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Volumn 19, Issue 3, 2014, Pages 416-428

Physiological and pathological implications of cholesterol

Author keywords

Atherosclerosis; Cholesterol; Development; Malformation; Membrane; Mevalonate pathway; Review

Indexed keywords

CHOLESTEROL;

EID: 84904307782     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/4216     Document Type: Review
Times cited : (88)

References (78)
  • 1
    • 0031888449 scopus 로고    scopus 로고
    • Discovery of the Lipoproteins, Their Role in Fat Transport and Their Significance as Risk Factors
    • R. E. Olson: Discovery of the Lipoproteins, Their Role in Fat Transport and Their Significance as Risk Factors. The Journal of Nutrition 128, 439S-443S (1998)
    • (1998) The Journal of Nutrition , vol.128
    • Olson, R.E.1
  • 2
    • 0022549920 scopus 로고
    • A receptor-mediated pathway for cholesterol homeostasis
    • M. S. Brown and J. L. Goldstein: A receptor-mediated pathway for cholesterol homeostasis. Science 232, 34-47. (1986)
    • (1986) Science , vol.232 , pp. 34-47
    • Brown, M.S.1    Goldstein, J.L.2
  • 3
    • 84904326785 scopus 로고    scopus 로고
    • Nobelprize.org. http://nobelprize.org/index.html
  • 4
    • 0020648725 scopus 로고
    • Sterol structure and membrane function
    • K. E. Bloch: Sterol structure and membrane function. CRC Crit Rev Biochem 14, 47-92 (1983)
    • (1983) CRC Crit Rev Biochem , vol.14 , pp. 47-92
    • Bloch, K.E.1
  • 5
    • 0033384957 scopus 로고    scopus 로고
    • Regulation of endoplasmic reticulum cholesterol by plasma membrane cholesterol
    • Y. Lange, J. Ye, M. Rigney and T. L. Steck: Regulation of endoplasmic reticulum cholesterol by plasma membrane cholesterol. J Lipid Res 40, 2264-70 (1999)
    • (1999) J Lipid Res , vol.40 , pp. 2264-2270
    • Lange, Y.1    Ye, J.2    Rigney, M.3    Steck, T.L.4
  • 6
    • 0033583562 scopus 로고    scopus 로고
    • Intracellular cholesterol transport
    • L. Liscum and N. J. Munn: Intracellular cholesterol transport. Biochim Biophys Acta 1438, 19-37 (1999)
    • (1999) Biochim Biophys Acta , vol.1438 , pp. 19-37
    • Liscum, L.1    Munn, N.J.2
  • 7
    • 0021076445 scopus 로고
    • Analysis of the distribution of cholesterol in the intact cell
    • Y. Lange and B. V. Ramos: Analysis of the distribution of cholesterol in the intact cell. J Biol Chem 258, 15130-4 (1983)
    • (1983) J Biol Chem , vol.258 , pp. 15130-15134
    • Lange, Y.1    Ramos, B.V.2
  • 8
    • 0034969390 scopus 로고    scopus 로고
    • Do sterols reduce proton and sodium leaks through lipid bilayers?
    • T. H. Haines: Do sterols reduce proton and sodium leaks through lipid bilayers? Prog Lipid Res 40, 299-324 (2001)
    • (2001) Prog Lipid Res , vol.40 , pp. 299-324
    • Haines, T.H.1
  • 9
    • 0036733578 scopus 로고    scopus 로고
    • Cholesterol, lipid rafts, and disease
    • K. Simons and R. Ehehalt: Cholesterol, lipid rafts, and disease. J Clin Invest 110, 597-603 (2002)
    • (2002) J Clin Invest , vol.110 , pp. 597-603
    • Simons, K.1    Ehehalt, R.2
  • 10
    • 0034304851 scopus 로고    scopus 로고
    • Lipid rafts and signal transduction
    • K. Simons and D. Toomre: Lipid rafts and signal transduction. Nat Rev Mol Cell Biol 1, 31-9 (2000)
    • (2000) Nat Rev Mol Cell Biol , vol.1 , pp. 31-39
    • Simons, K.1    Toomre, D.2
  • 11
    • 0033062981 scopus 로고    scopus 로고
    • Variability of metabolism and function of sterols in insects
    • J. A. Svoboda: Variability of metabolism and function of sterols in insects. Crit Rev Biochem Mol Biol 34, 49-57 (1999)
    • (1999) Crit Rev Biochem Mol Biol , vol.34 , pp. 49-57
    • Svoboda, J.A.1
  • 12
    • 0043198069 scopus 로고    scopus 로고
    • Why do worms need cholesterol?
