Osteoclastogenesis and osteoimmunology

Frontiers in Bioscience - Landmark

Volumn 19, Issue 5, 2014, Pages 758-767

  Feng, Wei ^a,b   Xia, Wei ^a   Ye, Qing ^a   Wu, Weibing ^c  

^a SHANGHAI SEVENTH PEOPLE S HOSPITAL   (China)

^b SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^c SHANGHAI UNIVERSITY OF SPORT   (China)

Author keywords

Osteoclast; Osteoimmunology; Receptor, Activator Of Nuclear Factor KappaB, Ligand, Review

Indexed keywords

COLONY STIMULATING FACTOR 1; NFATC1 PROTEIN, HUMAN; OSTEOCLAST DIFFERENTIATION FACTOR; TRANSCRIPTION FACTOR NFAT;

ARTICLE; CALCIUM SIGNALING; CYTOLOGY; HUMAN; IMMUNOLOGY; OSTEOCLAST; PHYSIOLOGY; SIGNAL TRANSDUCTION;

CALCIUM SIGNALING; HUMANS; MACROPHAGE COLONY-STIMULATING FACTOR; NFATC TRANSCRIPTION FACTORS; OSTEOCLASTS; RANK LIGAND; SIGNAL TRANSDUCTION;

EID: 84904348346     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/4242     Document Type: Article

References (97)

