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Volumn 61, Issue 12, 2013, Pages 2023-2037

Astrocytes inhibit nitric oxide-dependent Ca2+ dynamics in activated microglia: Involvement of ATP released via pannexin 1 channels

Author keywords

Calcium; Glia; Neuroinflammation

Indexed keywords

ADENOSINE TRIPHOSPHATE; CONNEXIN 43; INDUCIBLE NITRIC OXIDE SYNTHASE; MEMBRANE PROTEIN; NITRIC OXIDE; PANNEXIN 1 CHANNEL; PROSTAGLANDIN E RECEPTOR 1; PROSTAGLANDIN SYNTHASE; PURINERGIC P2Y1 RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

EID: 84886639249     PISSN: 08941491     EISSN: 10981136     Source Type: Journal    
DOI: 10.1002/glia.22573     Document Type: Article
Times cited : (61)

References (53)
  • 1
    • 80054694701 scopus 로고    scopus 로고
    • Purinergic signaling induces cyclooxygenase-1-dependent prostanoid synthesis in microglia: roles in the outcome of excitotoxic brain injury
    • Anrather J, Gallo EF, Kawano T, Orio M, Abe T, Gooden C, Zhou P, Iadecola C. 2011. Purinergic signaling induces cyclooxygenase-1-dependent prostanoid synthesis in microglia: roles in the outcome of excitotoxic brain injury. PLoS One 6:e25916.
    • (2011) PLoS One , vol.6
    • Anrather, J.1    Gallo, E.F.2    Kawano, T.3    Orio, M.4    Abe, T.5    Gooden, C.6    Zhou, P.7    Iadecola, C.8
  • 2
    • 33845768784 scopus 로고    scopus 로고
    • Microglia-mediated neurotoxicity: Uncovering the molecular mechanisms
    • Block ML, Zecca L, Hong JS. 2007. Microglia-mediated neurotoxicity: Uncovering the molecular mechanisms. Nat Rev Neurosci 8:57-69.
    • (2007) Nat Rev Neurosci , vol.8 , pp. 57-69
    • Block, M.L.1    Zecca, L.2    Hong, J.S.3
  • 4
    • 78651273920 scopus 로고    scopus 로고
    • TGF-beta and LPS modulate ADP-induced migration of microglial cells through P2Y1 and P2Y12 receptor expression
    • De Simone R, Niturad CE, De Nuccio C, Ajmone-Cat MA, Visentin S, Minghetti L. 2010. TGF-beta and LPS modulate ADP-induced migration of microglial cells through P2Y1 and P2Y12 receptor expression. J Neurochem 115:450-459.
    • (2010) J Neurochem , vol.115 , pp. 450-459
    • De Simone, R.1    Niturad, C.E.2    De Nuccio, C.3    Ajmone-Cat, M.A.4    Visentin, S.5    Minghetti, L.6
  • 5
    • 59049100727 scopus 로고    scopus 로고
    • Targeted activation of astrocytes: A potential neuroprotective strategy
    • Escartin C, Bonvento G. 2008. Targeted activation of astrocytes: A potential neuroprotective strategy. Mol Neurobiol 38:231-241.
    • (2008) Mol Neurobiol , vol.38 , pp. 231-241
    • Escartin, C.1    Bonvento, G.2
  • 6
    • 42149125581 scopus 로고    scopus 로고
    • Mimetic peptides as blockers of connexin channel-facilitated intercellular communication
    • Evans WH, Leybaert L. 2007. Mimetic peptides as blockers of connexin channel-facilitated intercellular communication. Cell Commun Adhes 14:265-273.
    • (2007) Cell Commun Adhes , vol.14 , pp. 265-273
    • Evans, W.H.1    Leybaert, L.2
  • 7
    • 33750305578 scopus 로고    scopus 로고
    • Functional role of calcium signals for microglial function
    • Farber K, Kettenmann H. 2006. Functional role of calcium signals for microglial function. Glia 54:656-665.
    • (2006) Glia , vol.54 , pp. 656-665
    • Farber, K.1    Kettenmann, H.2
  • 8
    • 0031054641 scopus 로고    scopus 로고
    • Purinergic modulation of interleukin-1 beta release from microglial cells stimulated with bacterial endotoxin
    • Ferrari D, Chiozzi P, Falzoni S, Hanau S, Di Virgilio F. 1997. Purinergic modulation of interleukin-1 beta release from microglial cells stimulated with bacterial endotoxin. J Exp Med 185:579-582.
