Salivary protein profiles and sensitivity to the bitter taste of caffeine

Chemical Senses

Volumn 37, Issue 1, 2012, Pages 87-95

  Dsamou, Micheline ^a   Palicki, Olivier ^a   Septier, Chantal ^a   Chabanet, Claire ^a   Lucchi, Géraldine ^b   Ducoroy, Patrick ^b   Chagnon, Marie Christine ^a   Morzel, Martine ^a  

^a CENTRE DES SCIENCES DU GOÛT ET DE L ALIMENTATION   (France)

^b UNIVERSITÉ DE BOURGOGNE   (France)

Author keywords

Bitterness, cystatin; Proteolysis; Proteome; Saliva; Two dimensional electrophoresis

Indexed keywords

ALBUMIN; AMYLASE; CAFFEINE; CYSTATIN; CYSTATIN SN; IMMUNOGLOBULIN; PROTEOME; SALIVA PROTEIN; UNCLASSIFIED DRUG;

ADULT; ALBUMIN BLOOD LEVEL; ARTICLE; BITTER TASTE; CONTROLLED STUDY; HUMAN; HUMAN EXPERIMENT; MALE; MOUTH CAVITY; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONTENT; PROTEIN DEGRADATION; STIMULUS RESPONSE; TASK PERFORMANCE; TASTE ACUITY; TASTE DISCRIMINATION; TWO DIMENSIONAL ELECTROPHORESIS;

EID: 84555187707     PISSN: 0379864X     EISSN: 14643553     Source Type: Journal    
DOI: 10.1093/chemse/bjr070     Document Type: Article

References (39)

