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Volumn 36, Issue SUPPL.2, 2013, Pages

How do we continue treatment in patients with type 2 diabetes when therapeutic goals are not reached with oral antidiabetes agents and lifestyle? incretin versus insulin treatment

Author keywords

[No Author keywords available]

Indexed keywords

ALBIGLUTIDE; ALPHA GLUCOSIDASE INHIBITOR; DIPEPTIDYL PEPTIDASE IV INHIBITOR; EXENDIN 4; GLIMEPIRIDE; GLUCAGON LIKE PEPTIDE 1 RECEPTOR AGONIST; HEMOGLOBIN A1C; INSULIN; INSULIN ASPART; INSULIN GLARGINE; LIRAGLUTIDE; LIXISENATIDE; METFORMIN; ORAL ANTIDIABETIC AGENT; PIOGLITAZONE; PLACEBO; SULFONYLUREA; SULFONYLUREA DERIVATIVE;

EID: 84891802218     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dcS13-2012     Document Type: Article
Times cited : (15)

References (72)
  • 1
    • 84891792977 scopus 로고    scopus 로고
    • International Diabetes Federation. Diabetes atlas [article online], Accessed 14 December 2012
    • International Diabetes Federation. Diabetes atlas [article online], 2011. Available from http://www.idf.org/diabetesatlas/5e/the-global-burden. Accessed 14 December 2012
    • (2011)
  • 3
    • 38949210220 scopus 로고    scopus 로고
    • Effect of a multifactorial intervention on mortality in type 2 diabetes
    • Gaede P, Lund-Andersen H, Parving HH, Pedersen O. Effect of a multifactorial intervention on mortality in type 2 diabetes. N Engl J Med 2008;358:580-591
    • (2008) N Engl J Med , vol.358 , pp. 580-591
    • Gaede, P.1    Lund-Andersen, H.2    Parving, H.H.3    Pedersen, O.4
  • 4
    • 84891778825 scopus 로고    scopus 로고
    • U.S. Renal Data System. USRDS 2011 Annual Data Report: Atlas of Chronic Kidney Disease and End-Stage Renal Disease in the United States. Bethesda, MD, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases
    • U.S. Renal Data System. USRDS 2011 Annual Data Report: Atlas of Chronic Kidney Disease and End-Stage Renal Disease in the United States. Bethesda, MD, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, 2011
    • (2011)
  • 5
    • 84866268783 scopus 로고    scopus 로고
    • Management of hyper-glycemia in type 2 diabetes: A patient-centered approach: Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
    • American Diabetes Association (ADA); European Association for the Study of Diabetes (EASD).
    • Inzucchi SE, Bergenstal RM, Buse JB, et al.; American Diabetes Association (ADA); European Association for the Study of Diabetes (EASD). Management of hyper-glycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care 2012;35:1364-1379
    • (2012) Diabetes Care , vol.35 , pp. 1364-1379
    • Inzucchi, S.E.1    Bergenstal, R.M.2    Buse, J.B.3
  • 6
    • 84862302997 scopus 로고    scopus 로고
    • Ex-enatide twice daily versus glimepiride for prevention of glycaemic deterioration in patients with type 2 diabetes with met-formin failure (EUREXA): An open-label, randomised controlled trial
    • Gallwitz B, Guzman J, Dotta F, et al. Ex-enatide twice daily versus glimepiride for prevention of glycaemic deterioration in patients with type 2 diabetes with met-formin failure (EUREXA): an open-label, randomised controlled trial. Lancet 2012; 379:2270-2278
    • (2012) Lancet , vol.379 , pp. 2270-2278
    • Gallwitz, B.1    Guzman, J.2    Dotta, F.3
  • 7
    • 84864270406 scopus 로고    scopus 로고
    • Basal insulin and cardiovascular and other outcomes in dys-glycemia
    • ORIGIN Trial Investigators.
