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Volumn 461, Issue 3, 2014, Pages 209-520

PKG and NHR-49 signalling co-ordinately regulate short-term fasting-induced lysosomal lipid accumulation in C. elegans

Author keywords

Caenorhabditis elegans; Cyclic GMP dependent protein kinase; Lysosomal lipid; Nuclear hormone receptor 49 (NHR 49); Stress response

Indexed keywords

CAENORHABDITIS ELEGANS PROTEIN; CALCIUM INDEPENDENT PHOSPHOLIPASE A2; CYCLIC GMP DEPENDENT PROTEIN KINASE; DAF 3 PROTEIN; EGL 4 PROTEIN; HORMONE RECEPTOR; HYDROLASE; LIPID; NUCLEAR HORMONE RECEPTOR 49; RAB7 PROTEIN; SMAD PROTEIN; UNCLASSIFIED DRUG; CELL RECEPTOR; DAF 3 PROTEIN, C ELEGANS; DAF-3 PROTEIN, C ELEGANS; EGL 4 PROTEIN, C ELEGANS; EGL-4 PROTEIN, C ELEGANS; NERVE PROTEIN; NHR 49 PROTEIN, C ELEGANS; NHR-49 PROTEIN, C ELEGANS;

EID: 84904128472     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20140191     Document Type: Article
Times cited : (13)

References (61)
  • 1
    • 0013865801 scopus 로고
    • Functions of lysosomes
    • CrossRef PubMed
    • De Duve, C. and Wattiaux, R. (1966) Functions of lysosomes. Annu. Rev. Physiol. 28, 435-492 CrossRef PubMed
    • (1966) Annu. Rev. Physiol. , vol.28 , pp. 435-492
    • De Duve, C.1    Wattiaux, R.2
  • 2
    • 14044277429 scopus 로고    scopus 로고
    • The molecular machinery of autophagy: Unanswered questions
    • CrossRef PubMed
    • Klionsky, D. J. (2005) The molecular machinery of autophagy: unanswered questions. J. Cell Sci. 118, 7-18 CrossRef PubMed
    • (2005) J. Cell Sci. , vol.118 , pp. 7-18
    • Klionsky, D.J.1
  • 3
    • 49349090381 scopus 로고    scopus 로고
    • Lysosomes and oxidative stress in aging and apoptosis
    • CrossRef PubMed
    • Kurz, T., Terman, A., Gustafsson, B. and Brunk, U. T. (2008) Lysosomes and oxidative stress in aging and apoptosis. Biochim. Biophys. Acta 1780, 1291-1303 CrossRef PubMed
    • (2008) Biochim. Biophys. Acta , vol.1780 , pp. 1291-1303
    • Kurz, T.1    Terman, A.2    Gustafsson, B.3    Brunk, U.T.4
  • 4
    • 3142592401 scopus 로고    scopus 로고
    • Not just a sink: Endosomes in control of signal transduction
    • DOI 10.1016/j.ceb.2004.06.005, PII S0955067404000742
    • Miaczynska, M., Pelkmans, L. and Zerial, M. (2004) Not just a sink: endosomes in control of signal transduction. Curr. Opin. Cell Biol. 16, 400-406 CrossRef PubMed (Pubitemid 38903146)
    • (2004) Current Opinion in Cell Biology , vol.16 , Issue.4 , pp. 400-406
    • Miaczynska, M.1    Pelkmans, L.2    Zerial, M.3
  • 5
    • 21344469549 scopus 로고    scopus 로고
    • 2-induced apoptosis of alveolar type II cells
    • DOI 10.1002/jcb.20277
    • Yin, L., Stearns, R. and Gonzalez-Flecha, B. (2005) Lysosomal and mitochondrial pathways in H2O2-induced apoptosis of alveolar type II cells. J. Cell. Biochem. 94, 433-445 CrossRef PubMed (Pubitemid 41420282)
    • (2005) Journal of Cellular Biochemistry , vol.94 , Issue.3 , pp. 433-445
    • Yin, L.1    Stearns, R.2    Gonzalez-Flecha, B.3
  • 7
    • 25444443570 scopus 로고    scopus 로고
    • Principles of lysosomal membrane digestion: Stimulation of sphingolipid degradation by sphingolipid activator proteins and anionic lysosomal lipids
    • DOI 10.1146/annurev.cellbio.21.122303.120013
