Folate deficiency enhances the inflammatory response of macrophages

Molecular Immunology

Volumn 54, Issue 2, 2013, Pages 164-172

  Kolb, Andreas F ^a   Petrie, Linda ^a  

^a ROWETT RESEARCH INSTITUTE   (United Kingdom)

Author keywords

DNA methylation; Gene expression; Nitric oxide

Indexed keywords

DNA; FOLIC ACID; INTERLEUKIN 1BETA; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; NITRIC OXIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELLULAR IMMUNITY; CONTROLLED STUDY; DNA METHYLATION; FOLIC ACID DEFICIENCY; GROWTH RATE; IN VITRO STUDY; INFLAMMATION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CELL LINE; CULTURE MEDIA; CYTOKINES; DNA METHYLATION; FOLIC ACID; FOLIC ACID DEFICIENCY; INFLAMMATION; INFLAMMATION MEDIATORS; MACROPHAGES; MICE; NITRIC OXIDE;

EID: 84871829504     PISSN: 01615890     EISSN: 18729142     Source Type: Journal    
DOI: 10.1016/j.molimm.2012.11.012     Document Type: Article

References (49)

1. Ara A.I., Meng X., Komal R., José M.M., Shelly C.L. S-adenosylmethionine inhibits lipopolysaccharide-induced gene expression via modulation of histone methylation. Hepatology 2008, 47:1655-1666.
2. Au-Yeung K.K., Yip J.C., Siow Y.L.O.K. Folic acid inhibits homocysteine-induced superoxide anion production and nuclear factor kappa B activation in macrophages. Canadian Journal of Physiology and Pharmacology 2006, 84:141-147.
3. Brattstrom L., Wilcken D.E. Homocysteine and cardiovascular disease: cause or effect?. American Journal of Clinical Nutrition 2000, 72:315-323.
4. Chen Z., Karaplis A.C., Ackerman S.L., Pogribny I.P., Melnyk S., Lussier-Cacan S., Chen M.F., Pai A., John S.W.M., Smith R.S., Bottiglieri T., Bagley P., Selhub J., Rudnicki M.A., James S.J., Rozen R. Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition. Human Molecular Genetics 2001, 10:433-443.
5. Chung H.K., Kim O.Y., Lee H., Do H.J., Kim Y.S., Oh J., Kang S.M., Shin M.J. Relationship between dietary folate intake and plasma monocyte chemoattractant protein-1 and interleukin-8 in heart failure patients. Journal of Clinical Biochemistry and Nutrition 2011, 49:62.
6. Cook J.W., Taylor L.M., Orloff S.L., Landry G.J., Moneta G.L., Porter J.M. Homocysteine and arterial disease. Experimental mechanisms. Vascular Pharmacology 2002, 38:293-300.
7. Cullen P., Rauterberg J., Lorkowski S., Eckardstein A. The pathogenesis of atherosclerosis. Atherosclerosis: Diet and Drugs 2005, vol. 170. Springer, Berlin/Heidelberg, p. 3.
8. Dayal S., Bottiglieri T., Arning E., Maeda N., Malinow M.R., Sigmund C.D., Heistad D.D., Faraci F.M., Lentz S.R. Endothelial dysfunction and elevation of S-adenosylhomocysteine in cystathionine beta-synthase-deficient mice. Circulation Research 2001, 88:1203-1209.
9. Devlin A.M., Arning E., Bottiglieri T., Faraci F.M., Rozen R., Lentz S.R. Effect of Mthfr genotype on diet-induced hyperhomocysteinemia and vascular function in mice. Blood 2004, 103:2624-2629.
10. Doshi S.N., McDowell I.F., Moat S.J., Lang D., Newcombe R.G., Kredan M.B., Lewis M.J., Goodfellow J. Folate improves endothelial function in coronary artery disease: an effect mediated by reduction of intracellular superoxide?. Arteriosclerosis, Thrombosis, and Vascular Biology 2001, 21:1196-1202.
11. Ebbesen L.S. Hyperhomocysteinemia, thrombosis and vascular biology. Cellular and Molecular Biology (Noisy-le-Grand, France) 2004, 50:917-930.
12. Ebbing M., Bleie O., Ueland P.M., Nordrehaug J.E., Nilsen D.W., Vollset S.E., Refsum H., Pedersen E.K., Nygard O. Mortality and cardiovascular events in patients treated with homocysteine-lowering B vitamins after coronary angiography: a randomized controlled trial. The Journal of the American Medical Association 2008, 300:795-804.
13. Feng D., Zhou Y., Xia M., Ma J. Folic acid inhibits lipopolysaccharide-induced inflammatory response in RAW264.7 macrophages by suppressing MAPKs and NF-κB activation. Inflammation Research 2011, 60:817.