    • Gerstein HC, Bosch J, Dagenais GR, et al.; ORIGIN Trial Investigators. Basal insulin and cardiovascular and other outcomes in dys-glycemia. N Engl J Med 2012;367:319-328
    • (2012) N Engl J Med , vol.367 , pp. 319-328
    • Gerstein, H.C.1    Bosch, J.2    Dagenais, G.R.3
  • 8
    • 84862152967 scopus 로고    scopus 로고
    • Efficacy of GLP-1 receptor agonists and DPP-4 inhibitors: Meta-analysis and systematic review
    • Aroda VR, Henry RR, Han J, et al. Efficacy of GLP-1 receptor agonists and DPP-4 inhibitors: meta-analysis and systematic review. Clin Ther 2012;34:1247-1258
    • (2012) Clin Ther , vol.34 , pp. 1247-1258
    • Aroda, V.R.1    Henry, R.R.2    Han, J.3
  • 9
    • 80052645534 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 analogues for type 2 diabetes mellitus: Current and emerging agents
    • Gallwitz B. Glucagon-like peptide-1 analogues for type 2 diabetes mellitus: current and emerging agents. Drugs 2011;71: 1675-1688
    • (2011) Drugs , vol.71 , pp. 1675-1688
    • Gallwitz, B.1
  • 10
    • 75649136250 scopus 로고    scopus 로고
    • Benefit-risk assessment of ex-enatide in the therapy of type 2 diabetes mellitus
    • Gallwitz B. Benefit-risk assessment of ex-enatide in the therapy of type 2 diabetes mellitus. Drug Saf 2010;33:87-100
    • (2010) Drug Saf , vol.33 , pp. 87-100
    • Gallwitz, B.1
  • 11
    • 84858139421 scopus 로고    scopus 로고
    • Liraglutide in oral antidiabetic drug combination therapy
    • Garber AJ. Liraglutide in oral antidiabetic drug combination therapy. Diabetes Obes Metab 2012;14(Suppl. 2):13-19
    • (2012) Diabetes Obes Metab , vol.14 , Issue.SUPPL. 2 , pp. 13-19
    • Garber, A.J.1
  • 12
    • 79953040963 scopus 로고    scopus 로고
    • An overview of once-weekly glucagon-like peptide-1 receptor agonistsdavailable efficacy and safety data and perspectives for the future
    • Madsbad S, Kielgast U, Asmar M, Deacon CF, Torekov SS, Holst JJ. An overview of once-weekly glucagon-like peptide-1 receptor agonistsdavailable efficacy and safety data and perspectives for the future. Diabetes Obes Metab 2011;13:394-407
    • (2011) Diabetes Obes Metab , vol.13 , pp. 394-407
    • Madsbad, S.1    Kielgast, U.2    Asmar, M.3    Deacon, C.F.4    Torekov, S.S.5    Holst, J.J.6
  • 13
    • 38549162147 scopus 로고    scopus 로고
    • Exenatide effects on diabetes, obesity, cardiovascular risk factors and hepatic biomarkers in patients with type 2 diabetes treated for at least 3 years
    • Klonoff DC, Buse JB, Nielsen LL, et al. Exenatide effects on diabetes, obesity, cardiovascular risk factors and hepatic biomarkers in patients with type 2 diabetes treated for at least 3 years. Curr Med Res Opin 2008;24:275-286
    • (2008) Curr Med Res Opin , vol.24 , pp. 275-286
    • Klonoff, D.C.1    Buse, J.B.2    Nielsen, L.L.3
  • 14
    • 67649666737 scopus 로고    scopus 로고
    • Liraglutide once a day versus exenatide twice a day for type 2 diabetes: A 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)
    • LEAD-6 Study Group.
    • Buse JB, Rosenstock J, Sesti G, et al.; LEAD-6 Study Group. Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6). Lancet 2009;374:39-47
    • (2009) Lancet , vol.374 , pp. 39-47
    • Buse, J.B.1    Rosenstock, J.2    Sesti, G.3
  • 15
    • 84859003663 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide-1 receptor agonists on weight loss: Systematic review and meta-analyses of randomised controlled trials
    • Vilsbøll T, Christensen M, Junker AE, Knop FK, Gluud LL. Effects of glucagon-like peptide-1 receptor agonists on weight loss: systematic review and meta-analyses of randomised controlled trials. BMJ 2012;344:d7771
    • (2012) BMJ , vol.344
    • Vilsbøll, T.1    Christensen, M.2    Junker, A.E.3    Knop, F.K.4    Gluud, L.L.5
  • 16
    • 26944477362 scopus 로고    scopus 로고
    • Exenatide versus insulin glargine in patients with suboptimally controlled type 2 diabetes: A randomized trial
    • GWAA Study Group
    • Heine RJ, Van Gaal LF, Johns D, Mihm MJ, Widel MH, Brodows RG; GWAA Study Group. Exenatide versus insulin glargine in patients with suboptimally controlled type 2 diabetes: a randomized trial. Ann Intern Med 2005;143:559-569
    • (2005) Ann Intern Med , vol.143 , pp. 559-569
    • Heine, R.J.1    Van Gaal, L.F.2    Johns, D.3    Mihm, M.J.4    Widel, M.H.5    Brodows, R.G.6
  • 17
    • 34247195226 scopus 로고    scopus 로고
    • A comparison of twice-daily exenatide and biphasic insulin aspart in patients with type 2 diabetes who were suboptimally controlled with sulfonylurea and metfor-min: A non-inferiority study
    • Nauck MA, Duran S, Kim D, et al. A comparison of twice-daily exenatide and biphasic insulin aspart in patients with type 2 diabetes who were suboptimally controlled with sulfonylurea and metfor-min: a non-inferiority study. Diabetologia 2007;50:259-267
    • (2007) Diabetologia , vol.50 , pp. 259-267
    • Nauck, M.A.1    Duran, S.2    Kim, D.3
  • 18
    • 37349008890 scopus 로고    scopus 로고
    • Tol-erability and efficacy of exenatide and titrated insulin glargine in adult patients with type 2 diabetes previously uncontrolled with metformin or a sulfonylurea: A multinational, randomized, open-label, two-period, crossover noninferiority trial
    • Barnett AH, Burger J, Johns D, et al. Tol-erability and efficacy of exenatide and titrated insulin glargine in adult patients with type 2 diabetes previously uncontrolled with metformin or a sulfonylurea: a multinational, randomized, open-label, two-period, crossover noninferiority trial. Clin Ther 2007;29:2333-2348
    • (2007) Clin Ther , vol.29 , pp. 2333-2348
    • Barnett, A.H.1    Burger, J.2    Johns, D.3
  • 19
    • 64249143715 scopus 로고    scopus 로고
    • Efficacy and safety of biphasic insulin aspart 70/30 versus exenatide in subjects with type 2 diabetes failing to achieve glycemic control with metformin and a sulfonylurea
    • NovoLog Mix-vs.-Exenatide Study Group.