    • (1997) J Exp Med , vol.185 , pp. 579-582
    • Ferrari, D.1    Chiozzi, P.2    Falzoni, S.3    Hanau, S.4    Di Virgilio, F.5
  • 10
    • 0032432275 scopus 로고    scopus 로고
    • Protein kinase C-mediated regulation of inducible nitric oxide synthase expression in cultured microglial cells
    • Fiebich BL, Butcher RD, Gebicke-Haerter PJ. 1998. Protein kinase C-mediated regulation of inducible nitric oxide synthase expression in cultured microglial cells. J Neuroimmunol 92:170-178.
    • (1998) J Neuroimmunol , vol.92 , pp. 170-178
    • Fiebich, B.L.1    Butcher, R.D.2    Gebicke-Haerter, P.J.3
  • 11
    • 33745738972 scopus 로고    scopus 로고
    • Purinergic signalling in neuron-glia interactions
    • Fields RD, Burnstock G. 2006. Purinergic signalling in neuron-glia interactions. Nat Rev Neurosci 7:423-436.
    • (2006) Nat Rev Neurosci , vol.7 , pp. 423-436
    • Fields, R.D.1    Burnstock, G.2
  • 12
    • 84866260694 scopus 로고    scopus 로고
    • Transforming growth factor beta1 modulates amyloid beta-induced glial activation through the Smad3-dependent induction of MAPK phosphatase-1
    • Flores B, von Bernhardi R. 2012. Transforming growth factor beta1 modulates amyloid beta-induced glial activation through the Smad3-dependent induction of MAPK phosphatase-1. J Alzheimers Dis 32:417-429.
    • (2012) J Alzheimers Dis , vol.32 , pp. 417-429
    • Flores, B.1    von Bernhardi, R.2
  • 13
    • 51849155044 scopus 로고    scopus 로고
    • Lysophosphatidic acid-induced membrane ruffling and brain-derived neurotrophic factor gene expression are mediated by ATP release in primary microglia
    • Fujita R, Ma Y, Ueda H. 2008. Lysophosphatidic acid-induced membrane ruffling and brain-derived neurotrophic factor gene expression are mediated by ATP release in primary microglia. J Neurochem 107:152-160.
    • (2008) J Neurochem , vol.107 , pp. 152-160
    • Fujita, R.1    Ma, Y.2    Ueda, H.3
  • 14
    • 0021895138 scopus 로고
    • A new generation of Ca2+ indicators with greatly improved fluorescence properties
    • Grynkiewicz G, Poenie M, Tsien RY. 1985. A new generation of Ca2+ indicators with greatly improved fluorescence properties. J Biol Chem 260:3440-3450.
    • (1985) J Biol Chem , vol.260 , pp. 3440-3450
    • Grynkiewicz, G.1    Poenie, M.2    Tsien, R.Y.3
  • 15
    • 38349177105 scopus 로고    scopus 로고
    • Apigenin inhibits the production of NO and PGE2 in microglia and inhibits neuronal cell death in a middle cerebral artery occlusion-induced focal ischemia mice model
    • Ha SK, Lee P, Park JA, Oh HR, Lee SY, Park JH, Lee EH, Ryu JH, Lee KR, Kim SY. 2008. Apigenin inhibits the production of NO and PGE2 in microglia and inhibits neuronal cell death in a middle cerebral artery occlusion-induced focal ischemia mice model. Neurochem Int 52:878-886.
    • (2008) Neurochem Int , vol.52 , pp. 878-886
    • Ha, S.K.1    Lee, P.2    Park, J.A.3    Oh, H.R.4    Lee, S.Y.5    Park, J.H.6    Lee, E.H.7    Ryu, J.H.8    Lee, K.R.9    Kim, S.Y.10
  • 16
    • 0034790995 scopus 로고    scopus 로고
    • Antioxidant enzymes suppress nitric oxide production through the inhibition of NF-kappa B activation: role of H(2)O(2) and nitric oxide in inducible nitric oxide synthase expression in macrophages
    • Han YJ, Kwon YG, Chung HT, Lee SK, Simmons RL, Billiar TR, Kim YM. 2001. Antioxidant enzymes suppress nitric oxide production through the inhibition of NF-kappa B activation: role of H(2)O(2) and nitric oxide in inducible nitric oxide synthase expression in macrophages. Nitric Oxide 5:504-513.