    • T. V. Kurzchalia and S. Ward: Why do worms need cholesterol? Nat Cell Biol 5, 684-8 (2003)
    • (2003) Nat Cell Biol , vol.5 , pp. 684-688
    • Kurzchalia, T.V.1    Ward, S.2
  • 14
    • 0037244289 scopus 로고    scopus 로고
    • Sterol effects and sites of sterol accumulation in Caenorhabditis elegans: Developmental requirement for 4alpha-methyl sterols
    • M. Merris, W. G. Wadsworth, U. Khamrai, R. Bittman, D. J. Chitwood and J. Lenard: Sterol effects and sites of sterol accumulation in Caenorhabditis elegans: developmental requirement for 4alpha-methyl sterols. J Lipid Res 44, 172-81 (2003)
    • (2003) J Lipid Res , vol.44 , pp. 172-181
    • Merris, M.1    Wadsworth, W.G.2    Khamrai, U.3    Bittman, R.4    Chitwood, D.J.5    Lenard, J.6
  • 16
    • 0002380192 scopus 로고
    • The biological synthesis of cholesterol
    • K. Bloch: The biological synthesis of cholesterol. Science 150, 19-28 (1965)
    • (1965) Science , vol.150 , pp. 19-28
    • Bloch, K.1
  • 17
    • 0025120211 scopus 로고
    • Regulation of the mevalonate pathway
    • J. L. Goldstein and M. S. Brown: Regulation of the mevalonate pathway. Nature 343, 425-430 (1990)
    • (1990) Nature , vol.343 , pp. 425-430
    • Goldstein, J.L.1    Brown, M.S.2
  • 18
    • 0016241915 scopus 로고
    • Binding and degradation of low density lipoproteins by cultured human fibroblasts. Comparison of cells from a normal subject and from a patient with homozygous familial hypercholesterolemia
    • J. L. Goldstein and M. S. Brown: Binding and degradation of low density lipoproteins by cultured human fibroblasts. Comparison of cells from a normal subject and from a patient with homozygous familial hypercholesterolemia. J Biol Chem 249, 5153-5162 (1974)
    • (1974) J Biol Chem , vol.249 , pp. 5153-5162
    • Goldstein, J.L.1    Brown, M.S.2
  • 19
    • 33644814231 scopus 로고    scopus 로고
    • NPC2 is expressed in human and murine liver and secreted into bile: Potential implications for body cholesterol homeostasis
    • A. Klein, L. Amigo, M. J. Retamal, M. G. Morales, J. F. Miquel, A. Rigotti and S. Zanlungo: NPC2 is expressed in human and murine liver and secreted into bile: potential implications for body cholesterol homeostasis. Hepatology 43, 126-33 (2006)
    • (2006) Hepatology , vol.43 , pp. 126-133
    • Klein, A.1    Amigo, L.2    Retamal, M.J.3    Morales, M.G.4    Miquel, J.F.5    Rigotti, A.6    Zanlungo, S.7
  • 20
    • 67549105629 scopus 로고    scopus 로고
    • Structure of N-Terminal Domain of NPC1 Reveals Distinct Subdomains for Binding and Transfer of Cholesterol
    • H. J. Kwon, L. Abi-Mosleh, M. L. Wang, J. Deisenhofer, J. L. Goldstein, M. S. Brown and R. E. Infante: Structure of N-Terminal Domain of NPC1 Reveals Distinct Subdomains for Binding and Transfer of Cholesterol. Cell 137, 1213-1224 (2009)
    • (2009) Cell , vol.137 , pp. 1213-1224
    • Kwon, H.J.1    Abi-Mosleh, L.2    Wang, M.L.3    Deisenhofer, J.4    Goldstein, J.L.5    Brown, M.S.6    Infante, R.E.7
  • 21
    • 78649916808 scopus 로고    scopus 로고
    • Identification of Surface Residues on Niemann-Pick C2 Essential for Hydrophobic Handoff of Cholesterol to NPC1 in Lysosomes
    • M. L. Wang, M. Motamed, R. E. Infante, L. Abi-Mosleh, H. J. Kwon, M. S. Brown and J. L. Goldstein: Identification of Surface Residues on Niemann-Pick C2 Essential for Hydrophobic Handoff of Cholesterol to NPC1 in Lysosomes. Cell Metabolism 12, 166-173 (2010)