    • Bergenstal R, Lewin A, Bailey T, Chang D, Gylvin T, Roberts V; NovoLog Mix-vs.-Exenatide Study Group. Efficacy and safety of biphasic insulin aspart 70/30 versus exenatide in subjects with type 2 diabetes failing to achieve glycemic control with metformin and a sulfonylurea. Curr Med Res Opin 2009;25:65-75
    • (2009) Curr Med Res Opin , vol.25 , pp. 65-75
    • Bergenstal, R.1    Lewin, A.2    Bailey, T.3    Chang, D.4    Gylvin, T.5    Roberts, V.6
  • 20
    • 79956151964 scopus 로고    scopus 로고
    • Exenatide twice daily versus premixed insulin aspart 70/30 in metformin-treated patients with type 2 diabetes: A randomized 26-week study on glycemic control and hypoglycemia
    • Gallwitz B, Böhmer M, Segiet T, et al. Exenatide twice daily versus premixed insulin aspart 70/30 in metformin-treated patients with type 2 diabetes: a randomized 26-week study on glycemic control and hypoglycemia. Diabetes Care 2011; 34:604-606
    • (2011) Diabetes Care , vol.34 , pp. 604-606
    • Gallwitz, B.1    Böhmer, M.2    Segiet, T.3
  • 21
    • 80054090833 scopus 로고    scopus 로고
    • Effects of exenatide on measures of b-cell function after 3 years in metformin-treated patients with type 2 diabetes
    • Bunck MC, Cornér A, Eliasson B, et al. Effects of exenatide on measures of b-cell function after 3 years in metformin-treated patients with type 2 diabetes. Diabetes Care 2011;34:2041-2047
    • (2011) Diabetes Care , vol.34 , pp. 2041-2047
    • Bunck, M.C.1    Cornér, A.2    Eliasson, B.3
  • 22
    • 84860618430 scopus 로고    scopus 로고
    • Safety and efficacy of once-weekly ex-enatide compared with insulin glargine titrated to target in patients with type 2 diabetes over 84 weeks
    • Diamant M, Van Gaal L, Stranks S, et al. Safety and efficacy of once-weekly ex-enatide compared with insulin glargine titrated to target in patients with type 2 diabetes over 84 weeks. Diabetes Care 2012;35:683-689
    • (2012) Diabetes Care , vol.35 , pp. 683-689
    • Diamant, M.1    Van Gaal, L.2    Stranks, S.3
  • 23
    • 69949117621 scopus 로고    scopus 로고
    • Liraglu-tide vs insulin glargine and placebo in combination with metformin and sulfo-nylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU): A randomised controlled trial
    • Liraglutide Effect and Action in Diabetes 5 (LEAD-5) met+SU Study Group.
    • Russell-Jones D, Vaag A, Schmitz O, et al.; Liraglutide Effect and Action in Diabetes 5 (LEAD-5) met+SU Study Group. Liraglu-tide vs insulin glargine and placebo in combination with metformin and sulfo-nylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU): a randomised controlled trial. Diabetologia 2009;52:2046-2055
    • (2009) Diabetologia , vol.52 , pp. 2046-2055
    • Russell-Jones, D.1    Vaag, A.2    Schmitz, O.3
  • 24
    • 80053401330 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor agonists versus insulin in inadequately controlled patients with type 2 diabetes mellitus: A meta-analysis of clinical trials
    • Wang Y, Li L, Yang M, Liu H, Boden G, Yang G. Glucagon-like peptide-1 receptor agonists versus insulin in inadequately controlled patients with type 2 diabetes mellitus: a meta-analysis of clinical trials. Diabetes Obes Metab 2011;13: 972-981
    • (2011) Diabetes Obes Metab , vol.13 , pp. 972-981
    • Wang, Y.1    Li, L.2    Yang, M.3    Liu, H.4    Boden, G.5    Yang, G.6
  • 25
    • 84891803789 scopus 로고    scopus 로고
    • Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results-A Long Term Evaluation (LEADER) [article online], Accessed 17 June 2012
    • Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results-A Long Term Evaluation (LEADER) [article online], 2012. Available from http://clinicaltrials.gov/ct2/show/NCT01179048. Accessed 17 June 2012
    • (2012)
  • 26
    • 84891775290 scopus 로고    scopus 로고
    • Exenatide Study of Cardiovascular Event Lowering Trial (EXSCEL): a trial to evaluate cardiovascular outcomes after treatment with exenatide once weekly in patients with type 2 diabetes mellitus [article online], Accessed 17 June 2012
    • Exenatide Study of Cardiovascular Event Lowering Trial (EXSCEL): a trial to evaluate cardiovascular outcomes after treatment with exenatide once weekly in patients with type 2 diabetes mellitus [article online]. Available from http://www.clinicaltrials.gov/ct2/show/NCT01144338. Accessed 17 June 2012
  • 27
    • 60449089649 scopus 로고    scopus 로고
    • Medical management of hyperglycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy: A consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes
    • American Diabetes Association; European Association for Study of Diabetes
    • Nathan DM, Buse JB, Davidson MB, et al.; American Diabetes Association; European Association for Study of Diabetes. Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 2009;32:193-203
    • (2009) Diabetes Care , vol.32 , pp. 193-203
    • Nathan, D.M.1    Buse, J.B.2    Davidson, M.B.3
  • 28
    • 67649111182 scopus 로고    scopus 로고
    • Trajectories of glycaemia, insulin sensitivity, and insulin secretion before diagnosis of type 2 diabetes: An analysis from the Whitehall II study
    • Tabak AG, Jokela M, Akbaraly TN, Brunner EJ, Kivimäki M, Witte DR. Trajectories of glycaemia, insulin sensitivity, and insulin secretion before diagnosis of type 2 diabetes: an analysis from the Whitehall II study. Lancet 2009;373: 2215-2221
    • (2009) Lancet , vol.373 , pp. 2215-2221
    • Tabak, A.G.1    Jokela, M.2    Akbaraly, T.N.3    Brunner, E.J.4    Kivimäki, M.5    Witte, D.R.6
  • 29
    • 0028817815 scopus 로고
    • Overview of 6 years' therapy of type II diabetes: A progressive disease
    • U.K. Prospective Diabetes Study Group. U.K. prospective diabetes study 16.
