Three genetic polymorphisms of homocysteine-metabolizing enzymes and risk of coronary heart disease: A meta-analysis based on 23 case-control studies

DNA and Cell Biology

Volumn 31, Issue 2, 2012, Pages 238-249

  Chen, Ling ^a   Liu, Liu ^a   Hong, Kui ^a   Hu, Jianxin ^a   Cheng, Xiaoshu ^a  

^a NANCHANG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); METHIONINE SYNTHASE; METHIONINE SYNTHASE REDUCTASE;

ALLELE; ARTICLE; CARDIOVASCULAR RISK; CASE CONTROL STUDY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENOTYPE; HEART INFARCTION; HUMAN; ISCHEMIC HEART DISEASE; PRIORITY JOURNAL;

5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINE S-METHYLTRANSFERASE; ALGORITHMS; CASE-CONTROL STUDIES; CORONARY DISEASE; EUROPEAN CONTINENTAL ANCESTRY GROUP; FERREDOXIN-NADP REDUCTASE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HOMOCYSTEINE; HUMANS; METABOLIC NETWORKS AND PATHWAYS; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); POLYMORPHISM, SINGLE NUCLEOTIDE; REVIEW LITERATURE AS TOPIC; RISK FACTORS;

EID: 84863018527     PISSN: 10445498     EISSN: 15577430     Source Type: Journal    
DOI: 10.1089/dna.2011.1281     Document Type: Article

References (48)