    • (2001) Nitric Oxide , vol.5 , pp. 504-513
    • Han, Y.J.1    Kwon, Y.G.2    Chung, H.T.3    Lee, S.K.4    Simmons, R.L.5    Billiar, T.R.6    Kim, Y.M.7
  • 17
    • 33745873475 scopus 로고    scopus 로고
    • Astrocyte control of synaptic transmission and neurovascular coupling
    • Haydon PG, Carmignoto G. 2006. Astrocyte control of synaptic transmission and neurovascular coupling. Physiol Rev 86:1009-1031.
    • (2006) Physiol Rev , vol.86 , pp. 1009-1031
    • Haydon, P.G.1    Carmignoto, G.2
  • 18
    • 84866256725 scopus 로고    scopus 로고
    • Modulation of interferon-gamma-induced glial cell activation by transforming growth factor beta1: A role for STAT1 and MAPK pathways
    • Herrera-Molina R, Flores B, Orellana JA, von Bernhardi R. 2012. Modulation of interferon-gamma-induced glial cell activation by transforming growth factor beta1: A role for STAT1 and MAPK pathways. J Neurochem 123:113-123.
    • (2012) J Neurochem , vol.123 , pp. 113-123
    • Herrera-Molina, R.1    Flores, B.2    Orellana, J.A.3    von Bernhardi, R.4
  • 19
    • 17444363424 scopus 로고    scopus 로고
    • Transforming growth factor-beta 1 produced by hippocampal cells modulates microglial reactivity in culture
    • Herrera-Molina R, von Bernhardi R. 2005. Transforming growth factor-beta 1 produced by hippocampal cells modulates microglial reactivity in culture. Neurobiol Dis 19:229-236.
    • (2005) Neurobiol Dis , vol.19 , pp. 229-236
    • Herrera-Molina, R.1    von Bernhardi, R.2
  • 20
    • 80053566487 scopus 로고    scopus 로고
    • Microglial zinc uptake via zinc transporters induces ATP release and the activation of microglia
    • Higashi Y, Segawa S, Matsuo T, Nakamura S, Kikkawa Y, Nishida K, Nagasawa K. 2011. Microglial zinc uptake via zinc transporters induces ATP release and the activation of microglia. Glia 59:1933-1945.
    • (2011) Glia , vol.59 , pp. 1933-1945
    • Higashi, Y.1    Segawa, S.2    Matsuo, T.3    Nakamura, S.4    Kikkawa, Y.5    Nishida, K.6    Nagasawa, K.7
  • 21
    • 0038795206 scopus 로고    scopus 로고
    • Elevation of basal intracellular calcium as a central element in the activation of brain macrophages (microglia): Suppression of receptor-evoked calcium signaling and control of release function
    • Hoffmann A, Kann O, Ohlemeyer C, Hanisch UK, Kettenmann H. 2003. Elevation of basal intracellular calcium as a central element in the activation of brain macrophages (microglia): Suppression of receptor-evoked calcium signaling and control of release function. J Neurosci 23:4410-9.
    • (2003) J Neurosci , vol.23 , pp. 4410-4419
    • Hoffmann, A.1    Kann, O.2    Ohlemeyer, C.3    Hanisch, U.K.4    Kettenmann, H.5
  • 22
    • 38049188027 scopus 로고    scopus 로고
    • ATP released from beta-amyloid-stimulated microglia induces reactive oxygen species production in an autocrine fashion
    • Kim SY, Moon JH, Lee HG, Kim SU, Lee YB. 2007. ATP released from beta-amyloid-stimulated microglia induces reactive oxygen species production in an autocrine fashion. Exp Mol Med 39:820-827.
    • (2007) Exp Mol Med , vol.39 , pp. 820-827
    • Kim, S.Y.1    Moon, J.H.2    Lee, H.G.3    Kim, S.U.4    Lee, Y.B.5
  • 23
    • 0035120226 scopus 로고    scopus 로고
    • Effect of lipopolysaccharide on the morphology and integrin immunoreactivity of ramified microglia in the mouse brain and in cell culture
    • Kloss CU, Bohatschek M, Kreutzberg GW, Raivich G. 2001. Effect of lipopolysaccharide on the morphology and integrin immunoreactivity of ramified microglia in the mouse brain and in cell culture. Exp Neurol 168:32-46.