1. M. Zaidi: Skeletal remodeling in health and disease. Nat Med 13(7), 791-801 (2007)
2. L. F. Bonewald: The amazing osteocyte. J Bone Miner Res 26(2), 229-38 (2011)
3. R. L. Duncan and C. H. Turner: Mechanotransduction and the functional response of bone to mechanical strain. Calcif Tissue Int 57(5) 344-58 (1995)
4. E. H. Burger, J. Klein-Nulend, A. van der Plas and P. J. Nijweide: Function of osteocytes in bone - their role in mechanotransduction. J Nutr 125(7 Suppl)2020S-2023S (1995)
5. C. M. Reijnders, N. Bravenboer, P. J. Holzmann, F. Bhoelan, M. A. Blankenstein and P. Lips: In vivo mechanical loading modulates insulin-like growth factor binding protein-2 gene expression in rat osteocytes. Calcif Tissue Int 80(2), 137-43 (2007)
6. C. Lin, X. Jiang, Z. Dai, X. Guo, T. Weng, J. Wang, Y. Li, G. Feng, X. Gao and L. He: Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/beta-catenin signaling. J Bone Miner Res 24(10), 1651-61 (2009)
7. K. Matsuo and N. Irie: Osteoclast-osteoblast communication. Arch Biochem Biophys 473(2), 201-9 (2008)
8. F. P. Ross and S. L. Teitelbaum: alphavbeta3 and macrophage colony-stimulating factor: partners in osteoclast biology. Immunol Rev 208, 88-105 (2005)
9. M. Asagiri and H. Takayanagi: The molecular understanding of osteoclast differentiation. Bone 40(2), 251-64 (2007)
10. H. Yoshida, S. Hayashi, T. Kunisada, M. Ogawa, S. Nishikawa, H. Okamura, T. Sudo and L. D. Shultz: The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene. Nature 345(6274), 442-4 (1990)
11. J. E. Horton, L. G. Raisz, H. A. Simmons, J. J. Oppenheim and S. E. Mergenhagen: Bone resorbing activity in supernatant fluid from cultured human peripheral blood leukocytes. Science 177(4051), 793-5 (1972)
12. F. E. Dewhirst, P. P. Stashenko, J. E. Mole and T. Tsurumachi: Purification and partial sequence of human osteoclast-activating factor: identity with interleukin 1 beta. J Immunol 135(4), 2562-8 (1985)
13. H. Takayanagi: Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. Nat Rev Immunol 7(4), 292-304 (2007)
14. P. J. Delves and I. M. Roitt: The immune system. First of two parts. N Engl J Med 343(1), 37-49 (2000)
15. W. Wiktor-Jedrzejczak, A. Bartocci, A. W. Ferrante, Jr., A. Ahmed-Ansari, K. W. Sell, J. W. Pollard and E. R. Stanley: Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op/op) mouse. Proc Natl Acad Sci U S A 87(12), 4828-32 (1990)
16. M. M. Tondravi, S. R. McKercher, K. Anderson, J. M. Erdmann, M. Quiroz, R. Maki and S. L. Teitelbaum: Osteopetrosis in mice lacking haematopoietic transcription factor PU.1. Nature 386(6620), 81-4 (1997)
17. G. G. McGill, M. Horstmann, H. R. Widlund, J. Du, G. Motyckova, E. K. Nishimura, Y. L. Lin, S. Ramaswamy, W. Avery, H. F. Ding, S. A. Jordan, I. J. Jackson, S. J. Korsmeyer, T. R. Golub and D. E. Fisher: Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability. Cell 109(6), 707-18 (2002)
18. E. Lagasse and I. L. Weissman: Enforced expression of Bcl-2 in monocytes rescues macrophages and partially reverses osteopetrosis in op/op mice. Cell 89(7), 1021-31 (1997)
19. F. P. Ross: M-CSF, c-Fms, and signaling in osteoclasts and their precursors. Ann N Y Acad Sci 1068, 110-6 (2006)
20. C. A. O'Brien: Control of RANKL gene expression. Bone 46(4), 911-9 (2010)
21. N. Takahashi, T. Akatsu, N. Udagawa, T. Sasaki, A. Yamaguchi, J. M. Moseley, T. J. Martin and T. Suda: Osteoblastic cells are involved in osteoclast formation. Endocrinology 123(5), 2600-2 (1988)
