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Volumn 105, Issue 7, 2014, Pages 749-754

Specific molecular signatures of non-tumor liver tissue may predict a risk of hepatocarcinogenesis

Author keywords

Carcinogenesis; DNA methylation; Epigenetics; Hepatocellular carcinoma; Microarray

Indexed keywords

HEPATITIS B CORE ANTIBODY;

EID: 84904333634     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/cas.12431     Document Type: Review
Times cited : (20)

References (66)
  • 2
    • 33747830764 scopus 로고    scopus 로고
    • Hepatocellular carcinoma pathogenesis: from genes to environment
    • Farazi PA, DePinho RA. Hepatocellular carcinoma pathogenesis: from genes to environment. Nat Rev Cancer 2006; 6: 674-87.
    • (2006) Nat Rev Cancer , vol.6 , pp. 674-687
    • Farazi, P.A.1    DePinho, R.A.2
  • 3
    • 0028241689 scopus 로고
    • Viruses and hepatocellular carcinoma
    • Sherlock S. Viruses and hepatocellular carcinoma. Gut 1994; 35: 828-32.
    • (1994) Gut , vol.35 , pp. 828-832
    • Sherlock, S.1
  • 4
    • 58849087179 scopus 로고    scopus 로고
    • Early HCC: diagnosis and molecular markers
    • Sakamoto M. Early HCC: diagnosis and molecular markers. J Gastroenterol 2009; 44: 108-11.
    • (2009) J Gastroenterol , vol.44 , pp. 108-111
    • Sakamoto, M.1
  • 5
    • 0037443891 scopus 로고    scopus 로고
    • Oligonucleotide microarray for prediction of early intrahepatic recurrence of hepatocellular carcinoma after curative resection
    • Iizuka N, Oka M, Yamada Okabe H et al. Oligonucleotide microarray for prediction of early intrahepatic recurrence of hepatocellular carcinoma after curative resection. Lancet 2003; 361: 923-9.
    • (2003) Lancet , vol.361 , pp. 923-929
    • Iizuka, N.1    Oka, M.2    Yamada Okabe, H.3
  • 6
    • 61349127144 scopus 로고    scopus 로고
    • Molecular prediction of early recurrence after resection of hepatocellular carcinoma
    • Yoshioka S, Takemasa I, Nagano H et al. Molecular prediction of early recurrence after resection of hepatocellular carcinoma. Eur J Cancer 2009; 45: 881-9.
    • (2009) Eur J Cancer , vol.45 , pp. 881-889
    • Yoshioka, S.1    Takemasa, I.2    Nagano, H.3
  • 7
    • 0034255520 scopus 로고    scopus 로고
    • Different risk factors and prognosis for early and late intrahepatic recurrence after resection of hepatocellular carcinoma
    • Poon RT, Fan ST, Ng IO, Lo CM, Liu CL, Wong J. Different risk factors and prognosis for early and late intrahepatic recurrence after resection of hepatocellular carcinoma. Cancer 2000; 89: 500-7.
    • (2000) Cancer , vol.89 , pp. 500-507
    • Poon, R.T.1    Fan, S.T.2    Ng, I.O.3    Lo, C.M.4    Liu, C.L.5    Wong, J.6
  • 8
    • 0028316863 scopus 로고
    • Possible multicentric occurrence of hepatocellular carcinoma: a clinicopathological study
    • Takenaka K, Adachi E, Nishizaki T et al. Possible multicentric occurrence of hepatocellular carcinoma: a clinicopathological study. Hepatology 1994; 19: 889-94.
    • (1994) Hepatology , vol.19 , pp. 889-894
    • Takenaka, K.1    Adachi, E.2    Nishizaki, T.3
  • 9
    • 1242336973 scopus 로고    scopus 로고
    • Cancer-associated molecular signature in the tissue samples of patients with cirrhosis
    • Kim JW, Ye Q, Forgues M et al. Cancer-associated molecular signature in the tissue samples of patients with cirrhosis. Hepatology 2004; 39: 518-27.
