Inhibition of ATR kinase with the selective inhibitor VE-821 results in radiosensitization of cells of promyelocytic leukaemia (HL-60)

Radiation and Environmental Biophysics

Volumn 52, Issue 4, 2013, Pages 471-479

  Vávrová, Jiřina ^a   Zárybnická, Lenka ^a   Lukášová, Emilie ^c   Řezáčová, Martina ^b   Novotná, Eva ^a   Šinkorová, Zuzana ^a   Tichý, Aleš ^a   Pejchal, Jaroslav ^a   Ďurišová, Kamila ^a  

^a UNIVERSITY OF DEFENCE   (Czech Republic)

^b CHARLES UNIVERSITY   (Czech Republic)

^c INSTITUTE OF BIOPHYSICS   (Czech Republic)

Author keywords

ATM and ATR inhibitors; Ionizing radiation; KU55933; Radiosensitization; VE 821

Indexed keywords

FUNCTIONAL PROTEINS; GAMMA IRRADIATION; KU55933; NON-IRRADIATED CELLS; RADIO-SENSITIZATION; SELECTIVE INHIBITORS; SPECIFIC INHIBITORS; VE-821;

AMINO ACIDS; CALCIUM ION SENSORS; CELL DEATH; IONIZING RADIATION; IRRADIATION; PHOSPHORYLATION; PROTEINS; RADIATION DAMAGE; REPAIR;

ENZYMES;

2-MORPHOLIN-4-YL-6-THIANTHREN-1-YL-PYRAN-4-ONE; 3-AMINO-6-(4-(METHYLSULFONYL)PHENYL)-N-PHENYLPYRAZINE-2-CARBOXAMIDE; ATM PROTEIN; ATR PROTEIN, HUMAN; MORPHOLINE DERIVATIVE; PROTEIN KINASE INHIBITOR; PYRAZINE DERIVATIVE; PYRONE DERIVATIVE; SULFONE;

ANTAGONISTS AND INHIBITORS; APOPTOSIS; DNA REPAIR; DRUG EFFECTS; G2 PHASE CELL CYCLE CHECKPOINT; HL-60 CELL LINE; HUMAN; PATHOLOGY; PROMYELOCYTIC LEUKEMIA; RADIATION TOLERANCE;

APOPTOSIS; ATAXIA TELANGIECTASIA MUTATED PROTEINS; DNA REPAIR; G2 PHASE CELL CYCLE CHECKPOINTS; HL-60 CELLS; HUMANS; LEUKEMIA, PROMYELOCYTIC, ACUTE; MORPHOLINES; PROTEIN KINASE INHIBITORS; PYRAZINES; PYRONES; RADIATION TOLERANCE; SULFONES;

MLCS; MLOWN;

EID: 84887118586     PISSN: 0301634X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00411-013-0486-5     Document Type: Article

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