Salivary markers of taste sensitivity to oleic acid: A combined proteomics and metabolomics approach

Metabolomics

Volumn 10, Issue 4, 2014, Pages 688-696

  Mounayar, Rana ^a   Morzel, Martine ^a   Brignot, Hélène ^a   Tremblay Franco, Marie ^b,c   Canlet, Cécile ^b,c   Lucchi, Géraldine ^d   Ducoroy, Patrick ^d   Feron, Gilles ^a   Neyraud, Eric ^a  

^a CENTRE DES SCIENCES DU GOÛT ET DE L ALIMENTATION   (France)

^b TOXALIM RESEARCH CENTRE IN FOOD TOXICOLOGY   (France)

^c UNIVERSITÉ DE TOULOUSE   (France)

^d IFR Sante STIC   (France)

Author keywords

Fat taste; Metabolome; Oleic acid; Proteome; Saliva

Indexed keywords

EID: 84904393285     PISSN: 15733882     EISSN: 15733890     Source Type: Journal    
DOI: 10.1007/s11306-013-0602-1     Document Type: Article

References (34)

1. Aimetti, M., Cacciatore, S., Graziano, A., & Tenori, L. (2012). Metabonomic analysis of saliva reveals generalized chronic periodontitis signature. Metabolomics, 8, 465-474.
2. Amerongen, A. V. N., & Veerman, E. C. I. (2002). Saliva-the defender of the oral cavity. Oral Diseases, 8, 12-22.
3. Bartoshuk, L. M. (1978). Psychophysics of taste. American Journal of Clinical Nutrition, 31, 1068-1077.
4. Bennick, A. (1982). Salivary proline-rich proteins. Molecular and Cellular Biochemistry, 45, 83-99.
5. Bertram, H. C., Eggers, N., & Eller, N. (2009). Potential of human saliva for nuclear magnetic resonance-based metabolomics and for health-related biomarker identification. Analytical Chemistry, 81, 9188-9193.
6. Brinkman, A. B., Ettema, T. J. G., de Vos, W. M., & van der Oost, J. (2003). The Lrp family of transcriptional regulators. Molecular Microbiology, 48, 287-294.
7. Cabras, T., Melis, M., Castagnola, M., Padiglia, A., Tepper, B. J., Messana, I., et al. (2012). Responsiveness to 6-n-propylthiouracil (PROP) is associated with salivary levels of two specific basic proline-rich proteins in humans. PLoS One, 7, e30962. doi: 10. 1371/journal. pone. 0030962.
8. Calo, C., Padiglia, A., Zonza, A., Corrias, L., Contu, P., Tepper, B. J., et al. (2011). Polymorphisrns in TAS2R38 and the taste bud trophic factor, gustin gene co-operate in modulating PROP taste phenotype. Physiology & Behavior, 104, 1065-1071.
9. Chale-Rush, A., Burgess, J. R., & Mattes, R. D. (2007). Evidence for human orosensory (taste?) sensitivity to free fatty acids. Chemical Senses, 32, 423-431.
10. Dickinson, D. P. (2002). Salivary (SD-type) cystatins: Over one billion years in the making-but to what purpose? Critical Reviews in Oral Biology and Medicine, 13, 485-508.
11. Dsamou, M., Palicki, O., Septier, C., Chabanet, C., Lucchi, G., Ducoroy, P., et al. (2012). Salivary protein profiles and sensitivity to the bitter taste of caffeine. Chemical Senses, 37, 87-95.
12. Fidalgo, T. K. S., Freitas-Fernandes, L. B., Angeli, R., Muniz, A. M. S., Gonsalves, E., Santos, R., et al. (2013). Salivary metabolite signatures of children with and without dental caries lesions. Metabolomics, 9, 657-666.
13. Galindo, M. M., Voigt, N., Stein, J., van Lengerich, J., Raguse, J. D., Hofmann, T., et al. (2012). G protein-coupled receptors in human fat taste perception. Chemical Senses, 37, 123-139.
14. Hassan, M. I., Waheed, A., Yadav, S., Singh, T. P., & Ahmad, F. (2008). Zinc alpha 2-glycoprotein: A multidisciplinary protein. Molecular Cancer Research, 6, 892-906.
15. Henkin, R. I., Lippoldt, R. E., Bilstad, J., & Edelhoch, H. (1975). Zinc protein isolated from human parotid saliva. Proceedings of the National Academy of Sciences of the United States of America, 72, 488-492.
16. Henkin, R. I., Martin, B. M., & Agarwal, R. P. (1999). Decreased parotid saliva gustin/carbonic anhydrase VI secretion: An enzyme disorder manifested by gustatory and olfactory dysfunction. American Journal of the Medical Sciences, 318, 380-391.
17. Hirtz, C., Chevalier, F., Centeno, D., Rofidal, V., Egea, J. C., Rossignol, M., et al. (2005). MS characterization of multiple forms of alpha-amylase in human saliva. Proteomics, 5, 4597-4607.