1. Bajec MR, Pickering GJ. 2008. Astringency: mechanisms and perception. Crit Rev Food Sci Nutr. 48:858-875.
2. Baron AC, DeCarlo AA, Featherstone JDB. 1999. Functional aspects of the human salivary cystatins in the oral environment. Oral Dis. 5:234-240.
3. Baron AC, Gansky SA, Ryder MI, Featherstone JDB. 1999. Cysteine protease inhibitory activity and levels of salivary cystatins in whole saliva of periodontally diseased patients. J Periodontal Res. 34:437-444.
4. Bradway SD, Bergey EJ, Jones PC, Levine MJ. 1989. Oral mucosal pellicle-adsorption and transpeptidation of salivary components to buccal epithelial cells. Biochem J. 261:887-896.
5. Bradway SD, Bergey EJ, Scannapieco FA, Ramasubbu N, Zawacki S, Levine MJ. 1992. Formation of salivary mucosal pellicle-the role of transglutaminase. Biochem J. 284:557-564.
6. Bufe B, Breslin PA, Kuhn C, Reed DR, Tharp CD, Slack JP, Kim UK, Drayna D, Meyerhof W. 2005. The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception. Curr Biol. 15:322-327.
7. Candiano G, Bruschi M, Musante L, Santucci L, Ghiggeri GM, Carnemolla B, Orecchia P, Zardi L, Righetti PG. 2004. Blue silver: a very sensitive colloidal Coomassie G-250 staining for proteome analysis. Electrophoresis. 25:1327-1333.
8. Chandrashekar J, Mueller KL, Hoon MA, Adler E, Feng LX, Guo W, Zuker CS, Ryba NJP. 2000. T2Rs function as bitter taste receptors. Cell. 100:703-711.
9. Dickinson DP. 2002. Salivary (SD-type) cystatins: over one billion years in the making-but to what purpose? Crit Rev Oral Biol Med. 13:485-508.
10. Dinnella C, Recchia A, Fia G, Bertuccioli M, Monteleone E. 2009. Saliva characteristics and individual sensitivity to phenolic astringent stimuli. Chem Senses. 34:295-304.
11. Dinnella C, Recchia A, Vincenzi S, Tuorila H, Monteleone E. 2010. Temporary modification of salivary protein profile and individual responses to repeated phenolic astringent stimuli. Chem Senses. 35:75-85.
12. Drewnowski A, Gomez-Carneros C. 2000. Bitter taste, phytonutrients, and the consumer: a review. Am J Clin Nutr. 72:1424-1435.
13. Gonçalves LD, Soares MR, Nogueira FCS, Garcia C, Camisasca DR, Domont G, Feitosa ACR, Pereira DD, Zingali RB, Alves G. 2010. Comparative proteomic analysis of whole saliva from chronic periodontitis patients. J Proteomics. 73:1334-1341.
14. Hansen JL, Reed DR, Wright MJ, Martin NG, Breslin PAS. 2006. Heritability and genetic covariation of sensitivity to PROP, SOA, quinine HCl, and caffeine. Chem Senses. 31:403-413.
15. Henskens YMC, Vandervelden U, Veerman ECI, Amerongen AVN. 1993. Protein, albumin and cystatin concentrations in saliva of healthy subjects and of patients with gingivitis or periodontitis. J Periodontal Res. 28:43-48.
16. Hershkovich O, Nagler RM. 2004. Biochemical analysis of saliva and taste acuity evaluation in patients with burning mouth syndrome, xerostomia and/or gustatory disturbances. Arch Oral Biol. 49:515-522.
17. Hirtz C, Chevalier F, Centeno D, Rofidal V, Egea JC, Rossignol M, Sommerer N, Deville de Perière D. 2005. MS characterization of multiple forms of alpha-amylase in human saliva. Proteomics. 5:4597-4607.
18. Hirtz C, Chevalier F, Sommerer N, Raingeard I, Bringer J, Rossignol M, Deville de Perière D. 2006. Salivary protein profiling in type I diabetes using twodimensional electrophoresis and mass spectrometry. Clin Proteomics. 2:117-127.
19. Hucklebridge F, Clow A, Evans P. 1998. The relationship between salivary secretory immunoglobulin A and cortisol: neuroendocrine response to awakening and the diurnal cycle. Int J Psychophysiol. 31:69-76.
20. Humphrey SP, Williamson RT. 2001. A review of saliva: normal composition, flow and unction. J Prosthet Dent. 85:162-169.
21. Igarashi A, Ito K, Funayama S, Hitomi Y, Ikui A, Ikeda M, Nomura S. 2008. The salivary protein profiles in the patients with taste disorders: the comparison of salivary protein profiles by two-dimensional gel electrophoresis between the patients with taste disorders and healthy subjects. Clin Chim Acta. 388:204-206.
22. Keast RSJ, Roper J. 2007. A complex relationship among chemical concentration, detection threshold, and suprathreshold intensity of bitter compounds. Chem Senses. 32:245-253.
23. Kim UK, Jorgenson E, Coon H, Leppert M, Risch N, Drayna D. 2003. Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide. Science. 299: 1221-1225.
24. Laemmli UK. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227:680-685.
25. Marcotte H, Lavoie MC. 1998. Oral microbial ecology and the role of salivary immunoglobulin A. Microbiol Mol Biol Rev. 62:71-109.
26. Meyerhof W, Batram C, Kuhn C, Brockhoff A, Chudoba E, Bufe B, Appendino G, Behrens M. 2010. The molecular receptive ranges of human TAS2R bitter taste receptors. Chem Senses. 35:157-170.
27. Nater UM, La Marca R, Florin L, Moses A, Langhans W, Koller MM, Ehlert U. 2006. Stress-induced changes in human salivary alphaamylase activity-associations with adrenergic activity. Psychoneuroendocrinology. 31:49-58.
28. Quintana M, Palicki O, Lucchi G, Ducoroy P, Chambon C, Salles C, Morzel M. 2009. Inter-individual variability of protein patterns in saliva of healthy adults. J Proteomics. 72:822-830.
29. Rudney JD, Ji Z, Larson CJ, Liljemark WF, Hickey KL. 1995. Saliva protein binding to layers of oral streptococci in vitro and in vivo. J Dent Res. 74:1280-1288.
30. Schiffman SS, Gatlin LA, Frey AE, Heiman SA, Stagner WC, Cooper DC. 1994. Taste perception of bitter compounds in young and elderly persons-relation to lipophilicity of bitter compounds. Neurobiol Aging. 15:743-750.
31. Schiffman SS, Zervakis J, Heffron S, Heald AE. 1999. Effect of protease inhibitors on the sense of taste. Nutrition. 15:767-772.
32. Shatzman AR, Henkin RI. 1981. Gustin concentration changes relative to salivary zinc and taste in humans. Proc Natl Acad Sci U S A. 78: 3867-3871.
33. Siqueira WL, Zhang W, Helmerhorst EJ, Gygi SP, Oppenheim FG. 2007. Identification of protein components in in vivo human acquired enamel pellicle using LC-ESI-MS/MS. J Proteome Res. 6:2152-2160.
34. Sistig S, Vucevic-Boras V, Lukac J, Kusic Z. 2002. Salivary IgA and IgG subclasses in oral mucosal diseases. Oral Dis. 8:282-286.
35. Teeuw W, Bosch JA, Veerman ECI, Amerongen AN. 2004. Neuroendocrine regulation of salivary IgA synthesis and secretion: implications for oral health. Biol Chem. 385:1137-1146.
36. Valdez IH, Fox PC. 1991. Interactions of the salivary and gastrointestinal systems. I. the role of saliva in digestion. Dig Dis. 9:125-132.
37. Wang H, Zhou ML, Brand J, Huang LQ. 2007. Inflammation activates the interferon signaling pathways in taste bud cells. J Neurosci. 27: 10703-10713.
38. Wickström C, Herzberg MC, Beighton D, Svensater G. 2009. Proteolytic degradation of human salivary MUC5B by dental biofilms. Microbiology. 155:2866-2872.
39. Wu Y, Shu R, Luo LJ, Ge LH, Xie YF. 2009. Initial comparison of proteomic profiles of whole unstimulated saliva obtained from generalized aggressive periodontitis patients and healthy control subjects. J Periodontal Res. 44:636-644.