    • Kolter, T. and Sandhoff, K. (2005) Principles of lysosomal membrane digestion: stimulation of sphingolipid degradation by sphingolipid activator proteins and anionic lysosomal lipids. Annu. Rev. Cell Dev. Biol. 21, 81-103 CrossRef PubMed (Pubitemid 41740628)
    • (2005) Annual Review of Cell and Developmental Biology , vol.21 , pp. 81-103
    • Kolter, T.1    Sandhoff, K.2
  • 8
    • 77951924919 scopus 로고    scopus 로고
    • Lysosomal degradation of membrane lipids
    • CrossRef PubMed
    • Kolter, T. and Sandhoff, K. (2010) Lysosomal degradation of membrane lipids. FEBS Lett. 584, 1700-1712 CrossRef PubMed
    • (2010) FEBS Lett. , vol.584 , pp. 1700-1712
    • Kolter, T.1    Sandhoff, K.2
  • 9
    • 78649742242 scopus 로고    scopus 로고
    • Treatments for lysosomal storage disorders
    • CrossRef PubMed
    • Lachmann, R. (2010) Treatments for lysosomal storage disorders. Biochem. Soc. Trans. 38, 1465-1468 CrossRef PubMed
    • (2010) Biochem. Soc. Trans. , vol.38 , pp. 1465-1468
    • Lachmann, R.1
  • 10
    • 84878533962 scopus 로고    scopus 로고
    • MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability
    • CrossRef PubMed
    • O'Rourke, E. J. and Ruvkun, G. (2013) MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability. Nat. Cell Biol. 15, 668-676 CrossRef PubMed
    • (2013) Nat. Cell Biol. , vol.15 , pp. 668-676
    • O'Rourke, E.J.1    Ruvkun, G.2
  • 14
    • 77951926114 scopus 로고    scopus 로고
    • Label-free quantitative analysis of lipid metabolism in living Caenorhabditis elegans
    • CrossRef PubMed
    • Le, T. T., Duren, H. M., Slipchenko, M. N., Hu, C. D. and Cheng, J. X. (2010) Label-free quantitative analysis of lipid metabolism in living Caenorhabditis elegans. J. Lipid Res. 51, 672-677 CrossRef PubMed
    • (2010) J. Lipid Res. , vol.51 , pp. 672-677
    • Le, T.T.1    Duren, H.M.2    Slipchenko, M.N.3    Hu, C.D.4    Cheng, J.X.5
  • 15
    • 70350365111 scopus 로고    scopus 로고
    • C. elegans major fats are stored in vesicles distinct from lysosome-related organelles
    • CrossRef PubMed
    • O'Rourke, E. J., Soukas, A. A., Carr, C. E. and Ruvkun, G. (2009) C. elegans major fats are stored in vesicles distinct from lysosome-related organelles. Cell. Metab. 10, 430-435 CrossRef PubMed
    • (2009) Cell. Metab. , vol.10 , pp. 430-435
    • O'Rourke, E.J.1    Soukas, A.A.2    Carr, C.E.3    Ruvkun, G.4
  • 16
    • 77958586133 scopus 로고    scopus 로고
    • A comparative study of fat storage quantitation in nematode Caenorhabditis elegans using label and label-free methods
    • CrossRef PubMed
    • Yen, K., Le, T. T., Bansal, A., Narasimhan, S. D., Cheng, J. X. and Tissenbaum, H. A. (2010) A comparative study of fat storage quantitation in nematode Caenorhabditis elegans using label and label-free methods. PLoS ONE 5, e12810 CrossRef PubMed
    • (2010) PLoS ONE , vol.5
    • Yen, K.1    Le, T.T.2    Bansal, A.3    Narasimhan, S.D.4    Cheng, J.X.5    Tissenbaum, H.A.6
  • 17
    • 78649772040 scopus 로고    scopus 로고
    • Lipid droplets as ubiquitous fat storage organelles in C. elegans
    • CrossRef PubMed
    • Zhang, S. O., Trimble, R., Guo, F. and Mak, H. Y. (2010) Lipid droplets as ubiquitous fat storage organelles in C. elegans. BMC Cell Biol. 11, 96 CrossRef PubMed
    • (2010) BMC Cell Biol. , vol.11 , pp. 96