22. D. M. Anderson, E. Maraskovsky, W. L. Billingsley, W. C. Dougall, M. E. Tometsko, E. R. Roux, M. C. Teepe, R. F. DuBose, D. Cosman and L. Galibert: A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature 390(6656), 175-9 (1997)
23. B. R. Wong, J. Rho, J. Arron, E. Robinson, J. Orlinick, M. Chao, S. Kalachikov, E. Cayani, F. S. Bartlett, 3rd, W. N. Frankel, S. Y. Lee and Y. Choi: TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells. J Biol Chem 272(40), 25190-4 (1997)
24. J. Schlondorff, L. Lum and C. P. Blobel: Biochemical and pharmacological criteria define two shedding activities for TRANCE/OPGL that are distinct from the tumor necrosis factor alpha convertase. J Biol Chem 276(18), 14665-74 (2001)
25. T. Nakashima, Y. Kobayashi, S. Yamasaki, A. Kawakami, K. Eguchi, H. Sasaki and H. Sakai: Protein expression and functional difference of membrane-bound and soluble receptor activator of NF-kappaB ligand: modulation of the expression by osteotropic factors and cytokines. Biochem Biophys Res Commun 275(3), 768-75 (2000)
26. H. Yasuda, N. Shima, N. Nakagawa, K. Yamaguchi, M. Kinosaki, S. Mochizuki, A. Tomoyasu, K. Yano, M. Goto, A. Murakami, E. Tsuda, T. Morinaga, K. Higashio, N. Udagawa, N. Takahashi and T. Suda: Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc Natl Acad Sci U S A 95(7), 3597-602 (1998)
27. L. E. Theill, W. J. Boyle and J. M. Penninger: RANK-L and RANK: T cells, bone loss, and mammalian evolution. Annu Rev Immunol 20, 795-823 (2002)
28. T. J. Yun, P. M. Chaudhary, G. L. Shu, J. K. Frazer, M. K. Ewings, S. M. Schwartz, V. Pascual, L. E. Hood and E. A. Clark: OPG/FDCR-1, a TNF receptor family member, is expressed in lymphoid cells and is up-regulated by ligating CD40. J Immunol 161(11), 6113-21 (1998)
29. W. J. Boyle, W. S. Simonet and D. L. Lacey: Osteoclast differentiation and activation. Nature 423(6937), 337-42 (2003)
30. N. J. Horwood, V. Kartsogiannis, J. M. Quinn, E. Romas, T. J. Martin and M. T. Gillespie: Activated T lymphocytes support osteoclast formation in vitro. Biochem Biophys Res Commun 265(1), 144-50 (1999)
31. Y. Y. Kong, U. Feige, I. Sarosi, B. Bolon, A. Tafuri, S. Morony, C. Capparelli, J. Li, R. Elliott, S. McCabe, T. Wong, G. Campagnuolo, E. Moran, E. R. Bogoch, G. Van, L. T. Nguyen, P. S. Ohashi, D. L. Lacey, E. Fish, W. J. Boyle and J. M. Penninger: Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand. Nature 402(6759), 304-9 (1999)
32. S. Kotake, N. Udagawa, M. Hakoda, M. Mogi, K. Yano, E. Tsuda, K. Takahashi, T. Furuya, S. Ishiyama, K. J. Kim, S. Saito, T. Nishikawa, N. Takahashi, A. Togari, T. Tomatsu, T. Suda and N. Kamatani: Activated human T cells directly induce osteoclastogenesis from human monocytes: possible role of T cells in bone destruction in rheumatoid arthritis patients. Arthritis Rheum, 44(5), 1003-12 (2001)
33. A. Hikita, I. Yana, H. Wakeyama, M. Nakamura, Y. Kadono, Y. Oshima, K. Nakamura, M. Seiki and S. Tanaka: Negative regulation of osteoclastogenesis by ectodomain shedding of receptor activator of NF-kappaB ligand. J Biol Chem 281(48), 36846-55 (2006)
34. Y. Y. Kong, H. Yoshida, I. Sarosi, H. L. Tan, E. Timms, C. Capparelli, S. Morony, A. J. Oliveira-dos-Santos, G. Van, A. Itie, W. Khoo, A. Wakeham, C. R. Dunstan, D. L. Lacey, T. W. Mak, W. J. Boyle and J. M. Penninger: OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature 397(6717), 315-23 (1999)