    • (2010) Cell Metabolism , vol.12 , pp. 166-173
    • Wang, M.L.1    Motamed, M.2    Infante, R.E.3    Abi-Mosleh, L.4    Kwon, H.J.5    Brown, M.S.6    Goldstein, J.L.7
  • 22
    • 0038646175 scopus 로고    scopus 로고
    • The role of the high-density lipoprotein receptor SR-BI in the lipid metabolism of endocrine and other tissues
    • A. Rigotti, H. E. Miettinen and M. Krieger: The role of the high-density lipoprotein receptor SR-BI in the lipid metabolism of endocrine and other tissues. Endocr Rev 24, 357-87 (2003)
    • (2003) Endocr Rev , vol.24 , pp. 357-387
    • Rigotti, A.1    Miettinen, H.E.2    Krieger, M.3
  • 23
    • 79960698521 scopus 로고    scopus 로고
    • Mechanisms regulating hepatic SRBI expression and their impact on HDL metabolism
    • A. Leiva, H. Verdejo, M. L. Benitez, A. Martinez, D. Busso and A. Rigotti: Mechanisms regulating hepatic SRBI expression and their impact on HDL metabolism. Atherosclerosis 217, 299-307 (2011)
    • (2011) Atherosclerosis , vol.217 , pp. 299-307
    • Leiva, A.1    Verdejo, H.2    Benitez, M.L.3    Martinez, A.4    Busso, D.5    Rigotti, A.6
  • 24
    • 0029082507 scopus 로고
    • Defective removal of cellular cholesterol and phospholipids by apolipoprotein A-I in Tangier Disease
    • G. A. Francis, R. H. Knopp and J. F. Oram: Defective removal of cellular cholesterol and phospholipids by apolipoprotein A-I in Tangier Disease. J Clin Invest 96, 78-87 (1995)
    • (1995) J Clin Invest , vol.96 , pp. 78-87
    • Francis, G.A.1    Knopp, R.H.2    Oram, J.F.3
  • 25
    • 3042798281 scopus 로고    scopus 로고
    • ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins
    • N. Wang, D. Lan, W. Chen, F. Matsuura and A. R. Tall: ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins. Proc Natl Acad Sci U S A 101, 9774-9 (2004)
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 9774-9779
    • Wang, N.1    Lan, D.2    Chen, W.3    Matsuura, F.4    Tall, A.R.5
  • 29
    • 0036790413 scopus 로고    scopus 로고
    • Consequences of cellular cholesterol accumulation: Basic concepts and physiological implications
    • I. Tabas: Consequences of cellular cholesterol accumulation: basic concepts and physiological implications. J Clin Invest 110, 905-11 (2002)
    • (2002) J Clin Invest , vol.110 , pp. 905-911
    • Tabas, I.1
  • 30
    • 0036251153 scopus 로고    scopus 로고
    • SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver
    • J. D. Horton, J. L. Goldstein and M. S. Brown: SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 109, 1125-31 (2002)
    • (2002) J Clin Invest , vol.109 , pp. 1125-1131
    • Horton, J.D.1    Goldstein, J.L.2    Brown, M.S.3
  • 31
    • 0030941803 scopus 로고    scopus 로고
    • The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
    • M. S. Brown and J. L. Goldstein: The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 89, 331-340 (1997)
    • (1997) Cell , vol.89 , pp. 331-340
    • Brown, M.S.1    Goldstein, J.L.2
  • 32
    • 2142751644 scopus 로고    scopus 로고
    • Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis
    • L. J. Engelking, H. Kuriyama, R. E. Hammer, J. D. Horton, M. S. Brown, J. L. Goldstein and G. Liang: Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis. J Clin Invest 113, 1168-75 (2004)
