Haptoglobin genotype modifies the association between dietary vitamin C and serum ascorbic acid deficiency

American Journal of Clinical Nutrition

Volumn 92, Issue 6, 2010, Pages 1494-1500

  Cahill, Leah E ^a   El Sohemy, Ahmed ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ASCORBIC ACID; HAPTOGLOBIN;

ADULT; ARTICLE; ASCORBIC ACID DEFICIENCY; BLOOD SAMPLING; DNA POLYMORPHISM; FEMALE; FOOD FREQUENCY QUESTIONNAIRE; GENE; GENOTYPE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HP GENE; HP1 GENE; HP2 GENE; HUMAN; MAJOR CLINICAL STUDY; MALE; VITAMIN INTAKE;

ADULT; ALLELES; ASCORBIC ACID; ASCORBIC ACID DEFICIENCY; DIET; FEMALE; GENOTYPE; HAPTOGLOBINS; HUMANS; MALE; ODDS RATIO; POLYMORPHISM, GENETIC; QUESTIONNAIRES; YOUNG ADULT;

EID: 78651288315     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.2010.29306     Document Type: Article

References (53)

1. Hughes RE. Nonscorbutic effects of vitamin C: biochemical aspects. Proc R Soc Med 1977;70:86-9.
2. Cahill L, Corey P, El-Sohemy A. Vitamin C deficiency in a population of young Canadian adults. Am J Epidemiol 2009;170:464-71.
3. Schleicher RL, Carroll MD, Ford ES, Lacher DA. Serum vitamin C and the prevalence of vitamin C deficiency in the United States: 2003-2004 National Health and Nutrition Examination Survey (NHANES). Am J Clin Nutr 2009;90:1252-63.
4. Wrieden WL, Hannah MK, Bolton-Smith C, Tavendale R, Morrison C, Tunstall-Pedoe H. Plasma vitamin C and food choice in the third Glasgow MONICA population survey. J Epidemiol Community Health 2000;54:355-60.
5. Mosdol A, Erens B, Brunner EJ. Estimated prevalence and predictors of vitamin C deficiency within UK's low-income population. J Public Health (Oxf) 2008;30:456-60.
6. Paolisso G, D'Amore A, Balbi V, et al. Plasma vitamin C affects glucose homeostasis in healthy subjects and in non-insulin-dependent diabetics. Am J Physiol 1994;266:E261-8.
7. Toohey L, Harris MA, Allen KG, Melby CL. Plasma ascorbic acid concentrations are related to cardiovascular risk factors in African-Americans. J Nutr 1996;126:121-8.
8. Block G, Jensen CD, Norkus EP, Hudes M, Crawford PB. Vitamin C in plasma is inversely related to blood pressure and change in blood pressure during the previous year in young Black and White women. Nutr J 2008;7:35.
9. Block G, Dietrich M, Norkus EP, et al. Factors associated with oxidative stress in human populations. Am J Epidemiol 2002;156:274-85.
10. Johnston CS, Beezhold BL, Mostow B, Swan PD. Plasma vitamin C is inversely related to body mass index and waist circumference but not to plasma adiponectin in nonsmoking adults. J Nutr 2007;137:1757-62.
11. Ford ES, Liu S, Mannino DM, Giles WH, Smith SJ. C-reactive protein concentration and concentrations of blood vitamins, carotenoids, and selenium among United States adults. Eur J Clin Nutr 2003;57:1157-63.
12. Canoy D, Wareham N, Welch A, et al. Plasma ascorbic acid concentrations and fat distribution in 19,068 British men and women in the European Prospective Investigation into Cancer and Nutrition Norfolk cohort study. Am J Clin Nutr 2005;82:1203-9.
13. Boekholdt SM, Meuwese MC, Day NE, et al. Plasma concentrations of ascorbic acid and C-reactive protein, and risk of future coronary artery disease, in apparently healthy men and women: the EPIC-Norfolk prospective population study. Br J Nutr 2006;96:516-22.
14. Jacob RA, Sotoudeh G. Vitamin C function and status in chronic disease. Nutr Clin Care 2002;5:66-74.