    • Zhang, S.O.1    Trimble, R.2    Guo, F.3    Mak, H.Y.4
  • 18
    • 70449560405 scopus 로고    scopus 로고
    • The influence of bacterial diet on fat storage in C. elegans
    • CrossRef PubMed
    • Brooks, K. K., Liang, B. and Watts, J. L. (2009) The influence of bacterial diet on fat storage in C. elegans. PLoS ONE 4, e7545 CrossRef PubMed
    • (2009) PLoS ONE , vol.4
    • Brooks, K.K.1    Liang, B.2    Watts, J.L.3
  • 19
    • 0016063911 scopus 로고
    • The genetics of Caenorhabditis elegans
    • PubMed
    • Brenner, S. (1974) The genetics of Caenorhabditis elegans. Genetics 77, 71-94 PubMed
    • (1974) Genetics , vol.77 , pp. 71-94
    • Brenner, S.1
  • 20
    • 0025942107 scopus 로고
    • Efficient gene transfer in C.elegans: Extrachromosomal maintenance and integration of transforming sequences
    • Mello, C. C., Kramer, J. M., Stinchcomb, D. and Ambros, V. (1991) Efficient gene transfer in C. elegans: extrachromosomal maintenance and integration of transforming sequences. EMBO J. 10, 3959-3970 PubMed (Pubitemid 21905425)
    • (1991) EMBO Journal , vol.10 , Issue.12 , pp. 3959-3970
    • Mello, C.C.1    Kramer, J.M.2    Stinchcomb, D.3    Ambros, V.4
  • 22
    • 0034676457 scopus 로고    scopus 로고
    • Functional genomic analysis of C. elegans chromosome I by systematic RNA interference
    • CrossRef PubMed
    • Fraser, A. G., Kamath, R. S., Zipperlen, P., Martinez-Campos, M., Sohrmann, M. and Ahringer, J. (2000) Functional genomic analysis of C. elegans chromosome I by systematic RNA interference. Nature 408, 325-330 CrossRef PubMed
    • (2000) Nature , vol.408 , pp. 325-330
    • Fraser, A.G.1    Kamath, R.S.2    Zipperlen, P.3    Martinez-Campos, M.4    Sohrmann, M.5    Ahringer, J.6
  • 23
    • 0042691506 scopus 로고    scopus 로고
    • Autophagy genes are essential for dauer development and life-span extension in C. elegans
    • DOI 10.1126/science.1087782
    • Melendez, A., Talloczy, Z., Seaman, M., Eskelinen, E. L., Hall, D. H. and Levine, B. (2003) Autophagy genes are essential for dauer development and life-span extension in C. elegans. Science 301, 1387-1391 CrossRef PubMed (Pubitemid 37075816)
    • (2003) Science , vol.301 , Issue.5638 , pp. 1387-1391
    • Melendez, A.1    Talloczy, Z.2    Seaman, M.3    Eskelinen, E.-L.4    Hall, D.H.5    Levine, B.6
  • 24
    • 0029841758 scopus 로고    scopus 로고
    • Neutral red retention by lysosomes from earthworm (Lumbricus rubellus) coelomocytes: A simple biomarker of exposure to soil copper
    • DOI 10.1897/1551-5028(1996)015<1801:NRRBLF>2.3
    • Weeks, J. M. and Svendsen, C. (1996) Neutral red retention by lysosomes from earthworm (Lumbricus rubellus) Coelomocytes: a simple biomarker of exposure to soil copper. Environ. Toxicol. Chem. 15, 1801-1805 CrossRef (Pubitemid 26342344)
    • (1996) Environmental Toxicology and Chemistry , vol.15 , Issue.10 , pp. 1801-1805
    • Weeks, J.M.1    Svendsen, C.2
  • 25
    • 0021816546 scopus 로고
    • Spectrofluorometric studies of the lipid probe, nile red
    • Greenspan, P. and Fowler, S. D. (1985) Spectrofluorometric studies of the lipid probe, nile red. J. Lipid Res. 26, 781-789 PubMed (Pubitemid 15046441)
    • (1985) Journal of Lipid Research , vol.26 , Issue.7 , pp. 781-789
    • Greenspan, P.1    Fowler, S.D.2