    • (2004) J Clin Invest , vol.113 , pp. 1168-1175
    • Engelking, L.J.1    Kuriyama, H.2    Hammer, R.E.3    Horton, J.D.4    Brown, M.S.5    Goldstein, J.L.6    Liang, G.7
  • 34
    • 30344473341 scopus 로고    scopus 로고
    • Protein sensors for membrane sterols
    • J. L. Goldstein, R. A. DeBose-Boyd and M. S. Brown: Protein sensors for membrane sterols. Cell 124, 35-46 (2006)
    • (2006) Cell , vol.124 , pp. 35-46
    • Goldstein, J.L.1    DeBose-Boyd, R.A.2    Brown, M.S.3
  • 35
    • 32244445264 scopus 로고    scopus 로고
    • New heterodimeric nuclear receptors: Key metabolic regulators with relevance in the pathophysiology and therapy of dyslipidemias and diabetes mellitus
    • V. Cortes, N. Quezada, A. Rigotti and A. Maiz: [New heterodimeric nuclear receptors: key metabolic regulators with relevance in the pathophysiology and therapy of dyslipidemias and diabetes mellitus.]. Rev Med Chil 133, 1483-92 (2005)
    • (2005) Rev Med Chil , vol.133 , pp. 1483-1492
    • Cortes, V.1    Quezada, N.2    Rigotti, A.3    Maiz, A.4
  • 36
    • 0345255889 scopus 로고    scopus 로고
    • Human malformation syndromes due to inborn errors of cholesterol synthesis
    • F. D. Porter: Human malformation syndromes due to inborn errors of cholesterol synthesis. Curr Opin Pediatr 15, 607-13 (2003)
    • (2003) Curr Opin Pediatr , vol.15 , pp. 607-613
    • Porter, F.D.1
  • 37
    • 35548983852 scopus 로고    scopus 로고
    • Lipoproteins and their receptors in embryonic development: More than cholesterol clearance
    • T. E. Willnow, A. Hammes and S. Eaton: Lipoproteins and their receptors in embryonic development: more than cholesterol clearance. Development 134, 3239-49 (2007)
    • (2007) Development , vol.134 , pp. 3239-3249
    • Willnow, T.E.1    Hammes, A.2    Eaton, S.3
  • 38
    • 68949161543 scopus 로고    scopus 로고
    • Lipid-modified morphogens: Functions of fats
    • J. Steinhauer and J. E. Treisman: Lipid-modified morphogens: functions of fats. Curr Opin Genet Dev 19, 308-14 (2009)
    • (2009) Curr Opin Genet Dev , vol.19 , pp. 308-314
    • Steinhauer, J.1    Treisman, J.E.2
  • 39
    • 36849089066 scopus 로고    scopus 로고
    • Inability to fully suppress sterol synthesis rates with exogenous sterol in embryonic and extraembyronic fetal tissues
    • L. Yao, K. Jenkins, P. S. Horn, M. H. Lichtenberg and L. A. Woollett: Inability to fully suppress sterol synthesis rates with exogenous sterol in embryonic and extraembyronic fetal tissues. Biochim Biophys Acta 1771, 1372-9 (2007)
    • (2007) Biochim Biophys Acta , vol.1771 , pp. 1372-1379
    • Yao, L.1    Jenkins, K.2    Horn, P.S.3    Lichtenberg, M.H.4    Woollett, L.A.5
  • 40
    • 0142213168 scopus 로고    scopus 로고
    • Differential effects of polyunsaturated fatty acids on sterol synthesis rates in adult and fetal tissues of the hamster: Consequence of altered sterol balance
    • K. E. Schmid and L. A. Woollett: Differential effects of polyunsaturated fatty acids on sterol synthesis rates in adult and fetal tissues of the hamster: consequence of altered sterol balance. Am J Physiol Gastrointest Liver Physiol 285, G796-803 (2003)
    • (2003) Am J Physiol Gastrointest Liver Physiol , vol.285
    • Schmid, K.E.1    Woollett, L.A.2
