Neuropharmacology 68:2-82.
64. Minihane AM. 2009. Nutrient gene interactions in lipid metabolism. Curr Opin Clin Nutr Metab Care 12:357-363.
65. Molloy AM, Daly S, Mills JL, Kirke PN, Whitehead AS, Ramsbottom D, Conley MR, et al. 1997. Thermolabile variant of 5, 10-methylenete-trahydrofolate reductase associated with low red-cell folates: implications for folate intake recommendations. Lancet 349:1591-1593.
66. Mutch DM, Wahli W, Williamson G. 2005. Nutrigenomics and nutrigenetics: the emerging faces of nutrition. FASEB J 19:1602-1616.
67. Na N, Delanghe JR, Taes YE, Torck M, Baeyens WR, Ouyang J. 2006. Serum vitamin C concentration is influenced by haptoglobin polymorphism and iron status in Chinese. Clin Chim Acta 365:319-324.
68. Nabi H, Bochud M, Glaus J, Lasserre AM, Waeber G, Vollenweider P, Preisig M. 2013. Association of serum homocysteine with major depressive disorder: results from a large population-based study. Psychoneuroendocrinology 38:2309-2318.
69. Naismith SL, Norrie LM, Mowszowski L, Hickie IB. 2012. The neurobiology of depression in later-life: clinical, neuropsychological, neuroimaging and pathophysiological features. Prog Neurobiol 98: 99-143.
70. Padh H. 1991. Vitamin C: newer insights into its biochemical functions. Nutr Rev 49:65-70.
71. Papakostas GI, Cassiello CF, Iovieno N. 2012. Folates and S-adenosylmethionine for major depressive disorder. Can J Psychiatr 57:406-413.
72. Pemble S, Schroeder KR, Spencer SR, Meyer DJ, Hallier E, Bolt HM, Ketterer B, Taylor JB. 1994. Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism. Biochem J 300:271-276.
73. Pereira TV, Rudnicki M, Pereira AC, Pombo-de-Oliveira MS, Franco RF. 2006. 5, 10-Methylenetetrahydrofolate reductase polymorphisms and acute lymphoblastic leukemia risk: a meta-analysis. Cancer Epidemiol Biomarkers Prev 15:1956-1963.
74. Polidori MC, Mecocci P, Levine M, Frei B. 2004. Short-term and long-term vitamin C supplementation in humans dose-dependently increases the resistance of plasma to ex vivo lipid peroxidation. Arch Biochem Biophys 423:109-115
75. Rai V. 2011. Evaluation of methylenetetrahydrofolate reductase gene variant (C677T) as risk factor for bipolar disorder. Cell Mol Biol (Noisy-le-grand) 57:OL1558-1566.
76. Reidling JC, Rubin SA. 2011. Promoter analysis of the human ascorbic acid transporters SVCT1 and 2: mechanisms of adaptive regulation in liver epithelial cells. J Nutr Biochem 22:344-350.
77. Rivas CI, Zuniga FA, Salas-Burgos A, Mardones L, Ormazabal V, Vera JC. 2008. Vitamin C transporters. J Physiol Biochem 64:357-375.
78. Saedisomeolia A, Djalali M, Moghadam AM, Ramezankhani O, Najmi L. 2011. Folate and vitamin B12 status in schizophrenic patients. J Res Med Sci 16:S437-S441.
79. Sanhueza C, Ryan L, Foxcroft DR. 2013. Diet and the risk of unipolar depression in adults: systematic review of cohort studies. J Hum Nutr Diet 26:56-70.
80. Savini I, Rossi A, Pierro C, Avigliano L, Catani MV. 2008. SVCT1 and SVCT2: key proteins for vitamin C uptake. Amino Acids 34:347-355.
81. Seshadri S, Beiser A, Selhub J, Jacques PF, Rosenberg IH, D'Agostino RB, Wilson PW, Wolf PA. 2002. Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med 346:476-483.
82. Siega-Riz AM, Promislow JH, Savitz DA, Thorp Jr JM, McDonald T. 2003. Vitamin C intake and the risk of preterm delivery. Am J Obstet Gynecol 189:519-525.
83. Silva RM, Fontes AC, Silva KA, Sant'Ana TA, Ramos FJ, Marques-Salles Tde J, Pombo-de-Oliveira MS, Muniz MT. 2013. Polymorphisms involved in folate metabolism pathways and the risk of the development of childhood acute leukemia. Genet Test Mol Biomarkers 17: 147-152.
