Galangin induces apoptosis in hepatocellular carcinoma cells through the caspase 8/t-Bid mitochondrial pathway

Journal of Asian Natural Products Research

Volumn 14, Issue 7, 2012, Pages 626-633

  Zhang, Hai Tao ^a   Wu, Jun ^a   Wen, Min ^a   Su, Li Juan ^a   Luo, Hui ^a  

^a GUANGDONG MEDICAL UNIVERSITY   (China)

Author keywords

Alpinia officinarum; apoptosis; Bid; caspase 8; galangin; hepatocellular carcinoma

Indexed keywords

4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; BENZYLOXYCARBONYLISOLEUCYLGLUTAMYLTHREONYLASPARTYL FLUOROMETHYL KETONE; CASPASE 8; GALANGIN; PROPIDIUM IODIDE; PROTEIN BCL 2; PROTEIN BID; SMALL INTERFERING RNA;

APOPTOSIS; ARTICLE; CANCER CELL; COLORIMETRY; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; MITOCHONDRION; PROTEIN ANALYSIS; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; WESTERN BLOTTING;

ALPINIA; APOPTOSIS; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; CASPASE 8; FLAVONOIDS; HEP G2 CELLS; HUMANS; LIVER; OLIGOPEPTIDES; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, SMALL INTERFERING;

ALPINIA OFFICINARUM;

EID: 84864705611     PISSN: 10286020     EISSN: 14772213     Source Type: Journal    
DOI: 10.1080/10286020.2012.682152     Document Type: Article

References (11)

1. Harvey, A.L. 2008. Drug Discov. Today, 13: 894
2. Wang, S., Penchala, S., Prabhu, S., Wang, J., and, Huang, Y. 2010. Curr. Drug Discov. Technol., 7: 67
3. Zhang, H.T., Luo, H., Wu, J., Lan, L.B., Fan, D.H., Zhu, K.D., Chen, X.Y., Wen, M., and, Liu, H.M. 2010. World J. Gastroenterol., 16: 3377
4. Zhang, H.T., Feng, Z.L., Wu, J., Wang, Y.J., Guo, X., Liang, N.C., Zhu, Z.Y., and, Ma, J.Q. 2007. Acta. Pharmacol. Sin., 28: 1783
5. Moon, Y.J., Wang, X., and, Morris, M.E. 2006. Toxicol. In Vitro, 20: 187
6. Tolomeo, M., Grimaudo, S., Di Cristina, A., Pipitone, R.M., Dusonchet, L., Meli, M., Crosta, L., Gebbia, N., Invidiata, F.P., Titone, L., and, Simoni, D. 2008. Cancer Lett., 265: 289
7. Fricker, N., Beaudouin, J., Richter, P., Eils, R., Krammer, P.H., and, Lavrik, I.N. 2010. J. Cell Biol., 190: 377
8. Samraj, A.K., Keil, E., Ueffing, N., Schulze-Osthoff, K., and, Schmitz, I. 2006. J. Biol. Chem., 281: 29652
9. Wang, X. 2001. Genes Dev., 15: 2922
10. Chao, D.T., Linette, G.P., Boise, L.H., White, L.S., Thompson, C.B., and, Korsmeyer, S.J. 1995. J. Exp. Med., 182: 821
11. Yi, X., Yin, X.M., and, Dong, Z. 2003. J. Biol. Chem., 278: 16992