  • 41
    • 17444439499 scopus 로고
    • Teratogenic action in the rat of an inhibitor of cholesterol synthesis, AY 9944
    • C. Roux and M. Aubry: [Teratogenic action in the rat of an inhibitor of cholesterol synthesis, AY 9944]. C R Seances Soc Biol Fil 160, 1353-7 (1966)
    • (1966) C R Seances Soc Biol Fil , vol.160 , pp. 1353-1357
    • Roux, C.1    Aubry, M.2
  • 42
    • 33748307382 scopus 로고    scopus 로고
    • The mevalonate pathway controls heart formation in Drosophila by isoprenylation of Ggamma1
    • P. Yi, Z. Han, X. Li and E. N. Olson: The mevalonate pathway controls heart formation in Drosophila by isoprenylation of Ggamma1. Science 313, 1301-3 (2006)
    • (2006) Science , vol.313 , pp. 1301-1303
    • Yi, P.1    Han, Z.2    Li, X.3    Olson, E.N.4
  • 43
    • 23344441314 scopus 로고    scopus 로고
    • Gestational exposure to lovastatin followed by cardiac malformation misclassified as holoprosencephaly
    • R. J. Edison and M. Muenke: Gestational exposure to lovastatin followed by cardiac malformation misclassified as holoprosencephaly. N Engl J Med 352, 2759 (2005)
    • (2005) N Engl J Med , vol.352 , pp. 2759
    • Edison, R.J.1    Muenke, M.2
  • 44
    • 33748297599 scopus 로고    scopus 로고
    • Severe facial clefting in Insig-deficient mouse embryos caused by sterol accumulation and reversed by lovastatin
    • L. J. Engelking, B. M. Evers, J. A. Richardson, J. L. Goldstein, M. S. Brown and G. Liang: Severe facial clefting in Insig-deficient mouse embryos caused by sterol accumulation and reversed by lovastatin. J Clin Invest 116, 2356-65 (2006)
    • (2006) J Clin Invest , vol.116 , pp. 2356-2365
    • Engelking, L.J.1    Evers, B.M.2    Richardson, J.A.3    Goldstein, J.L.4    Brown, M.S.5    Liang, G.6
  • 46
    • 33746095457 scopus 로고    scopus 로고
    • The use of the Dhcr7 knockout mouse to accurately determine the origin of fetal sterols
    • G. S. Tint, H. Yu, Q. Shang, G. Xu and S. B. Patel: The use of the Dhcr7 knockout mouse to accurately determine the origin of fetal sterols. J Lipid Res 47, 1535-41 (2006)
    • (2006) J Lipid Res , vol.47 , pp. 1535-1541
    • Tint, G.S.1    Yu, H.2    Shang, Q.3    Xu, G.4    Patel, S.B.5
  • 47
    • 67650564159 scopus 로고    scopus 로고
    • Transport of maternal cholesterol to the fetus is affected by maternal plasma cholesterol concentrations in the golden Syrian hamster
    • K. T. Burke, P. L. Colvin, L. Myatt, G. A. Graf, F. Schroeder and L. A. Woollett: Transport of maternal cholesterol to the fetus is affected by maternal plasma cholesterol concentrations in the golden Syrian hamster. J Lipid Res 50, 1146-55 (2009)
    • (2009) J Lipid Res , vol.50 , pp. 1146-1155
    • Burke, K.T.1    Colvin, P.L.2    Myatt, L.3    Graf, G.A.4    Schroeder, F.5    Woollett, L.A.6
  • 48
    • 0034068935 scopus 로고    scopus 로고
    • Maternal high density lipoproteins affect fetal mass and extra-embryonic fetal tissue sterol metabolism in the mouse
    • J. A. McConihay, A. M. Honkomp, N. A. Granholm and L. A. Woollett: Maternal high density lipoproteins affect fetal mass and extra-embryonic fetal tissue sterol metabolism in the mouse. J Lipid Res 41, 424-32 (2000)
    • (2000) J Lipid Res , vol.41 , pp. 424-432
    • McConihay, J.A.1    Honkomp, A.M.2    Granholm, N.A.3    Woollett, L.A.4
  • 49
