The human homologue (PEG3) of the mouse paternally expressed gene 3 (Peg3) is maternally imprinted but not mutated in women with familial recurrent hydatidiform molar pregnancies

Journal of the Society for Gynecologic Investigation

Volumn 8, Issue 5, 2001, Pages 305-313

  Van den Veyver, Ignatia B ^a   Norman, Bridget ^a   Tran, Charles Q ^a   Bourjac, Jamile ^b   Slim, Rima ^b  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b AMERICAN UNIVERSITY OF BEIRUT   (Lebanon)

Author keywords

Autosomal recessive; Hydatidiform mole; Imprinting; PEG3 gene

Indexed keywords

COMPLEMENTARY DNA; DNA; RNA; ZINC FINGER PROTEIN;

ARTICLE; AUTOSOMAL RECESSIVE DISORDER; CHROMOSOME 19Q; CONTROLLED STUDY; CPG ISLAND; DATA BASE; DNA LIBRARY; DNA POLYMORPHISM; EXON; FEMALE; GENE EXPRESSION; GENE LOCUS; GENE MAPPING; GENE MUTATION; GENE SEQUENCE; GENE STRUCTURE; GENOME IMPRINTING; HUMAN; HYDATIDIFORM MOLE; INTRON; LYMPHOBLAST; METHYLATION; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PREGNANCY; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; TRANSCRIPTION REGULATION;

ANIMALS; BASE SEQUENCE; BLOTTING, SOUTHERN; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 19; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOMIC IMPRINTING; HUMANS; HYDATIDIFORM MOLE; MALE; MICE; MOLECULAR SEQUENCE DATA; PEDIGREE; PREGNANCY; PROTEIN KINASES; PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA; TRANSCRIPTION FACTORS;

EID: 0035839754     PISSN: 10715576     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1071-5576(01)00129-0     Document Type: Article

References (30)

1. Trophoblastic diseases: Complete and partial hydatidiform moles
2. Molecular genetic analysis of complete hydatidiform moles
3. Genetic analysis of repeated, biparental, diploid, hydatidiform moles
4. Gestational trophoblastic disease. Subsequent pregnancy outcome, including repeat molar pregnancy
5. A familial case of recurrent hydatidiform molar pregnancies with biparental genomic contribution
6. Genetic mapping of a maternal locus responsible for familial hydatidiform moles
7. Detailed comparative map of human chromosome 19q and related regions of the mouse genome
8. Discovery of a novel, paternally expressed ubiquitin-specific processing protease gene through comparative analysis of an imprinted region of mouse chromosome 7 and human chromosome 19q13.4
9. The human homolog of a mouse-imprinted gene, Peg3, maps to a zinc finger gene-rich region of human chromosome 19q13.4
10. Zim1, a maternally expressed mouse Kruppel-type zinc-finger gene located in proximal chromosome 7
11. Peg3 imprinted gene on proximal chromosome 7 encodes for a zinc finger protein
12. Genome imprinting and development in the mouse
13. Peg3/Pw1 is an imprinted gene involved in the TNF-NFkappaB signal transduction pathway
14. The imprinted gene Peg3 is not essential for tumor necrosis factor alpha signaling
15. Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis
16. Peg3/Pw1 promotes p53-mediated apoptosis by inducing Bax translocation from cytosol to mitochondria
17. Regulation of maternal behavior and offspring growth by paternally expressed Peg3
18. Exon sharing of a novel human zinc-finger gene, ZIM2, and paternally expressed gene 3 (PEG3)
19. Imprinting of peg3, the human homologue of a mouse gene involved in nurturing behavior
20. Pw1, a novel zinc finger gene implicated in the myogenic and neuronal lineages
21. Imprinted genes have few and small introns
22. Genetic imprinting in the mouse: Implications for gene regulation
23. Gametic imprinting in mammals
24. Ocat, a paternally expressed gene closely linked and transcribed in the opposite direction to Peg3
25. A comprehensive genetic map of the human genome based on 5,264 microsatellites
26. Imprinted chromosomal regions of the human genome display sex-specific meiotic recombination frequencies
27. Sex-specific meiotic recombination in the Prader-Willi/Angelman syndrome imprinted region
28. Gestational trophoblastic disease. Molecular and genetic studies
29. Mole maker phenotype: Possible narrowing of the candidate region
30. Repetitive complete hydatidiform mole can be biparental in origin and either male or female