In vitro culture increases the frequency of stochastic epigenetic errors at imprinted genes in placental tissues from mouse concepti produced through assisted reproductive technologies

Biology of Reproduction

Volumn 90, Issue 2, 2014, Pages

  de Waal, Eric ^a   Mak, Winifred ^a,c   Calhoun, Sondra ^a   Stein, Paula ^b   Ord, Teri ^a   Krapp, Christopher ^a   Coutifaris, Christos ^a   Schultz, Richard M ^b   Bartolomei, Marisa S ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Assisted reproductive technologies; DNA methylation; Epigenetic reprogramming; Gene regulation; Genomic imprinting; In vitro fertilization

Indexed keywords

OXYGEN;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA METHYLATION; EMBRYO; EMBRYONAL TISSUE; EPIGENETICS; FEMALE; FERTILIZATION IN VITRO; GENE EXPRESSION PROFILING; GENETIC DISORDER; GENOME IMPRINTING; IN VITRO STUDY; INFERTILITY THERAPY; MOUSE; MOUSE EMBRYO; NONHUMAN; OXYGEN CONCENTRATION; OXYGEN TENSION; PLACENTA; PRIORITY JOURNAL; STATISTICS; TISSUE CULTURE; ANIMAL; ANIMAL EMBRYO; BLASTOCYST; C57BL MOUSE; CHROMOSOME ABERRATION; CYTOLOGY; EMBRYO CULTURE; EMBRYOLOGY; GENETIC EPIGENESIS; GENETICS; INCIDENCE; MALE; METABOLISM; PATHOLOGY; PLACENTA DISORDER; PREGNANCY; STATISTICS AND NUMERICAL DATA;

ANIMALS; BLASTOCYST; CHROMOSOME ABERRATIONS; EMBRYO CULTURE TECHNIQUES; EMBRYO, MAMMALIAN; EPIGENESIS, GENETIC; FEMALE; GENOMIC IMPRINTING; INCIDENCE; MALE; MICE; MICE, INBRED C57BL; PLACENTA; PLACENTA DISEASES; PREGNANCY; REPRODUCTIVE TECHNIQUES, ASSISTED; STOCHASTIC PROCESSES;

EID: 84899980569     PISSN: 00063363     EISSN: 15297268     Source Type: Journal    
DOI: 10.1095/biolreprod.113.114785     Document Type: Article

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