    • 25444530715 scopus 로고    scopus 로고
    • Transfer of maternal cholesterol to embryo and fetus in pregnant mice
    • S. Yoshida and Y. Wada: Transfer of maternal cholesterol to embryo and fetus in pregnant mice. J Lipid Res 46, 2168-74 (2005)
    • (2005) J Lipid Res , vol.46 , pp. 2168-2174
    • Yoshida, S.1    Wada, Y.2
  • 51
    • 39649111551 scopus 로고    scopus 로고
    • Developmental programming: Maternal hypercholesterolemia and immunity influence susceptibility to atherosclerosis
    • W. Palinski, T. Yamashita, S. Freigang and C. Napoli: Developmental programming: maternal hypercholesterolemia and immunity influence susceptibility to atherosclerosis. Nutr Rev 65, S182-7 (2007)
    • (2007) Nutr Rev , vol.65
    • Palinski, W.1    Yamashita, T.2    Freigang, S.3    Napoli, C.4
  • 53
    • 0028918775 scopus 로고
    • Knockout of the mouse apolipoprotein B gene results in embryonic lethality in homozygotes and protection against diet-induced hypercholesterolemia in heterozygotes
    • R. V. Farese, Jr., S. L. Ruland, L. M. Flynn, R. P. Stokowski and S. G. Young: Knockout of the mouse apolipoprotein B gene results in embryonic lethality in homozygotes and protection against diet-induced hypercholesterolemia in heterozygotes. Proc Natl Acad Sci U S A 92, 1774-8 (1995)
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 1774-1778
    • Farese Jr., R.V.1    Ruland, S.L.2    Flynn, L.M.3    Stokowski, R.P.4    Young, S.G.5
  • 54
    • 0035406530 scopus 로고    scopus 로고
    • Placental development: Lessons from mouse mutants
    • J. Rossant and J. C. Cross: Placental development: lessons from mouse mutants. Nat Rev Genet 2, 538-48 (2001)
    • (2001) Nat Rev Genet , vol.2 , pp. 538-548
    • Rossant, J.1    Cross, J.C.2
  • 56
    • 79951977727 scopus 로고    scopus 로고
    • Review: Transport of maternal cholesterol to the fetal circulation
    • L. A. Woollett: Review: Transport of maternal cholesterol to the fetal circulation. Placenta 32 Suppl 2, S218-21 (2011)
    • (2011) Placenta , vol.32 , Issue.SUPPL. 2
    • Woollett, L.A.1
  • 58
    • 4644255907 scopus 로고    scopus 로고
    • Thematic review series: The Pathogenesis of Atherosclerosis. An interpretive history of the cholesterol controversy: Part I
    • D. Steinberg: Thematic review series: The Pathogenesis of Atherosclerosis. An interpretive history of the cholesterol controversy: part I. J Lipid Res 45, 1583-1593 (2004)
    • (2004) J Lipid Res , vol.45 , pp. 1583-1593
    • Steinberg, D.1
  • 59
    • 0033552883 scopus 로고    scopus 로고
    • Atherosclerosis - An inflammatory disease
    • R. Ross: Atherosclerosis - an inflammatory disease. N Engl J Med 340, 115-26 (1999)
    • (1999) N Engl J Med , vol.340 , pp. 115-126
    • Ross, R.1
  • 60
    • 0034648768 scopus 로고    scopus 로고
    • Atherosclerosis
    • A. J. Lusis: Atherosclerosis. Nature 407, 233-41 (2000)
    • (2000) Nature , vol.407 , pp. 233-241
    • Lusis, A.J.1
  • 62
    • 18444396937 scopus 로고    scopus 로고
    • Reduced ABCA1-mediated cholesterol efflux and accelerated atherosclerosis in apolipoprotein E-deficient mice lacking macrophage-derived ACAT1
    • Y. R. Su, D. E. Dove, A. S. Major, A. H. Hasty, B. Boone, M. F. Linton and S. Fazio: Reduced ABCA1-mediated cholesterol efflux and accelerated atherosclerosis in apolipoprotein E-deficient mice lacking macrophage-derived ACAT1. Circulation 111, 2373-81 (2005)
