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Volumn 56, Issue 5, 2012, Pages 1817-1827

Methylome analysis and integrative profiling of human HCCs identify novel protumorigenic factors

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; BISULFITE; FATTY ACID BINDING PROTEIN; SOMATOMEDIN BINDING PROTEIN;

EID: 84868201629     PISSN: 02709139     EISSN: 15273350     Source Type: Journal    
DOI: 10.1002/hep.25870     Document Type: Article
Times cited : (140)

References (50)
  • 1
  • 2
    • 0033959151 scopus 로고    scopus 로고
    • Hepatocellular carcinoma
    • Badvie S. Hepatocellular carcinoma. Postgrad Med J 2000; 76: 4-11.
    • (2000) Postgrad Med J , vol.76 , pp. 4-11
    • Badvie, S.1
  • 3
    • 33847065486 scopus 로고    scopus 로고
    • The epigenomics of cancer
    • Jones PA, Baylin SB. The epigenomics of cancer. Cell 2007; 128: 683-692.
    • (2007) Cell , vol.128 , pp. 683-692
    • Jones, P.A.1    Baylin, S.B.2
  • 4
    • 78751662908 scopus 로고    scopus 로고
    • The Polycomb complex PRC2 and its mark in life
    • Margueron R, Reinberg D. The Polycomb complex PRC2 and its mark in life. Nature 2011; 469: 343-349.
    • (2011) Nature , vol.469 , pp. 343-349
    • Margueron, R.1    Reinberg, D.2
  • 5
    • 0035839126 scopus 로고    scopus 로고
    • Epigenetic reprogramming in mammalian development
    • Reik W, Dean W, Walter J. Epigenetic reprogramming in mammalian development. Science 2001; 293: 1089-1093.
    • (2001) Science , vol.293 , pp. 1089-1093
    • Reik, W.1    Dean, W.2    Walter, J.3
  • 6
    • 77955449906 scopus 로고    scopus 로고
    • Epigenetic memory in induced pluripotent stem cells
    • Kim K, Doi A, Wen B, Ng K, Zhao R, Cahan P, et al. Epigenetic memory in induced pluripotent stem cells. Nature 2010; 467: 285-290.
    • (2010) Nature , vol.467 , pp. 285-290
    • Kim, K.1    Doi, A.2    Wen, B.3    Ng, K.4    Zhao, R.5    Cahan, P.6
  • 7
    • 79960711532 scopus 로고    scopus 로고
    • Choreographing pluripotency and cell fate with transcription factors
    • Gonzales KA, Ng HH. Choreographing pluripotency and cell fate with transcription factors. Biochim Biophys Acta 2011; 1809: 337-349.
    • (2011) Biochim Biophys Acta , vol.1809 , pp. 337-349
    • Gonzales, K.A.1    Ng, H.H.2
  • 8
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144: 646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 9
    • 18444369018 scopus 로고    scopus 로고
    • Methylation framework of cell cycle gene inhibitors in cirrhosis and associated hepatocellular carcinoma
    • Roncalli M, Bianchi P, Bruni B, Laghi L, Destro A, Di Gioia S, et al. Methylation framework of cell cycle gene inhibitors in cirrhosis and associated hepatocellular carcinoma. HEPATOLOGY 2002; 36: 427-432.
    • (2002) HEPATOLOGY , vol.36 , pp. 427-432
    • Roncalli, M.1    Bianchi, P.2    Bruni, B.3    Laghi, L.4    Destro, A.5    Di Gioia, S.6
  • 10
    • 40949161396 scopus 로고    scopus 로고
    • Aberrant methylation of multiple tumor suppressor genes in aging liver, chronic hepatitis, and hepatocellular carcinoma
    • Nishida N, Nagasaka T, Nishimura T, Ikai I, Boland CR, Goel A. Aberrant methylation of multiple tumor suppressor genes in aging liver, chronic hepatitis, and hepatocellular carcinoma. HEPATOLOGY 2008; 47: 908-918.
    • (2008) HEPATOLOGY , vol.47 , pp. 908-918
    • Nishida, N.1    Nagasaka, T.2    Nishimura, T.3    Ikai, I.4    Boland, C.R.5    Goel, A.6
  • 12
    • 17344392308 scopus 로고    scopus 로고
    • A new mathematical model for relative quantification in real-time RT-PCR
    • Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001; 29: e45.