  • 26
    • 0026586638 scopus 로고
    • Nile red staining of lysosomal phospholipid inclusions
    • CrossRef PubMed
    • Brown, W. J., Sullivan, T. R. and Greenspan, P. (1992) Nile red staining of lysosomal phospholipid inclusions. Histochemistry 97, 349-354 CrossRef PubMed
    • (1992) Histochemistry , vol.97 , pp. 349-354
    • Brown, W.J.1    Sullivan, T.R.2    Greenspan, P.3
  • 27
    • 77957675740 scopus 로고    scopus 로고
    • Regulation of C. elegans fat uptake and storage by acyl-CoA synthase-3 is dependent on NR5A family nuclear hormone receptor nhr-25
    • CrossRef PubMed
    • Mullaney, B. C., Blind, R. D., Lemieux, G. A., Perez, C. L., Elle, I. C., Faergeman, N. J., Van Gilst, M. R., Ingraham, H. A. and Ashrafi, K. (2010) Regulation of C. elegans fat uptake and storage by acyl-CoA synthase-3 is dependent on NR5A family nuclear hormone receptor nhr-25. Cell. Metab. 12, 398-410 CrossRef PubMed
    • (2010) Cell. Metab. , vol.12 , pp. 398-410
    • Mullaney, B.C.1    Blind, R.D.2    Lemieux, G.A.3    Perez, C.L.4    Elle, I.C.5    Faergeman, N.J.6    Van Gilst, M.R.7    Ingraham, H.A.8    Ashrafi, K.9
  • 28
    • 34547904254 scopus 로고    scopus 로고
    • In vitro detection of drug-induced phospholipidosis using gene expression and fluorescent phospholipid-based methodologies
    • DOI 10.1093/toxsci/kfm157
    • Nioi, P., Perry, B. K., Wang, E. J., Gu, Y. Z. and Snyder, R. D. (2007) In vitro detection of drug-induced phospholipidosis using gene expression and fluorescent phospholipid based methodologies. Toxicol. Sci. 99, 162-173 CrossRef PubMed (Pubitemid 47250376)
    • (2007) Toxicological Sciences , vol.99 , Issue.1 , pp. 162-173
    • Nioi, P.1    Perry, B.K.2    Wang, E.-J.3    Gu, Y.-Z.4    Snyder, R.D.5
  • 29
    • 70449707473 scopus 로고    scopus 로고
    • the C. elegans Research Community, ed., doi:10.1895/wormbook.1.7.1
    • Melendez, A. and Levine, B. (2009) Autophagy in C. elegans. WormBook (the C. elegans Research Community, ed.), pp. 1-26, doi:10.1895/wormbook.1.7.1, http://www.wormbook.org
    • (2009) Autophagy in C. Elegans , pp. 1-26
    • Melendez, A.1    Levine, B.2
  • 30
    • 23044501264 scopus 로고    scopus 로고
    • Autophagy in development, tumor suppression, and innate immunity
    • PubMed
    • Levine, B. (2003) Autophagy in development, tumor suppression, and innate immunity. Harvey Lect. 99, 47-76 PubMed
    • (2003) Harvey Lect. , vol.99 , pp. 47-76
    • Levine, B.1
  • 31
    • 1842583789 scopus 로고    scopus 로고
    • Development by self-digestion: Molecular mechanisms and biological functions of autophagy
    • DOI 10.1016/S1534-5807(04)00099-1, PII S1534580704000991
    • Levine, B. and Klionsky, D. J. (2004) Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev. Cell 6, 463-477 CrossRef PubMed (Pubitemid 38456176)
    • (2004) Developmental Cell , vol.6 , Issue.4 , pp. 463-477
    • Levine, B.1    Klionsky, D.J.2
  • 32
    • 34548421950 scopus 로고    scopus 로고
    • Dual roles of autophagy in the survival of Caenorhabditis elegans during starvation
    • DOI 10.1101/gad.1573107
    • Kang, C., You, Y. J. and Avery, L. (2007) Dual roles of autophagy in the survival of Caenorhabditis elegans during starvation. Genes Dev. 21, 2161-2171 CrossRef PubMed (Pubitemid 47360838)
