Differential effects of polyunsaturated fatty acids on sterol synthesis rates in adult and fetal tissues of the hamster: Consequence of altered sterol balance

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 285, Issue 5 48-5, 2003, Pages

  Schmid, Kara E ^a   Woollett, Laura A ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Cholesterol; Fetus; Gestation; Placenta; Yolk sac

Indexed keywords

POLYUNSATURATED FATTY ACID; STEROL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; FETUS GROWTH; GENE EXPRESSION; HAMSTER; MATERNAL NUTRITION; NONHUMAN; PRIORITY JOURNAL; STEROL SYNTHESIS;

EID: 0142213168     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.00226.2003     Document Type: Article

References (58)

1. Barak Y, Nelson MC, Ong ES, Jones YZ, Ruiz-Lozano P, Chien KR, Koder A, and Evans RM. PPAR gamma is required for placental, cardiac and adipose tissue development. Mol Cell 4: 585-595, 1999.
2. Beck F, Plummer S, Senior PV, Byrne S, Green S, and Brammar WJ. The ontogeny of peroxisome-proliferator-activated receptor gene expression in the mouse and rat. Proc R Soc Lond B Biol Sci 247: 83-87, 1992.
3. Belknap WM and Dietschy JM. Sterol synthesis and low density lipoprotein clearance in vivo in the pregnant rat, placenta, and fetus. Sources for tissue cholesterol during fetal development. J Clin Invest 82: 2077-2085, 1988.
4. Botolin D and Jump DB. Selective proteolytic processing of rat hepatic sterol regulatory element binding protein-1 (SREBP-1) and SREBP-2 during postnatal development. J Biol Chem 278: 6959-6962, 2003.
5. Braissant O and Wahli W. Differential expression of peroxisome proliferator-activated receptor-α, -β, and -γ during rat embryonic development. Endocrinology 139: 2748-2754, 1998.
6. Daumerie CM, Woollett LA, and Dietschy JM. Fatty acids regulate hepatic low density lipoprotein receptor activity through redistribution of intracellular cholesterol pools. Proc Natl Acad Sci USA 89: 10797-10801, 1992.
7. Dehart BD, Lanoue L, Tint GS, and Sulik KK. Pathogenesis of malformations in a rodent model for Smith-Lemli-Opitz syndrome. Am J Med Genet 68: 328-337, 1997.
8. Dietschy JM and Spady DK. Measurement of rates of cholesterol synthesis using tritiated water. J Lipid Res 25: 1469-1476, 1984.
9. Dietschy JM, Turley SD, and Spady DK. Role of liver in the maintenance of cholesterol and low density lipoprotein homeostasis in different animal species, including humans. J Lipid Res 34: 1637-1659, 1993.
10. Diomede L, Salmona M, Albani D, Bianchi M, Bruno A, Salmona S, and Nicolini U. Alteration of SREBP activation in liver of trisomy 21 fetuses. Biochem Biophys Res Commun 260: 499-503, 1999.
11. Dutta-Roy AK. Transport mechanisms for long-chain polyunsaturated fatty acids in the human placenta. Am J Clin Nutr 71: 315S-322S, 2000.
12. Field FJ, Born E, and Mathur SN. Fatty acid flux suppresses fatty acid synthesis in hamster intestine independently of sterol regulatory element-binding protein-1 expression. J Lipid Res 44: 1199-1208, 2003.
13. Forman BM, Chen J, and Evans RM. Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta. Proc Natl Acad Sci USA 94: 4312-4317, 1997.
14. Glatz JFC and Katan MB. Dietary saturated fatty acids increase cholesterol synthesis and fecal steroid excretion in healthy men and women. Eur J Clin Invest 23: 648-655, 1993.
15. Gurr Fats M. In: Human nutrition and Dietetics, edited by Garrow JS and James WPT. Edinburgh, UK: Churchill & Livingstone, 1993, p. 77-102.
16. Haggarty P, Page K, Abramovich DR, Ashton J, and Brown D. Long-chain polyunsaturated fatty acid transport across the perfused human placenta. Placenta 18: 635-642, 1997.
17. Horton JD, Cuthbert JA, and Spady DK. Regulation of hepatic 7a-hydroxylase expression and response to dietary cholesterol in the rat and hamster. J Biol Chem 270: 5381-5387, 1995.