    • (2001) Nucleic Acids Res , vol.29
    • Pfaffl, M.W.1
  • 13
    • 12144260822 scopus 로고    scopus 로고
    • Factors of transforming growth factor beta signalling are co-regulated in human hepatocellular carcinoma
    • Longerich T, Breuhahn K, Odenthal M, Petmecky K, Schirmacher P. Factors of transforming growth factor beta signalling are co-regulated in human hepatocellular carcinoma. Virchows Arch 2004; 445: 589-596.
    • (2004) Virchows Arch , vol.445 , pp. 589-596
    • Longerich, T.1    Breuhahn, K.2    Odenthal, M.3    Petmecky, K.4    Schirmacher, P.5
  • 14
    • 80054767010 scopus 로고    scopus 로고
    • Nuclear expression of the ubiquitin ligase seven in absentia homolog (SIAH)-1 induces proliferation and migration of liver cancer cells
    • Brauckhoff A, Malz M, Tschaharganeh D, Malek N, Weber A, Riener MO, et al. Nuclear expression of the ubiquitin ligase seven in absentia homolog (SIAH)-1 induces proliferation and migration of liver cancer cells. J Hepatol 2011; 55: 1049-1057.
    • (2011) J Hepatol , vol.55 , pp. 1049-1057
    • Brauckhoff, A.1    Malz, M.2    Tschaharganeh, D.3    Malek, N.4    Weber, A.5    Riener, M.O.6
  • 16
    • 33846649587 scopus 로고    scopus 로고
    • Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer
    • Schlesinger Y, Straussman R, Keshet I, Farkash S, Hecht M, Zimmerman J, et al. Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer. Nat Genet 2007; 39: 232-236.
    • (2007) Nat Genet , vol.39 , pp. 232-236
    • Schlesinger, Y.1    Straussman, R.2    Keshet, I.3    Farkash, S.4    Hecht, M.5    Zimmerman, J.6
  • 17
    • 77950628676 scopus 로고    scopus 로고
    • DNA methylation changes in normal liver tissues and hepatocellular carcinoma with different viral infection
    • Feng Q, Stern JE, Hawes SE, Lu H, Jiang M, Kiviat NB. DNA methylation changes in normal liver tissues and hepatocellular carcinoma with different viral infection. Exp Mol Pathol 2010; 88: 287-292.
    • (2010) Exp Mol Pathol , vol.88 , pp. 287-292
    • Feng, Q.1    Stern, J.E.2    Hawes, S.E.3    Lu, H.4    Jiang, M.5    Kiviat, N.B.6
  • 18
    • 78751566393 scopus 로고    scopus 로고
    • Inactivation of Ras GTPase-activating proteins promotes unrestrained activity of wild-type Ras in human liver cancer
    • Calvisi DF, Ladu S, Conner EA, Seo D, Hsieh JT, Factor VM, Thorgeirsson SS. Inactivation of Ras GTPase-activating proteins promotes unrestrained activity of wild-type Ras in human liver cancer. J Hepatol 2011; 54: 311-319.
    • (2011) J Hepatol , vol.54 , pp. 311-319
    • Calvisi, D.F.1    Ladu, S.2    Conner, E.A.3    Seo, D.4    Hsieh, J.T.5    Factor, V.M.6    Thorgeirsson, S.S.7
  • 19
    • 42249100305 scopus 로고    scopus 로고
    • Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice
    • Martinez-Chantar ML, Vazquez-Chantada M, Ariz U, Martinez N, Varela M, Luka Z, et al. Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice. HEPATOLOGY 2008; 47: 1191-1199.
    • (2008) HEPATOLOGY , vol.47 , pp. 1191-1199
    • Martinez-Chantar, M.L.1    Vazquez-Chantada, M.2    Ariz, U.3    Martinez, N.4    Varela, M.5    Luka, Z.6
  • 20
    • 53349171172 scopus 로고    scopus 로고
    • Variable DNA methylation patterns associated with progression of disease in hepatocellular carcinomas
    • Gao W, Kondo Y, Shen L, Shimizu Y, Sano T, Yamao K, et al. Variable DNA methylation patterns associated with progression of disease in hepatocellular carcinomas. Carcinogenesis 2008; 29: 1901-1910.