    • (2004) Hepatology , vol.39 , pp. 518-527
    • Kim, J.W.1    Ye, Q.2    Forgues, M.3
  • 10
    • 77949265477 scopus 로고    scopus 로고
    • Molecular signatures of noncancerous liver tissue can predict the risk for late recurrence of hepatocellular carcinoma
    • Utsunomiya T, Shimada M, Imura S et al. Molecular signatures of noncancerous liver tissue can predict the risk for late recurrence of hepatocellular carcinoma. J Gastroenterol 2010; 45: 146-52.
    • (2010) J Gastroenterol , vol.45 , pp. 146-152
    • Utsunomiya, T.1    Shimada, M.2    Imura, S.3
  • 11
    • 80053305648 scopus 로고    scopus 로고
    • Oxidative stress pathways in noncancerous human liver tissue to predict hepatocellular carcinoma recurrence: a prospective, multicenter study
    • Tanaka S, Mogushi K, Yasen M et al. Oxidative stress pathways in noncancerous human liver tissue to predict hepatocellular carcinoma recurrence: a prospective, multicenter study. Hepatology 2011; 54: 1273-81.
    • (2011) Hepatology , vol.54 , pp. 1273-1281
    • Tanaka, S.1    Mogushi, K.2    Yasen, M.3
  • 12
    • 78651056338 scopus 로고
    • Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin
    • Slaughter DP, Southwick HW, Smejkal W. Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin. Cancer 1953; 6: 963-8.
    • (1953) Cancer , vol.6 , pp. 963-968
    • Slaughter, D.P.1    Southwick, H.W.2    Smejkal, W.3
  • 13
    • 25144518262 scopus 로고    scopus 로고
    • MGMT promoter methylation and field defect in sporadic colorectal cancer
    • Shen L, Kondo Y, Rosner GL et al. MGMT promoter methylation and field defect in sporadic colorectal cancer. J Natl Cancer Inst 2005; 97: 1330-8.
    • (2005) J Natl Cancer Inst , vol.97 , pp. 1330-1338
    • Shen, L.1    Kondo, Y.2    Rosner, G.L.3
  • 14
    • 33846332769 scopus 로고    scopus 로고
    • Clonality and prognostic implications of p53 and epidermal growth factor receptor somatic aberrations in multiple primary lung cancers
    • Chang YL, Wu CT, Lin SC, Hsiao CF, Jou YS, Lee YC. Clonality and prognostic implications of p53 and epidermal growth factor receptor somatic aberrations in multiple primary lung cancers. Clin Cancer Res 2007; 13: 52-8.
    • (2007) Clin Cancer Res , vol.13 , pp. 52-58
    • Chang, Y.L.1    Wu, C.T.2    Lin, S.C.3    Hsiao, C.F.4    Jou, Y.S.5    Lee, Y.C.6
  • 15
    • 67649870740 scopus 로고    scopus 로고
    • Aberrant DNA methylation profile of hepatocellular carcinoma and surgically resected margin
    • Lou C, Du Z, Yang B, Gao Y, Wang Y, Fang S. Aberrant DNA methylation profile of hepatocellular carcinoma and surgically resected margin. Cancer Sci 2009; 100: 996-1004.
    • (2009) Cancer Sci , vol.100 , pp. 996-1004
    • Lou, C.1    Du, Z.2    Yang, B.3    Gao, Y.4    Wang, Y.5    Fang, S.6
  • 16
    • 33745225917 scopus 로고    scopus 로고
    • Specific gene-expression profiles of noncancerous liver tissue predict the risk for multicentric occurrence of hepatocellular carcinoma in hepatitis C virus-positive patients
    • Utsunomiya T, Okamoto M, Wakiyama S et al. Specific gene-expression profiles of noncancerous liver tissue predict the risk for multicentric occurrence of hepatocellular carcinoma in hepatitis C virus-positive patients. Ann Surg Oncol 2006; 13: 947-54.
    • (2006) Ann Surg Oncol , vol.13 , pp. 947-954
    • Utsunomiya, T.1    Okamoto, M.2    Wakiyama, S.3
  • 17
    • 57349090407 scopus 로고    scopus 로고
    • Gene expression in fixed tissues and outcome in hepatocellular carcinoma
    • Hoshida Y, Villanueva A, Kobayashi M et al. Gene expression in fixed tissues and outcome in hepatocellular carcinoma. N Engl J Med 2008; 359: 1995-2004.