1. Abu-Amero, K.K., Wyngaard, C.A., and Dzimiri, N. (2003). Prevalence and role of methylenetetrahydrofolate reductase 677 C/T and 1298A/C polymorphisms in coronary artery disease in Arabs. Arch Pathol Lab Med 127, 1349-1352. (Pubitemid 37248335)
2. Albus, C. (2010). Psychological and social factors in coronary heart disease. Ann Med 42, 487-494.
3. Angeline, T., Jeyaraj, N., and Tsongalis, G.J. (2007). MTHFR Gene polymorphisms, B-vitamins and hyperhomocystinemia in young and middle-aged acute myocardial infarction patients. Exp Mol Pathol 82, 227-233. (Pubitemid 46686663)
4. Attia, J., Thakkinstian, A., and D'Este, C. (2003). Meta-analyses of molecular association studies: methodologic lessons for genetic epidemiology. J Clin Epidemiol 56, 297-303. (Pubitemid 36593307)
5. Begg, C.B., and Mazumdar, M. (1994). Operating characteristics of a rank correlation test for publication bias. Biometrics 50, 1088-1101.
6. Biselli, P.M., Guerzoni, A.R., de Godoy, M.F., Eberlin, M.N., Haddad, R., Carvalho, V.M., Vannucchi, H., Pavarino-Bertelli, E.C., and Goloni-Bertollo, E.M. (2010). Genetic polymorphisms involved in folate metabolism and concentrations of methylmalonic acid and folate on plasma homocysteine and risk of coronary artery disease. J Thromb Thrombolysis 29, 32-40.
7. Biselli, P.M., Guerzoni, A.R., Goloni-Bertollo, E.M., Godoy, M.F., Abou-Chahla, J.A., and Pavarino-Bertelli, E.C. (2009). [MTHFR genetic variability on coronary artery disease development]. Rev Assoc Med Bras 55, 274-278.
8. Boccia, S., De Feo, E., Galli, P., Gianfagna, F., Amore, R., and Ricciardi, G. (2010). A systematic review evaluating the methodological aspects of meta-analyses of genetic association studies in cancer research. Eur J Epidemiol 25, 765-775.
9. Botto, N., Andreassi, M.G., Manfredi, S., Masetti, S., Cocci, F., Colombo, M.G., Storti, S., Rizza, A., and Biagini, A. (2003). Genetic polymorphisms in folate and homocysteine metabolism as risk factors for DNA damage. Eur J Hum Genet 11, 671-678. (Pubitemid 37160988)
10. Brattstrom, L., and Wilcken, D.E. (2000). Homocysteine and cardiovascular disease: cause or effect? Am J Clin Nutr 72, 315-323. (Pubitemid 30620632)
11. Brilakis, E.S., Berger, P.B., Ballman, K.V., and Rozen, R. (2003). Methylenetetrahydrofolate reductase (MTHFR) 677C> T andmethionine synthase reductase (MTRR) 66A > G polymorphisms: association with serum homocysteine and angiographic coronary artery disease in the era of flour products fortified with folic acid. Atherosclerosis 168, 315-322. (Pubitemid 36703331)
12. Brouwer, D.A., Welten, H.T., Reijngoud, D.J., van Doormaal, J.J., and Muskiet, F.A. (1998). Plasma folic acid cutoff value, derived from its relationship with homocyst(e)ine. Clin Chem 44, 1545-1550. (Pubitemid 28309118)
13. Brown, C.A., McKinney, K.Q., Kaufman, J.S., Gravel, R.A., and Rozen, R. (2000). A common polymorphism in methionine synthase reductase increases risk of premature coronary artery disease. J Cardiovasc Risk 7, 197-200. (Pubitemid 30463749)
14. Chen, B., Cao, L., Zhou, Y., Yang, P., Wan, H.W., Jia, G.Q., Liu, L., and Wu, X.T. (2010). Glutathione S-transferase T1 (GSTT1) gene polymorphism and gastric cancer susceptibility: a meta-analysis of epidemiologic studies. Dig Dis Sci 55, 1831-1838.
15. Dai, C.W., and Zhang, G.S. (2001). [Study on homocysteine metabolism related enzymes gene mutations in Chinese patients with ischemic cardiovascular and cerebrovascular diseases]. Zhong Hua Xue Ye Bing Xue Za Zhi 22, 484-487 [Chinese].
16. den Heijer, M., Rosendaal, F.R., Blom, H.J., Gerrits, W.B., and Bos, G.M. (1998). Hyperhomocysteinemia and venous thrombosis: a meta-analysis. Thromb Haemost 80, 874-877. (Pubitemid 28556684)
17. Drenos, F., Whittaker, J.C., and Humphries, S.E. (2007). The use of meta-analysis risk estimates for candidate genes in combination to predict coronary heart disease risk. Ann Hum Genet 71, 611-619. (Pubitemid 47087069)
18. Egger, M., Davey Smith, G., Schneider, M., and Minder, C. (1997). Bias in meta-analysis detected by a simple, graphical test. BMJ 315, 629-634. (Pubitemid 27387172)
19. Fang, S., Wang, L., and Jia, C. (2010). Association of p22phox gene C242T polymorphism with coronary artery disease: a meta-analysis. Thromb Res 125, e197-e201.