    • (2008) Carcinogenesis , vol.29 , pp. 1901-1910
    • Gao, W.1    Kondo, Y.2    Shen, L.3    Shimizu, Y.4    Sano, T.5    Yamao, K.6
  • 23
    • 79956368802 scopus 로고    scopus 로고
    • Methylation profile of single hepatocytes derived from hepatitis B virus-related hepatocellular carcinoma
    • Tao R, Li J, Xin J, Wu J, Guo J, Zhang L, et al. Methylation profile of single hepatocytes derived from hepatitis B virus-related hepatocellular carcinoma. PLoS One 2011; 6: e19862.
    • (2011) PLoS One , vol.6
    • Tao, R.1    Li, J.2    Xin, J.3    Wu, J.4    Guo, J.5    Zhang, L.6
  • 24
    • 84861572881 scopus 로고    scopus 로고
    • Genome-wide DNA methylation profiles in hepatocellular carcinoma
    • Shen J, Wang S, Zhang YJ, Kappil M, Wu HC, Kibriya MG, et al. Genome-wide DNA methylation profiles in hepatocellular carcinoma. HEPATOLOGY 2012; 55: 1799-1808.
    • (2012) HEPATOLOGY , vol.55 , pp. 1799-1808
    • Shen, J.1    Wang, S.2    Zhang, Y.J.3    Kappil, M.4    Wu, H.C.5    Kibriya, M.G.6
  • 25
    • 0141961143 scopus 로고    scopus 로고
    • Beta-catenin accumulation in the progression of human hepatocarcinogenesis correlates with loss of E-cadherin and accumulation of p53, but not with expression of conventional WNT-1 target genes
    • Prange W, Breuhahn K, Fischer F, Zilkens C, Pietsch T, Petmecky K, et al. Beta-catenin accumulation in the progression of human hepatocarcinogenesis correlates with loss of E-cadherin and accumulation of p53, but not with expression of conventional WNT-1 target genes. J Pathol 2003; 201: 250-259.
    • (2003) J Pathol , vol.201 , pp. 250-259
    • Prange, W.1    Breuhahn, K.2    Fischer, F.3    Zilkens, C.4    Pietsch, T.5    Petmecky, K.6
  • 26
    • 0034995765 scopus 로고    scopus 로고
    • Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis
    • Laurent-Puig P, Legoix P, Bluteau O, Belghiti J, Franco D, Binot F, et al. Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis. Gastroenterology 2001; 120: 1763-1773.
    • (2001) Gastroenterology , vol.120 , pp. 1763-1773
    • Laurent-Puig, P.1    Legoix, P.2    Bluteau, O.3    Belghiti, J.4    Franco, D.5    Binot, F.6
  • 27
    • 33846463379 scopus 로고    scopus 로고
    • Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets
    • Boyault S, Rickman DS, de Reynies A, Balabaud C, Rebouissou S, Jeannot E, et al. Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets. HEPATOLOGY 2007; 45: 42-52.
    • (2007) HEPATOLOGY , vol.45 , pp. 42-52
    • Boyault, S.1    Rickman, D.S.2    de Reynies, A.3    Balabaud, C.4    Rebouissou, S.5    Jeannot, E.6
  • 28
    • 34250342495 scopus 로고    scopus 로고
    • Extensive methylation is associated with beta-catenin mutations in hepatocellular carcinoma: evidence for two distinct pathways of human hepatocarcinogenesis
    • Nishida N, Nishimura T, Nagasaka T, Ikai I, Goel A, Boland CR. Extensive methylation is associated with beta-catenin mutations in hepatocellular carcinoma: evidence for two distinct pathways of human hepatocarcinogenesis. Cancer Res 2007; 67: 4586-4594.
    • (2007) Cancer Res , vol.67 , pp. 4586-4594
    • Nishida, N.1    Nishimura, T.2    Nagasaka, T.3    Ikai, I.4    Goel, A.5    Boland, C.R.6
  • 29
    • 0036830642 scopus 로고    scopus 로고
    • Role of histone H3 lysine 27 methylation in Polycomb-group silencing
    • Cao R, Wang L, Wang H, Xia L, Erdjument-Bromage H, Tempst P, et al. Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science 2002; 298: 1039-1043.
    • (2002) Science , vol.298 , pp. 1039-1043
    • Cao, R.1    Wang, L.2    Wang, H.3    Xia, L.4    Erdjument-Bromage, H.5    Tempst, P.6
  • 30
    • 18644383738 scopus 로고    scopus 로고
    • Histone methyltransferase activity of a Drosophila Polycomb group repressor complex
    • Muller J, Hart CM, Francis NJ, Vargas ML, Sengupta A, Wild B, et al. Histone methyltransferase activity of a Drosophila Polycomb group repressor complex. Cell 2002; 111: 197-208.