    • (2008) N Engl J Med , vol.359 , pp. 1995-2004
    • Hoshida, Y.1    Villanueva, A.2    Kobayashi, M.3
  • 18
    • 77950670673 scopus 로고    scopus 로고
    • Gene expression in nontumoral liver tissue and recurrence-free survival in hepatitis C virus-positive hepatocellular carcinoma
    • Tsuchiya M, Parker JS, Kono H et al. Gene expression in nontumoral liver tissue and recurrence-free survival in hepatitis C virus-positive hepatocellular carcinoma. Mol Cancer 2010; 9: 74.
    • (2010) Mol Cancer , vol.9 , pp. 74
    • Tsuchiya, M.1    Parker, J.S.2    Kono, H.3
  • 19
    • 58249088751 scopus 로고    scopus 로고
    • MicroRNAs: target recognition and regulatory functions
    • Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell 2009; 136: 215-33.
    • (2009) Cell , vol.136 , pp. 215-233
    • Bartel, D.P.1
  • 20
    • 33845317603 scopus 로고    scopus 로고
    • A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure
    • van Rooij E, Sutherland LB, Liu N et al. A signature pattern of stress-responsive microRNAs that can evoke cardiac hypertrophy and heart failure. Proc Natl Acad Sci U S A 2006; 103: 18255-60.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 18255-18260
    • van Rooij, E.1    Sutherland, L.B.2    Liu, N.3
  • 21
    • 33845312687 scopus 로고    scopus 로고
    • MicroRNA responses to cellular stress
    • Marsit CJ, Eddy K, Kelsey KT. MicroRNA responses to cellular stress. Cancer Res 2006; 66: 10843-8.
    • (2006) Cancer Res , vol.66 , pp. 10843-10848
    • Marsit, C.J.1    Eddy, K.2    Kelsey, K.T.3
  • 22
    • 55149109188 scopus 로고    scopus 로고
    • Regulation of microRNA processing in development, differentiation and cancer
    • Schmittgen TD. Regulation of microRNA processing in development, differentiation and cancer. J Cell Mol Med 2008; 12: 1811-9.
    • (2008) J Cell Mol Med , vol.12 , pp. 1811-1819
    • Schmittgen, T.D.1
  • 23
    • 20444460289 scopus 로고    scopus 로고
    • MicroRNA expression profiles classify human cancers
    • Lu J, Getz G, Miska EA et al. MicroRNA expression profiles classify human cancers. Nature 2005; 435: 834-8.
    • (2005) Nature , vol.435 , pp. 834-838
    • Lu, J.1    Getz, G.2    Miska, E.A.3
  • 24
    • 65349117527 scopus 로고    scopus 로고
    • MiRNAs and cancer
    • Visone R, Croce CM. MiRNAs and cancer. Am J Pathol 2009; 174: 1131-8.
    • (2009) Am J Pathol , vol.174 , pp. 1131-1138
    • Visone, R.1    Croce, C.M.2
  • 25
    • 70349871321 scopus 로고    scopus 로고
    • MicroRNA expression, survival, and response to interferon in liver cancer
    • Ji J, Shi J, Budhu A et al. MicroRNA expression, survival, and response to interferon in liver cancer. N Engl J Med 2009; 361: 1437-47.
    • (2009) N Engl J Med , vol.361 , pp. 1437-1447
    • Ji, J.1    Shi, J.2    Budhu, A.3
  • 26
    • 38949184246 scopus 로고    scopus 로고
    • Association of MicroRNA expression in hepatocellular carcinomas with hepatitis infection, cirrhosis, and patient survival
    • Jiang J, Gusev Y, Aderca I et al. Association of MicroRNA expression in hepatocellular carcinomas with hepatitis infection, cirrhosis, and patient survival. Clin Cancer Res 2008; 142: 419-27.
    • (2008) Clin Cancer Res , vol.142 , pp. 419-427
    • Jiang, J.1    Gusev, Y.2    Aderca, I.3
  • 27
    • 40949087185 scopus 로고    scopus 로고
    • Identification of metastasis-related microRNAs in hepatocellular carcinoma
    • Budhu A, Jia HL, Forgues M et al. Identification of metastasis-related microRNAs in hepatocellular carcinoma. Hepatology 2008; 473: 897-907.