35. M. F. Bachmann, B. R. Wong, R. Josien, R. M. Steinman, A. Oxenius and Y. Choi: TRANCE, a tumor necrosis factor family member critical for CD40 ligand-independent T helper cell activation. J Exp Med 189(7), 1025-31 (1999)
36. A. R. Moschen, A. Kaser, B. Enrich, O. Ludwiczek, M. Gabriel, P. Obrist, A. M. Wolf and H. Tilg: The RANKL/OPG system is activated in inflammatory bowel disease and relates to the state of bone loss. Gut 54(4), 479-87 (2005)
37. A. J. Ashcroft, S. M. Cruickshank, P. I. Croucher, M. J. Perry, S. Rollinson, J. M. Lippitt, J. A. Child, C. Dunstan, P. J. Felsburg, G. J. Morgan and S. R. Carding: Colonic dendritic cells, intestinal inflammation, and T cell-mediated bone destruction are modulated by recombinant osteoprotegerin. Immunity 19(6), 849-61 (2003)
38. E. A. Green, Y. Choi and R. A. Flavell: Pancreatic lymph node-derived CD4(+)CD25(+) Treg cells: highly potent regulators of diabetes that require TRANCE-RANK signals. Immunity 16(2), 183-91 (2002)
39. K. Loser, A. Mehling, S. Loeser, J. Apelt, A. Kuhn, S. Grabbe, T. Schwarz, J. M. Penninger and S. Beissert: Epidermal RANKL controls regulatory T-cell numbers via activation of dendritic cells. Nat Med 12(12), 1372-9 (2006)
40. D. H. Jones, T. Nakashima, O. H. Sanchez, I. Kozieradzki, S. V. Komarova, I. Sarosi, S. Morony, E. Rubin, R. Sarao, C. V. Hojilla, V. Komnenovic, Y. Y. Kong, M. Schreiber, S. J. Dixon, S. M. Sims, R. Khokha, T. Wada and J. M. Penninger: Regulation of cancer cell migration and bone metastasis by RANKL. Nature 440(7084), 692-6 (2006)
41. J. L. Bodmer, P. Schneider and J. Tschopp: The molecular architecture of the TNF superfamily. Trends Biochem Sci 27(1), 19-26 (2002)
42. M. A. Lomaga, W. C. Yeh, I. Sarosi, G. S. Duncan, C. Furlonger, A. Ho, S. Morony, C. Capparelli, G. Van, S. Kaufman, A. van der Heiden, A. Itie, A. Wakeham, W. Khoo, T. Sasaki, Z. Cao, J. M. Penninger, C. J. Paige, D. L. Lacey, C. R. Dunstan, W. J. Boyle, D. V. Goeddel and T. W. Mak: TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling. Genes Dev 13(8), 1015-24 (1999)
43. A. Naito, S. Azuma, S. Tanaka, T. Miyazaki, S. Takaki, K. Takatsu, K. Nakao, K. Nakamura, M. Katsuki, T. Yamamoto and J. Inoue: Severe osteopetrosis, defective interleukin-1 signalling and lymph node organogenesis in TRAF6-deficient mice. Genes Cells 4(6), 353-62 (1999)
44. B. R. Wong, D. Besser, N. Kim, J. R. Arron, M. Vologodskaia, H. Hanafusa and Y. Choi: TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src. Mol Cell 4(6), 1041-9 (1999)
45. X. Feng: RANKing intracellular signaling in osteoclasts. IUBMB Life 57(6), 389-95 (2005)
46. W. Liu, D. Xu, H. Yang, H. Xu, Z. Shi, X. Cao, S. Takeshita, J. Liu, M. Teale and X. Feng: Functional identification of three receptor activator of NF-kappa B cytoplasmic motifs mediating osteoclast differentiation and function. J Biol Chem 279(52), 54759-69 (2004)
47. G. Franzoso, L. Carlson, L. Xing, L. Poljak, E. W. Shores, K. D. Brown, A. Leonardi, T. Tran, B. F. Boyce and U. Siebenlist: Requirement for NF-kappaB in osteoclast and B-cell development. Genes Dev 11(24), 3482-96 (1997)
48. V. Iotsova, J. Caamano, J. Loy, Y. Yang, A. Lewin and R. Bravo: Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2. Nat Med 3(11), 1285-9 (1997)
49. N. Kobayashi, Y. Kadono, A. Naito, K. Matsumoto, T. Yamamoto, S. Tanaka and J. Inoue: Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesis. EMBO J 20(6), 1271-80 (2001)