    • (2002) Cell , vol.111 , pp. 197-208
    • Muller, J.1    Hart, C.M.2    Francis, N.J.3    Vargas, M.L.4    Sengupta, A.5    Wild, B.6
  • 31
    • 33646882068 scopus 로고    scopus 로고
    • Polycomb complexes repress developmental regulators in murine embryonic stem cells
    • Boyer LA, Plath K, Zeitlinger J, Brambrink T, Medeiros LA, Lee TI, et al. Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature 2006; 441: 349-353.
    • (2006) Nature , vol.441 , pp. 349-353
    • Boyer, L.A.1    Plath, K.2    Zeitlinger, J.3    Brambrink, T.4    Medeiros, L.A.5    Lee, T.I.6
  • 32
    • 13244279419 scopus 로고    scopus 로고
    • Role of polycomb group proteins in stem cell self-renewal and cancer
    • Gil J, Bernard D, Peters G. Role of polycomb group proteins in stem cell self-renewal and cancer. DNA Cell Biol 2005; 24: 117-125.
    • (2005) DNA Cell Biol , vol.24 , pp. 117-125
    • Gil, J.1    Bernard, D.2    Peters, G.3
  • 34
    • 34247625135 scopus 로고    scopus 로고
    • Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells
    • Tan J, Yang X, Zhuang L, Jiang X, Chen W, Lee PL, et al. Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells. Genes Dev 2007; 21: 1050-1063.
    • (2007) Genes Dev , vol.21 , pp. 1050-1063
    • Tan, J.1    Yang, X.2    Zhuang, L.3    Jiang, X.4    Chen, W.5    Lee, P.L.6
  • 35
    • 70350236515 scopus 로고    scopus 로고
    • Aberrant DNA methylation profile and frequent methylation of KLK10 and OXGR1 genes in hepatocellular carcinoma
    • Lu CY, Hsieh SY, Lu YJ, Wu CS, Chen LC, Lo SJ, et al. Aberrant DNA methylation profile and frequent methylation of KLK10 and OXGR1 genes in hepatocellular carcinoma. Genes Chromosomes Cancer 2009; 48: 1057-1068.
    • (2009) Genes Chromosomes Cancer , vol.48 , pp. 1057-1068
    • Lu, C.Y.1    Hsieh, S.Y.2    Lu, Y.J.3    Wu, C.S.4    Chen, L.C.5    Lo, S.J.6
  • 36
    • 79951557451 scopus 로고    scopus 로고
    • Reduced expression of reelin (RELN) gene is associated with high recurrence rate of hepatocellular carcinoma
    • Okamura Y, Nomoto S, Kanda M, Hayashi M, Nishikawa Y, Fujii T, et al. Reduced expression of reelin (RELN) gene is associated with high recurrence rate of hepatocellular carcinoma. Ann Surg Oncol 2011; 18: 572-579.
    • (2011) Ann Surg Oncol , vol.18 , pp. 572-579
    • Okamura, Y.1    Nomoto, S.2    Kanda, M.3    Hayashi, M.4    Nishikawa, Y.5    Fujii, T.6
  • 38
    • 56749176759 scopus 로고    scopus 로고
    • Disturbance of circadian gene expression in hepatocellular carcinoma
    • Lin YM, Chang JH, Yeh KT, Yang MY, Liu TC, Lin SF, et al. Disturbance of circadian gene expression in hepatocellular carcinoma. Mol Carcinog 2008; 47: 925-933.
    • (2008) Mol Carcinog , vol.47 , pp. 925-933
    • Lin, Y.M.1    Chang, J.H.2    Yeh, K.T.3    Yang, M.Y.4    Liu, T.C.5    Lin, S.F.6
  • 39
    • 75449104468 scopus 로고    scopus 로고
    • Alpha-fetoprotein and tumour size are associated with microvascular invasion in explanted livers of patients undergoing transplantation with hepatocellular carcinoma
    • McHugh PP, Gilbert J, Vera S, Koch A, Ranjan D, Gedaly R. Alpha-fetoprotein and tumour size are associated with microvascular invasion in explanted livers of patients undergoing transplantation with hepatocellular carcinoma. HPB (Oxford) 2010; 12: 56-61.
