Benzimidazole and imidazole inhibitors of histone deacetylases: Synthesis and biological activity

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 10, 2010, Pages 3138-3141

  Bressi, Jerome C ^a   Jong, Ron de ^a   Wu, Yiqin ^a   Jennings, Andy J ^a   Brown, Jason W ^a   O'Connell, Shawn ^a   Tari, Leslie W ^a   Skene, Robert J ^a   Vu, Phong ^a   Navre, Marc ^a   Cao, Xiaodong ^a   Gangloff, Anthony R ^a  

^a Takeda San Diego Inc   (United States)

Author keywords

HDAC; Histone deacetylase inhibitors; Oncology

Indexed keywords

2 (3 BROMOPHENYL) 1,4,5 TRISUBSTITUTED IH IMIDAZOLE; 3 (3 FORMYLPHENYL)ACRYLIC ACID; 3 [3 (1 SUBSTITUTED 1H BENZOIMIDAZOL 2 YL)PHENYL]ACRYLIC ACID; BENZIMIDAZOLE DERIVATIVE; CYCLIN DEPENDENT KINASE INHIBITOR 1; HISTONE H3; HISTONE H4; IMIDAZOLE DERIVATIVE; N HYDROXY 3 [3 (1 SUBSTITUTED 1H BENZOIMIDAZOL 2 YL)PHENYL]ACRYLAMIDE DERIVATIVE; N HYDROXY 3 [3 (1,4,5 TRISUBSTITUTED 1H IMIDAZOL 2 YL)PHENYL]ACRYLAMIDE DERIVATIVE; N HYDROXY 3 [3 (2,3,5 TRISUBSTITUTED 3H IMIDAZOL 4 YL)PHENYL]ACRYLAMIDE; N SUBSTITUTED 1,2 DIAMINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CANCER INHIBITION; CONTROLLED STUDY; DRUG ACETYLATION; DRUG DESIGN; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; TUMOR XENOGRAFT;

ACETYLATION; ANIMALS; BENZIMIDAZOLES; CELL LINE, TUMOR; HISTONE DEACETYLASE INHIBITORS; HISTONE DEACETYLASES; HL-60 CELLS; HUMANS; IMIDAZOLES; MICE; MICE, NUDE; STRUCTURE-ACTIVITY RELATIONSHIP; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 77952105264     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.03.092     Document Type: Article

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