    • (2001) Exp Neurol , vol.168 , pp. 32-46
    • Kloss, C.U.1    Bohatschek, M.2    Kreutzberg, G.W.3    Raivich, G.4
  • 24
    • 74549174601 scopus 로고    scopus 로고
    • Synchronization of Ca2+ oscillations: Involvement of ATP release in astrocytes
    • Koizumi S. 2010. Synchronization of Ca2+ oscillations: Involvement of ATP release in astrocytes. FEBS J 277:286-292.
    • (2010) FEBS J , vol.277 , pp. 286-292
    • Koizumi, S.1
  • 25
    • 79851480221 scopus 로고    scopus 로고
    • Suppressed microglial E prostanoid receptor 1 signaling selectively reduces tumor necrosis factor alpha and interleukin 6 secretion from toll-like receptor 3 activation
    • Li X, Cudaback E, Keene CD, Breyer RM, Montine TJ. 2011. Suppressed microglial E prostanoid receptor 1 signaling selectively reduces tumor necrosis factor alpha and interleukin 6 secretion from toll-like receptor 3 activation. Glia 59:569-576.
    • (2011) Glia , vol.59 , pp. 569-576
    • Li, X.1    Cudaback, E.2    Keene, C.D.3    Breyer, R.M.4    Montine, T.J.5
  • 26
    • 80051782344 scopus 로고    scopus 로고
    • Cross talk between activation of microglia and astrocytes in pathological conditions in the central nervous system
    • Liu W, Tang Y, Feng J. 2011. Cross talk between activation of microglia and astrocytes in pathological conditions in the central nervous system. Life Sci 89:141-146.
    • (2011) Life Sci , vol.89 , pp. 141-146
    • Liu, W.1    Tang, Y.2    Feng, J.3
  • 27
    • 29344452180 scopus 로고    scopus 로고
    • Activation of pannexin 1 channels by ATP through P2Y receptors and by cytoplasmic calcium
    • Locovei S, Wang J, Dahl G. 2006. Activation of pannexin 1 channels by ATP through P2Y receptors and by cytoplasmic calcium. FEBS Lett 580:239-244.
    • (2006) FEBS Lett , vol.580 , pp. 239-244
    • Locovei, S.1    Wang, J.2    Dahl, G.3
  • 28
    • 75749152627 scopus 로고    scopus 로고
    • Non-junction functions of pannexin-1 channels
    • MacVicar BA, Thompson RJ. 2010. Non-junction functions of pannexin-1 channels. Trends Neurosci 33:93-102.
    • (2010) Trends Neurosci , vol.33 , pp. 93-102
    • MacVicar, B.A.1    Thompson, R.J.2
  • 29
    • 0141769473 scopus 로고    scopus 로고
    • Activation of mouse microglial cells affects P2 receptor signaling
    • Moller T, Kann O, Verkhratsky A, Kettenmann H. 2000. Activation of mouse microglial cells affects P2 receptor signaling. Brain Res 853:49-59.
    • (2000) Brain Res , vol.853 , pp. 49-59
    • Moller, T.1    Kann, O.2    Verkhratsky, A.3    Kettenmann, H.4
  • 30
    • 0030908028 scopus 로고    scopus 로고
    • Latent transforming growth factor-beta: Structural features and mechanisms of activation
    • Munger JS, Harpel JG, Gleizes PE, Mazzieri R, Nunes I, Rifkin DB. 1997. Latent transforming growth factor-beta: Structural features and mechanisms of activation. Kidney Int 51:1376-1382.
    • (1997) Kidney Int , vol.51 , pp. 1376-1382
    • Munger, J.S.1    Harpel, J.G.2    Gleizes, P.E.3    Mazzieri, R.4    Nunes, I.5    Rifkin, D.B.6
  • 31
    • 75849165091 scopus 로고    scopus 로고
    • Hypoxia in high glucose followed by reoxygenation in normal glucose reduces the viability of cortical astrocytes through increased permeability of connexin 43 hemichannels
    • Orellana JA, Hernandez DE, Ezan P, Velarde V, Bennett MV, Giaume C, Saez JC. 2010. Hypoxia in high glucose followed by reoxygenation in normal glucose reduces the viability of cortical astrocytes through increased permeability of connexin 43 hemichannels. Glia 58:329-343.