    • (2010) HPB (Oxford) , vol.12 , pp. 56-61
    • McHugh, P.P.1    Gilbert, J.2    Vera, S.3    Koch, A.4    Ranjan, D.5    Gedaly, R.6
  • 42
    • 33749031807 scopus 로고    scopus 로고
    • Molecular components of the mammalian circadian clock
    • Spec No
    • Ko CH, Takahashi JS. Molecular components of the mammalian circadian clock. Hum Mol Genet 2006; 15 Spec No 2: R271-R277.
    • (2006) Hum Mol Genet , vol.15 , Issue.2
    • Ko, C.H.1    Takahashi, J.S.2
  • 43
    • 22844451414 scopus 로고    scopus 로고
    • Deregulated expression of the PER1, PER2, and PER3 genes in breast cancers
    • Chen ST, Choo KB, Hou MF, Yeh KT, Kuo SJ, Chang JG. Deregulated expression of the PER1, PER2, and PER3 genes in breast cancers. Carcinogenesis 2005; 26: 1241-1246.
    • (2005) Carcinogenesis , vol.26 , pp. 1241-1246
    • Chen, S.T.1    Choo, K.B.2    Hou, M.F.3    Yeh, K.T.4    Kuo, S.J.5    Chang, J.G.6
  • 44
    • 34247515224 scopus 로고    scopus 로고
    • Riding tandem: circadian clocks and the cell cycle
    • Hunt T, Sassone-Corsi P. Riding tandem: circadian clocks and the cell cycle. Cell 2007; 129: 461-464.
    • (2007) Cell , vol.129 , pp. 461-464
    • Hunt, T.1    Sassone-Corsi, P.2
  • 45
    • 33646084831 scopus 로고    scopus 로고
    • The circadian gene per1 plays an important role in cell growth and DNA damage control in human cancer cells
    • Gery S, Komatsu N, Baldjyan L, Yu A, Koo D, Koeffler HP. The circadian gene per1 plays an important role in cell growth and DNA damage control in human cancer cells. Mol Cell 2006; 22: 375-382.
    • (2006) Mol Cell , vol.22 , pp. 375-382
    • Gery, S.1    Komatsu, N.2    Baldjyan, L.3    Yu, A.4    Koo, D.5    Koeffler, H.P.6
  • 47
    • 78649668031 scopus 로고    scopus 로고
    • Per3, a circadian gene, is required for Chk2 activation in human cells
    • Im JS, Jung BH, Kim SE, Lee KH, Lee JK. Per3, a circadian gene, is required for Chk2 activation in human cells. FEBS Lett 2010; 584: 4731-4734.
    • (2010) FEBS Lett , vol.584 , pp. 4731-4734
    • Im, J.S.1    Jung, B.H.2    Kim, S.E.3    Lee, K.H.4    Lee, J.K.5
  • 48
    • 70149107144 scopus 로고    scopus 로고
    • Human acid-labile subunit deficiency: clinical, endocrine and metabolic consequences
    • Domene HM, Hwa V, Argente J, Wit JM, Camacho-Hubner C, Jasper HG, et al. Human acid-labile subunit deficiency: clinical, endocrine and metabolic consequences. Horm Res 2009; 72: 129-141.
    • (2009) Horm Res , vol.72 , pp. 129-141
    • Domene, H.M.1    Hwa, V.2    Argente, J.3    Wit, J.M.4    Camacho-Hubner, C.5    Jasper, H.G.6
  • 49
    • 33745552897 scopus 로고    scopus 로고
    • Dysregulation of growth factor signaling in human hepatocellular carcinoma
    • Breuhahn K, Longerich T, Schirmacher P. Dysregulation of growth factor signaling in human hepatocellular carcinoma. Oncogene 2006; 25: 3787-3800.
    • (2006) Oncogene , vol.25 , pp. 3787-3800
    • Breuhahn, K.1    Longerich, T.2    Schirmacher, P.3
  • 50
    • 80052439448 scopus 로고    scopus 로고
    • The protein Z/protein Z-dependent protease inhibitor complex. Systemic or local control of coagulation?
    • 160-164.
    • Vasse M. The protein Z/protein Z-dependent protease inhibitor complex. Systemic or local control of coagulation? Hamostaseologie 2011; 31: 155-158, 160-164.
    • (2011) Hamostaseologie , vol.31 , pp. 155-158
    • Vasse, M.1


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