A novel series of l-2-benzyloxycarbonylamino-8-(2-pyridyl)- disulfidyloctanoic acid derivatives as histone deacetylase inhibitors: Design, synthesis and molecular modeling study

European Journal of Medicinal Chemistry

Volumn 52, Issue , 2012, Pages 111-122

  Huang, Dawei ^a   Li, Xiaohui ^a   Wei, Yingdong ^a   Xiu, Zhilong ^a  

^a DALIAN UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

Docking; Histone deacetylase; Histone deacetylase inhibitor; Molecular dynamics

Indexed keywords

2 BENZOYLOXYCARBONYLAMINO 8 (2 PYRIDYL)DISULFIDYLOCTANOIC ACID DERIVATIVE; HISTONE DEACETYLASE; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE INHIBITOR; OCTANOIC ACID DERIVATIVE; UNCLASSIFIED DRUG; ZINC ION;

ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR MODEL; STRUCTURE ANALYSIS;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CHEMISTRY TECHNIQUES, SYNTHETIC; DRUG DESIGN; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE INHIBITORS; HUMANS; MOLECULAR DYNAMICS SIMULATION; OCTANOIC ACIDS; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

EID: 84860334379     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.03.009     Document Type: Article

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