    • (2005) Circulation , vol.111 , pp. 2373-2381
    • Su, Y.R.1    Dove, D.E.2    Major, A.S.3    Hasty, A.H.4    Boone, B.5    Linton, M.F.6    Fazio, S.7
  • 65
    • 0041335569 scopus 로고    scopus 로고
    • Niemann-Pick C heterozygosity confers resistance to lesional necrosis and macrophage apoptosis in murine atherosclerosis
    • B. Feng, D. Zhang, G. Kuriakose, C. M. Devlin, M. Kockx and I. Tabas: Niemann-Pick C heterozygosity confers resistance to lesional necrosis and macrophage apoptosis in murine atherosclerosis. Proc Natl Acad Sci U S A 100, 10423-8 (2003)
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 10423-10428
    • Feng, B.1    Zhang, D.2    Kuriakose, G.3    Devlin, C.M.4    Kockx, M.5    Tabas, I.6
  • 67
    • 77958003056 scopus 로고    scopus 로고
    • The Role of Endoplasmic Reticulum Stress in the Progression of Atherosclerosis
    • I. Tabas: The Role of Endoplasmic Reticulum Stress in the Progression of Atherosclerosis. Circ Res, 107(7), 839-850 (2010)
    • (2010) Circ Res , vol.107 , Issue.7 , pp. 839-850
    • Tabas, I.1
  • 69
    • 0037114662 scopus 로고    scopus 로고
    • Desmosterolosis presenting with multiple congenital anomalies and profound developmental delay
    • H. C. Andersson, L. Kratz and R. Kelley: Desmosterolosis presenting with multiple congenital anomalies and profound developmental delay. Am J Med Genet 113, 315-9 (2002)
    • (2002) Am J Med Genet , vol.113 , pp. 315-319
    • Andersson, H.C.1    Kratz, L.2    Kelley, R.3
  • 74
    • 66349126280 scopus 로고    scopus 로고
    • PCSK9: A convertase that coordinates LDL catabolism
    • J. D. Horton, J. C. Cohen and H. H. Hobbs: PCSK9: a convertase that coordinates LDL catabolism. J Lipid Res 50 Suppl, S172-7 (2009)
    • (2009) J Lipid Res , vol.50 , Issue.SUPPL.
    • Horton, J.D.1    Cohen, J.C.2    Hobbs, H.H.3
  • 75
    • 33645103550 scopus 로고    scopus 로고
    • Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
    • J. C. Cohen, E. Boerwinkle, T. H. Mosley, Jr. and H. H. Hobbs: Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N Engl J Med 354, 1264-72 (2006)
    • (2006) N Engl J Med , vol.354 , pp. 1264-1272
    • Cohen, J.C.1    Boerwinkle, E.2    Mosley Jr., T.H.3    Hobbs, H.H.4
  • 76
    • 0016293002 scopus 로고
    • Neonatal plasma lipids as measured in cord blood
    • M. A. Mishkel: Neonatal plasma lipids as measured in cord blood. Can Med Assoc J 111, 775-80 (1974)
    • (1974) Can Med Assoc J , vol.111 , pp. 775-780
    • Mishkel, M.A.1
  • 77
    • 0000755347 scopus 로고
    • Effects of Triparanol (Mer-29) on Cholesterol Biosynthesis and on Blood Sterol Levels in Man
    • D. Steinberg, J. Avigan and E. B. Feigelson: Effects of Triparanol (Mer-29) on Cholesterol Biosynthesis and on Blood Sterol Levels in Man. J Clin Invest 40, 884-93 (1961)
    • (1961) J Clin Invest , vol.40 , pp. 884-893
    • Steinberg, D.1    Avigan, J.2    Feigelson, E.B.3
  • 78
    • 0014212924 scopus 로고
    • Mass drug catastrophes and the roles of science and technology
    • W. Modell: Mass drug catastrophes and the roles of science and technology. Science 156, 346-51 (1967)
    • (1967) Science , vol.156 , pp. 346-351
    • Modell, W.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.