    • U.K. Prospective Diabetes Study Group. U.K. prospective diabetes study 16. Overview of 6 years' therapy of type II diabetes: a progressive disease. Diabetes 1995;44:1249-1258
    • (1995) Diabetes , vol.44 , pp. 1249-1258
  • 30
    • 0031961242 scopus 로고    scopus 로고
    • Beta-cell deterioration determines the onset and rate of progression of secondary dietary failure in type 2 diabetes mellitus: The 10-year follow-up of the Belfast Diet Study
    • Levy J, Atkinson AB, Bell PM, McCance DR, Hadden DR. Beta-cell deterioration determines the onset and rate of progression of secondary dietary failure in type 2 diabetes mellitus: the 10-year follow-up of the Belfast Diet Study. Diabet Med 1998;15:290-296
    • (1998) Diabet Med , vol.15 , pp. 290-296
    • Levy, J.1    Atkinson, A.B.2    Bell, P.M.3    McCance, D.R.4    Hadden, D.R.5
  • 32
    • 84862516777 scopus 로고    scopus 로고
    • Pancreatic diabetes manifests when beta cell area declines by approximately 65% in humans
    • Meier JJ, Breuer TGK, Bonadonna RC, et al. Pancreatic diabetes manifests when beta cell area declines by approximately 65% in humans. Diabetologia 2012;55: 1346-1354
    • (2012) Diabetologia , vol.55 , pp. 1346-1354
    • Meier, J.J.1    Breuer, T.G.K.2    Bonadonna, R.C.3
  • 33
    • 70549113397 scopus 로고    scopus 로고
    • Role of glucotoxicity and lipotoxicity in the pathophysiology of Type 2 diabetes mellitus and emerging treatment strategies
    • Del Prato S. Role of glucotoxicity and lipotoxicity in the pathophysiology of Type 2 diabetes mellitus and emerging treatment strategies. Diabet Med 2009;26: 1185-1192
    • (2009) Diabet Med , vol.26 , pp. 1185-1192
    • Del Prato, S.1
  • 34
    • 79959808984 scopus 로고    scopus 로고
    • Pivotal role of timely basal insulin replacement after metformin failure in sustaining long-term blood glucose control at a target in type 2 diabetes
    • Bolli GB, Lucidi P, Porcellati F, Fanelli CG. Pivotal role of timely basal insulin replacement after metformin failure in sustaining long-term blood glucose control at a target in type 2 diabetes. Diabetes Care 2011;34(Suppl. 2):S220-S224
    • (2011) Diabetes Care , vol.34 , Issue.SUPPL. 2
    • Bolli, G.B.1    Lucidi, P.2    Porcellati, F.3    Fanelli, C.G.4
  • 35
    • 43849105857 scopus 로고    scopus 로고
    • Effect of intensive insulin therapy on (3-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes: A multicentre randomised parallel-group trial
    • Weng J, Li Y, Xu W, et al. Effect of intensive insulin therapy on (3-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes: a multicentre randomised parallel-group trial. Lancet 2008;371:1753-1760
    • (2008) Lancet , vol.371 , pp. 1753-1760
    • Weng, J.1    Li, Y.2    Xu, W.3
  • 36
    • 43849096854 scopus 로고    scopus 로고
    • Intensive insulin therapy in newly diagnosed type 2 diabetes
    • Retnakaran R, Drucker DJ. Intensive insulin therapy in newly diagnosed type 2 diabetes. Lancet 2008;371:1725-1726
    • (2008) Lancet , vol.371 , pp. 1725-1726
    • Retnakaran, R.1    Drucker, D.J.2
  • 38
    • 1042291148 scopus 로고    scopus 로고
    • 3.5 years of insulin therapy with insulin glargine improves in vivo endothelial function in type 2 diabetes
    • Vehkavaara S, Yki-Järvinen H. 3.5 years of insulin therapy with insulin glargine improves in vivo endothelial function in type 2 diabetes. Arterioscler Thromb Vasc Biol 2004;24:325-330
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 325-330
    • Vehkavaara, S.1    Yki-Järvinen, H.2
  • 39
    • 0032955646 scopus 로고    scopus 로고
    • Insulin signal transduction: Possible mechanisms for insulin resistance
    • Kellerer M, Lammers R, Häring HU. Insulin signal transduction: possible mechanisms for insulin resistance. Exp Clin Endocrinol Diabetes 1999;107:97-106
    • (1999) Exp Clin Endocrinol Diabetes , vol.107 , pp. 97-106
    • Kellerer, M.1    Lammers, R.2    Häring, H.U.3
  • 40
    • 0017236889 scopus 로고
    • Relationships between fasting plasma glucose levels and insulin secretion during intravenous glucose tolerance tests
    • Brunzell JD, Robertson RP, Lerner RL, et al. Relationships between fasting plasma glucose levels and insulin secretion during intravenous glucose tolerance tests. J Clin Endocrinol Metab 1976;42: 222-229
    • (1976) J Clin Endocrinol Metab , vol.42 , pp. 222-229
    • Brunzell, J.D.1    Robertson, R.P.2    Lerner, R.L.3