20. Friso, S., Girelli, D., Trabetti, E., Stranieri, C., Olivieri, O., Tinazzi, E., Martinelli, N., Faccini, G., Pignatti, P.F., and Corrocher, R. (2002). A1298C methylenetetrahydrofolate reductase mutation and coronary artery disease: relationships with C677T polymorphism and homocysteine/folate metabolism. Clin Exp Med 2, 7-12. (Pubitemid 34743942)
21. Frosst, P., Blom, H.J., Milos, R., Goyette, P., Sheppard, C.A., Matthews, R.G., Boers, G.J., den Heijer, M., Kluijtmans, L.A., van den Heuvel, L.P., et al. (1995). A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet 10, 111-113.
22. Gaughan, D.J., Kluijtmans, L.A., Barbaux, S., McMaster, D., Young, I.S., Yarnell, J.W., Evans, A., and Whitehead, A.S. (2001). The methionine synthase reductase (MTRR) A66G polymorphism is a novel genetic determinant of plasma bhomocysteine concentrations. Atherosclerosis 157, 451-456. (Pubitemid 32710025)
23. Ghazouani, L., Abboud, N., Mtiraoui, N., Zammiti, W., Addad, F., Amin, H., Almawi, W.Y., and Mahjoub, T. (2009). Homocysteine and methylenetetrahydrofolate reductase C677T and A1298C polymorphisms in Tunisian patients with severe coronary artery disease. J Thromb Thrombolysis 27, 191-197.
24. Gueant-Rodriguez, R.M., Juilliere, Y., Candito, M., Adjalla, C.E., Gibelin, P., Herbeth, B., Van Obberghen, E., and Gueant, J.L. (2005). Association of MTRRA66G polymorphism (but not of MTHFR C677T and A1298C, MTRA2756G, TCN C776G) with homocysteine and coronary artery disease in the French population. Thromb Haemost 94, 510-515. (Pubitemid 41300844)
25. Helfenstein, T., Fonseca, F.A., Relvas, W.G., Santos, A.O., Dabela, M.L., Matheus, S.C., D'Almeida, V., Tufik, S., Souza, F.G., Rodrigues, P.R., Taglieri, R., Sousa, E.F., and Izar, M.C. (2005). Prevalence of myocardial infarction is related to hyperhomocysteinemia but not influenced by C677T methylenetetrahydrofolate reductase and A2756G methionine synthase polymorphisms in diabetic and non-diabetic subjects. Clin Chim Acta 355, 165-172.
26. Janosikova, B., Pavlikova, M., Kocmanova, D., Vitova, A., Vesela, K., Krupkova, L., Kahleova, R., Krijt, J., Kraml, P., Hyanek, J., Zvarova, J., Andel, M., and Kozich, V. (2003). Genetic variants of homocysteine metabolizing enzymes and the risk of coronary artery disease. Mol Genet Metab 79, 167-175. (Pubitemid 36809043)
27. Jemaa, R., Achouri, A., Kallel, A., Ali, S.B., Mourali, S., Feki, M., Elasmi, M., Taieb, S.H., Sanhaji, H., Omar, S., Mechmeche, R., and Kaabachi, N. (2008). Association between the 2756A > G variant in the gene encoding methionine synthase and myocardial infarction in Tunisian patients. Clin Chem Lab Med 46, 1364-1368.
28. Kerkeni, M., Addad, F., Chauffert, M., Myara, A., Gerhardt, M., Chevenne, D., Trivin, F., Farhat, M.B., Miled, A., and Maaroufi, K. (2006). Hyperhomocysteinaemia, methylenetetrahydrofolate reductase polymorphism and risk of coronary artery disease. Ann Clin Biochem 43, 200-206. (Pubitemid 43668152)
29. Klerk, M., Lievers, K.J., Kluijtmans, L.A., Blom, H.J., den Heijer, M., Schouten, E.G., Kok, F.J., and Verhoef, P. (2003). The 2756A > G variant in the gene encoding methionine synthase: its relation with plasma homocysteine levels and risk of coronary heart disease in a Dutch case-control study. Thromb Res 110, 87-91. (Pubitemid 37329446)
30. Klerk, M., Verhoef, P., Clarke, R., Blom, H.J., Kok, F.J., and Schouten, E.G. (2002). MTHFR 677C/ T polymorphism and risk of coronary heart disease: a meta-analysis. JAMA 288, 2023-2031. (Pubitemid 35204693)
31. Kolling, K., Ndrepepa, G., Koch, W., Braun, S., Mehilli, J., Schomig, A., and Kastrati, A. (2004). Methylenetetrahydrofolate reductase gene C677T and A1298C polymorphisms, plasma homocysteine, folate, and vitamin B12 levels and the extent of coronary artery disease. Am J Cardiol 93, 1201-1206. (Pubitemid 38595670)
32. Kruger, W.D., Evans, A.A., Wang, L., Malinow, M.R., Duell, P.B., Anderson, P.H., Block, P.C., Hess, D.L., Graf, E.E., and Upson, B. (2000). Polymorphisms in the CBS gene associated with decreased risk of coronary artery disease and increased responsiveness to total homocysteine lowering by folic acid. Mol Genet Metab 70, 53-60. (Pubitemid 30396204)