15. Harding AH, Wareham NJ, Bingham SA, et al. Plasma vitamin C level, fruit and vegetable consumption, and the risk of new-onset type 2 diabetes mellitus: the European prospective investigation of cancer-Norfolk prospective study. Arch Intern Med 2008;168:1493-9.
16. Simon JA, Hudes ES, Tice JA. Relation of serum ascorbic acid to mortality among US adults. J Am Coll Nutr 2001;20:255-63.
17. Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C. Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases. Cochrane Database Syst Rev 2008; CD007176.
18. Willcox BJ, Curb JD, Rodriguez BL. Antioxidants in cardiovascular health and disease: key lessons from epidemiologic studies. Am J Cardiol 2008;101:75D-86D.
19. Loria CM, Whelton PK, Caulfield LE, Szklo M, Klag MJ. Agreement among indicators of vitamin C status. Am J Epidemiol 1998;147: 587-96.
20. Gutteridge JM. The antioxidant activity of haptoglobin towards haemoglobin-stimulated lipid peroxidation. Biochim Biophys Acta 1987;917:219-23.
21. Levy AP, Asleh R, Blum S, et al. Haptoglobin: basic and clinical aspects. Antioxid Redox Signal 2010;12:293-304.
22. Asleh R, Levy AP. In vivo and in vitro studies establishing haptoglobin as a major susceptibility gene for diabetic vascular disease. Vasc Health Risk Manag 2005;1:19-28.
23. Carter K, Worwood M. Haptoglobin: a review of the major allele frequencies worldwide and their association with diseases. Int J Lab Hematol 2007;29:92-110.
24. Delanghe JR, Langlois MR, De Buyzere ML, Torck MA. Vitamin C deficiency and scurvy are not only a dietary problem but are code-termined by the haptoglobin polymorphism. Clin Chem 2007;53: 1397-400.
25. Langlois MR, Delanghe JR, De Buyzere ML, Bernard DR, Ouyang J. Effect of haptoglobin on the metabolism of vitamin C. Am J Clin Nutr 1997;66:606-10.
26. Lee YW, Min WK, Chun S, et al. Lack of association between oxidized LDL-cholesterol concentrations and haptoglobin phenotypes in healthy subjects. Ann Clin Biochem 2004;41:485-7.
27. Na N, Delanghe JR, Taes YE, Torck M, Baeyens WR, Ouyang J. Serum vitamin C concentration is influenced by haptoglobin polymorphism and iron status in Chinese. Clin Chim Acta 2006;365:319-24.
28. Faure H, Preziosi P, Roussel AM, et al. Factors influencing blood concentration of retinol, alpha-tocopherol, vitamin C, and beta-carotene in the French participants of the SU.VI.MAX trial. Eur J Clin Nutr 2006; 60:706-17.
29. Galan P, Viteri FE, Bertrais S, et al. Serum concentrations of beta-carotene, vitamins C and E, zinc and selenium are influenced by sex, age, diet, smoking status, alcohol consumption and corpulence in a general French adult population. Eur J Clin Nutr 2005;59:1181-90.
30. Health Canada. Eating well with Canada's Food Guide. Ottawa, Canada: Minister of Public Works and Government Services Canada, 2007.
31. Ainsworth BE, Haskell WL, Leon AS, et al. Compendium of physical activities: classification of energy costs of human physical activities. Med Sci Sports Exerc 1993;25:71-80.
32. Bradley DW, Emery G, Maynard JE. Vitamin C in plasma: a comparative study of the vitamin stabilized with trichloroacetic acid or metaphosphoric acid and the effects of storage at -70 degrees, -20 degrees, 4 degrees, and 25 degrees on the stabilized vitamin. Clin Chim Acta 1973;44:47-52.
33. Lykkesfeldt J, Loft S, Poulsen HE. Determination of ascorbic acid and dehydroascorbic acid in plasma by high-performance liquid chromatography with coulometric detection-are they reliable biomarkers of oxidative stress? Anal Biochem 1995;229:329-35.