14. Friso S., Choi S.W., Dolnikowski G.G., Selhub J. A method to assess genomic DNA methylation using high-performance liquid chromatography/electrospray ionization mass spectrometry. Analytical Chemistry 2002, 74:4526-4531.
15. Friso S., Jacques P.F., Wilson P.W., Rosenberg I.H., Selhub J. Low circulating vitamin B(6) is associated with elevation of the inflammation marker C-reactive protein independently of plasma homocysteine levels. Circulation 2001, 103:2788-2791.
16. Gao J.J., Diesl V., Wittmann T., Morrison D.C., Ryan J.L., Vogel S.N., Follettie M.T. Regulation of gene expression in mouse macrophages stimulated with bacterial CpG-DNA and lipopolysaccharide. Journal of Leukocyte Biology 2002, 72:1234-1245.
17. Ghoshal K., Li X., Datta J., Bai S., Pogribny I., Pogribny M., Huang Y., Young D., Jacob S.T. A folate- and methyl-deficient diet alters the expression of DNA methyltransferases and methyl CpG binding proteins involved in epigenetic gene silencing in livers of F344 Rats. Journal of Nutrition 2006, 136:1522-1527.
18. Hajjar K.A. Homocysteine: a sulph'rous fire. The Journal of Clinical Investigation 2001, 107:663.
19. Haynes W.G. Hyperhomocysteinemia, vascular function and atherosclerosis: effects of vitamins. Cardiovascular Drugs and Therapy 2002, 16:391.
20. Hiltunen M.O., Turunen M.P., Hakkinen T.P., Rutanen J., Hedman M., Makinen K., Turunen A.M., Aalto-Setala K., Yla-Herttuala S. DNA hypomethylation and methyltransferase expression in atherosclerotic lesions. Vascular Medicine 2002, 7:5-11.
21. Hiltunen M.O., Yla-Herttuala S. DNA methylation, smooth muscle cells, and atherogenesis. Arteriosclerosis, Thrombosis, and Vascular Biology 2003, 23:1750-1753.
22. Hofmann M.A., Lalla E., Lu Y., Gleason M.R., Wolf B.M., Tanji N., Ferran L.J., Kohl B., Rao V., Kisiel W., Stern D.M., Schmidt A.M. Hyperhomocysteinemia enhances vascular inflammation and accelerates atherosclerosis in a murine model. Journal of Clinical Investigation 2001, 107:675-683.
23. Ishihara T., Kohno K., Ushio S., Iwaki K., Ikeda M., Kurimoto M. Tryptanthrin inhibits nitric oxide and prostaglandin E2 synthesis by murine macrophages. European Journal of Pharmacology 2000, 407:197.
24. James S.J., Basnakian A.G., Miller B.J. In vitro folate deficiency induces deoxynucleotide pool imbalance, apoptosis, and mutagenesis in Chinese hamster ovary cells. Cancer Research 1994, 54:5075-5080.
25. Jiang Y.-D., Sun T., Zhang H.-P., Xiong J.-T., Cao J., Li G.-Z., Wang S.-R. Folate and ApoE DNA methylation induced by homocysteine in human monocytes. DNA and Cell Biology 2007, 26:737.
26. Jiang Y., Zhang J., Xiong J., Cao J., Li G., Wang S. Ligands of peroxisome proliferator-activated receptor inhibit homocysteine induced DNA methylation of inducible nitric oxide synthase gene. Acta Biochimica et Biophysica Sinica 2007, 39:366-376.
27. Kluijtmans L.A., van den Heuvel L.P., Boers G.H., Frosst P., Stevens E.M., van Oost B.A., den Heijer M., Trijbels F.J., Rozen R., Blom H.J. Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease. American Journal of Human Genetics 1996, 58:35-41.
28. Kolb A.F., Maile J., Heister A., Siddell S.G. Characterization of functional domains in the human coronavirus HCV 229E receptor. Journal of General Virology 1996, 77:2515-2521.
29. Maloney C.A., Hay S.M., Young L.E., Sinclair K.D., Rees W.D. A methyl-deficient diet fed to rat dams during the peri-conception period programs glucose homeostasis in adult male but not female offspring. The Journal of Nutrition 2011, 141:95-100.
30. Margot J.B., Aguirre-Arteta A.M., Di Giacco B.V., Pradhan S., Roberts R.J., Cardoso M.C., Leonhardt H. Structure and function of the mouse DNA methyltransferase gene: Dnmt1 shows a tripartite structure. Journal of Molecular Biology 2000, 297:293.
