Identification of LRRC8 heteromers as an essential component of the volume-regulated anion channel VRAC

Science

Volumn 344, Issue 6184, 2014, Pages 634-638

  Voss, Felizia K ^a,b,c   Ullrich, Florian ^a,b,c   Mun̈ch, Jonas ^a,b,c   Lazarow, Katina ^a   Lutte, Darius ^a,b,c   Mah, Nancy ^b   Andrade Navarro, Miguel A ^b   Von Kries, Jens P ^a   Stauber, Tobias ^a,b   Jentsch, Thomas J ^a,b,d  

^a LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

^b MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^c FREIE UNIVERSITÄT BERLIN   (Germany)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

LRRC8 PROTEIN; MEMBRANE PROTEIN; SMALL INTERFERING RNA; TAURINE; UNCLASSIFIED DRUG; VOLUME REGULATED CHLORIDE CHANNEL; ZINC FINGER NUCLEASE; CHLORIDE CHANNEL; LRRC8A PROTEIN, HUMAN;

GENETIC ANALYSIS; GENOME; MAMMAL; MEMBRANE; OSMOSIS; PROTEIN; RNA;

ARTICLE; CELL VOLUME; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; INSECT CELL; MAMMAL CELL; PATCH CLAMP TECHNIQUE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REGULATORY MECHANISM; RNA INTERFERENCE; AGAMMAGLOBULINEMIA; CELL SIZE; GENE INACTIVATION; GENETIC ASSOCIATION; GENETIC TRANSFECTION; GENETICS; HCT116 CELL LINE; HEK293 CELL LINE; METABOLISM; MUTATION; PROTEIN MULTIMERIZATION;

MAMMALIA;

AGAMMAGLOBULINEMIA; CELL SIZE; CHLORIDE CHANNELS; GENE KNOCKOUT TECHNIQUES; GENOME-WIDE ASSOCIATION STUDY; HCT116 CELLS; HEK293 CELLS; HUMANS; MEMBRANE PROTEINS; MUTATION; PROTEIN MULTIMERIZATION; RNA INTERFERENCE; RNA, SMALL INTERFERING; TAURINE; TRANSFECTION;

EID: 84900461401     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1252826     Document Type: Article

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