    • (2008) Hepatology , vol.473 , pp. 897-907
    • Budhu, A.1    Jia, H.L.2    Forgues, M.3
  • 28
    • 79551507191 scopus 로고    scopus 로고
    • MicroRNA profile predicts recurrence after resection in patients with hepatocellular carcinoma within the Milan criteria
    • Sato F, Hatano E, Kitamura K et al. MicroRNA profile predicts recurrence after resection in patients with hepatocellular carcinoma within the Milan criteria. PLoS One 2011; 61: e16435.
    • (2011) PLoS One , vol.61
    • Sato, F.1    Hatano, E.2    Kitamura, K.3
  • 29
    • 67649881121 scopus 로고    scopus 로고
    • Lin28 promotes transformation and is associated with advanced human malignancies
    • Viswanathan SR, Powers JT, Einhorn W et al. Lin28 promotes transformation and is associated with advanced human malignancies. Nat Genet 2009; 417: 843-8.
    • (2009) Nat Genet , vol.417 , pp. 843-848
    • Viswanathan, S.R.1    Powers, J.T.2    Einhorn, W.3
  • 30
    • 84859986442 scopus 로고    scopus 로고
    • Sequential alterations of microRNA expression in hepatocellular carcinoma development and venous metastasis
    • Wong CM, Wong CC, Lee JM, Fan DN, Au SL, Ng IO. Sequential alterations of microRNA expression in hepatocellular carcinoma development and venous metastasis. Hepatology 2012; 55: 1453-61.
    • (2012) Hepatology , vol.55 , pp. 1453-1461
    • Wong, C.M.1    Wong, C.C.2    Lee, J.M.3    Fan, D.N.4    Au, S.L.5    Ng, I.O.6
  • 31
    • 84874414022 scopus 로고    scopus 로고
    • The expression level of miR-18b in hepatocellular carcinoma is associated with the grade of malignancy and prognosis
    • Murakami Y, Tamori A, Itami S et al. The expression level of miR-18b in hepatocellular carcinoma is associated with the grade of malignancy and prognosis. BMC Cancer 2013; 13: 99.
    • (2013) BMC Cancer , vol.13 , pp. 99
    • Murakami, Y.1    Tamori, A.2    Itami, S.3
  • 32
    • 84901914956 scopus 로고    scopus 로고
    • Specific miRNA expression profiles of non-tumor liver tissue predict a risk for recurrence of hepatocellular carcinoma
    • doi: 10.1111/hepr.12164 [Epub ahead of print].
    • Utsunomiya T, Ishikawa D, Asanoma M et al. Specific miRNA expression profiles of non-tumor liver tissue predict a risk for recurrence of hepatocellular carcinoma. Hepatol Res 2013; doi: 10.1111/hepr.12164 [Epub ahead of print].
    • (2013) Hepatol Res
    • Utsunomiya, T.1    Ishikawa, D.2    Asanoma, M.3
  • 33
    • 73949158230 scopus 로고    scopus 로고
    • n-3 Polyunsaturated fatty acids modulate carcinogen-directed non-coding microRNA signatures in rat colon
    • Davidson LA, Wang N, Shah MS, Lupton JR, Ivanov I, Chapkin RS. n-3 Polyunsaturated fatty acids modulate carcinogen-directed non-coding microRNA signatures in rat colon. Carcinogenesis 2009; 30: 2077-84.
    • (2009) Carcinogenesis , vol.30 , pp. 2077-2084
    • Davidson, L.A.1    Wang, N.2    Shah, M.S.3    Lupton, J.R.4    Ivanov, I.5    Chapkin, R.S.6
  • 34
    • 84857468335 scopus 로고    scopus 로고
    • MicroRNAs targeting oncogenes are down-regulated in pancreatic malignant transformation from benign tumors
    • Jiao LR, Frampton AE, Jacob J et al. MicroRNAs targeting oncogenes are down-regulated in pancreatic malignant transformation from benign tumors. PLoS One 2012; 7: e32068.