34. Margolis SA, Vangel M, Duewer DL. Certification of standard reference material 970, ascorbic acid in serum, and analysis of associated inter-laboratory bias in the measurement process. Clin Chem 2003;49:463-9.
35. Jacob RA. Assessment of human vitamin C status. J Nutr 1990;120 (suppl 11):1480-5.
36. Panel on Dietary Antioxidants and Related Compounds, Subcommittees on Upper Reference Levels of Nutrients and Interpretation and Uses of Dietary Reference Intakes, Standing Committee on the Scientific Evaluation of Dietary Reference Intakes. Dietary Reference Intakes for vitamin C, vitamin E, selenium, and beta-carotene and other carotenoids. Washington, DC: National Academy Press, 2000.
37. Koch W, Latz W, Eichinger M, et al. Genotyping of the common haptoglobin Hp 1/2 polymorphism based on PCR. Clin Chem 2002;48: 1377-82.
38. Zhang M, Lee AH, Binns CW. Reproductive and dietary risk factors for epithelial ovarian cancer in China. Gynecol Oncol 2004;92:320-6.
39. Qiu JL, Chen K, Zheng JN, Wang JY, Zhang LJ, Sui LM. Nutritional factors and gastric cancer in Zhoushan Islands, China. World J Gastroenterol 2005;11:4311-6.
40. Melamed-Frank M, Lache O, Enav BI, et al. Structure-function analysis of the antioxidant properties of haptoglobin. Blood 2001;98:3693-8.
41. Bamm VV, Tsemakhovich VA, Shaklai M, Shaklai N. Haptoglobin phenotypes differ in their ability to inhibit heme transfer from hemoglobin to LDL. Biochemistry 2004;43:3899-906.
42. Asleh R, Marsh S, Shilkrut M, et al. Genetically determined heterogeneity in hemoglobin scavenging and susceptibility to diabetic cardiovascular disease. Circ Res 2003;92:1193-200.
43. Asleh R, Guetta J, Kalet-Litman S, Miller-Lotan R, Levy AP. Haptoglobin genotype- and diabetes-dependent differences in iron-mediated oxidative stress in vitro and in vivo. Circ Res 2005;96:435-41.
44. Asleh R, Levy AP. Divergent effects of alpha-tocopherol and vitamin C on the generation of dysfunctional HDL associated with diabetes and the Hp 2-2 genotype. Antioxid Redox Signal 2010;12:209-17.
45. Asleh R, Blum S, Kalet-Litman S, et al. Correction of HDL dysfunction in individuals with diabetes and the haptoglobin 2-2 genotype. Diabetes 2008;57:2794-800.
46. Nakhoul FM, Miller-Lotan R, Awaad H, Asleh R, Levy AP. Hypothesis haptoglobin genotype and diabetic nephropathy. Nat Clin Pract Nephrol 2007;3:339-44.
47. Levy AP, Friedenberg P, Lotan R, et al. The effect of vitamin therapy on the progression of coronary artery atherosclerosis varies by haptoglobin type in postmenopausal women. Diabetes Care 2004;27:925-30.
48. Khaw KT, Bingham S,Welch A, et al. Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition. Lancet 2001;357:657-63.
49. Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. JAMA 2007; 297:842-57.
50. Dusinska M, Ficek A, Horska A, et al. Glutathione S-transferase polymorphisms influence the level of oxidative DNA damage and antioxidant protection in humans. Mutat Res 2001;482:47-55.
51. Cahill LE, Fontaine-Bisson B, El-Sohemy A. Functional genetic variants of glutathione S-transferase protect against serum ascorbic acid deficiency. Am J Clin Nutr 2009;90:1411-7.
52. Cahill LE, El-Sohemy A. Vitamin C transporter gene polymorphisms, dietary vitamin c and serum ascorbic acid. J Nutrigenet Nutrigenomics 2009;2:292-301.
53. Timpson NJ, Forouhi NG, Brion MJ, et al. Genetic variation at the SLC23A1 locus is associated with circulating concentrations of L-ascorbic acid (vitamin C): evidence from 5 independent studies with >15,000 participants. Am J Clin Nutr 2010;92:375-82.