84. Simopoulos AP. 2010. Nutrigenetics/nutrigenomics. Annu Rev Public Health 31:53-68.
85. Skibola CF, Bracci PM, Halperin E, Nieters A, Hubbard A, Paynter RA, Skibola DR, et al. 2008. Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma. PLoS One 3:e2816.
86. Smits LJ, Essed GG. 2001. Short interpregnancy intervals and unfavourable pregnancy outcome: role of folate depletion. Lancet 358: 2074-2077.
87. Sylvia LG., Peters AT, Deckersbach T, Nierenberg AA. 2013. Nutrient-based therapies for bipolar disorder: a systematic review. Psychother Psychosom 82:10-19.
88. Tehlivets O. 2011. Homocysteine as a risk factor for atherosclerosis: is its conversion to s-adenosyl-L-homocysteine the key to deregulated lipid metabolism? J Lipids 2011:702853.
89. Tiemeier H, van Tuijl HR, Hofman A, Meijer J, Kiliaan AJ, Breteler MM. 2002. Vitamin B12, folate, and homocysteine in depression: the Rotterdam Study. Am J Psychiatr 159:2099-2101.
90. Timpson NJ, Forouhi NG, Brion MJ, Harbord RM, Cook DG, Johnson P, McConnachie A, et al. 2010. Genetic variation at the SLC23A1 locus is associated with circulating concentrations of L-ascorbic acid (vitamin C): evidence from 5 independent studies with 415, 000 participants. Am J Clin Nutr 92:375-382.
91. Vanden Heuvel JP. 2009. Cardiovascular disease-related genes and regulation by diet. Curr Atheroscler Rep 11:448-455.
92. Vanden Heuvel JP. 2012. Nutrigenomics and nutrigenetics of omega3 polyunsaturated fatty acids. Prog Mol Biol Transl Sci 108: 75-112.
93. Weisberg IS, Jacques PF, Selhub J, Bostom AG, Chen Z, Curtis Ellison R, Eckfeldt JH, Rozen R. 2001. The 1298A-4C polymorphism in methylenetetrahydrofolate reductase (MTHFR): in vitro expression and association with homocysteine. Atherosclerosis 156:409-415.
94. Wittwer J, Rubio-Aliaga I, Hoeft B, Bendik I, Weber P, Daniel H. 2011. Nutrigenomics in human intervention studies: current status, lessons learned and future perspectives. Mol Nutr Food Res 55: 341-358.
95. Wright ME, Andreotti G, Lissowska J, Yeager M, Zatonski W, Chanock SJ, Chow WH, Hou L. 2009. Genetic variation in sodium-dependent ascorbic acid transporters and risk of gastric cancer in Poland. Eur J Cancer 45:1824-1830.
96. Wu G. 2009. Amino acids: metabolism, functions, and nutrition. Amino Acids 37:1-17.
97. Yan L, Zhao L, Long Y, Zou P, Ji G, Gu A, Zhao P. 2012. Association of the maternal MTHFR C677T polymorphism with susceptibility to neural tube defects in offsprings: evidence from 25 case-control studies. PLoS One 7:e41689.
98. Yang HT, Lee M, Hong KS, Ovbiagele B, Saver JL. 2012. Efficacy of folic acid supplementation in cardiovascular disease prevention: an updated meta-analysis of randomized controlled trials. Eur J Intern Med 23:745-754.
99. Yin M, Dong L, Zheng J, Zhang H, Liu J, Xu Z. 2012. Meta analysis of the association between MTHFR C677T polymorphism and the risk of congenital heart defects. Ann Hum Genet 76:9-16.
100. Zappacosta B, Mastroiacovo P, Persichilli S, Pounis G, Ruggeri S, Minucci A, Carnovale E, et al. 2013. Homocysteine lowering by folate-rich diet or pharmacological supplementations in subjects with moderate hyperhomocysteinemia. Nutrients 5:1531-1543.
101. Zhang C, Xie B, Du Y, Cheng W, Fang Y, Yu S. 2010. Further evidence that methylenetetrahydrofolate reductase A1298C polymorphism is a risk factor for schizophrenia. J Neural Transm 117:1115-1117.
102. Zhang Y, Yan H, Tian L, Wang F, Lu T, Wang L, Yan J, et al. 2013. Association of MTHFR C677T polymorphism with schizophrenia and its effect on episodic memory and gray matter density in patients. Behav Brain Res 243:146-152.