    • (2007) Genes and Development , vol.21 , Issue.17 , pp. 2161-2171
    • Kang, C.1    You, N.-J.2    Avery, L.3
  • 33
    • 0034329418 scopus 로고    scopus 로고
    • LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
    • CrossRef PubMed
    • Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y. and Yoshimori, T. (2000) LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 19, 5720-5728 CrossRef PubMed
    • (2000) EMBO J. , vol.19 , pp. 5720-5728
    • Kabeya, Y.1    Mizushima, N.2    Ueno, T.3    Yamamoto, A.4    Kirisako, T.5    Noda, T.6    Kominami, E.7    Ohsumi, Y.8    Yoshimori, T.9
  • 35
    • 4344712684 scopus 로고    scopus 로고
    • Methods for monitoring autophagy
    • CrossRef PubMed
    • Mizushima, N. (2004) Methods for monitoring autophagy. Int. J. Biochem. Cell Biol. 36, 2491-2502 CrossRef PubMed
    • (2004) Int. J. Biochem. Cell Biol. , vol.36 , pp. 2491-2502
    • Mizushima, N.1
  • 36
    • 33846549315 scopus 로고    scopus 로고
    • Caenorhabditis elegans SAND-1 is essential for RAB-7 function in endosomal traffic
    • DOI 10.1038/sj.emboj.7601498, PII 7601498
    • Poteryaev, D., Fares, H., Bowerman, B. and Spang, A. (2007) Caenorhabditis elegans SAND-1 is essential for RAB-7 function in endosomal traffic. EMBO J. 26, 301-312 CrossRef PubMed (Pubitemid 46160932)
    • (2007) EMBO Journal , vol.26 , Issue.2 , pp. 301-312
    • Poteryaev, D.1    Fares, H.2    Bowerman, B.3    Spang, A.4
  • 37
    • 0342743204 scopus 로고    scopus 로고
    • Ethylene-mediated phospholipid catabolic pathway in glucose-starved carrot suspension cells
    • Lee, S. H., Chae, H. S., Lee, T. K., Kim, S. H., Shin, S. H., Cho, B. H., Cho, S. H., Kang, B. G. and Lee, W. S. (1998) Ethylene-mediated phospholipid catabolic pathway in glucose-starved carrot suspension cells. Plant Physiol. 116, 223-229 CrossRef (Pubitemid 28503857)
    • (1998) Plant Physiology , vol.116 , Issue.1 , pp. 223-229
    • Lee, S.H.1    Chae, H.S.2    Lee, T.K.3    Kim, S.H.4    Shin, S.H.5    Cho, B.H.6    Cho, S.H.7    Kang, B.G.8    Lee, W.S.9
  • 39
    • 0025139206 scopus 로고
    • 2 activity in rat pancreatic islets
    • Tadayyon, M., Bonney, R. C. and Green, I. C. (1990) Starvation decreases insulin secretion, prostaglandin E2 production and phospholipase A2 activity in rat pancreatic islets. J. Endocrinol. 124, 455-461 CrossRef PubMed (Pubitemid 20070452)
    • (1990) Journal of Endocrinology , vol.124 , Issue.3 , pp. 455-461
    • Tadayyon, M.1    Bonney, R.C.2    Green, I.C.3
  • 40
    • 84869062844 scopus 로고    scopus 로고
    • Roles of acidic phospholipids and nucleotides in regulating membrane binding and activity of a calcium-independent phospholipase A2 isoform
    • CrossRef PubMed
    • Morrison, K., Witte, K., Mayers, J. R., Schuh, A. L. and Audhya, A. (2012) Roles of acidic phospholipids and nucleotides in regulating membrane binding and activity of a calcium-independent phospholipase A2 isoform. J. Biol. Chem. 287, 38824-38834 CrossRef PubMed
    • (2012) J. Biol. Chem. , vol.287 , pp. 38824-38834
    • Morrison, K.1    Witte, K.2    Mayers, J.R.3    Schuh, A.L.4    Audhya, A.5
  • 41
    • 33750941731 scopus 로고    scopus 로고
    • 2: A key regulator of inflammatory signalling and a connector to fibrosis development in atherosclerosis
