Radiosensitization of human leukemic HL-60 cells by ATR kinase inhibitor (VE-821): Phosphoproteomic analysis

International Journal of Molecular Sciences

Volumn 15, Issue 7, 2014, Pages 12007-12026

  Šalovská, Barbora ^a   Fabrik, Ivo ^b   Ďurišová, Kamila ^b   Link, Marek ^b   Vávrová, Jiřina ^b   Řezáčová, Martina ^a   Tichý, Aleš ^b  

^a CHARLES UNIVERSITY   (Czech Republic)

^b UNIVERSITY OF DEFENCE   (Czech Republic)

Author keywords

ATR kinase; DNA damage response; HL 60 cells; Leukemia; Quantitative phosphoproteomics; Radio sensitization; SILAC; Small molecule kinase inhibitors; Titanium dioxide chromatography; VE 821

Indexed keywords

3 AMINO 6 (4 (METHYLSULFONYL)PHENYL) N PHENYLPYRAZINE 2 CARBOXAMIDE; ATR PROTEIN; CHECKPOINT KINASE 1; PHOSPHOPEPTIDE; PROTEIN SERINE THREONINE KINASE INHIBITOR; SERINE; UNCLASSIFIED DRUG; VE 821; 3-AMINO-6-(4-(METHYLSULFONYL)PHENYL)-N-PHENYLPYRAZINE-2-CARBOXAMIDE; ATM PROTEIN; ATR PROTEIN, HUMAN; PROTEIN KINASE INHIBITOR; PROTEOME; PYRAZINE DERIVATIVE; RADIOSENSITIZING AGENT; SULFONE;

APOPTOSIS; ARTICLE; CELL CULTURE; CELL CYCLE REGULATION; CONTROLLED STUDY; CYTOLYSIS; DNA REPAIR; DOWN REGULATION; ELECTROPHORESIS; FRACTIONATION; GAMMA IRRADIATION; GENE EXPRESSION; GENE ONTOLOGY; HL 60 CELL LINE; HUMAN; HUMAN CELL; HYDROPHILIC INTERACTION CHROMATOGRAPHY; IONIZING RADIATION; LEUKEMIA CELL; PROMYELOCYTIC LEUKEMIA; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PROTEOMICS; RADIOSENSITIZATION; SIGNAL TRANSDUCTION; TANDEM MASS SPECTROMETRY; UPREGULATION; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; GAMMA RADIATION; METABOLISM; PHOSPHORYLATION; RADIATION RESPONSE; TUMOR CELL LINE;

ATAXIA TELANGIECTASIA MUTATED PROTEINS; CELL LINE, TUMOR; GAMMA RAYS; HUMANS; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEOME; PYRAZINES; RADIATION-SENSITIZING AGENTS; SULFONES;

EID: 84904052266     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms150712007     Document Type: Article

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