18. Horton JD, Goldstein JL, and Brown MS. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 109: 1125-1131, 2002.
19. Hua X, Nohturfft A, Goldstein JL, and Brown MS. Sterol resistance in CHO cells traced to point mutation in SREBP cleavage activating protein (SCAP). Cell 87: 415-426, 1996.
20. Irons M, Elias ER, Salen G, Tint GS, and Batta AK. Defective cholesterol biosynthesis in Smith-Lemli-Opitz syndrome. Lancet 341: 1414, 1993.
21. Jump DB. Dietary polyunsaturated fatty acids and regulation of gene transcription. Curr Opin Lipidol 13: 155-164, 2002.
22. Kelley RI. Inborn errors of cholesterol biosynthesis. Adv Pediatr 47: 1-52, 2000.
23. Kim HJ, Miyazaki M, Man WC, and Ntambi JM. Sterol regulatory element-binding proteins (SREBPs) as regulators of lipid metabolism. Polyunsaturated fatty acids oppose cholesterol-mediated induction of SREBP-1 maturation. Ann NY Acad Sci 967: 34-42, 2002.
24. Kim HJ, Takahashi M, and Ezaki O. Fish oil feeding decreases mature sterol regulatory element-binding protein 1 (SREBP-1) by down-regulation of SREBP-1c mRNA in mouse liver. J Biol Chem 274: 25892-25898, 1999.
25. Kliewer SA, Sundseth SS, Jones SA, Brown PJ, Wisely GB, Koble CS, Devchand P, Wahli W, Wilson TM, Lenhard JM, and Lehmann JM. Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma. Proc Natl Acad Sci USA 94: 4318-4323, 1997.
26. Kremarik-Bouillaud P, Schohn H, and Dauca M. Regional distribution of PPAR beta in the cerebellum of the rat. J Chem Neuroanat 19: 225-232, 2000.
27. Lee SS, Pineau T, Drago J, Lee EJ, Owens JW, Kroetz DL, Fernandez-Salguero PM, Westphal H, and Gonzalez FJ. Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol Cell Biol 15: 3012-3022, 1995.
28. Mazier MJ and Jones PJ. Diet fat saturation and feeding state modulate rates of cholesterol synthesis in normolipidemic men. J Nutr 127: 332-340, 1997.
29. Miguel SG and Abraham S. Effect of maternal diet on fetal hepatic lipogenesis. Biochim Biophys Acta 424: 213-234, 1976.
30. Morrison WR and Smith LM. Preparation of fatty acid methyl esters and dimethylacetals from lipids with boron fluoride-methanol. J Lipid Res 5: 600-608, 1964.
31. Muoio DM, MacLean PS, Lang DB, Li S, Houmard JA, Way JM, Winegar DA, Corton JC, Dohm GL, and Kraus WE. Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) a knock-out mice. J Biol Chem 277: 26089-26097, 2002.
32. Nohturfft A, DeBose-Boyd RA, Scheek S, Goldstein JL, and Brown MS. Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and Golgi. Proc Natl Acad Sci USA 96: 11235-11240, 1999.
33. Ntambi JM and Bene H. Polyunsaturated fatty acid regulation of gene expression. J Mol Neurosci 16: 273-278, 2001.
34. Porter JA, Young KE, and Beachy PA. Cholesterol modification of hedgehog signaling proteins in animal development. Science 274: 255-259, 1996.
35. R: prevention by a hypercholesterolemia-provoking diet. Teratology 19: 35-38, 1979.
36. Roux C, Wolf C, Mulliez N, Gaoua W, Cormier V, Chevy F, and Citadelle D. Role of cholesterol in embryonic development. Am J Clin Nutr 71 Suppl: 1270S-1279S, 2000.
37. Shimomura I, Bashmakov Y, Shimano H, Horton JD, Goldstein JL, and Brown MS. Cholesterol feeding reduces nuclear forms of sterol regulatory element binding proteins in hamster liver. Proc Natl Acad Sci USA 94: 12354-12359, 1997.
38. Smith DW, Lemli L, and Opitz JM. A newly recognized syndrome of multiple congenital anomalies. J Pediatr 64: 210-217, 1964.
39. Spady DK and Dietschy JM. Interaction of dietary cholesterol and triglycerides in the regulation of hepatic low density lipoprotein transport in the hamster. J Clin Invest 81: 300-309, 1988.
40. Spady DK, Woollett LA, and Dietschy JM. Regulation of plasma LDL-cholesterol levels by dietary cholesterol and fatty acids. Annu Rev Nutr 13: 355-381, 1993.