    • DOI 10.1016/j.bbalip.2006.06.003, PII S1388198106001843
    • Oestvang, J. and Johansen, B. (2006) PhospholipaseA2: a key regulator of inflammatory signalling and a connector to fibrosis development in atherosclerosis. Biochim. Biophys. Acta 1761, 1309-1316 CrossRef PubMed (Pubitemid 44738702)
    • (2006) Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids , vol.1761 , Issue.11 , pp. 1309-1316
    • Oestvang, J.1    Johansen, B.2
  • 42
    • 0842263182 scopus 로고    scopus 로고
    • 2β movements in response to stimulation with insulin secretagogues in INS-1 cells
    • CrossRef PubMed
    • 2β movements in response to stimulation with insulin secretagogues in INS-1 cells. Diabetes. 53 Suppl. 1, S186-S189 CrossRef PubMed
    • (2004) Diabetes. , vol.53 , Issue.SUPPL. 1
    • Bao, S.1    Jin, C.2    Zhang, S.3    Turk, J.4    Ma, Z.5    Ramanadham, S.6
  • 43
    • 0842265868 scopus 로고    scopus 로고
    • 2 in β-Cells
    • Ramanadham, S., Song, H., Bao, S., Hsu, F. F., Zhang, S., Ma, Z., Jin, C. and Turk, J. (2004) Islet complex lipids: involvement in the actions of group VIA calcium-independent phospholipase A2 in β-cells. Diabetes. 53 Suppl. 1, S179-S185 CrossRef PubMed (Pubitemid 38173043)
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 1
    • Ramanadham, S.1    Song, H.2    Bao, S.3    Hsu, F.-F.4    Zhang, S.5    Ma, Z.6    Jin, C.7    Turk, J.8
  • 44
    • 70450240760 scopus 로고    scopus 로고
    • Fatty-acid metabolism is involved in stress-resistance mechanisms of Caenorhabditis elegans
    • CrossRef PubMed
    • Horikawa, M. and Sakamoto, K. (2009) Fatty-acid metabolism is involved in stress-resistance mechanisms of Caenorhabditis elegans. Biochem. Biophys. Res. Commun. 390, 1402-1407 CrossRef PubMed
    • (2009) Biochem. Biophys. Res. Commun. , vol.390 , pp. 1402-1407
    • Horikawa, M.1    Sakamoto, K.2
  • 45
    • 15744386624 scopus 로고    scopus 로고
    • Nuclear hormone receptor NHR-49 controls fat consumption and fatty acid composition in C. elegans
    • CrossRef PubMed
    • Van Gilst, M. R., Hadjivassiliou, H., Jolly, A. and Yamamoto, K. R. (2005) Nuclear hormone receptor NHR-49 controls fat consumption and fatty acid composition in C. elegans. PLoS Biol. 3, e53 CrossRef PubMed
    • (2005) PLoS Biol. , vol.3
    • Van Gilst, M.R.1    Hadjivassiliou, H.2    Jolly, A.3    Yamamoto, K.R.4
  • 46
    • 15744386624 scopus 로고    scopus 로고
    • Nuclear hormone receptor NHR-49 controls fat consumption and fatty acid composition in C-elegans
    • CrossRef
    • Van Gilst, M. R., Hadjivassiliou, H., Jolly, A. and Yamamoto, K. R. (2005) Nuclear hormone receptor NHR-49 controls fat consumption and fatty acid composition in C-elegans. PLoS Biol. 3, 301-312 CrossRef
    • (2005) PLoS Biol. , vol.3 , pp. 301-312
    • Van Gilst, M.R.1    Hadjivassiliou, H.2    Jolly, A.3    Yamamoto, K.R.4
  • 47
    • 84905041609 scopus 로고    scopus 로고
    • A novel kinase regulates dietary restriction-mediated longevity in Caenorhabditis elegans
    • doi: 10.1111/acel.12218
    • Chamoli, M., Singh, A., Malik, Y. and Mukhopadhyay, A. (2014) A novel kinase regulates dietary restriction-mediated longevity in Caenorhabditis elegans. Aging Cell, doi: 10.1111/acel.12218
    • (2014) Aging Cell
