Comparison of the frequency of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in depressed versus nondepressed patients

Journal of Psychiatric Practice

Volumn 17, Issue 6, 2011, Pages 404-409

  Lizer, Mitsi H ^a   Bogdan, Renee L ^b   Kidd, Robert S ^a  

^a SHENANDOAH UNIVERSITY   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

Depression; Folic acid; L methylfolate; Methylenetetrahydrofolate reductase; MTHFR gene; Pharmacogenomics

Indexed keywords

5 METHYLTETRAHYDROFOLIC ACID; 5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); FOLIC ACID; GENOMIC DNA;

ALLELE; CAUCASIAN; CLINICAL TRIAL (TOPIC); DEPRESSION; DIET SUPPLEMENTATION; DRUG COST; GENETIC VARIABILITY; GENOTYPE; HAMILTON SCALE; HUMAN; MENTAL DISEASE; MONOTHERAPY; PHARMACOGENOMICS; POLYMERASE CHAIN REACTION; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; TREATMENT OUTCOME; UNITED STATES;

ADULT; CROSS-SECTIONAL STUDIES; DEPRESSIVE DISORDER; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); ODDS RATIO; POLYMORPHISM, GENETIC; REAL-TIME POLYMERASE CHAIN REACTION; RISK FACTORS; UNITED STATES;

EID: 84856450745     PISSN: 15274160     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.pra.0000407963.26981.a6     Document Type: Review

References (27)

1. 12, and homocysteine in major depressive disorder, Part 1: Predictors of clinical response in fluoxetine-resistant depression. J Clin Psychiatry 2004;65:1090-5.
2. 12. J Psychopharmacol 2005;19:59-65.
3. Coppen A, Bailey J. Enhancement of the antidepressant action of fluoxetine by folic acid: A randomized, placebo controlled trial. J Affect Disord 2000;60:121-30.
4. Morris MS, Fava M, Jacques PF, et al. Depression and folate status in the US Population. Psychother Psychosom 2003;72:80-7. (Pubitemid 36302476)
5. Gilbody S, Lewis S, Lightfoot T. Methylenete tra hydrofolate reductase (MTHFR) genetic polymorphisms and psychiatric disorders: A HuGE Review. Am J Epidemiol 2007;165:1-13. (Pubitemid 46026203)
6. Taylor MJ, Carney D, Goodwin GM, et al. Folate for depressive disorders: Systematic review and meta-analysis of randomized controlled trials. J Psychopharmacol 2004;18:251-6. (Pubitemid 38954914)
7. Roberts S, Bedson E, Hughes D, et al. Folate Augmentation of Treatment-Evaluation for Depression (FolATED): Protocol of a randomized controlled trial. BMC Psychiatry 2007;7:65-83.
8. 12 and homocysteine levels in major depressive disorder and the timing of improvement with fluoxetine. Int J Neuropsychopharmacol 2005;8:523-8. (Pubitemid 41400882)
9. Fava M. Augmenting antidepressants with folate: A clinical perspective. J Clin Psychiatry 2007;68:4-7. (Pubitemid 47507830)
10. Mischoulon D, Raab M. The role of folate in depression and dementia. J Clin Psychiatry 2007;68:28-33. (Pubitemid 47507835)
11. 12, and homocysteine in major depressive disorder. Am J Psychiatry 1997;154:426-8. (Pubitemid 27098298)
12. Papakostas G, Iosifescu D, Renshaw R, et al. Brain MRI white matter hyperintensities and one-carbon cycle metabolism in non-geriatric outpatients with major depressive disorder (Part III). Psychiatry Res 2005;140:301-7. (Pubitemid 41660974)
13. Alpert JE, Mischoulon D, Rubenstein GE, et al. Folinic acid as an adjunctive treatment for SSRI-refractory depression. Ann Clin Psychiatry 2002;14:33-8. (Pubitemid 34538830)
14. Stahl SM. Novel therapeutics for depression: L-methylfolate as a trimonoamine modulator and antidepressantaugmenting agent. CNS Spectr 2007;12:739-44. (Pubitemid 350072170)
15. Bottiglieri T, Hyland K, Laundy M, et al. Folate deficiency, biopterin and monoamine metabolism in depression. Psychol Med 1992;22:871-6. (Pubitemid 23006998)
16. Tan EC, Chong SA, Lim LC, et al. Genetic analysis of thermolabile methylenetetrahydrofolate reductase in schizophrenia and mood disorders. Psychiatr Genet 2004;14:227-31. (Pubitemid 40054351)
17. Botto LD, Yang Q. 5, 10-methylenetetrahydrofolate reductase gene variants and congenital anomalies: A HuGE review. Am J Epidemiol 2000;151:862-77. (Pubitemid 30461127)
18. Arinami T, Yamada N, Yamakawa-Kobayashi K, et al. Methylenetetrahydrofolate reductase variant and schizophrenia/depression. Am J Med Genet 1997;74:526-8. (Pubitemid 27424220)
19. Lewis SJ, Lawlor DA, Davey Smith G, et al. The thermolabile variant of MTHFR is associated with depression in the British Women's Heart and Health Study and a metaanalysis. Mol Psychiatry 2006;11:352-60.
20. 12, homocysteine, and the MTHFR 677C →T polymorphism in anxiety and depression: The Hordaland homocysteine study. Arch Gen Psychiatry 2003;60:618-26. (Pubitemid 36682319)
21. Kelly CB, McDonnell AP, Johnston TG, et al. The MTHFR C677T polymorphism is associated with depressive episodes in patients from Northern Ireland. J Psychopharmacol 2004;18:567-71. (Pubitemid 39665125)
22. Hickie I, Scott E, Naismith S, et al. Late-onset depression: Genetic, vascular and clinical contributions. Psychol Med 2001;31:1403-12. (Pubitemid 33040364)
23. Kunugi H, Fukuda R, Hattori M, et al. C677T polymorphism in methylenetetrahydrofolate reductase gene and psychoses. Mol Psychiatry 1998;3:435-37. (Pubitemid 28442418)
24. Almeida O, Flicker L, Lautenschlager N, et al. Contribution of the MTHFR gene to the casual pathway for depression, anxiety and cognitive impairment in later life. Neurobiol Aging 2005;26:251-7. (Pubitemid 39600581)
25. ® (package insert). Covington, LA: Pamlab, 2010 (available at www.deplin.com/media/Deplin-Package - Insert.pdf, accessed August 4, 2011).
26. Guaraldi GP, Fava M, Maxxi R, et al. An open trial of methyltetrahydrofolate in elderly depressed patients. Ann Clin Psychiatry 1993;5:101-5. (Pubitemid 23210906)
27. Di Palma C, Urani R, Agricola R, et al. Is methylfolate effective in relieving major depression in chronic alcoholics? A hypothesis or treatment. Current Therapeutic Research 1994;55:559-67.