    • (2010) Glia , vol.58 , pp. 329-343
    • Orellana, J.A.1    Hernandez, D.E.2    Ezan, P.3    Velarde, V.4    Bennett, M.V.5    Giaume, C.6    Saez, J.C.7
  • 33
    • 33750473352 scopus 로고    scopus 로고
    • Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor
    • Pelegrin P, Surprenant A. 2006. Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor. EMBO J 25:5071-5082.
    • (2006) EMBO J , vol.25 , pp. 5071-5082
    • Pelegrin, P.1    Surprenant, A.2
  • 34
    • 0033771987 scopus 로고    scopus 로고
    • Selective upregulation of inducible nitric oxide synthase (iNOS) by lipopolysaccharide (LPS) and cytokines in microglia: in vitro and in vivo studies
    • Possel H, Noack H, Putzke J, Wolf G, Sies H. 2000. Selective upregulation of inducible nitric oxide synthase (iNOS) by lipopolysaccharide (LPS) and cytokines in microglia: in vitro and in vivo studies. Glia 32:51-59.
    • (2000) Glia , vol.32 , pp. 51-59
    • Possel, H.1    Noack, H.2    Putzke, J.3    Wolf, G.4    Sies, H.5
  • 35
    • 60849084461 scopus 로고    scopus 로고
    • A permeant regulating its permeation pore: Inhibition of pannexin 1 channels by ATP
    • Qiu F, Dahl G. 2009. A permeant regulating its permeation pore: Inhibition of pannexin 1 channels by ATP. Am J Physiol Cell Physiol 296:C250-C255.
    • (2009) Am J Physiol Cell Physiol , vol.296
    • Qiu, F.1    Dahl, G.2
  • 36
    • 52449104934 scopus 로고    scopus 로고
    • Proinflammatory stimuli are needed for induction of microglial cell-mediated AbetaPP_{244-C} and Abeta-neurotoxicity in hippocampal cultures
    • Ramirez G, Rey S, von Bernhardi R. 2008. Proinflammatory stimuli are needed for induction of microglial cell-mediated AbetaPP_{244-C} and Abeta-neurotoxicity in hippocampal cultures. J Alzheimers Dis 15:45-59.
    • (2008) J Alzheimers Dis , vol.15 , pp. 45-59
    • Ramirez, G.1    Rey, S.2    von Bernhardi, R.3
  • 37
    • 33745807628 scopus 로고    scopus 로고
    • Regulation of inducible nitric oxide synthase gene in glial cells
    • Saha RN, Pahan K. 2006. Regulation of inducible nitric oxide synthase gene in glial cells. Antioxid Redox Signal 8:929-947.
    • (2006) Antioxid Redox Signal , vol.8 , pp. 929-947
    • Saha, R.N.1    Pahan, K.2
  • 39
  • 43
    • 33746354022 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner
    • Takeuchi H, Jin S, Wang J, Zhang G, Kawanokuchi J, Kuno R, Sonobe Y, Mizuno T, Suzumura A. 2006. Tumor necrosis factor-alpha induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner. J Biol Chem 281:21362-21368.
    • (2006) J Biol Chem , vol.281 , pp. 21362-21368
    • Takeuchi, H.1    Jin, S.2    Wang, J.3    Zhang, G.4    Kawanokuchi, J.5    Kuno, R.6    Sonobe, Y.7    Mizuno, T.8    Suzumura, A.9
  • 44
    • 37049017788 scopus 로고    scopus 로고
    • Modulation by astrocytes of microglial cell-mediated neuroinflammation: Effect on the activation of microglial signaling pathways
    • Tichauer J, Saud K, von Bernhardi R. 2007. Modulation by astrocytes of microglial cell-mediated neuroinflammation: Effect on the activation of microglial signaling pathways. Neuroimmunomodulation 14:168-174.
    • (2007) Neuroimmunomodulation , vol.14 , pp. 168-174
    • Tichauer, J.1    Saud, K.2    von Bernhardi, R.3
  • 45
    • 60149101605 scopus 로고    scopus 로고
    • Reduction of beta-amyloid-induced neurotoxicity on hippocampal cell cultures by moderate acidosis is mediated by transforming growth factor beta
    • Uribe-San Martin R, Herrera-Molina R, Olavarria L, Ramirez G, von Bernhardi R. 2009. Reduction of beta-amyloid-induced neurotoxicity on hippocampal cell cultures by moderate acidosis is mediated by transforming growth factor beta. Neuroscience 158:1338-1347.