50. S. W. Lee, S. I. Han, H. H. Kim and Z. H. Lee: TAK1-dependent activation of AP-1 and c-Jun N-terminal kinase by receptor activator of NF-kappaB. J Biochem Mol Biol 35(4), 371-6 (2002)
51. B. Ge, H. Gram, F. Di Padova, B. Huang, L. New, R. J. Ulevitch, Y. Luo and J. Han: MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha. Science 295(5558), 1291-4 (2002)
52. J. Gohda, T. Akiyama, T. Koga, H. Takayanagi, S. Tanaka and J. Inoue: RANK-mediated amplification of TRAF6 signaling leads to NFATc1 induction during osteoclastogenesis. EMBO J 24(4), 790-9 (2005)
53. T. Wada, T. Nakashima, A. J. Oliveira-dos-Santos, J. Gasser, H. Hara, G. Schett and J. M. Penninger: The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis. Nat Med 11(4), 394-9 (2005)
54. H. Takayanagi, S. Kim, T. Koga, H. Nishina, M. Isshiki, H. Yoshida, A. Saiura, M. Isobe, T. Yokochi, J. Inoue, E. F. Wagner, T. W. Mak, T. Kodama and T. Taniguchi: Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Dev Cell 3(6), 889-901 (2002)
55. G. R. Crabtree and E. N. Olson: NFAT signaling: choreographing the social lives of cells. Cell 109 Suppl, S67-79 (2002)
56. P. G. Hogan, L. Chen, J. Nardone and A. Rao: Transcriptional regulation by calcium, calcineurin, and NFAT. Genes Dev 17(18), 2205-32 (2003)
57. B. Zhao, M. Takami, A. Yamada, X. Wang, T. Koga, X. Hu, T. Tamura, K. Ozato, Y. Choi, L. B. Ivashkiv, H. Takayanagi and R. Kamijo: Interferon regulatory factor-8 regulates bone metabolism by suppressing osteoclastogenesis. Nat Med 15(9), 1066-71 (2009)
58. Y. Miyauchi, K. Ninomiya, H. Miyamoto, A. Sakamoto, R. Iwasaki, H. Hoshi, K. Miyamoto, W. Hao, S. Yoshida, H. Morioka, K. Chiba, S. Kato, T. Tokuhisa, M. Saitou, Y. Toyama, T. Suda and T. Miyamoto: The Blimp1-Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis. J Exp Med 207(4), 751-62 (2010)
59. K. Kim, J. H. Kim, J. Lee, H. M. Jin, H. Kook, K. K. Kim, S. Y. Lee and N. Kim: MafB negatively regulates RANKL-mediated osteoclast differentiation. Blood 109(8), 3253-9 (2007)
60. M. Asagiri, K. Sato, T. Usami, S. Ochi, H. Nishina, H. Yoshida, I. Morita, E. F. Wagner, T. W. Mak, E. Serfling and H. Takayanagi: Autoamplification of NFATc1 expression determines its essential role in bone homeostasis. J Exp Med 202(9), 1261-9 (2005)
61. A. O. Aliprantis, Y. Ueki, R. Sulyanto, A. Park, K. S. Sigrist, S. M. Sharma, M. C. Ostrowski, B. R. Olsen and L. H. Glimcher: NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism. J Clin Invest 118(11), 3775-89 (2008)
62. K. Matsuo, D. L. Galson, C. Zhao, L. Peng, C. Laplace, K. Z. Wang, M. A. Bachler, H. Amano, H. Aburatani, H. Ishikawa and E. F. Wagner: Nuclear factor of activated T-cells (NFAT) rescues osteoclastogenesis in precursors lacking c-Fos. J Biol Chem 279(25), 26475-80 (2004)
63. S. V. Komarova, A. Pereverzev, J. W. Shum, S. M. Sims and S. J. Dixon: Convergent signaling by acidosis and receptor activator of NF-kappaB ligand (RANKL) on the calcium/calcineurin/NFAT pathway in osteoclasts. Proc Natl Acad Sci U S A 102(7), 2643-8 (2005)
64. R. E. Dolmetsch, R. S. Lewis, C. C. Goodnow and J. I. Healy: Differential activation of transcription factors induced by Ca2+ response amplitude and duration. Nature 386(6627), 855-8 (1997)
65. R. E. Dolmetsch, K. Xu and R. S. Lewis: Calcium oscillations increase the efficiency and specificity of gene expression. Nature 392(6679), 933-6 (1998)
