In silico investigation of traditional chinese medicine compounds to inhibit human histone deacetylase 2 for patients with Alzheimer's disease

BioMed Research International

Volumn 2014, Issue , 2014, Pages

  Hung, Tzu Chieh ^a   Lee, Wen Yuan ^a,b,c   Chen, Kuen Bao ^a,b,c   Chan, Yueh Chiu ^b   Lee, Cheng Chun ^b   Chen, Calvin Yu Chian ^a,b,c,d  

^a ASIA UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

BONTL FERULATE; CHINESE DRUG; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE INHIBITOR; MONOMETHYLCURCUMIN; NATURAL PRODUCT; NINGPOSIDE C; SPINACETIN; UNCLASSIFIED DRUG; YAKUCHINONE B; ENZYME INHIBITOR; HDAC2 PROTEIN, HUMAN; LIGAND;

ALZHEIMER DISEASE; ARTICLE; BAYES THEOREM; BIOLOGICAL ACTIVITY; CHINESE MEDICINE; COMPUTER MODEL; CONTROLLED STUDY; DATA BASE; DRUG STRUCTURE; ENZYME INHIBITION; HYDROGEN BOND; HYDROPHOBICITY; IC 50; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MULTIPLE LINEAR REGRESSION ANALYSIS; PREDICTION; PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; SUPPORT VECTOR MACHINE; ANTAGONISTS AND INHIBITORS; CHEMISTRY; COMPUTER SIMULATION; HUMAN; PATHOLOGY; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

ALZHEIMER DISEASE; COMPUTER SIMULATION; ENZYME INHIBITORS; HISTONE DEACETYLASE 2; HUMANS; LIGANDS; MEDICINE, CHINESE TRADITIONAL; MOLECULAR DOCKING SIMULATION; MOLECULAR DYNAMICS SIMULATION; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; SUPPORT VECTOR MACHINES;

EID: 84904103306     PISSN: 23146133     EISSN: 23146141     Source Type: Journal    
DOI: 10.1155/2014/769867     Document Type: Article

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