    • (2012) PLoS One , vol.7
    • Jiao, L.R.1    Frampton, A.E.2    Jacob, J.3
  • 35
    • 10344260184 scopus 로고    scopus 로고
    • CpG island methylator phenotype in cancer
    • Issa JP. CpG island methylator phenotype in cancer. Nat Rev Cancer 2004; 4: 988-93.
    • (2004) Nat Rev Cancer , vol.4 , pp. 988-993
    • Issa, J.P.1
  • 36
    • 29344455676 scopus 로고    scopus 로고
    • The relationship between global methylation level, loss of heterozygosity, and microsatellite instability in sporadic colorectal cancer
    • Matsuzaki K, Deng G, Tanaka H, Kakar S, Miura S, Kim YS. The relationship between global methylation level, loss of heterozygosity, and microsatellite instability in sporadic colorectal cancer. Clin Cancer Res 2005; 11: 8564-9.
    • (2005) Clin Cancer Res , vol.11 , pp. 8564-8569
    • Matsuzaki, K.1    Deng, G.2    Tanaka, H.3    Kakar, S.4    Miura, S.5    Kim, Y.S.6
  • 37
    • 0035872493 scopus 로고    scopus 로고
    • Genome-wide hypomethylation in hepatocellular carcinogenesis
    • Lin CH, Hsieh SY, Sheen IS et al. Genome-wide hypomethylation in hepatocellular carcinogenesis. Cancer Res 2001; 61: 4238-43.
    • (2001) Cancer Res , vol.61 , pp. 4238-4243
    • Lin, C.H.1    Hsieh, S.Y.2    Sheen, I.S.3
  • 38
    • 0037094189 scopus 로고    scopus 로고
    • DNA methylation and environmental exposures in human hepatocellular car- cinoma
    • Shen L, Ahuja N, Shen Y et al. DNA methylation and environmental exposures in human hepatocellular car- cinoma. J Natl Cancer Inst 2002; 94: 755-61.
    • (2002) J Natl Cancer Inst , vol.94 , pp. 755-761
    • Shen, L.1    Ahuja, N.2    Shen, Y.3
  • 39
    • 34848881905 scopus 로고    scopus 로고
    • Mechanistic and prognostic significance of aberrant methylation in the molecular pathogenesis of human hepatocellular carcinoma
    • Calvisi DF, Ladu S, Gorden A et al. Mechanistic and prognostic significance of aberrant methylation in the molecular pathogenesis of human hepatocellular carcinoma. J Clin Invest 2007; 117: 2713-22.
    • (2007) J Clin Invest , vol.117 , pp. 2713-2722
    • Calvisi, D.F.1    Ladu, S.2    Gorden, A.3
  • 40
    • 53349171172 scopus 로고    scopus 로고
    • Variable DNA methylation patterns associated with progression of disease in hepatocellular carcinomas
    • Gao W, Kondo Y, Shen L et al. Variable DNA methylation patterns associated with progression of disease in hepatocellular carcinomas. Carcinogenesis 2008; 29: 1901-10.
    • (2008) Carcinogenesis , vol.29 , pp. 1901-1910
    • Gao, W.1    Kondo, Y.2    Shen, L.3
  • 41
    • 77957361278 scopus 로고    scopus 로고
    • Hepatocellular carcinoma displays distinct DNA methylation signatures with potential as clinical predictors
    • Hernandez-Vargas H, Lambert MP, Le Calvez-Kelm F et al. Hepatocellular carcinoma displays distinct DNA methylation signatures with potential as clinical predictors. PLoS One 2010; 5: e9749.
    • (2010) PLoS One , vol.5
    • Hernandez-Vargas, H.1    Lambert, M.P.2    Le Calvez-Kelm, F.3
  • 42
    • 79956368802 scopus 로고    scopus 로고
    • Methylation profile of single hepatocytes derived from hepatitis B virus-related hepatocellular carcinoma
    • Tao R, Li J, Xin J et al. Methylation profile of single hepatocytes derived from hepatitis B virus-related hepatocellular carcinoma. PLoS One 2011; 6: e19862.