66. T. Tomida, K. Hirose, A. Takizawa, F. Shibasaki and M. Iino: NFAT functions as a working memory of Ca2+ signals in decoding Ca2+ oscillation. EMBO J 22(15), 3825-32 (2003)
67. T. Koga, Y. Matsui, M. Asagiri, T. Kodama, B. de Crombrugghe, K. Nakashima and H. Takayanagi: NFAT and Osterix cooperatively regulate bone formation. Nat Med 11(8), 880-5 (2005)
68. R. S. Lewis: The molecular choreography of a store-operated calcium channel. Nature 446(7133), 284-7 (2007)
69. M. J. Berridge, M. D. Bootman and H. L. Roderick: Calcium signalling: dynamics, homeostasis and remodelling. Nat Rev Mol Cell Biol 4(7), 517-29 (2003)
70. M. D. Bootman and M. J. Berridge: The elemental principles of calcium signaling. Cell 83(5), 675-8 (1995)
71. D. E. Clapham: Calcium signaling. Cell 131(6), 1047-58 (2007)
72. Y. Kuroda, C. Hisatsune, T. Nakamura, K. Matsuo and K. Mikoshiba: Osteoblasts induce Ca2+ oscillationin-dependent NFATc1 activation during osteoclastogenesis. Proc Natl Acad Sci U S A 105(25), 8643-8 (2008)
73. T. Koga, M. Inui, K. Inoue, S. Kim, A. Suematsu, E. Kobayashi, T. Iwata, H. Ohnishi, T. Matozaki, T. Kodama, T. Taniguchi, H. Takayanagi and T. Takai: Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis. Nature 428(6984), 758-63 (2004)
74. A. D. Barrow, N. Raynal, T. L. Andersen, D. A. Slatter, D. Bihan, N. Pugh, M. Cella, T. Kim, J. Rho, T. Negishi-Koga, J. M. Delaisse, H. Takayanagi, J. Lorenzo, M. Colonna, R. W. Farndale, Y. Choi and J. Trowsdale: OSCAR is a collagen receptor that costimulates osteoclastogenesis in DAP12-deficient humans and mice. J Clin Invest 121(9), 3505-16 (2011)
75. W. Zou, J. L. Reeve, Y. Liu, S. L. Teitelbaum and F. P. Ross: DAP12 couples c-Fms activation to the osteoclast cytoskeleton by recruitment of Syk. Mol Cell 31(3), 422-31 (2008)
76. M. Shinohara, T. Koga, K. Okamoto, S. Sakaguchi, K. Arai, H. Yasuda, T. Takai, T. Kodama, T. Morio, R. S. Geha, D. Kitamura, T. Kurosaki, W. Ellmeier and H. Takayanagi: Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals. Cell 132(5), 794-806 (2008)
77. S. B. Cohen, R. K. Dore, N. E. Lane, P. A. Ory, C. G. Peterfy, J. T. Sharp, D. van der Heijde, L. Zhou, W. Tsuji and R. Newmark: Denosumab treatment effects on structural damage, bone mineral density, and bone turnover in rheumatoid arthritis: a twelve-month, multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial. Arthritis Rheum 58(5), 1299-309 (2008)
78. A. Deodhar, R. K. Dore, D. Mandel, J. Schechtman, W. Shergy, R. Trapp, P. A. Ory, C. G. Peterfy, T. Fuerst, H. Wang, L. Zhou, W. Tsuji and R. Newmark: Denosumab-mediated increase in hand bone mineral density associated with decreased progression of bone erosion in rheumatoid arthritis patients. Arthritis Care Res (Hoboken) 62(4), 569-74 (2010)
79. H. Takayanagi, K. Ogasawara, S. Hida, T. Chiba, S. Murata, K. Sato, A. Takaoka, T. Yokochi, H. Oda, K. Tanaka, K. Nakamura and T. Taniguchi: T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma. Nature 408(6812), 600-5 (2000)
80. K. A. Mensah, A. Mathian, L. Ma, L. Xing, C. T. Ritchlin and E. M. Schwarz: Mediation of nonerosive arthritis in a mouse model of lupus by interferon-alpha-stimulated monocyte differentiation that is nonpermissive of osteoclastogenesis. Arthritis Rheum 62(4), 1127-37 (2010)
81. M. M. Zaiss, B. Frey, A. Hess, J. Zwerina, J. Luther, F. Nimmerjahn, K. Engelke, G. Kollias, T. Hunig, G. Schett and J. P. David: Regulatory T cells protect from local and systemic bone destruction in arthritis. J Immunol 184(12), 7238-46 (2010)
