Clonal heterogeneity of thymic B cells from early-onset myasthenia gravis patients with antibodies against the acetylcholine receptor

Journal of Autoimmunity

Volumn 52, Issue , 2014, Pages 101-112

  Vrolix, Kathleen ^a   Fraussen, Judith ^b   Losen, Mario ^a   Stevens, Jo ^a   Lazaridis, Konstantinos ^c   Molenaar, Peter C ^a   Somers, Veerle ^b   Bracho, Maria Alma ^d,e,f   Le Panse, Rozen ^g   Stinissen, Piet ^b   Berrih Aknin, Sonia ^g   Maessen, Jos G ^h   Van Garsse, Leen ^h   Buurman, Wim A ^a   Tzartos, Socrates J ^c   De Baets, Marc H ^a,b   Martinez Martinez, Pilar ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b HASSELT UNIVERSITY   (Belgium)

^c HELLENIC PASTEUR INSTITUTE   (Greece)

^d Centre Superior d'Investigació en Salut Pública CSISP FISABIO Área de Desigualtats en Salut   (Spain)

^e UNIVERSITY OF VALENCIA   (Spain)

^f CIBER EPIDEMIOLOGÍA Y SALUD PÚBLICA CIBERESP   (Spain)

^g Sorbonne Université   (France)

^h MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

B cell immortalization; Clonal expansion; Myasthenia gravis; Striational autoantibodies

Indexed keywords

CHOLINERGIC RECEPTOR ANTIBODY; MONOCLONAL ANTIBODY; MUSCLE PROTEIN; AUTOANTIBODY; CHOLINERGIC RECEPTOR; NANOBODY; TOLL LIKE RECEPTOR 9; B LYMPHOCYTE ANTIBODY; CD22 ANTIGEN; COMPLEMENT COMPONENT C3D RECEPTOR; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN M; PROTEIN P90;

ADULT; ARTICLE; B LYMPHOCYTE; CELL HETEROGENEITY; CLINICAL ARTICLE; CONTROLLED STUDY; DEMYELINATING DISEASE; FEMALE; GENE SEQUENCE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; MULTIGENE FAMILY; MULTIPLE SCLEROSIS; MUTATION RATE; MYASTHENIA GRAVIS; PRIORITY JOURNAL; SKELETAL MUSCLE; SOMATIC HYPERMUTATION; SYSTEMIC LUPUS ERYTHEMATOSUS; THYMOCYTE; BLOOD; CELL CLONE; EPSTEIN BARR VIRUS; GENETICS; HYPERPLASIA; IMMUNOLOGY; METABOLISM; MUTATION; PATHOLOGY; PHYSIOLOGY; THYMUS; TRANSFORMED CELL LINE; VIRUS CELL TRANSFORMATION; YOUNG ADULT; ANIMAL TISSUE; ANTIBODY PRODUCTION; ANTIGEN BINDING; CELL CLONING; CELL EXPANSION; CELL IMMORTALIZATION; CELL ISOLATION; CELL SURFACE; CROSS REACTION; FLOW CYTOMETRY; GENE REARRANGEMENT; GERMINAL CENTER; HAPLORHINI; HUMAN TISSUE; HUMORAL IMMUNITY; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOGLOBULIN HEAVY CHAIN GENE; IN VITRO STUDY; INFANT; INTERNALIZATION; MOUSE; NONHUMAN; PHYLOGENETIC TREE; POLYACRYLAMIDE GEL ELECTROPHORESIS; RAT; SEQUENCE ANALYSIS; WESTERN BLOTTING;

ADULT; AUTOANTIBODIES; B-LYMPHOCYTES; CELL LINE, TRANSFORMED; CELL TRANSFORMATION, VIRAL; CLONE CELLS; FEMALE; HERPESVIRUS 4, HUMAN; HUMANS; HYPERPLASIA; MUSCLE, STRIATED; MUTATION; MYASTHENIA GRAVIS; RECEPTORS, CHOLINERGIC; SINGLE-DOMAIN ANTIBODIES; THYMUS GLAND; TOLL-LIKE RECEPTOR 9; YOUNG ADULT;

EID: 84904276464     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2013.12.008     Document Type: Article

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