41. Stewart J, Kaplan ML, and Beitz DC. Pork with a high content of polyunsaturated fatty acids lowers LDL cholesterol in women. Am J Clin Nutr 74: 179-187, 2001.
42. Tint GS, Irons M, Elias ER, Batta AK, Frieden R, Chen TS, and Salen G. Defective cholesterol biosynthesis associated with the Smith-Lemli-Opitz syndrome. N Engl J Med 330: 107-113, 1994.
43. Turley SD, Daggy BP, and Dietschy JM. Effect of feeding psyllium and cholestyramine in combination on low density lipoprotein metabolism and fecal bile acid excretion in hamsters with dietary-induced hypercholesterolemia. J Cardiovasc Pharmacol 27: 71-79, 1996.
44. Turley SD, Daggy BP, and Dietschy JM. Psyllium augments the cholesterol-lowering action of cholestyramine in hamsters by enhancing sterol loss from the liver. Gastroenterology 107: 444-452, 1994.
45. Turley SD and Dietschy JM. Effects of clofibrate, cholestyramine, zanchol, probucol, and AOMA feeding on hepatic and intestinal cholesterol metabolism and on biliary lipid secretion in the rat. J Cardiovasc Pharmacol 2: 281-297, 1980.
46. Turley SD, Herndon MW, and Dietschy JM. Reevaluation and application of the dual-isotope plasma ratio method for the measurement of intestinal cholesterol absorption in the hamster. J Lipid Res 35: 328-339, 1994.
47. Turley SD, Spady DK, and Dietschy JM. Identification of a metabolic difference accounting for the hyper- and hyporesponder phenotypes of cynomolgus monkey. J Lipid Res 38: 1598-1611, 1997.
48. Wang H, Liu F, Millette CF, and Kilpatrick DL. Expression of a novel, sterol-insensitive form of sterol regulatory element binding protein 2 (SREBP2) in male germ cells suggests important cell- and stage-specific functions for SREBP targets during spermatogenesis. Mol Cell Biol 22: 8478-8490, 2002.
49. Wilentz RE, Witters LA, and Pizer ES. Lipogenic enzymes fatty acid synthase and acetyl-co-enzyme A carboxylase are coexpressed with sterol regulatory element binding protein and Ki-67 in fetal tissues. Ped Devel Path 3: 525-531, 2000.
50. Willy PJ, Umesono K, Ong ES, Evans RM, Heyman RA, and Mangelsdorf DJ. LXR, a nuclear receptor that defines a distinct retinoid response pathway. Genes Dev 9: 1033-1045, 1005.
51. Woollett LA. Origin of cholesterol in the fetal Golden Syrian hamster: contribution of de novo sterol synthesis and maternal-derived lipoprotein cholesterol. J Lipid Res 37: 1246-1257, 1996.
52. Woollett LA, Spady DK, and Dietschy JM. Regulatory effects of the saturated fatty acids 6:0 through 18:0 on hepatic low density lipoprotein receptor activity in the hamster. J Clin Invest 89: 1133-1141, 1992.
53. Woollett LA, Spady DK, and Dietschy JM. Mechanisms by which saturated triacylglycerols elevate the plasma low density lipoprotein-cholesterol concentration in hamsters. Differential effects of fatty acid chain length. J Clin Invest 84: 119-128, 1989.
54. Woollett LA, Spady DK, and Dietschy JM. Saturated and unsaturated fatty acids independently regulate low density lipoprotein receptor activity and production rate. J Lipid Res 33: 77-88, 1992.
55. Worgall TS, Sturley SL, Seo T, Osborne TF, and Deckelbaum RJ. Polyunsaturated fatty acids decrease expression of promoters with sterol regulatory elements by decreasing levels of mature sterol regulatory element-binding protein. J Biol Chem 273: 25537-25540, 1998.
56. Xu J, Cho H, O'Malley S, Park JHY, and Clarke SD. Dietary polyunsaturated fats regulate rat liver sterol regulatory element binding proteins-1 and -2 in three distinct stages and by different mechanisms. J Nutr 132: 3333-3339, 2002.
57. Yang J, Sato R, Goldstein JL, and Brown MS. Sterol-resistant transcription in CHO cells caused by gene rearrangement that truncates SREBP-2. Genes Dev 8: 1910-1919, 1994.
58. Yang T, Goldstein JL, and Brown MS. Overexpression of membrane domain of SCAP prevents sterols from inhibiting SCAP-SREBP exit from endoplasmic reticulum. J Biol Chem 275: 29881-29886, 2000.