82. M. M. Zaiss, R. Axmann, J. Zwerina, K. Polzer, E. Guckel, A. Skapenko, H. Schulze-Koops, N. Horwood, A. Cope and G. Schett: Treg cells suppress osteoclast formation: a new link between the immune system and bone. Arthritis Rheum 56(12), 4104-12 (2007)
83. J. J. Goronzy and C. M. Weyand: Rheumatoid arthritis. Immunol Rev 204, 55-73 (2005)
84. G. Husby and R. C. Williams, Jr.: Immunohistochemical studies of interleukin-2 and gamma-interferon in rheumatoid arthritis. Arthritis Rheum 28(2), 174-81 (1985)
85. L. E. Harrington, R. D. Hatton, P. R. Mangan, H. Turner, T. L. Murphy, K. M. Murphy and C. T. Weaver: Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 6(11), 1123-32 (2005)
86. H. Park, Z. Li, X. O. Yang, S. H. Chang, R. Nurieva, Y. H. Wang, Y. Wang, L. Hood, Z. Zhu, Q. Tian and C. Dong: A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 6(11), 1133-41 (2005)
87. K. Raza, F. Falciani, S. J. Curnow, E. J. Ross, C. Y. Lee, A. N. Akbar, J. M. Lord, C. Gordon, C. D. Buckley and M. Salmon: Early rheumatoid arthritis is characterized by a distinct and transient synovial fluid cytokine profile of T cell and stromal cell origin. Arthritis Res Ther 7(4), R784-95 (2005)
88. N. J. Wilson, K. Boniface, J. R. Chan, B. S. McKenzie, W. M. Blumenschein, J. D. Mattson, B. Basham, K. Smith, T. Chen, F. Morel, J. C. Lecron, R. A. Kastelein, D. J. Cua, T. K. McClanahan, E. P. Bowman and R. de Waal Malefyt: Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nat Immunol 8(9), 950-7 (2007)
89. E. V. Acosta-Rodriguez, G. Napolitani, A. Lanzavecchia and F. Sallusto: Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat Immunol 8(9), 942-9 (2007)
90. Q. Tang and J. A. Bluestone: The Foxp3+ regulatory T cell: a jack of all trades, master of regulation. Nat Immunol 9(3), 239-44 (2008)
91. M. R. Ehrenstein, J. G. Evans, A. Singh, S. Moore, G. Warnes, D. A. Isenberg and C. Mauri: Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy. J Exp Med 200(3), 277-85 (2004)
92. E. M. Gravallese, Y. Harada, J. T. Wang, A. H. Gorn, T. S. Thornhill and S. R. Goldring: Identification of cell types responsible for bone resorption in rheumatoid arthritis and juvenile rheumatoid arthritis. Am J Pathol 152(4), 943-51 (1998)
93. H. Takayanagi, H. Oda, S. Yamamoto, H. Kawaguchi, S. Tanaka, T. Nishikawa and Y. Koshihara: A new mechanism of bone destruction in rheumatoid arthritis: synovial fibroblasts induce osteoclastogenesis. Biochem Biophys Res Commun 240(2), 279-86 (1997)
94. H. Takayanagi, H. Iizuka, T. Juji, T. Nakagawa, A. Yamamoto, T. Miyazaki, Y. Koshihara, H. Oda, K. Nakamura and S. Tanaka: Involvement of receptor activator of nuclear factor kappaB ligand/osteoclast differentiation factor in osteoclastogenesis from synoviocytes in rheumatoid arthritis. Arthritis Rheum 43(2), 259-69 (2000)
95. E. M. Gravallese, C. Manning, A. Tsay, A. Naito, C. Pan, E. Amento and S. R. Goldring: Synovial tissue in rheumatoid arthritis is a source of osteoclast differentiation factor. Arthritis Rheum 43(2), 250-8 (2000)
96. Y. Kadono, S. Tanaka, J. Nishino, K. Nishimura, I. Nakamura, T. Miyazaki, H. Takayanagi and K. Nakamura: Rheumatoid arthritis associated with osteopetrosis. Mod Rheumatol 19(6), 687-90 (2009)
97. A. R. Pettit, H. Ji, D. von Stechow, R. Muller, S. R. Goldring, Y. Choi, C. Benoist and E. M. Gravallese: TRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis. Am J Pathol 159(5), 1689-99 (2001)