    • (2011) PLoS One , vol.6
    • Tao, R.1    Li, J.2    Xin, J.3
  • 43
    • 77957149560 scopus 로고    scopus 로고
    • Comparative analysis of promoter methylation and gene expression endpoints between tumorous and non-tumorous tissues from HCV-positive patients with hepatocellular carcinoma
    • Formeister EJ, Tsuchiya M, Fujii H, Shpyleva S, Pogribny IP, Rusyn I. Comparative analysis of promoter methylation and gene expression endpoints between tumorous and non-tumorous tissues from HCV-positive patients with hepatocellular carcinoma. Mutat Res 2010; 692: 26-33.
    • (2010) Mutat Res , vol.692 , pp. 26-33
    • Formeister, E.J.1    Tsuchiya, M.2    Fujii, H.3    Shpyleva, S.4    Pogribny, I.P.5    Rusyn, I.6
  • 44
    • 79954692738 scopus 로고    scopus 로고
    • Aberrant CpG island hypermethylation in dysplastic nodules and early HCC of hepatitis B virus-related human multistep hepatocarcinogenesis
    • Um TH, Kim H, Oh BK et al. Aberrant CpG island hypermethylation in dysplastic nodules and early HCC of hepatitis B virus-related human multistep hepatocarcinogenesis. J Hepatol 2011; 54: 939-47.
    • (2011) J Hepatol , vol.54 , pp. 939-947
    • Um, T.H.1    Kim, H.2    Oh, B.K.3
  • 45
    • 77949877704 scopus 로고    scopus 로고
    • High-throughput assessment of CpG site methylation for distinguishing between HCV-cirrhosis and HCVassociated hepatocellular carcinoma
    • Archer KJ, Mas VR, Maluf DG, Fisher RA. High-throughput assessment of CpG site methylation for distinguishing between HCV-cirrhosis and HCVassociated hepatocellular carcinoma. Mol Genet Genomics 2010; 283: 341-9.
    • (2010) Mol Genet Genomics , vol.283 , pp. 341-349
    • Archer, K.J.1    Mas, V.R.2    Maluf, D.G.3    Fisher, R.A.4
  • 47
    • 71849115857 scopus 로고    scopus 로고
    • Genome-wide DNA methylation profiles in liver tissue at the precancerous stage and in hepatocellular carcinoma
    • Arai E, Ushijima S, Gotoh M et al. Genome-wide DNA methylation profiles in liver tissue at the precancerous stage and in hepatocellular carcinoma. Int J Cancer 2009; 125: 2854-62.
    • (2009) Int J Cancer , vol.125 , pp. 2854-2862
    • Arai, E.1    Ushijima, S.2    Gotoh, M.3
  • 48
    • 79959756667 scopus 로고    scopus 로고
    • Carcinogenetic risk estimation based on quantification of DNA methylation levels in liver tissue at the precancerous stage
    • Nagashio R, Arai E, Ojima H, Kosuge T, Kondo Y, Kanai Y. Carcinogenetic risk estimation based on quantification of DNA methylation levels in liver tissue at the precancerous stage. Int J Cancer 2011; 129: 1170-9.
    • (2011) Int J Cancer , vol.129 , pp. 1170-1179
    • Nagashio, R.1    Arai, E.2    Ojima, H.3    Kosuge, T.4    Kondo, Y.5    Kanai, Y.6
  • 49
    • 71849113808 scopus 로고    scopus 로고
    • Genome-wide DNA methylation profiles in precancerous conditions and cancers
    • Kanai Y. Genome-wide DNA methylation profiles in precancerous conditions and cancers. Cancer Sci 2010; 101: 36-45.
    • (2010) Cancer Sci , vol.101 , pp. 36-45
    • Kanai, Y.1
  • 50
    • 77956607702 scopus 로고    scopus 로고
    • Identification of novel methylation markers in hepatocellular carcinoma using a methylation array
    • Shin SH, Kim BH, Jang JJ, Suh KS, Kang GH. Identification of novel methylation markers in hepatocellular carcinoma using a methylation array. J Korean Med Sci 2010; 25: 1152-9.
    • (2010) J Korean Med Sci , vol.25 , pp. 1152-1159
    • Shin, S.H.1    Kim, B.H.2    Jang, J.J.3    Suh, K.S.4    Kang, G.H.5
  • 51
    • 84868201629 scopus 로고    scopus 로고
    • Methylome analysis and integrative profiling of human HCCs identify novel protumorigenic factors
    • Neumann O, Kesselmeier M, Geffers R et al. Methylome analysis and integrative profiling of human HCCs identify novel protumorigenic factors. Hepatology 2012; 56: 1817-27.