  • 41
    • 82155198455 scopus 로고    scopus 로고
    • Chronic reduction of fasting glycemia with insulin glargine improves first-and second-phase insulin secretion in patients with type 2 diabetes
    • Pennartz C, Schenker N, Menge BA, Schmidt WE, Nauck MA, Meier JJ. Chronic reduction of fasting glycemia with insulin glargine improves first-and second-phase insulin secretion in patients with type 2 diabetes. Diabetes Care 2011; 34:2048-2053
    • (2011) Diabetes Care , vol.34 , pp. 2048-2053
    • Pennartz, C.1    Schenker, N.2    Menge, B.A.3    Schmidt, W.E.4    Nauck, M.A.5    Meier, J.J.6
  • 42
    • 77952037659 scopus 로고    scopus 로고
    • Adding insulin glargine vs NPH insulin to metformin results in a more efficient postprandial b-cell protection in individuals with type 2 diabetes
    • Forst T, Larbig M, Hohberg C, et al. Adding insulin glargine vs. NPH insulin to metformin results in a more efficient postprandial b-cell protection in individuals with type 2 diabetes. Diabetes Obes Metab 2010;12:437-441
    • (2010) Diabetes Obes Metab , vol.12 , pp. 437-441
    • Forst, T.1    Larbig, M.2    Hohberg, C.3
  • 43
    • 38449097526 scopus 로고    scopus 로고
    • Advancing therapy in type 2 diabetes mellitus with early, comprehensive progression from oral agents to insulin therapy
    • Vinik A. Advancing therapy in type 2 diabetes mellitus with early, comprehensive progression from oral agents to insulin therapy. Clin Ther 2009;29:1236-1253
    • (2009) Clin Ther , vol.29 , pp. 1236-1253
    • Vinik, A.1
  • 44
    • 35548947584 scopus 로고    scopus 로고
    • Addition of biphasic prandial or basal insulin to oral therapy in type 2 diabetes
    • 4-T Study Group
    • Holman RR, Thorne KI, Farmer AJ, et al.; 4-T Study Group. Addition of biphasic, prandial, or basal insulin to oral therapy in type 2 diabetes. N Engl J Med 2007;357: 1716-1730
    • (2007) N Engl J Med , vol.357 , pp. 1716-1730
    • Holman, R.R.1    Thorne, K.I.2    Farmer, A.J.3
  • 45
    • 40949111213 scopus 로고    scopus 로고
    • Once-daily basal insulin glargine versus thrice-daily prandial insulin lispro in people with type 2 diabetes on oral hypoglycaemic agents (APOLLO): An open randomised controlled trial
    • Bretzel RG, Nuber U, Landgraf W, Owens DR, Bradley C, Linn T. Once-daily basal insulin glargine versus thrice-daily prandial insulin lispro in people with type 2 diabetes on oral hypoglycaemic agents (APOLLO): an open randomised controlled trial. Lancet 2008;371:1073-1084
    • (2008) Lancet , vol.371 , pp. 1073-1084
    • Bretzel, R.G.1    Nuber, U.2    Landgraf, W.3    Owens, D.R.4    Bradley, C.5    Linn, T.6
  • 46
    • 68849084773 scopus 로고    scopus 로고
    • Expertengruppe der Osterreichischen Diabetesgesellschaft.
    • [in German]
    • Ludvik B, Brath H, Wascher T, Toplak H; Expertengruppe der Osterreichischen Diabetesgesellschaft. The significance of long acting insulin analogues in the treatment of type 2 diabetes mellitus. Wien Klin Wochenschr 2009;121:473-482 [in German]
    • (2009) Wien Klin Wochenschr , vol.121 , pp. 473-482
    • Ludvik, B.1    Brath, H.2    Wascher, T.3    Toplak, H.4
  • 47
    • 53749102150 scopus 로고    scopus 로고
    • Nocturnal glucose metabolism after bedtime injection of insulin glargine or neutral protamine hagedorn insulin in patients with type 2 diabetes
    • Linn T, Fischer B, Soydan N, et al. Nocturnal glucose metabolism after bedtime injection of insulin glargine or neutral protamine hagedorn insulin in patients with type 2 diabetes. J Clin Endocrinol Metab 2008;93:3839-3846
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 3839-3846
    • Linn, T.1    Fischer, B.2    Soydan, N.3
  • 48
    • 67949100214 scopus 로고    scopus 로고
    • Comparison of treatment costs in inadequately controlled type 2 diabetes in Germany based on the APOLLO trial with insulin glargine
    • Bretzel RG, Dippel FW, Linn T, Neilson AR. Comparison of treatment costs in inadequately controlled type 2 diabetes in Germany based on the APOLLO trial with insulin glargine. J Media Econ 2009;12:1-11
    • (2009) J Media Econ , vol.12 , pp. 1-11
    • Bretzel, R.G.1    Dippel, F.W.2    Linn, T.3    Neilson, A.R.4
  • 49
    • 84891790147 scopus 로고    scopus 로고
    • Resistance to insulin therapy among patients and providers: Results of the cross-national Diabetes Attitudes Wishes and Needs (DAWN) study
    • The International DAWN Advisory Panel.