    • (2009) Neuroscience , vol.158 , pp. 1338-1347
    • Uribe-San Martin, R.1    Herrera-Molina, R.2    Olavarria, L.3    Ramirez, G.4    von Bernhardi, R.5
  • 46
    • 0035873729 scopus 로고    scopus 로고
    • ATP mediates calcium signaling between astrocytes and microglial cells: modulation by IFN-gamma
    • Verderio C, Matteoli M. 2001. ATP mediates calcium signaling between astrocytes and microglial cells: modulation by IFN-gamma. J Immunol 166:6383-6391.
    • (2001) J Immunol , vol.166 , pp. 6383-6391
    • Verderio, C.1    Matteoli, M.2
  • 47
    • 0031106002 scopus 로고    scopus 로고
    • Inhibition of endotoxin-induced nitric oxide synthase production in microglial cells by the presence of astroglial cells: A role for transforming growth factor beta
    • Vincent VA, Tilders FJ, Van Dam AM. 1997. Inhibition of endotoxin-induced nitric oxide synthase production in microglial cells by the presence of astroglial cells: A role for transforming growth factor beta. Glia 19:190-198.
    • (1997) Glia , vol.19 , pp. 190-198
    • Vincent, V.A.1    Tilders, F.J.2    Van Dam, A.M.3
  • 48
    • 0030174758 scopus 로고    scopus 로고
    • Gradual inhibition of inducible nitric oxide synthase but not of interleukin-1 beta production in rat microglial cells of endotoxin-treated mixed glial cell cultures
    • Vincent VA, Van Dam AM, Persoons JH, Schotanus K, Steinbusch HW, Schoffelmeer AN, Berkenbosch F. 1996. Gradual inhibition of inducible nitric oxide synthase but not of interleukin-1 beta production in rat microglial cells of endotoxin-treated mixed glial cell cultures. Glia 17:94-102.
    • (1996) Glia , vol.17 , pp. 94-102
    • Vincent, V.A.1    Van Dam, A.M.2    Persoons, J.H.3    Schotanus, K.4    Steinbusch, H.W.5    Schoffelmeer, A.N.6    Berkenbosch, F.7
  • 49
    • 41749116202 scopus 로고    scopus 로고
    • Glial cell dysregulation: A new perspective on Alzheimer disease
    • von Bernhardi R. 2007. Glial cell dysregulation: A new perspective on Alzheimer disease. Neurotox Res 12:215-232.
    • (2007) Neurotox Res , vol.12 , pp. 215-232
    • von Bernhardi, R.1
  • 50
    • 5344277492 scopus 로고    scopus 로고
    • Microglial reactivity to beta-amyloid is modulated by astrocytes and proinflammatory factors
    • von Bernhardi R, Eugenin J. 2004. Microglial reactivity to beta-amyloid is modulated by astrocytes and proinflammatory factors. Brain Res 1025:186-193.
    • (2004) Brain Res , vol.1025 , pp. 186-193
    • von Bernhardi, R.1    Eugenin, J.2
  • 52
    • 79955575162 scopus 로고    scopus 로고
    • International Union of Basic and Clinical Pharmacology. LXXXIII: Classification of prostanoid |receptors, #updating 15 years of progress
    • Woodward DF, Jones RL, Narumiya S. 2011. International Union of Basic and Clinical Pharmacology. LXXXIII: Classification of prostanoid |receptors, #updating 15 years of progress. Pharmacol Rev 63:471-538.
    • (2011) Pharmacol Rev , vol.63 , pp. 471-538
    • Woodward, D.F.1    Jones, R.L.2    Narumiya, S.3
  • 53
    • 0026554225 scopus 로고
    • Production of nitrite by neonatal rat microglial cells/brain macrophages
    • Zielasek J, Tausch M, Toyka KV, Hartung HP. 1992. Production of nitrite by neonatal rat microglial cells/brain macrophages. Cell Immunol 141:111-120.
    • (1992) Cell Immunol , vol.141 , pp. 111-120
    • Zielasek, J.1    Tausch, M.2    Toyka, K.V.3    Hartung, H.P.4


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