31. Moat S.J., Clarke Z.L., Madhavan A.K., Lewis M.J., Lang D. Folic acid reverses endothelial dysfunction induced by inhibition of tetrahydrobiopterin biosynthesis. European Journal of Pharmacology 2006, 530:250.
32. Niculescu M.D., Zeisel S.H. Diet, methyl donors and DNA methylation: interactions between dietary folate, methionine and choline. Journal of Nutrition 2002, 132:2333S-2335S.
33. Pepys M.B., Hirschfield G.M., Tennent G.A., Gallimore J.R., Kahan M.C., Bellotti V., Hawkins P.N., Myers R.M., Smith M.D., Polara A., Cobb A.J., Ley S.V., Aquilina J.A., Robinson C.V., Sharif I., Gray G.A., Sabin C.A., Jenvey M.C., Kolstoe S.E., Thompson D., Wood S.P. Targeting C-reactive protein for the treatment of cardiovascular disease. Nature 2006, 440:1217-1221.
34. Ross R. Atherosclerosis-an inflammatory disease. New England Journal of Medicine 1999, 340:115-126.
35. Schwammenthal Y., Tanne D. Homocysteine, B-vitamin supplementation, and stroke prevention: from observational to interventional trials. The Lancet Neurology 2004, 3:493.
36. Soehnlein O., Weber C. Myeloid cells in atherosclerosis: initiators and decision shapers. Seminars in Immunopathology 2009, 31:35.
37. Strain J.J., Dowey L., Ward M., Pentieva K., McNulty H. B-vitamins, homocysteine metabolism and CVD. Proceedings of the Nutrition Society 2004, 63:597-603.
38. Szymanowska M., Hendry K.A., Robinson C., Kolb A.F. EMMPRIN (basigin/CD147) expression is not correlated with MMP activity during adult mouse mammary gland development. Journal of Cellular Biochemistry 2009, 106:52-62.
39. Tsutsui M., Shimokawa H., Otsuji Y., Ueta Y., Sasaguri Y., Yanagihara N. Nitric oxide synthases and cardiovascular diseases; insights from genetically modified mice. Circulation Journal 2009, 73:986.
40. Wang G., Dai J., Mao J., Zeng X., Yang X., Wang X. Folic acid reverses hyper-responsiveness of LPS-induced chemokine secretion from monocytes in patients with hyperhomocysteinemia. Atherosclerosis 2005, 179:395.
41. Wang G., O K. Homocysteine stimulates the expression of monocyte chemoattractant protein-1 receptor (CCR2) in human monocytes: possible involvement of oxygen free radicals. Biochemical Journal 2001, 357:233-240.
42. Wang G., Siow Y.L., O K. Homocysteine induces monocyte chemoattractant protein-1 expression by activating NF-kappaB in THP-1 macrophages. American Journal of Physiology - Heart and Circulatory Physiology 2001, 280:H2840-H2847.
43. Wang Y., Ma Y.-Y., Song X.-L., Cai H.-Y., Chen J.-C., Song L.-N., Yang R., Lu J. Upregulations of glucocorticoid-induced leucine zipper by hypoxia and glucocorticoid inhibit proinflammatory cytokines under hypoxic conditions in macrophages. The Journal of Immunology 2012, 188:222-229.
44. Waterland R.A., Jirtle R.L. Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Molecular and Cellular Biology 2003, 23:5293-5300.
45. Watson W.H., Zhao Y., Chawla R.K. S-adenosylmethionine attenuates the lipopolysaccharide-induced expression of the gene for tumour necrosis factor alpha. Biochemical Journal 1999, 342(Pt. (1)):21-25.
46. Wells C.A., Chalk A.M., Forrest A., Taylor D., Waddell N., Schroder K., Himes S.R., Faulkner G., Lo S., Kasukawa T., Kawaji H., Kai C., Kawai J., Katayama S., Carninci P., Hayashizaki Y., Hume D.A., Grimmond S.M. Alternate transcription of the Toll-like receptor signaling cascade. Genome Biology 2006, 7:R10.
47. Wierzbicki A.S. Homocysteine and cardiovascular disease: a review of the evidence. Diabetes and Vascular Disease Research 2007, 4:143-150.
48. Wimalawansa S.J. Nitric oxide: new evidence for novel therapeutic indications. Expert Opinion on Pharmacotherapy 2008, 9:1935-1954.
49. Yoshida M. Potential role of statins in inflammation and atherosclerosis. Journal of Atherosclerosis and Thrombosis 2003, 10:140-144.