    • Peyrot M, Rubin RR, Lauritzen T, et al.; The International DAWN Advisory Panel. Resistance to insulin therapy among patients and providers: results of the cross-national Diabetes Attitudes, Wishes, and Needs (DAWN) study. Diabetes Care 2005;29:952-953
    • (2005) Diabetes Care , vol.29 , pp. 952-953
    • Peyrot, M.1    Rubin, R.R.2    Lauritzen, T.3
  • 50
    • 67949084828 scopus 로고    scopus 로고
    • Initiating insulin therapy in type 2 diabetic patients failing on oral hypoglycemic agents: Basal or prandial insulin? the APOLLO trial and beyond
    • Bretzel RG, Eckhard M, Landgraf W, Owens DR, Linn T. Initiating insulin therapy in type 2 diabetic patients failing on oral hypoglycemic agents: basal or prandial insulin? The APOLLO trial and beyond. Diabetes Care 2009;32(Suppl. 2):S260-S265
    • (2009) Diabetes Care , vol.32 , Issue.SUPPL. 2
    • Bretzel, R.G.1    Eckhard, M.2    Landgraf, W.3    Owens, D.R.4    Linn, T.5
  • 51
    • 77950891085 scopus 로고    scopus 로고
    • Effect of noninsulin antidi-abetic drugs added to metformin therapy on glycemic control, weight gain, and hypoglycemia in type 2 diabetes
    • Phung OJ, Scholle JM, Talwar M, Coleman CI. Effect of noninsulin antidi-abetic drugs added to metformin therapy on glycemic control, weight gain, and hypoglycemia in type 2 diabetes. JAMA 2010;303:1410-1418
    • (2010) JAMA , vol.303 , pp. 1410-1418
    • Phung, O.J.1    Scholle, J.M.2    Talwar, M.3    Coleman, C.I.4
  • 52
    • 79960758089 scopus 로고    scopus 로고
    • An analysis of early insulin glargine added to metformin with or without sulfonylurea: Impact on glycaemic control and hypo-glycaemia
    • Fonseca V, Gill J, Zhou R, Leahy J. An analysis of early insulin glargine added to metformin with or without sulfonylurea: impact on glycaemic control and hypo-glycaemia. Diabetes Obes Metab 2011;13: 814-822
    • (2011) Diabetes Obes Metab , vol.13 , pp. 814-822
    • Fonseca, V.1    Gill, J.2    Zhou, R.3    Leahy, J.4
  • 53
    • 0242269000 scopus 로고    scopus 로고
    • The treat-to-target trial: Randomized addition of glargine or human NPH insulin to oral therapy of type 2 diabetic patients
    • Insulin Glargine 4002 Study Investigators
    • Riddle MC, Rosenstock J, Gerich J; Insulin Glargine 4002 Study Investigators. The treat-to-target trial: randomized addition of glargine or human NPH insulin to oral therapy of type 2 diabetic patients. Diabetes Care 2003;26:3080-3086
    • (2003) Diabetes Care , vol.26 , pp. 3080-3086
    • Riddle, M.C.1    Rosenstock, J.2    Gerich, J.3
  • 54
    • 33748522381 scopus 로고    scopus 로고
    • A randomized trial of adding insulin glargine vs.avoidance of insulin in people with Type 2 diabetes on either no oral glucose-lowering agents or submaximal doses of metformin and/or sulphonylureas, the Canadian INSIGHT (Implementing New Strategies with Insulin Glargine for Hyperglycaemia Treatment) Study
    • Gerstein HC, Yale J-F, Harris SB, Issa M, Stewart JA, Dempsey E. A randomized trial of adding insulin glargine vs. avoidance of insulin in people with Type 2 diabetes on either no oral glucose-lowering agents or submaximal doses of metformin and/or sulphonylureas. The Canadian INSIGHT (Implementing New Strategies with Insulin Glargine for Hyperglycaemia Treatment) Study. Diabet Med 2006;23: 736-742
    • (2006) Diabet Med , vol.23 , pp. 736-742
    • Gerstein, H.C.1    Yale, J.-F.2    Harris, S.B.3    Issa, M.4    Stewart, J.A.5    Dempsey, E.6
  • 55
    • 33244479164 scopus 로고    scopus 로고
    • Insulin glargine or NPH combined with metformin in type 2 diabetes: The LANMET study
    • Yki-Järvinen H, Kauppinen-Mäkelin R, Tiikkainen M, et al. Insulin glargine or NPH combined with metformin in type 2 diabetes: the LANMET study. Diabetologia 2006;49:442-451
    • (2006) Diabetologia , vol.49 , pp. 442-451
    • Yki-Järvinen, H.1    Kauppinen-Mäkelin, R.2    Tiikkainen, M.3
  • 56
    • 34249903872 scopus 로고    scopus 로고
    • Initiate Insulin by Aggressive Titra-tion and Education (INITIATE): A randomized study to compare initiation of insulin combination therapy in type 2 diabetic patients individually and in groups
    • Yki-Järvinen H, Juurinen L, Alvarsson M, et al. Initiate Insulin by Aggressive Titra-tion and Education (INITIATE): a randomized study to compare initiation of insulin combination therapy in type 2 diabetic patients individually and in groups. Diabetes Care 2007;30:1364-1369