    • (2012) Hepatology , vol.56 , pp. 1817-1827
    • Neumann, O.1    Kesselmeier, M.2    Geffers, R.3
  • 52
    • 84861572881 scopus 로고    scopus 로고
    • Genome-wide DNA methylation profiles in hepatocellular carcinoma
    • Shen J, Wang S, Zhang YJ et al. Genome-wide DNA methylation profiles in hepatocellular carcinoma. Hepatology 2012; 55: 1799-808.
    • (2012) Hepatology , vol.55 , pp. 1799-1808
    • Shen, J.1    Wang, S.2    Zhang, Y.J.3
  • 53
    • 84856100724 scopus 로고    scopus 로고
    • Distinct DNA methylation patterns in cirrhotic liver and hepatocellular carcinoma
    • Ammerpohl O, Pratschke J, Schafmayer C et al. Distinct DNA methylation patterns in cirrhotic liver and hepatocellular carcinoma. Int J Cancer 2012; 130: 1319-28.
    • (2012) Int J Cancer , vol.130 , pp. 1319-1328
    • Ammerpohl, O.1    Pratschke, J.2    Schafmayer, C.3
  • 54
    • 84874266463 scopus 로고    scopus 로고
    • Elucidating the landscape of aberrant DNA methylation in hepatocellular carcinoma
    • Song MA, Tiirikainen M, Kwee S, Okimoto G, Yu H, Wong LL. Elucidating the landscape of aberrant DNA methylation in hepatocellular carcinoma. PLoS One 2013; 8: e55761.
    • (2013) PLoS One , vol.8
    • Song, M.A.1    Tiirikainen, M.2    Kwee, S.3    Okimoto, G.4    Yu, H.5    Wong, L.L.6
  • 55
    • 84872016931 scopus 로고    scopus 로고
    • Exploring genome-wide DNA methylation profiles altered in hepatocellular carcinoma using Infinium HumanMethylation 450 BeadChips
    • Shen J, Wang S, Zhang YJ et al. Exploring genome-wide DNA methylation profiles altered in hepatocellular carcinoma using Infinium HumanMethylation 450 BeadChips. Epigenetics 2013; 8: 34-43.
    • (2013) Epigenetics , vol.8 , pp. 34-43
    • Shen, J.1    Wang, S.2    Zhang, Y.J.3
  • 56
    • 21144431660 scopus 로고    scopus 로고
    • Identification and investigation of methylated genes in hepatoma
    • Chiba T, Yokosuka O, Fukai K et al. Identification and investigation of methylated genes in hepatoma. Eur J Cancer 2005; 41: 1185-94.
    • (2005) Eur J Cancer , vol.41 , pp. 1185-1194
    • Chiba, T.1    Yokosuka, O.2    Fukai, K.3
  • 57
    • 77950628676 scopus 로고    scopus 로고
    • DNA methylation changes in normal liver tissues and hepatocellular carcinoma with different viral infection
    • Feng Q, Stern JE, Hawes SE, Lu H, Jiang M, Kiviat NB. DNA methylation changes in normal liver tissues and hepatocellular carcinoma with different viral infection. Exp Mol Pathol 2010; 88: 287-92.
    • (2010) Exp Mol Pathol , vol.88 , pp. 287-292
    • Feng, Q.1    Stern, J.E.2    Hawes, S.E.3    Lu, H.4    Jiang, M.5    Kiviat, N.B.6
  • 58
    • 79952705527 scopus 로고    scopus 로고
    • Aberrant DNA methylation distinguishes hepatocellular carcinoma associated with HBV and HCV infection and alcohol intake
    • Lambert MP, Paliwal A, Vaissière T et al. Aberrant DNA methylation distinguishes hepatocellular carcinoma associated with HBV and HCV infection and alcohol intake. J Hepatol 2011; 54: 705-15.