33. Lakshmi, V.S., Naushad, S.M., Rupasree, Y., Rao, S.D., and Kutala, V.K. (2011). Interactions of 5'-UTR thymidylate synthase polymorphism with 677C/T methylene tetrahydrofolate reductase and 66A/G methyltetrahydrofolate homocysteine methyltransferase reductase polymorphisms determine susceptibility to coronary artery disease. J Atheroscler Thromb 18, 56-64.
34. Laraqui, A., Allami, A., Carrie, A., Coiffard, A.S., Benkouka, F., Benjouad, A., Bendriss, A., Kadiri, N., Bennouar, N., Benomar, A., Guedira, A., Raisonnier, A., Fellati, S., Srairi, J.E., and Benomar, M. (2006). Influence of methionine synthase (A2756G) and methionine synthase reductase (A66G) polymorphisms on plasma homocysteine levels and relation to risk of coronary artery disease. Acta Cardiol 61, 51-61. (Pubitemid 43198501)
35. Laraqui, A., Allami, A., Carrie, A., Raisonnier, A., Coiffard, A.S., Benkouka, F., Bendriss, A., Benjouad, A., Bennouar, N., El Kadiri, N., Benomar, A., Fellat, S., and Benomar, M. (2007). Relation between plasma homocysteine, gene polymorphisms of homocysteine metabolism-related enzymes, and angiographically proven coronary artery disease. Eur J Intern Med 18, 474-483. (Pubitemid 47379543)
36. Lewis, S.J., Ebrahim, S., and Davey Smith, G. (2005). Meta-analysis of MTHFR 677C/ T polymorphism and coronary heart disease: does totality of evidence support causal role for homocysteine and preventive potential of folate? BMJ 331, 1053.
37. Li, W., Xu, J., Wang, X., Chen, J., Zhang, C., Sun, K., and Hui, R. (2009). Cyclooxygenase-2 (COX-2) G-765C is a protective factor for coronary artery disease but not for ischemic stroke: a meta-analysis. Atherosclerosis 207, 492-495.
38. Mei, W., Rong, Y., Jinming, L., Yongjun, L., and Hui, Z. (2010). Effect of homocysteine interventions on the risk of cardiocerebrovascular events: a meta-analysis of randomised controlled trials. Int J Clin Pract 64, 208-215.
39. Ranjith, N., Pegoraro, R.J., and Rom, L. (2003). Risk factors and methylenetetrahydrofolate reductase gene polymorphisms in a young South African Indian-based population with acute myocardial infarction. Cardiovasc J S Afr 14, 127-132. (Pubitemid 37010267)
40. Rothenbacher, D., Fischer, H.G., Hoffmeister, A., Hoffmann, M.M., Marz, W., Bode, G., Rosenthal, J., Koenig, W., and Brenner, H. (2002). Homocysteine and methylenetetrahydrofolate reductase genotype: association with risk of coronary heart disease and relation to inflammatory, hemostatic, and lipid parameters. Atherosclerosis 162, 193-200. (Pubitemid 34327358)
41. Strauss, E., Gluszek, J., and Pawlak, A.L. (2005). Age and hypertension related changes in genotypes of MTHFR 677C > T, 1298A > C and PON1-108C > T SNPs in men with coronary artery disease (CAD). J Physiol Pharmacol 56 Suppl 2, 65-75. (Pubitemid 44933669)
42. Tobias, A. (1999). Assessing the influence of a single study in the meta-analysis estimate. Stata Tech Bull 8, 15-17.
43. Tsai, M.Y., Welge, B.G., Hanson, N.Q., Bignell, M.K., Vessey, J., Schwichtenberg, K., Yang, F., Bullemer, F.E., Rasmussen, R., and Graham, K.J. (1999). Genetic causes of mild hyperhomocysteinemia in patients with premature occlusive coronary artery diseases. Atherosclerosis 143, 163-170. (Pubitemid 29138714)
44. Verhoef, P., and de Groot, L.C. (2005).Dietary determinants of plasma homocysteine concentrations. Semin Vasc Med 5, 110-123. (Pubitemid 40944287)
45. Vinukonda, G., Shaik Mohammad, N., Md Nurul Jain, J., Prasad Chintakindi, K., and Rama Devi Akella, R. (2009). Genetic and environmental influences on total plasma homocysteine and coronary artery disease (CAD) risk among South Indians. Clin Chim Acta 405, 127-131.
46. Wald, D.S., Law, M., and Morris, J.K. (2002). Homocysteine and cardiovascular disease: evidence on causality from a metaanalysis. BMJ 325, 1202.
47. Weisberg, I.S., Jacques, P.F., Selhub, J., Bostom, A.G., Chen, Z., Curtis Ellison, R., Eckfeldt, J.H., and Rozen, R. (2001). The 1298A/C polymorphism in methylenetetrahydrofolate reductase (MTHFR): in vitro expression and association with homocysteine. Atherosclerosis 156, 409-415. (Pubitemid 32522922)
48. Zhang, G., and Dai, C. (2001). Gene polymorphisms of homocysteine metabolism-related enzymes in Chinese patients with occlusive coronary artery or cerebral vascular diseases. Thromb Res 104, 187-195 (Pubitemid 32973760)