    • Chamoli, M.1    Singh, A.2    Malik, Y.3    Mukhopadhyay, A.4
  • 48
    • 0034596988 scopus 로고    scopus 로고
    • A Caenorhabditis elegans MAP kinase kinase, MEK-1, is involved in stress responses
    • CrossRef PubMed
    • Koga, M., Zwaal, R., Guan, K. L., Avery, L. and Ohshima, Y. (2000) A Caenorhabditis elegans MAP kinase kinase, MEK-1, is involved in stress responses. EMBO J. 19, 5148-5156 CrossRef PubMed
    • (2000) EMBO J. , vol.19 , pp. 5148-5156
    • Koga, M.1    Zwaal, R.2    Guan, K.L.3    Avery, L.4    Ohshima, Y.5
  • 49
    • 33751382748 scopus 로고    scopus 로고
    • p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans
    • CrossRef PubMed
    • Troemel, E. R., Chu, S. W., Reinke, V., Lee, S. S., Ausubel, F. M. and Kim, D. H. (2006) p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans. PLoS Genet. 2, e183 CrossRef PubMed
    • (2006) PLoS Genet. , vol.2
    • Troemel, E.R.1    Chu, S.W.2    Reinke, V.3    Lee, S.S.4    Ausubel, F.M.5    Kim, D.H.6
  • 50
    • 0034015979 scopus 로고    scopus 로고
    • A transmembrane guanylyl cyclase (DAF-11) and Hsp90 (DAF-21) regulate a common set of chemosensory behaviors in Caenorhabditis elegans
    • Birnby, D. A., Link, E. M., Vowels, J. J., Tian, H., Colacurcio, P. L. and Thomas, J. H. (2000) A transmembrane guanylyl cyclase (DAF-11) and Hsp90 (DAF-21) regulate a common set of chemosensory behaviors in caenorhabditis elegans. Genetics 155, 85-104 PubMed (Pubitemid 30257112)
    • (2000) Genetics , vol.155 , Issue.1 , pp. 85-104
    • Birnby, D.A.1    Link, E.M.2    Vowels, J.J.3    Tian, H.4    Colacurcio, P.L.5    Thomas, J.H.6
  • 51
    • 0037380570 scopus 로고    scopus 로고
    • daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathway
    • DOI 10.1101/gad.1066503
    • Li, W., Kennedy, S. G. and Ruvkun, G. (2003) daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathway. Genes Dev. 17, 844-858 CrossRef PubMed (Pubitemid 36397373)
    • (2003) Genes and Development , vol.17 , Issue.7 , pp. 844-858
    • Li, W.1    Kennedy, S.G.2    Ruvkun, G.3
  • 52
    • 10544256181 scopus 로고    scopus 로고
    • Control of C. elegans larval development by neuronal expression of a TGF-β homolog
    • DOI 10.1126/science.274.5291.1389
    • Ren, P., Lim, C. S., Johnsen, R., Albert, P. S., Pilgrim, D. and Riddle, D. L. (1996) Control of C. elegans larval development by neuronal expression of a TGF-β homolog. Science 274, 1389-1391 CrossRef PubMed (Pubitemid 26391466)
    • (1996) Science , vol.274 , Issue.5291 , pp. 1389-1391
    • Ren, P.1    Lim, C.-S.2    Johnsen, R.3    Albert, P.S.4    Pilgrim, D.5    Riddle, D.L.6
  • 53
    • 39649094910 scopus 로고    scopus 로고
    • Insulin, cGMP, and TGF-β Signals Regulate Food Intake and Quiescence in C. elegans: A Model for Satiety
    • DOI 10.1016/j.cmet.2008.01.005, PII S1550413108000065
    • You, Y. J., Kim, J., Raizen, D. M. and Avery, L. (2008) Insulin, cGMP, and TGF-β signals regulate food intake and quiescence in C. elegans: a model for satiety. Cell. Metab. 7, 249-257 CrossRef PubMed (Pubitemid 351285528)
    • (2008) Cell Metabolism , vol.7 , Issue.3 , pp. 249-257
    • You, Y.-j.1    Kim, J.2    Raizen, D.M.3    Avery, L.4
  • 54
    • 0037137678 scopus 로고    scopus 로고
    • Regulation of body size and behavioral state of C. elegans by sensory perception and the egl-4 cGMP-dependent protein kinase