    • (2011) J Hepatol , vol.54 , pp. 705-715
    • Lambert, M.P.1    Paliwal, A.2    Vaissière, T.3
  • 59
    • 40949161396 scopus 로고    scopus 로고
    • Aberrant methylation of multiple tumor suppressor genes in aging liver, chronic hepatitis, and hepatocellular carcinoma
    • Nishida N, Nagasaka T, Nishimura T, Ikai I, Boland CR, Goel A. Aberrant methylation of multiple tumor suppressor genes in aging liver, chronic hepatitis, and hepatocellular carcinoma. Hepatology 2008; 47: 908-18.
    • (2008) Hepatology , vol.47 , pp. 908-918
    • Nishida, N.1    Nagasaka, T.2    Nishimura, T.3    Ikai, I.4    Boland, C.R.5    Goel, A.6
  • 60
    • 84865543987 scopus 로고    scopus 로고
    • Characteristic patterns of altered DNA methylation predict emergence of human hepatocellular carcinoma
    • Nishida N, Kudo M, Nagasaka T, Ikai I, Goel A. Characteristic patterns of altered DNA methylation predict emergence of human hepatocellular carcinoma. Hepatology 2012; 56: 994-1003.
    • (2012) Hepatology , vol.56 , pp. 994-1003
    • Nishida, N.1    Kudo, M.2    Nagasaka, T.3    Ikai, I.4    Goel, A.5
  • 61
    • 79960709110 scopus 로고    scopus 로고
    • Molecular characteristics of non-cancerous liver tissue in non-B non-C hepatocellular carcinoma
    • Utsunomiya T, Shimada M. Molecular characteristics of non-cancerous liver tissue in non-B non-C hepatocellular carcinoma. Hepatol Res 2011; 41: 711-21.
    • (2011) Hepatol Res , vol.41 , pp. 711-721
    • Utsunomiya, T.1    Shimada, M.2
  • 62
    • 84892926926 scopus 로고    scopus 로고
    • Nationwide study of 4741 patients with non-B non-C hepatocellular carcinoma with special reference to the therapeutic impact
    • Utsunomiya T, Shimada M, Kudo M. Nationwide study of 4741 patients with non-B non-C hepatocellular carcinoma with special reference to the therapeutic impact. Ann Surg 2014; 259: 336-45.
    • (2014) Ann Surg , vol.259 , pp. 336-345
    • Utsunomiya, T.1    Shimada, M.2    Kudo, M.3
  • 63
    • 84891713356 scopus 로고    scopus 로고
    • Plasma total homocysteine is associated with DNA methylation in patients with schizophrenia
    • Kinoshita M, Numata S, Tajima A, Shimodera S, Imoto I, Ohmori T. Plasma total homocysteine is associated with DNA methylation in patients with schizophrenia. Epigenetics 2013; 8: 584-90.
    • (2013) Epigenetics , vol.8 , pp. 584-590
    • Kinoshita, M.1    Numata, S.2    Tajima, A.3    Shimodera, S.4    Imoto, I.5    Ohmori, T.6
  • 64
    • 80053304450 scopus 로고    scopus 로고
    • High density DNA methylation array with single CpG site resolution
    • Bibikova M, Barnes B, Tsan C et al. High density DNA methylation array with single CpG site resolution. Genomics 2011; 98: 288-95.
    • (2011) Genomics , vol.98 , pp. 288-295
    • Bibikova, M.1    Barnes, B.2    Tsan, C.3
  • 65
    • 84884759753 scopus 로고    scopus 로고
    • Intragenic DNA methylation in transcriptional regulation, normal differentiation and cancer
    • Kulis M, Queirós AC, Beekman R, Martín-Subero JI. Intragenic DNA methylation in transcriptional regulation, normal differentiation and cancer. Biochim Biophys Acta 2013; 1829: 1161-74.
    • (2013) Biochim Biophys Acta , vol.1829 , pp. 1161-1174
    • Kulis, M.1    Queirós, A.C.2    Beekman, R.3    Martín-Subero, J.I.4
  • 66
    • 84874353239 scopus 로고    scopus 로고
    • Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray
    • Chen YA, Lemire M, Choufani S et al. Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray. Epigenetics 2013; 8: 203-9.
    • (2013) Epigenetics , vol.8 , pp. 203-209
    • Chen, Y.A.1    Lemire, M.2    Choufani, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.