18. Igarashi, A., Ito, K., Funayama, S., Hitomi, Y., Nomura, S., Ikui, A., et al. (2008). The salivary protein profiles in the patients with taste disorders: The comparison of salivary protein profiles by two-dimensional gel electrophoresis between the patients with taste disorders and healthy subjects. Clinica Chimica Acta, 388, 204-206.
19. Kennedy, M. W., Heikema, A. P., Cooper, A., Bjorkman, P. J., & Sanchez, L. M. (2001). Hydrophobic ligand binding by Zn-alpha(2)-glycoprotein, a soluble fat-depleting factor related to major histocompatibility complex proteins. Journal of Biological Chemistry, 276, 35008-35013.
20. Mattes, R. D. (2009). Is there a fatty acid taste? Annual Review of Nutrition, 29, 305-327.
21. Melis, M., Aragoni, M. C., Arca, M., Cabras, T., Caltagirone, C., Castagnola, M., et al. (2013). Marked increase in PROP taste responsiveness following oral supplementation with selected salivary proteins or their related free amino acids. PLos One, 8(3), e59810.
22. Mounayar, R., Septier, C., Chabanet, C., Feron, G., & Neyraud, E. (2013). Oral fat sensitivity in humans: Links to saliva composition before and after stimulation by oleic acid. Chemosensory Perception, 6, 118-126.
23. Neyraud, E., Palicki, O., Schwartz, C., Nicklaus, S., & Feron, G. (2012). Variability of human saliva composition: Possible relationships with fat perception and liking. Archives of Oral Biology, 57, 556-566.
24. Neyraud, E., Tremblay-Franco, M., Gregoire, S., Berdeaux, O., & Canlet, C. (2013). Relationships between the metabolome and the fatty acid composition of human saliva; effects of stimulation. Metabolomics, 9, 213-222.
25. Padiglia, A., Zonza, A., Atzori, E., Chillotti, C., Calo, C., Tepper, B. J., et al. (2010). Sensitivity to 6-n-propylthiouracil is associated with gustin (carbonic anhydrase VI) gene polymorphism, salivary zinc, and body mass index in humans. American Journal of Clinical Nutrition, 92, 539-545.
26. Poette, J., Mekoue, J., Neyraud, E., Berdeaux, O., Renault, A., Guichard, E., Genot, C., Feron G. (in press). Fat sensitivity in humans: Oleic acid detection threshold is linked to saliva composition and oral volume. Flavour and Fragrance Journal. doi: 10. 1002/ffj. 3177.
27. Silwood, C. J. L., Lynch, E. J., Seddon, S., Sheerin, A., Claxson, A. W. D., & Grootveld, M. C. (1999). H-1-NMR analysis of microbial-derived organic acids in primary root carious lesions and saliva. NMR in Biomedicine, 12, 345-356.
28. Simons, P. J., Kummer, J. A., Luiken, J., & Boon, L. (2011). Apical CD36 immunolocalization in human and porcine taste buds from circumvallate and foliate papillae. Acta Histochemica, 113, 839-843.
29. Stewart, J. E., Feinle-Bisset, C., Golding, M., Delahunty, C., Clifton, P. M., & Keast, R. S. J. (2010). Oral sensitivity to fatty acids, food consumption and BMI in human subjects. British Journal of Nutrition, 104, 145-152.
30. Stewart, J. E., Seimon, R. V., Otto, B., Keast, R. S. J., Clifton, P. M., & Feinle-Bisset, C. (2011). Marked differences in gustatory and gastrointestinal sensitivity to oleic acid between lean and obese men. American Journal of Clinical Nutrition, 93, 703-711.
31. Sugimoto, M., Saruta, J., Matsuki, C., To, M., Onuma, H., Kaneko, M., et al. (2013). Physiological and environmental parameters associated with mass spectrometry-based salivary metabolomic profiles. Metabolomics, 9, 454-463.
32. Sugimoto, M., Wong, D. T., Hirayama, A., Soga, T., & Tomita, M. (2010). Capillary electrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancer-specific profiles. Metabolomics, 6, 78-95.
33. Takeda, I., Stretch, C., Barnaby, P., Bhatnager, K., Rankin, K., Fu, H., et al. (2009). Understanding the human salivary metabolome. NMR in Biomedicine, 22, 577-584.
34. Vinolo, M. A. R., Rodrigues, H. G., Nachbar, R. T., & Curi, R. (2011). Regulation of inflammation by short chain fatty acids. Nutrients, 3, 858-876.