    • DOI 10.1016/S0896-6273(02)01093-0
    • Fujiwara, M., Sengupta, P. and McIntire, S. L. (2002) Regulation of body size and behavioral state of C. elegans by sensory perception and the EGL-4 cGMP-dependent protein kinase. Neuron 36, 1091-1102 CrossRef PubMed (Pubitemid 36044510)
    • (2002) Neuron , vol.36 , Issue.6 , pp. 1091-1102
    • Fujiwara, M.1    Sengupta, P.2    McIntire, S.L.3
  • 55
    • 0033824648 scopus 로고    scopus 로고
    • egl-4 acts through a transforming growth factor-β/SMAD pathway in Caenorhabditis elegans to regulate multiple neuronal circuits in response to sensory cues
    • PubMed
    • Daniels, S. A., Ailion, M., Thomas, J. H. and Sengupta, P. (2000) egl-4 acts through a transforming growth factor-β/SMAD pathway in Caenorhabditis elegans to regulate multiple neuronal circuits in response to sensory cues. Genetics 156, 123-141 PubMed
    • (2000) Genetics , vol.156 , pp. 123-141
    • Daniels, S.A.1    Ailion, M.2    Thomas, J.H.3    Sengupta, P.4
  • 57
    • 34248334659 scopus 로고    scopus 로고
    • Low density lipoprotein undergoes oxidation within lysosomes in cells
    • DOI 10.1161/CIRCRESAHA.107.151704
    • Wen, Y. and Leake, D. S. (2007) Low density lipoprotein undergoes oxidation within lysosomes in cells. Circ. Res. 100, 1337-1343 CrossRef PubMed (Pubitemid 46742924)
    • (2007) Circulation Research , vol.100 , Issue.9 , pp. 1337-1343
    • Wen, Y.1    Leake, D.S.2
  • 58
    • 0030776478 scopus 로고    scopus 로고
    • The DAF-3 Smad protein antagonizes TGF-β-related receptor signaling in the Caenorhabditis elegans dauer pathway
    • Patterson, G. I., Koweek, A., Wong, A., Liu, Y. and Ruvkun, G. (1997) The DAF-3 Smad protein antagonizes TGF-β-related receptor signaling in the Caenorhabditis elegans dauer pathway. Genes Dev. 11, 2679-2690 CrossRef PubMed (Pubitemid 27452391)
    • (1997) Genes and Development , vol.11 , Issue.20 , pp. 2679-2690
    • Patterson, G.I.1    Koweek, A.2    Wong, A.3    Liu, Y.4    Ruvkun, G.5
  • 60
    • 84860545577 scopus 로고    scopus 로고
    • Coordinate regulation of lipid metabolism by novel nuclear receptor partnerships
    • CrossRef PubMed
    • Pathare, P. P., Lin, A., Bornfeldt, K. E., Taubert, S. and Van Gilst, M. R. (2012) Coordinate regulation of lipid metabolism by novel nuclear receptor partnerships. PLoS Genet. 8, e1002645 CrossRef PubMed
    • (2012) PLoS Genet. , vol.8
    • Pathare, P.P.1    Lin, A.2    Bornfeldt, K.E.3    Taubert, S.4    Van Gilst, M.R.5
  • 61
    • 80051516676 scopus 로고    scopus 로고
    • Novel functions of lipid-binding protein 5 in Caenorhabditis elegans fat metabolism
    • CrossRef PubMed This work was supported by the Major State Basic Research Program of P.R. China [grant numbers 2011CB910203 and 2010CB833701].
    • Xu, M., Joo, H. J. and Paik, Y. K. (2011) Novel functions of lipid-binding protein 5 in Caenorhabditis elegans fat metabolism. J. Biol. Chem. 286, 28111-28118 CrossRef PubMed This work was supported by the Major State Basic Research Program of P.R. China [grant numbers 2011CB910203 and 2010CB833701].
    • (2011) J. Biol. Chem. , vol.286 , pp. 28111-28118
    • Xu, M.1    Joo, H.J.2    Paik, Y.K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.