    • (2007) Diabetes Care , vol.30 , pp. 1364-1369
    • Yki-Järvinen, H.1    Juurinen, L.2    Alvarsson, M.3
  • 57
    • 33644873468 scopus 로고    scopus 로고
    • Impact of active versus usual algorithmic titration of basal insulin and point-of-care versus laboratory measurement of HbA1c on glycemic control in patients with type 2 diabetes: The Glycemic Optimization with Algorithms and Labs at Point of Care (GOAL A1C) trial
    • GOAL AIC Team
    • Kennedy L, Herman WH, Strange P, Harris A; GOAL AIC Team. Impact of active versus usual algorithmic titration of basal insulin and point-of-care versus laboratory measurement of HbA1c on glycemic control in patients with type 2 diabetes: the Glycemic Optimization with Algorithms and Labs at Point of Care (GOAL A1C) trial. Diabetes Care2006;29: 1-8
    • (2006) Diabetes Care , vol.29 , pp. 1-8
    • Kennedy, L.1    Herman, W.H.2    Strange, P.3    Harris, A.4
  • 58
    • 33845540867 scopus 로고    scopus 로고
    • Insulin glargine benefits patients with type 2 diabetes inadequately controlled on oral antidia-betic treatment: An observational study of everyday practice in 12, 216 patients
    • Schreiber SA, Haak T. Insulin glargine benefits patients with type 2 diabetes inadequately controlled on oral antidia-betic treatment: an observational study of everyday practice in 12, 216 patients. Diabetes Obes Metab 2007;9:31-38
    • (2007) Diabetes Obes Metab , vol.9 , pp. 31-38
    • Schreiber, S.A.1    Haak, T.2
  • 59
    • 38949129060 scopus 로고    scopus 로고
    • The long-term efficacy of insulin glargine plus oral antidiabetic agents in a 32-month observational study of everyday clinical practice
    • Schreiber SA, Ferlinz K, Haak T. The long-term efficacy of insulin glargine plus oral antidiabetic agents in a 32-month observational study of everyday clinical practice. Diabetes Technol Ther 2008; 10:121-127
    • (2008) Diabetes Technol Ther , vol.10 , pp. 121-127
    • Schreiber, S.A.1    Ferlinz, K.2    Haak, T.3
  • 60
    • 84860761633 scopus 로고    scopus 로고
    • EARLY study: Early basal insulin therapy under real-life conditions in type 2 diabetics
    • Hanefeld M, Fleischmann H, Landgraf W, Pistrosch F. EARLY study: early basal insulin therapy under real-life conditions in type 2 diabetics. Diabetes Stoffw Herz 2012;21:91-97
    • (2012) Diabetes Stoffw Herz , vol.21 , pp. 91-97
    • Hanefeld, M.1    Fleischmann, H.2    Landgraf, W.3    Pistrosch, F.4
  • 61
    • 84855408801 scopus 로고    scopus 로고
    • Strategies for insulin initiation: Insights from the French LIGHT observational study
    • Vergès B, Brun JM, Tawil C, Alexandre B, Kerlan V. Strategies for insulin initiation: insights from the French LIGHT observational study. Diabetes Metab Res Rev 2012;28:97-105
    • (2012) Diabetes Metab Res Rev , vol.28 , pp. 97-105
    • Vergès, B.1    Brun, J.M.2    Tawil, C.3    Alexandre, B.4    Kerlan, V.5
  • 62
    • 84863809670 scopus 로고    scopus 로고
    • Dosing of insulin glargine to achieve the treatment target in Japanese type 2 diabetes on a basal supported oral therapy regimen in real life: ALOHA study sub-analysis
    • Odawara M, Ohtani T, Kadowaki T. Dosing of insulin glargine to achieve the treatment target in Japanese type 2 diabetes on a basal supported oral therapy regimen in real life: ALOHA study sub-analysis. Diabetes Technol Ther 2012;14: 635-643
    • (2012) Diabetes Technol Ther , vol.14 , pp. 635-643
    • Odawara, M.1    Ohtani, T.2    Kadowaki, T.3
  • 63
    • 85058248734 scopus 로고    scopus 로고
    • Rationale, design, and baseline characteristics for a large international trial of cardiovascular disease prevention in people with dysglycemia: The ORIGIN Trial (Outcome Reduction with an Initial Glargine Intervention)
    • The ORIGIN Trial Investigators
    • The ORIGIN Trial Investigators. Rationale, design, and baseline characteristics for a large international trial of cardiovascular disease prevention in people with dysglycemia: The ORIGIN Trial (Outcome Reduction with an Initial Glargine Intervention). Am Heart J 2008;155: 26-32
    • (2008) Am Heart J , vol.155 , pp. 26-32
  • 64
    • 77953821528 scopus 로고    scopus 로고
    • Diabetes mellitus fasting blood glucose concentration and risk of vascular disease: A collaborative meta-analysis of 102 prospective studies
    • Emerging Risk Factors Collaboration.
