Simvastatin induced HCT116 colorectal cancer cell apoptosis through p38MAPK-p53-survivin signaling cascade

Biochimica et Biophysica Acta - General Subjects

Volumn 1830, Issue 8, 2013, Pages 4053-4064

  Chang, Hang Lung ^a   Chen, Chih Yu ^b   Hsu, Ya Fen ^a   Kuo, Wen Shin ^c   Ou, George ^c   Chiu, Pei Ting ^c   Huang, Yu Han ^c   Hsu, Ming Jen ^c  

^a Landseed Hospital   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; Colorectal cancer; p38MAPK; p53; Simvastatin; Survivin

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1; LUCIFERASE; MEVINOLIN; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; PRAVASTATIN; PROTEIN P53; PROTEIN P63; SIMVASTATIN; SMALL INTERFERING RNA; SURVIVIN; TRANSCRIPTION FACTOR SP1;

ACETYLATION; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER CELL; CELL STRAIN HCT116; CELL VIABILITY; COLORECTAL CANCER; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE CONTROL; GENE SILENCING; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; SURVIVIN GENE;

ACETYLATION; APOPTOSIS; CELL SURVIVAL; HCT116 CELLS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INHIBITOR OF APOPTOSIS PROTEINS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROMOTER REGIONS, GENETIC; SIGNAL TRANSDUCTION; SIMVASTATIN; TUMOR SUPPRESSOR PROTEIN P53; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84877837671     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2013.04.011     Document Type: Article

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