Metformin inhibits the proliferation of A549/CDDP cells by activating p38 mitogen-activated protein kinase

Oncology Letters

Volumn 8, Issue 3, 2014, Pages 1269-1274

  Wang, Yajun ^a   Lin, Biyun ^a   Wu, Jun ^a   Zhang, Haitao ^a   Wu, Bin ^a  

^a GUANGDONG MEDICAL UNIVERSITY   (China)

Author keywords

Cisplatin resistant lung cancer cells; Metformin; p38 MAPK

Indexed keywords

EID: 84904254716     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2014.2270     Document Type: Article

References (21)

1. Winton T, Livingston R, Johnson D, Rigas J, Johnston M, Butts C, et al; National Cancer Institute of Canada Clinical Trials Group; National Cancer Institute of the United States Intergroup JBR.10 Trial Investigators: Vinorelbine plus cisplatin vs. observation in resected non-small-cell lung cancer. N Engl J Med 352: 2589-2597, 2005.
2. Risch A and Plass C: Lung cancer epigenetics and genetics. Int J Cancer 123: 1-7, 2008.
3. Stewart DJ: Mechanisms of resistance to cisplatin and carboplatin. Crit Rev Oncol Hematol 163: 12-31, 2007.
4. Gallwitz B and Bretzel RG: How do we continue treatment in patients with type 2 diabetes when therapeutic goals are not reached with oral antidiabetes agents and lifestyle? Incretin versus insulin treatment. Diabetes Care 36: S180-S189, 2013.
5. Evans JM, Donnelly LA, Emslie-Smith AM, Alessi DR and Morris AD: Metformin and reduced risk of cancer in diabetic patients. BMJ 330: 1304-1305, 2005.
6. Schneider MB, Matsuzaki H, Haorah J, Ulrich A, Standop J, Ding XZ, Adrian TE and Pour PM: Prevention of pancreatic cancer induction in hamsters by metformin. Gastroenterology 120: 1263-1270, 2001.
7. Anisimov VN, Berstein LM, Egormin PA, Piskunova TS, Popovich IG, Zabezhinski MA, Kovalenko IG, Poroshina TE, Semenchenko AV, Provinciali M, Re F and Franceschi C: Effect of metformin on life span and on the development of spontaneousmammary tumors in HER-2/neu transgenic mice. Exp Gerontol 40: 685-693, 2005.
8. Bowker SL, Majumdar SR, Veugelers P and Johnson JA: Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin. Diabetes Care 29: 254-258, 2006.
9. Buzzai M, Jones RG, Amaravadi RK, Lum JJ, DeBerardinis RJ, Zhao F, Viollet B and Thompson CB: Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth. Cancer Res 67: 6745-6752, 2007.
10. Ben Sahra I, Laurent K, Loubat A, Giorgetti-Peraldi S, Colosetti P, Auberger P, Tanti JF, Le Marchand-Brustel Y and Bost F: The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level. Oncogene 27: 3576-3586, 2008.
11. Zhang HT, Wu J, Wen M, Su LJ and Luo H: Galangin induces apoptosis in hepatocellular carcinoma cells through the caspase 8/t-Bid mitochondrial pathway. J Asian Nat Prod Res 14: 626-633, 2012.
12. Wu J, Hu CP, Gu QH, Li YP and Song M: Trichostatin A sensitizes cisplatin-resistant A549 cells to apoptosis by up-regulating death-associated protein kinase. Acta Pharmacol Sin 31: 93-101, 2010.
13. Jemal A, Murray T, Ward E, Samuels A, Tiwari RC, Ghafoor A, Feuer EJ and Thun MJ: Cancer statistics, 2005. CA Cancer J Clin 55: 10-30, 2005.
14. Jemal A, Siegel R, Ward E, Murray T, Xu J and Thun MJ: Cancer statistics, 2007. CA Cancer J Clin 57: 43-66, 2007.
15. Florea AM and Büsselberg D: Cisplatin as an anti-tumor drug: cellular mechanisms of activity, drug resistance and induced side effects. Cancers (Basel) 15: 1351-1371, 2011.
16. Jiang Q, Li F, Shi K, Wu P, An J, Yang Y and Xu C: ATF4 activation by the p38MAPK-eIF4E axis mediates apoptosis and autophagy induced by selenite in Jurkat cells. FEBS Lett 587: 2420-2429, 2013.
17. Neoh CA, Wang RY, Din ZH, Su JH, Chen YK, Tsai FJ, Weng SH and Wu YJ: Induction of apoptosis by sinulariolide from soft coral through mitochondrial-related and p38 MAPK pathways on human bladder carcinoma cells. Mar Drugs 10: 2893-2911, 2012.
18. Mandal C, Dutta A, Mallick A, Chandra S, Misra L, Sangwan RS, Mandal C: Withaferin A induces apoptosis by activating p38 mitogen-activated protein kinase signaling cascade in leukemic cells of lymphoid and myeloid origin through mitochondrial death cascade. Apoptosis 13: 1450-1464, 2008.
19. Chang HL, Chen CY, Hsu YF, Kuo WS, Ou G, Chiu PT, Huang YH and Hsu MJ: Simvastatin induced HCT116 colorectal cancer cell apoptosis through p38MAPK-p53-survivin signaling cascade. Biochim Biophys Acta 1830: 4053-4064, 2013.
20. Yang X, Yao J, Luo Y, Han Y, Wang Z and Du L: P38 MAP kinase mediates apoptosis after genipin treatment in non-small-cell lung cancer H1299 cells via a mitochondrial apoptotic cascade. J Pharmacol Sci 121: 272-281, 2013.
21. Khan R, Khan AQ, Qamar W, Lateef A, Tahir M, Rehman MU, Ali F and Sultana S: Chrysin protects against cisplatin-induced colon toxicity via amelioration of oxidative stress and apoptosis: probable role of p38MAPK and p53. Toxicol Appl Pharmacol 258: 315-329, 2012.