    • Sarwar N, Gao P, Seshasai SR, et al.; Emerging Risk Factors Collaboration. Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies. Lancet 2010;375: 2215-2222
    • (2010) Lancet , vol.375 , pp. 2215-2222
    • Sarwar, N.1    Gao, P.2    Seshasai, S.R.3
  • 65
    • 33846414720 scopus 로고    scopus 로고
    • Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: Executive summary
    • Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC); European Association for the Study of Diabetes (EASD).
    • Rydén L, Standl E, Bartnik M, et al.; Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC); European Association for the Study of Diabetes (EASD). Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: executive summary. Eur Heart J 2007;28:88-136
    • (2007) Eur Heart J , vol.28 , pp. 88-136
    • Rydén, L.1    Standl, E.2    Bartnik, M.3
  • 66
    • 84857029848 scopus 로고    scopus 로고
    • Proportion of patients at HbA1c target, 7% with eight classes of antidiabetic drugs in type 2 diabetes: Systematic review of 218 randomized controlled trials with 78 945 patients
    • Esposito K, Chiodini P, Bellastella G, Maiorino MI, Giugliano D. Proportion of patients at HbA1c target, 7% with eight classes of antidiabetic drugs in type 2 diabetes: systematic review of 218 randomized controlled trials with 78 945 patients. Diabetes Obes Metab 2012;14: 228-233
    • (2012) Diabetes Obes Metab , vol.14 , pp. 228-233
    • Esposito, K.1    Chiodini, P.2    Bellastella, G.3    Maiorino, M.I.4    Giugliano, D.5
  • 67
    • 34249807045 scopus 로고    scopus 로고
    • When basal insulin therapy in type 2 diabetes mellitus is not enoughdwhat next?
    • Raccah D, Bretzel RG, Owens D, Riddle M. When basal insulin therapy in type 2 diabetes mellitus is not enoughdwhat next? Diabetes Metab Res Rev 2007;23:257-264
    • (2007) Diabetes Metab Res Rev , vol.23 , pp. 257-264
    • Raccah, D.1    Bretzel, R.G.2    Owens, D.3    Riddle, M.4
  • 68
    • 84861889012 scopus 로고    scopus 로고
    • Non-insulin injectable treatments (glucagon-like pep-tide-1 and its analogs) and cardiovascular disease
    • Lebovitz HE, Banerji MA. Non-insulin injectable treatments (glucagon-like pep-tide-1 and its analogs) and cardiovascular disease. Diabetes Technol Ther 2012;14 (Suppl. 1):S43-S50
    • (2012) Diabetes Technol Ther , vol.14 , Issue.SUPPL. 1
    • Lebovitz, H.E.1    Banerji, M.A.2
  • 69
    • 68649099986 scopus 로고    scopus 로고
    • Exenatide added to insulin therapy: A retrospective review of clinical practice over two years in an academic endocrinology outpatient setting
    • Yoon NM, Cavaghan MK, Brunelle RL, Roach P. Exenatide added to insulin therapy: a retrospective review of clinical practice over two years in an academic endocrinology outpatient setting. Clin Ther 2009;31:1511-1523
    • (2009) Clin Ther , vol.31 , pp. 1511-1523
    • Yoon, N.M.1    Cavaghan, M.K.2    Brunelle, R.L.3    Roach, P.4
  • 70
    • 77955262909 scopus 로고    scopus 로고
    • Further improvement in postprandial glucose control with addition of exenatide or sitagliptin to combination therapy with insulin glargine and metformin: A proof-of-concept study
    • Arnolds S, Dellweg S, Clair J, et al. Further improvement in postprandial glucose control with addition of exenatide or sitagliptin to combination therapy with insulin glargine and metformin: a proof-of-concept study. Diabetes Care 2010;33: 1509-1515
    • (2010) Diabetes Care , vol.33 , pp. 1509-1515
    • Arnolds, S.1    Dellweg, S.2    Clair, J.3
  • 71
    • 79551615182 scopus 로고    scopus 로고
    • Use of twice-daily exenatide in basal insulin-treated patients with type 2 diabetes
    • Buse JB, Bergenstal RM, Glass LC, et al. Use of twice-daily exenatide in basal insulin-treated patients with type 2 diabetes. Ann Intern Med 2011;154: 1-11
    • (2011) Ann Intern Med , vol.154 , pp. 1-11
    • Buse, J.B.1    Bergenstal, R.M.2    Glass, L.C.3
  • 72
    • 67349251550 scopus 로고    scopus 로고
    • Megatrials in type 2 diabetes. from excitement to frustration?
    • Del Prato S. Megatrials in type 2 diabetes. From excitement to frustration? Dia-betologia 2009;52:1219-1226
    • (2009) Dia-betologia , vol.52 , pp. 1219-1226
    • Del Prato, S.1


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